当前位置： SCI文献检索 > PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA期刊下所有文献 > The relationship between evolutionary and physiological variation in hemoglobin.

The relationship between evolutionary and physiological variation in hemoglobin.

Abstract：

:Physiological and evolutionary adaptations operate at very different time scales. Nevertheless, there are reasons to believe there should be a strong relationship between the two, as together they modify the phenotype. Physiological adaptations change phenotype by altering certain microscopic parameters; evolutionary adaptation can either alter genetically these same parameters or others to achieve distinct or similar ends. Although qualitative discussions of this relationship abound, there has been very little quantitative analysis. Here, we use the hemoglobin molecule as a model system to quantify the relationship between physiological and evolutionary adaptations. We compare measurements of oxygen saturation curves of 25 mammals with those of human hemoglobin under a wide range of physiological conditions. We fit the data sets to the Monod-Wyman-Changeux model to extract microscopic parameters. Our analysis demonstrates that physiological and evolutionary change act on different parameters. The main parameter that changes in the physiology of hemoglobin is relatively constant in evolution, whereas the main parameter that changes in the evolution of hemoglobin is relatively constant in physiology. This orthogonality suggests continued selection for physiological adaptability and hints at a role for this adaptability in evolutionary change.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Milo R,Hou JH,Springer M,Brenner MP,Kirschner MW

doi

10.1073/pnas.0707673104

subject

Has Abstract

pub_date

2007-10-23 00:00:00

pages

16998-7003

issue

43

eissn

0027-8424

issn

1091-6490

pii

0707673104

journal_volume

104

pub_type

杂志文章

相关文献

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA文献大全
  • Multicopy plasmid with a structure related to the polyoma virus genome.

    abstract：:In a subclone derived from mouse L(tk-) cells, we found a plasmid present in a high copy number (greater than 5000 copies per cell) that was stably maintained extrachromosomally without any cytopathic effect to the host cells. This plasmid, termed L factor, has two forms: 5.3 and 5.5 kilobase pairs. DNA sequencing and...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.84.7.1789

    authors： Kusano T,Uehara H,Saito H,Segawa K,Oishi M

    更新日期：1987-04-01 00:00:00

  • Target neuron-specific process formation by embryonic mesencephalic dopamine neurons in vitro.

    abstract：:Mesencephalic dopamine neurons from the embryonic mouse brain were dissociated, aggregated in vitro in the presence of dissociated cells from appropriate or inappropriate target neuron areas, and visualized by the Falck-Hillarp histofluorescence technique after exposure to 1 microM exogenous dopamine. When aggregated ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.78.2.1264

    authors： Hemmendinger LM,Garber BB,Hoffmann PC,Heller A

    更新日期：1981-02-01 00:00:00

  • Impaired apoptosis, extended duration of immune responses, and a lupus-like autoimmune disease in IEX-1-transgenic mice.

    abstract：:Susceptibility of activated T cells to apoptosis must be tightly regulated to ensure sufficient T cell progeny for an effective response, while allowing a rapid depletion of them at the end of the immune response. We show here that a previously isolated, NF-kappa B/rel target gene IEX-1 (Immediate Early response gene ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.022326699

    authors： Zhang Y,Schlossman SF,Edwards RA,Ou CN,Gu J,Wu MX

    更新日期：2002-01-22 00:00:00

  • Spatiotemporal activation of the C/EBPβ/δ-secretase axis regulates the pathogenesis of Alzheimer's disease.

    abstract：:Alzheimer's disease (AD) neuropathological hallmarks include senile plaques with aggregated amyloid beta as a major component, neurofibrillary tangles (NFT) containing truncated and hyperphosphorylated Tau, extensive neuronal loss, and chronic neuroinflammation. However, the key molecular mechanism that dominates the ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1815915115

    authors： Wang H,Liu X,Chen S,Ye K

    更新日期：2018-12-26 00:00:00

  • Heparin-binding growth factor type 1 (acidic fibroblast growth factor): a potential biphasic autocrine and paracrine regulator of hepatocyte regeneration.

    abstract：:Heparin-binding growth factor type 1 (HBGF-1; sometimes termed acidic fibroblast growth factor) is potentially an important factor in liver regeneration. HBGF-1 alone (half-maximal effect at 60 pM) stimulated hepatocyte DNA synthesis and bound to a high-affinity receptor (Kd = 62 pM; 5000 per cell). Epidermal growth f...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.86.19.7432

    authors： Kan M,Huang JS,Mansson PE,Yasumitsu H,Carr B,McKeehan WL

    更新日期：1989-10-01 00:00:00

  • Interspecific competition slows range expansion and shapes range boundaries.

    abstract：:Species expanding into new habitats as a result of climate change or human introductions will frequently encounter resident competitors. Theoretical models suggest that such interspecific competition can alter the speed of expansion and the shape of expanding range boundaries. However, competitive interactions are rar...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.2009701117

    authors： Legault G,Bitters ME,Hastings A,Melbourne BA

    更新日期：2020-10-27 00:00:00

  • Pharmacokinetics, biodistribution, and stability of oligodeoxynucleotide phosphorothioates in mice.

    abstract：:We describe preliminary studies of the pharmacokinetics, biodistribution, and excretion of an oligodeoxy-nucleotide phosphorothioate ([S]oligonucleotide) in mice. After either intravenous or intraperitoneal administration of a single dose (30 mg/kg of body weight), [S]oligonucleotide (35S-labeled at each internucleoti...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.88.17.7595

    authors： Agrawal S,Temsamani J,Tang JY

    更新日期：1991-09-01 00:00:00

  • Correlation of individual papilloma latency time with DNA adducts, 8-hydroxy-2'-deoxyguanosine, and the rate of DNA synthesis in the epidermis of mice treated with 7,12-dimethylbenz[alpha]anthracene.

    abstract：:The question was addressed whether the risk of cancer of an individual in a heterogeneous population can be predicted on the basis of measurable biochemical and biological variables postulated to be associated with the process of chemical carcinogenesis. Using the skin tumor model with outbred male NMRI mice, the late...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.92.13.5900

    authors： Fischer WH,Lutz WK

    更新日期：1995-06-20 00:00:00

  • Functional correspondence between 30S ribosomal proteins of Escherichia coli and Bacillus stearothermophilus.

    abstract：:30S ribosomal proteins from Bacillus stearothermophilus (B. proteins) have been fractionated and characterized with respect to their ability to replace various E. coli 30S proteins (E. proteins) in the E. coli 30S ribosome reconstitution system. The functional counterparts of all the E. proteins, except S1, S6, S9, an...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.70.3.944

    authors： Higo K,Held W,Kahan L,Nomura M

    更新日期：1973-03-01 00:00:00

  • DNA-mediated redox signaling for transcriptional activation of SoxR.

    abstract：:In enteric bacteria, the cellular response to oxidative stress is activated by oxidation of the iron-sulfur clusters in SoxR, which then induces transcription of soxS, turning on a battery of defense genes. Here we demonstrate both in vitro and in cells that activation of SoxR can occur in a DNA-mediated reaction with...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0906429106

    authors： Lee PE,Demple B,Barton JK

    更新日期：2009-08-11 00:00:00

  • Glutamate receptors of Drosophila melanogaster: cloning of a kainate-selective subunit expressed in the central nervous system.

    abstract：:We report the isolation and functional characterization of cDNAs encoding a Drosophila kainate-selective glutamate receptor. The deduced mature 964-residue protein (DGluR-I) is 108,482 Da and exhibits significant homology to mammalian glutamate receptor subunits. Injection of DGluR-I cRNA into Xenopus oocytes generate...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.89.21.10484

    authors： Ultsch A,Schuster CM,Laube B,Schloss P,Schmitt B,Betz H

    更新日期：1992-11-01 00:00:00

  • Plant defense genes are regulated by ethylene.

    abstract：:One of the earliest detectable events during plant-pathogen interaction is a rapid increase in ethylene biosynthesis. This gaseous plant stress hormone may be a signal for plants to activate defense mechanisms against invading pathogens such as bacteria, fungi, and viruses. The effect of ethylene on four plant genes i...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.84.15.5202

    authors： Ecker JR,Davis RW

    更新日期：1987-08-01 00:00:00

  • Cocaine vaccines: antibody protection against relapse in a rat model.

    abstract：:The efficacy of active immunization with the cocaine immunogen GNC-keyhole limpet hemocyanin (KLH) in preventing cocaine self-administration reinstatement was assessed in rats. An animal model of relapse was used where rats were trained to self-administer cocaine, subjected to a period of extinction by substituting th...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.97.11.6202

    authors： Carrera MR,Ashley JA,Zhou B,Wirsching P,Koob GF,Janda KD

    更新日期：2000-05-23 00:00:00

  • Effects of intracellular expression of anti-huntingtin antibodies of various specificities on mutant huntingtin aggregation and toxicity.

    abstract：:We have generated eight mAbs (MW1-8) that bind the epitopes polyglutamine (polyQ), polyproline (polyP), or the C terminus of exon 1 in huntingtin (htt) protein. In the brains of Huntington's disease (HD) mouse models, the anti-polyQ mAbs bind to various cytoplasmic compartments, whereas the anti-polyP and anti-C termi...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.022631799

    authors： Khoshnan A,Ko J,Patterson PH

    更新日期：2002-01-22 00:00:00

  • Mixed-power scaling of whole-plant respiration from seedlings to giant trees.

    abstract：:The scaling of respiratory metabolism with body mass is one of the most pervasive phenomena in biology. Using a single allometric equation to characterize empirical scaling relationships and to evaluate alternative hypotheses about mechanisms has been controversial. We developed a method to directly measure respiratio...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0902554107

    authors： Mori S,Yamaji K,Ishida A,Prokushkin SG,Masyagina OV,Hagihara A,Hoque AT,Suwa R,Osawa A,Nishizono T,Ueda T,Kinjo M,Miyagi T,Kajimoto T,Koike T,Matsuura Y,Toma T,Zyryanova OA,Abaimov AP,Awaya Y,Araki MG,Kawasaki T

    更新日期：2010-01-26 00:00:00

  • Effects of dialyzable transfer factor in patients with breast cancer.

    abstract：:Five patients with advanced breast cancer were treated with pooled dialyzable transfer factor from healthy adult donors. The period of treatment ranged from 21 to 310 days, the total dose from 20 to 257 ml. Transfer factor did not elicit inflammatory or hypersensitivity reactions or detectable formation of antibody to...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.71.6.2319

    authors： Oettgen HF,Old LJ,Farrow JH,Valentine FT,Lawrence HS,Thomas L

    更新日期：1974-06-01 00:00:00

  • Vasopressin modulates the spontaneous electrical activity in aortic cells (line A7r5) by acting on three different types of ionic channels.

    abstract：:A7r5 smooth muscle (aorta) cells have a spontaneous electrical activity. Application of vasopressin produces a hyperpolarization accompanied by an interruption of the spontaneous activity, which is followed by a depolarization associated with a recovery of the spiking activity. Vasopressin action is produced by an act...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.85.23.9365

    authors： Van Renterghem C,Romey G,Lazdunski M

    更新日期：1988-12-01 00:00:00

  • Identification of a ubiquitin-binding interface using Rosetta and DEER.

    abstract：:ExoU is a type III-secreted cytotoxin expressing A2 phospholipase activity when injected into eukaryotic target cells by the bacterium Pseudomonas aeruginosa The enzymatic activity of ExoU is undetectable in vitro unless ubiquitin, a required cofactor, is added to the reaction. The role of ubiquitin in facilitating Ex...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1716861115

    authors： Tessmer MH,Anderson DM,Pickrum AM,Riegert MO,Moretti R,Meiler J,Feix JB,Frank DW

    更新日期：2018-01-16 00:00:00

  • Control of A-system amino acid transport by a second regulatory gene R2 in Chinese hamster ovary cells CHO-K1 and the possible connection of this gene with insulin activity.

    abstract：:Evidence based on a study of alanine-resistant (Alar), constitutive mutants of CHO-K1 cells and the conditions that favor stimulation of the A system of amino acid activity supports the model that the A system of amino acid transport in these cells is repressible and under negative control of regulatory gene R1. In th...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.84.22.8040

    authors： Moffett J,Périer F,Jones M,Englesberg E

    更新日期：1987-11-01 00:00:00

  • Discrete fracture patterns of virus shells reveal mechanical building blocks.

    abstract：:Viral shells are self-assembled protein nanocontainers with remarkable material properties. They combine simplicity of construction with toughness and complex functionality. These properties make them interesting for bionanotechnology. To date we know little about how virus structure determines assembly pathways and s...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1105586108

    authors： Ivanovska IL,Miranda R,Carrascosa JL,Wuite GJ,Schmidt CF

    更新日期：2011-08-02 00:00:00

  • Immune response to p53 is dependent upon p53/HSP70 complexes in breast cancers.

    abstract：:Overexpression of the p53 protein, resulting from gene mutations that increase protein stability, has been detected in greater than 25% of primary human breast cancers. In addition, approximately 10% of breast cancer patients have circulating antibodies to the p53 protein. In this study, the anti-p53 humoral response ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.89.8.3439

    authors： Davidoff AM,Iglehart JD,Marks JR

    更新日期：1992-04-15 00:00:00

  • Systematically perturbed folding patterns of amyotrophic lateral sclerosis (ALS)-associated SOD1 mutants.

    abstract：:Amyotrophic lateral sclerosis is a neurodegenerative syndrome associated with 114 mutations in the gene encoding the cytosolic homodimeric enzyme Cu/Zn superoxide dismutase (SOD). In this article, we report that amyotrophic lateral sclerosis-associated SOD mutations with distinctly different disease progression can be...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0501957102

    authors： Lindberg MJ,Byström R,Boknäs N,Andersen PM,Oliveberg M

    更新日期：2005-07-12 00:00:00

  • Chromatographic isolation of the hemagglutinin polypeptides from influenza virus vaccine and determination of their amino-terminal sequences.

    abstract：:The influenza virus hemagglutinin polypeptides, HA1 and HA2, have been purified by gel filtration in the presence of sodium dodecyl sulfate from a vaccine preparation of the recombinant strain Heq1N2. Use of this technique for purification of the hemagglutinin polypeptides eliminated the need for proteolytic agents fo...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.73.1.238

    authors： Bucher DJ,Li SS,Kehoe JM,Kilbourne ED

    更新日期：1976-01-01 00:00:00

  • Targeted overexpression of protein kinase C beta2 isoform in myocardium causes cardiomyopathy.

    abstract：:Increased cardiovascular mortality occurs in diabetic patients with or without coronary artery disease and is attributed to the presence of diabetic cardiomyopathy. One potential mechanism is hyperglycemia that has been reported to activate protein kinase C (PKC), preferentially the beta isoform, which has been associ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.94.17.9320

    authors： Wakasaki H,Koya D,Schoen FJ,Jirousek MR,Ways DK,Hoit BD,Walsh RA,King GL

    更新日期：1997-08-19 00:00:00

  • Wild-type p53 is a cell cycle checkpoint determinant following irradiation.

    abstract：:Cell cycle checkpoints appear to contribute to an increase in cell survival and a decrease in abnormal heritable genetic changes following exposure to DNA damaging agents. Though several radiation-sensitive yeast mutants have been identified, little is known about the genes that control these responses in mammalian ce...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.89.16.7491

    authors： Kuerbitz SJ,Plunkett BS,Walsh WV,Kastan MB

    更新日期：1992-08-15 00:00:00

  • Erk1/2 inactivation promotes a rapid redistribution of COP1 and degradation of COP1 substrates.

    abstract：:Anthrax lethal toxin (LT) is a protease virulence factor produced by Bacillus anthracis that is required for its pathogenicity. LT treatment causes a rapid degradation of c-Jun protein that follows inactivation of the MEK1/2-Erk1/2 signaling pathway. Here we identify COP1 as the ubiquitin E3 ligase that is essential f...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1913698117

    authors： Ouyang W,Guo P,Takeda K,Fu Q,Fang H,Frucht DM

    更新日期：2020-02-25 00:00:00

  • Moderate increase in histone acetylation activates the mouse mammary tumor virus promoter and remodels its nucleosome structure.

    abstract：:The mouse mammary tumor virus (MMTV) promoter is regulated by steroid hormones through a hormone-responsive region that is organized in a positioned nucleosome. Hormone induction leads to a structural change of this nucleosome which makes its DNA more sensitive to cleavage by DNase I and enables simultaneous binding o...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.93.20.10741

    authors： Bartsch J,Truss M,Bode J,Beato M

    更新日期：1996-10-01 00:00:00

  • Lumsden-Wilson theory of gene-culture coevolution.

    abstract：:A critique is presented of the Lumsden-Wilson theory [Lumsden, C. J. & Wilson, E. O. (1980) Proc. Natl. Acad. Sci. USA 77, 4382-4386] of the transmission of cultural traits. An analysis of the underlying assumptions and the mathematical nature of the theory clarifies its essentially reductionist and determinist qualit...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.78.6.3976

    authors： Alper JS,Lange RV

    更新日期：1981-06-01 00:00:00

  • Expression and nuclear envelope localization of biologically active fusion glycoprotein gB of herpes simplex virus in mammalian cells using cloned DNA.

    abstract：:Herpes simplex virus (HSV) is known to bud from the inner membrane of the nuclear envelope. The structural gene for the glycoprotein gB, which is essential for virus entry and cell fusion induced by HSV type 1, has been cloned in a transient expression vector containing the adenovirus major late promoter, tripartite l...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.84.16.5675

    authors： Ali MA,Butcher M,Ghosh HP

    更新日期：1987-08-01 00:00:00

  • Cytochrome P450c17 (steroid 17 alpha-hydroxylase/17,20 lyase): cloning of human adrenal and testis cDNAs indicates the same gene is expressed in both tissues.

    abstract：:P450c17 is the single enzyme mediating both 17 alpha-hydroxylase (steroid 17 alpha-monooxygenase, EC 1.14.99.9) and 17,20 lyase activities in the synthesis of steroid hormones. It has been suggested that different P450c17 isozymes mediate these activities in the adrenal gland and testis. We sequenced 423 of the 509 am...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.84.2.407

    authors： Chung BC,Picado-Leonard J,Haniu M,Bienkowski M,Hall PF,Shively JE,Miller WL

    更新日期：1987-01-01 00:00:00