Heparin-binding growth factor type 1 (acidic fibroblast growth factor): a potential biphasic autocrine and paracrine regulator of hepatocyte regeneration.

abstract：:Following antigen stimulation, naïve T cells differentiate into memory cells that mediate antigen clearance more efficiently upon repeat encounter. Donor-specific tolerance can be achieved in a subset of transplant recipients, but some of these grafts are rejected after years of stability, often following infections. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miller ML,McIntosh CM,Wang Y,Chen L,Wang P,Lei YM,Daniels MD,Watkins E,Mora Solano C,Chong AS,Alegre ML

更新日期：2019-11-19 00:00:00

abstract：:S-adenosyl-L-methionine (SAM)-dependent O-methyltransferases (OMTs) catalyze the methylation of hydroxycinnamic acid derivatives for the synthesis of methylated plant polyphenolics, including lignin. The distinction in the extent of methylation of lignins in angiosperms and gymnosperms, mediated by substrate-specific ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li L,Popko JL,Zhang XH,Osakabe K,Tsai CJ,Joshi CP,Chiang VL

更新日期：1997-05-13 00:00:00

abstract：:Optimal flowering time is critical to the success of modern agriculture. Sorghum is a short-day tropical species that exhibits substantial photoperiod sensitivity and delayed flowering in long days. Genotypes with reduced photoperiod sensitivity enabled sorghum's utilization as a grain crop in temperate zones worldwid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murphy RL,Klein RR,Morishige DT,Brady JA,Rooney WL,Miller FR,Dugas DV,Klein PE,Mullet JE

更新日期：2011-09-27 00:00:00

abstract：:In order to determine the chemical features of human placental lactogen (hPL) necessary for its biologic activity we prepared the following fragments from the plasmin-cleaved hormone: reduced and alkylated 1--134, reduced and alkylated 141--191, and a 1--134 dimer joined through the single cysteinyl residue at positio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Russell J,Sherwood LM,Kowalski K,Schneider AB

更新日期：1979-03-01 00:00:00

abstract：:In North America there are two generally recognized pathotypes (pathotypes 1 and 2) of the fungus Entomophaga grylli which show host-preferential infection of grasshopper subfamilies. Pathotype 3, discovered in Australia, has a broader grasshopper host range and was considered to be a good biocontrol agent. Between 19...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bidochka MJ,Walsh SR,Ramos ME,St Leger RJ,Silver JC,Roberts DW

更新日期：1996-01-23 00:00:00

abstract：:The transcription and processing of mitochondrial 21S rRNA in a petite strain of Saccharomyces cerevisiae has been examined by electron microscopic analysis of R-loop hybrids and by hybridization of labeled mitochondrial DNA probes to RNA transferred to diazobenzyloxymethyl paper. We have shown the presence of a large...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Merten S,Synenki RM,Locker J,Christianson T,Rabinowitz M

更新日期：1980-03-01 00:00:00

abstract：:Corticotropin (ACTH) and melanotropin (MSH) peptides (melanocortins) are produced not only in the pituitary but also in the brain, with highest concentrations in the arcuate nucleus of the hypothalamus and the commisural nucleus of the solitary tract. We have identified a receptor for MSH and ACTH peptides that is spe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roselli-Rehfuss L,Mountjoy KG,Robbins LS,Mortrud MT,Low MJ,Tatro JB,Entwistle ML,Simerly RB,Cone RD

更新日期：1993-10-01 00:00:00

abstract：:Retinoic acid receptor beta (RAR beta), which codes for a nuclear receptor for retinoic acid, is localized in a chromosomal region frequently deleted in lung cancer cells. The gene is expressed in normal lung tissue and in the majority of the cell lines derived from lung tumors but not in most of the lines derived fro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Houle B,Rochette-Egly C,Bradley WE

更新日期：1993-02-01 00:00:00

abstract：:Anti-idiotype antibodies (Ab2) were purified from a cancer patient treated with NP-4, a murine monoclonal antibody to carcinoembryonic antigen (CEA). These Ab2 were specific for NP-4 and inhibited the binding between NP-4 and CEA. BALB/c mice immunized with these human Ab2 produced anti-Ab2 antibodies that were also r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Losman MJ,Hansen HJ,Sharkey RM,Goldenberg DM,Monestier M

更新日期：1991-04-15 00:00:00

abstract：:Exposures to ambient and household fine-particulate matter (PM2.5) together are among the largest single causes of premature mortality in India according to the Global Burden of Disease Studies (GBD). Several recent investigations have estimated that household emissions are the largest contributor to ambient PM2.5 exp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chowdhury S,Dey S,Guttikunda S,Pillarisetti A,Smith KR,Di Girolamo L

更新日期：2019-05-28 00:00:00

abstract：:Evidence is presented for the simultaneous release of platelet-activating factor (PAF-acether) and of its deacetylated derivative (lyso-PAF-acether) from hog leukocytes. On the basis of spectroscopy and chemical reactions, the structure of O-deacetyl-PAF is shown to be 1-O-alkylglyceryl 3-phosphorylcholine, an alkyl e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Polonsky J,Tencé M,Varenne P,Das BC,Lunel J,Benveniste J

更新日期：1980-12-01 00:00:00

abstract：:Some monoclonal antibodies (mAbs) against interleukin (IL) 1 alpha have been found to activate antigen-presenting cells (APC, human peripheral blood monocytes and B lymphocytes), so that unstimulated T lymphocytes cultured with them are induced to proliferate and secrete IL-2. Control mAbs of the same isotypes and mAb...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eugui EM,Almquist SJ

更新日期：1990-02-01 00:00:00

abstract：:Human telomeres terminate with a single-stranded 3' G overhang, which can be recognized as a DNA damage site by replication protein A (RPA). The protection of telomeres (POT1)/POT1-interacting protein 1 (TPP1) heterodimer binds specifically to single-stranded telomeric DNA (ssTEL) and protects G overhangs against RPA ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ray S,Bandaria JN,Qureshi MH,Yildiz A,Balci H

更新日期：2014-02-25 00:00:00

abstract：:Using short-term cultures of hamster embryo cells, we have examined the effects of the free-radical scavenger superoxide dismutase (superoxide:superoxide oxidoreductase, EC 1.15.1.1) and the enzyme catalase (hydrogen-peroxide:hydrogenperoxide oxidoreductase, EC 1.11.1.6) on x-ray- and bleomycin-induced transformation ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Borek C,Troll W

更新日期：1983-03-01 00:00:00

abstract：:Ectopic expression of transcription factors can reprogram somatic cells to a pluripotent state. However, most of the studies used skin fibroblasts as the starting population for reprogramming, which usually take weeks for expansion from a single biopsy. We show here that induced pluripotent stem (iPS) cells can be gen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sun N,Panetta NJ,Gupta DM,Wilson KD,Lee A,Jia F,Hu S,Cherry AM,Robbins RC,Longaker MT,Wu JC

更新日期：2009-09-15 00:00:00

abstract：:Functionally differentiated chicken macrophages were derived by in vitro differentiation of embryonic yolk sac cells and were characterized by several macrophage-specific cell markers. Uniform, infected, virus-producing cultures were obtained after exposure of these macrophages to avian myoblastosis virus (AMV), avian...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Durban EM,Boettiger D

更新日期：1981-06-01 00:00:00

abstract：:The estrogen receptor (E2R) from rabbit uterus has an enhanced affinity for BrdUrd-substituted DNA compared to unsubstituted DNA. Increasing levels of BrdUrd substitution (from 0 to 100%) in a DNA sample are associated with increasingly tighter binding of E2R to that DNA as measured by equilibrium competition experime...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kallos J,Fasy TM,Hollander VP,Bick MD

更新日期：1978-10-01 00:00:00

abstract：:Mucosal surfaces are a main entry point for pathogens and the principal sites of defense against infection. Both bacteria and phage are associated with this mucus. Here we show that phage-to-bacteria ratios were increased, relative to the adjacent environment, on all mucosal surfaces sampled, ranging from cnidarians t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barr JJ,Auro R,Furlan M,Whiteson KL,Erb ML,Pogliano J,Stotland A,Wolkowicz R,Cutting AS,Doran KS,Salamon P,Youle M,Rohwer F

更新日期：2013-06-25 00:00:00

abstract：:A series of hairpin pyrrole-imidazole polyamide-fluorescein conjugates were synthesized and assayed for cellular localization. Thirteen cell lines, representing 11 human cancers, one human transformed kidney cell line, and one murine leukemia cell line, were treated with 5 microM polyamide-fluorescein conjugates for 1...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Best TP,Edelson BS,Nickols NG,Dervan PB

更新日期：2003-10-14 00:00:00

abstract：:The yeast genome becomes unstable during stress, which often results in adaptive aneuploidy, allowing rapid activation of protective mechanisms that restore cellular homeostasis. In this study, we performed a genetic screen in Saccharomyces cerevisiae to identify genome adaptations that confer resistance to tunicamyci...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Beaupere C,Dinatto L,Wasko BM,Chen RB,VanValkenburg L,Kiflezghi MG,Lee MB,Promislow DEL,Dang W,Kaeberlein M,Labunskyy VM

更新日期：2018-09-18 00:00:00

abstract：:Absorbance changes reflecting the formation of a transient radical-pair state, P(F), were measured in reaction centers from Rhodopseudomonas sphaeroides under conditions that blocked electron transfer to a later carrier (a quinone, Q). The temperature dependence of the absorbance changes suggests that P(F) is an equil...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shuvalov VA,Parson WW

更新日期：1981-02-01 00:00:00

abstract：:Recently, the highly invasive Asian tiger mosquito, Aedes albopictus, rapidly displaced resident populations of the yellow fever mosquito, Aedes aegypti in the southeastern United States and in Bermuda. Although multiple mechanisms of competitive displacement have been hypothesized, recent evidence of cross-inseminati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bargielowski IE,Lounibos LP,Carrasquilla MC

更新日期：2013-02-19 00:00:00

abstract：:Dopamine-beta-hydroxylase (EC 1.14.2.1), an enzyme localized in sympathetic synaptic vesicles, was released together with norepinephrine during in vitro stimulation of the hypogastric nerve that innervates the vas deferens of the guinea pig. Stimulation of the nerve in the presence of high concentrations of calcium (7...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Johnson DG,Thoa NB,Weinshilboum R,Axelrod J,Kopin IJ

更新日期：1971-09-01 00:00:00

abstract：:The p53 tumor-suppressor protein is a critical mediator of cellular growth arrest and the induction of apoptosis. To identify proteins involved in the modulation of p53 transcriptional activity, a gain-of-function cellular screen was carried out with an arrayed matrix of approximately 20,000 cDNAs. Nine genes previous...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huang Q,Raya A,DeJesus P,Chao SH,Quon KC,Caldwell JS,Chanda SK,Izpisua-Belmonte JC,Schultz PG

更新日期：2004-03-09 00:00:00

abstract：:Cholera vibrios produce a single polymeric protein that (i) causes hemagglutination; (ii) appears to participate in their attachment to gut epithelium; (iii) may mediate their detachment from gut epithelium; and (iv) is a protease that hydrolyzes fibronectin and mucin, cleaves lactoferrin, and nicks the A subunit of t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Finkelstein RA,Boesman-Finkelstein M,Holt P

更新日期：1983-02-01 00:00:00

abstract：:What determines the firing rate of cortical neurons in the absence of external sensory input or motor behavior, such as during sleep? Here we report that, in a familiar environment, the discharge frequency of simultaneously recorded individual CA1 pyramidal neurons and the coactivation of cell pairs remain highly corr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hirase H,Leinekugel X,Czurkó A,Csicsvari J,Buzsáki G

更新日期：2001-07-31 00:00:00

abstract：:Visual receptive fields (RFs) were mapped inside and outside the cortical representation of the optic disk in the striate cortex (area V1) of anesthetized and paralyzed Cebus monkeys. Unexpectedly, most cells were found to be binocularly driven, and the RFs mapped with contralateral-eye stimulation progressed in a top...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fiorani Júnior M,Rosa MG,Gattass R,Rocha-Miranda CE

更新日期：1992-09-15 00:00:00

abstract：:The capsids of neurotropic herpesviruses have the remarkable ability to move in specific directions within axons. By modulating bidirectional capsid transport to favor either retrograde (minus-end) or anterograde (plus-end) motion, these viruses travel to sensory ganglia or peripheral tissue at specific stages of infe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luxton GW,Haverlock S,Coller KE,Antinone SE,Pincetic A,Smith GA

更新日期：2005-04-19 00:00:00

abstract：:Brain serotonin (5-HT) deficiency and exposure to psychosocial stress have both been implicated in the etiology of depression and anxiety disorders, but whether 5-HT deficiency influences susceptibility to depression- and anxiety-like phenotypes induced by psychosocial stress has not been formally established. Most cl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sachs BD,Ni JR,Caron MG

更新日期：2015-02-24 00:00:00

abstract：:Ventilator-induced diaphragmatic dysfunction (VIDD) refers to the diaphragm muscle weakness that occurs following prolonged controlled mechanical ventilation (MV). The presence of VIDD impedes recovery from respiratory failure. However, the pathophysiological mechanisms accounting for VIDD are still not fully understo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Matecki S,Dridi H,Jung B,Saint N,Reiken SR,Scheuermann V,Mrozek S,Santulli G,Umanskaya A,Petrof BJ,Jaber S,Marks AR,Lacampagne A

更新日期：2016-08-09 00:00:00