Protein-tyrosine-phosphatase CD45 is phosphorylated transiently on tyrosine upon activation of Jurkat T cells.

abstract：:The mammalian retina contains an endogenous circadian pacemaker that broadly regulates retinal physiology and function, yet the cellular origin and organization of the mammalian retinal circadian clock remains unclear. Circadian clock neurons generate daily rhythms via cell-autonomous autoregulatory clock gene network...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ruan GX,Zhang DQ,Zhou T,Yamazaki S,McMahon DG

更新日期：2006-06-20 00:00:00

abstract：:Generating human single-nucleotide polymorphisms (SNPs) is no longer a rate-limiting step for genetic studies of disease. The number of SNPs in public databases already exceeds 200,000, and the total is expected to exceed 1,000,000 within a year. Rather, progress is limited by the inability to genotype large numbers o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hirschhorn JN,Sklar P,Lindblad-Toh K,Lim YM,Ruiz-Gutierrez M,Bolk S,Langhorst B,Schaffner S,Winchester E,Lander ES

更新日期：2000-10-24 00:00:00

abstract：:We previously reported that laminar flow activates peroxisome proliferator-activated receptor gamma (PPARgamma) in vascular endothelial cells in a ligand-dependent manner that involves phospholipase A2 and cytochrome P450 epoxygenases. In this study, we investigated whether epoxyeicosatrienoic acids (EETs), the cataly...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu Y,Zhang Y,Schmelzer K,Lee TS,Fang X,Zhu Y,Spector AA,Gill S,Morisseau C,Hammock BD,Shyy JY

更新日期：2005-11-15 00:00:00

abstract：:Earlier Monte Carlo studies on a single-helix model of the GTP cap at the end of a microtubule are extended here to a more realistic five-start helix model of the microtubule end. As in the earlier work, phase changes occur at the microtubule end: the end is either capped with GTP and growing slowly or uncapped and sh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen YD,Hill TL

更新日期：1985-02-01 00:00:00

abstract：:Whether mitotic structures like the centrosome can self-organize from the regulated mobility of their dynamic protein components remains unclear. Here, we combine fluorescence spectroscopy and chemical genetics to study in living cells the diffusion of polo-like kinase 1 (PLK1), an enzyme critical for centrosome matur...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mahen R,Jeyasekharan AD,Barry NP,Venkitaraman AR

更新日期：2011-05-31 00:00:00

abstract：:Interpretation of empirical results based on a taxa's lifetime distribution shows apparently conflicting results. Species' lifetime is reported to be exponentially distributed, whereas higher-order taxa, such as families or genera, follow a broader distribution, compatible with power-law decay. We show that both forms...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pigolotti S,Flammini A,Marsili M,Maritan A

更新日期：2005-11-01 00:00:00

abstract：:Neuromelanin (NM) isolated from the substantia nigra region of the human brain was studied by scanning probe and photoelectron emission microscopies. Atomic force microscopy reveals that NM granules are comprised of spherical structures with a diameter of approximately 30 nm, similar to that observed for Sepia cuttlef...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bush WD,Garguilo J,Zucca FA,Albertini A,Zecca L,Edwards GS,Nemanich RJ,Simon JD

更新日期：2006-10-03 00:00:00

abstract：:How subduction-the sinking of cold lithospheric plates into the mantle-is initiated is one of the key mysteries in understanding why Earth has plate tectonics. One of the favored locations for subduction triggering is at passive margins, where sea floor abuts continental margins. Such passive margin collapse is proble...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bercovici D,Mulyukova E

更新日期：2021-01-26 00:00:00

abstract：:Immediately after focal retinal lesions, receptive fields (RFs) in primary visual cortex expand considerably, even when the retinal damage is limited to the photoreceptor layer. The time course of these changes suggests that mere lack of stimulation in the vicinity of the RF accompanied by stimulation in the surroundi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pettet MW,Gilbert CD

更新日期：1992-09-01 00:00:00

abstract：:Xenopus laevis tadpole tails contain fast muscle fibers oriented in chevrons and two pairs of slow muscle "cords" along the length of the tail. When tail resorption is inhibited by a number of different treatments, fast muscle but not the slow cord muscle still is lost, demonstrating that the fast tail muscle is a dir...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Das B,Schreiber AM,Huang H,Brown DD

更新日期：2002-09-17 00:00:00

abstract：:The polycystic kidney diseases (PKDs) are a group of disorders characterized by the growth of epithelial cysts from the nephrons and collecting ducts of kidney tubules. The diseases can be inherited or can be provoked by environmental factors. To investigate the molecular basis of the abnormal cell growth associated w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cowley BD Jr,Smardo FL Jr,Grantham JJ,Calvet JP

更新日期：1987-12-01 00:00:00

abstract：:A patient with type II diabetes associated with hyperproinsulinemia has been shown to have a point mutation in one insulin gene allele, resulting in replacement of histidine with aspartic acid at position 10 of the B-chain. To investigate the basis of the proinsulin processing defect, we introduced an identical mutati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gross DJ,Halban PA,Kahn CR,Weir GC,Villa-Komaroff L

更新日期：1989-06-01 00:00:00

abstract：:We introduce a new genetic distance for microsatellite loci, incorporating features of the stepwise mutation model, and test its performance on microsatellite polymorphisms in humans, chimpanzees, and gorillas. We find that it performs well in determining the relations among the primates, but less well than other dist...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goldstein DB,Ruiz Linares A,Cavalli-Sforza LL,Feldman MW

更新日期：1995-07-18 00:00:00

abstract：:The potent transforming activity of membrane-targeted Raf-1 (Raf-CAAX) suggests that Ras transformation is triggered primarily by a Ras-mediated translocation of Raf-1 to the plasma membrane. However, whereas constitutively activated mutants of Ras [H-Ras(61L) and K-Ras4B(12V)] and Raf-1 (DeltaRaf-22W and Raf-CAAX) ca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oldham SM,Clark GJ,Gangarosa LM,Coffey RJ Jr,Der CJ

更新日期：1996-07-09 00:00:00

abstract：:An electron density map at 3 angstrom resolution has been calculated for Cu2+, Zn2+ superoxide dismutase from bovine erythrocytes, and the course of the main chain has been traced. The dominant structural feature is an 8-stranded barrel of antiparallel beta-pleated sheet. There is one very short helical section and tw...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Richardson J,Thomas KA,Rubin BH,Richardson DC

更新日期：1975-04-01 00:00:00

abstract：:The Mecp2 gene has been shown to be mutated in most cases of human Rett syndrome, and mouse models deleted for the ortholog have been generated. Lineage-specific deletion of the gene indicated that the Rett-like phenotype is caused by Mecp2 deficiency in neurons. Biochemical evidence suggests that Mecp2 acts as a glob...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tudor M,Akbarian S,Chen RZ,Jaenisch R

更新日期：2002-11-26 00:00:00

abstract：:The timing of human colonization of East Polynesia, a vast area lying between Hawai'i, Rapa Nui, and New Zealand, is much debated and the underlying causes of this great migration have been enigmatic. Our study generates evidence for human dispersal into eastern Polynesia from islands to the west from around AD 900 an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sear DA,Allen MS,Hassall JD,Maloney AE,Langdon PG,Morrison AE,Henderson ACG,Mackay H,Croudace IW,Clarke C,Sachs JP,Macdonald G,Chiverrell RC,Leng MJ,Cisneros-Dozal LM,Fonville T,Pearson E

更新日期：2020-04-21 00:00:00

abstract：:The neural crest (NC) emerges from combinatorial inductive events occurring within its progenitor domain, the neural border (NB). Several transcription factors act early at the NB, but the initiating molecular events remain elusive. Recent data from basal vertebrates suggest that ap2 might have been critical for NC em...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： de Crozé N,Maczkowiak F,Monsoro-Burq AH

更新日期：2011-01-04 00:00:00

abstract：:We have constructed an opal suppressor system in Escherichia coli to complement an existing amber suppressor system to study the structural basis of tRNA acceptor identity, particularly the role of middle anticodon nucleotide at position 35. The opal suppressor tRNA contains a UCA anticodon and the mRNA of the suppres...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McClain WH,Foss K,Jenkins RA,Schneider J

更新日期：1990-12-01 00:00:00

abstract：:Two continuous-suspension lymphocyte lines were isolated from the spleen and fibrosarcoma of a New Zealand Black female mouse. A C-type virus with a density of 1.16 g x cm(-3), 70S RNA, and RNA-directed DNA polymerase activity was isolated. The virus was infectious for NRK, NZB, (NZB x NZW)F(1), and (NZW x NZW)F(1) em...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lerner RA,Jensen F,Kennel SJ,Dixon FJ,Des Roches G,Francke U

更新日期：1972-10-01 00:00:00

abstract：:The role of intraspecific and interspecific interactions in structuring biotic communities at fine spatial scales is well documented, but the signature of species interactions at coarser spatial scales is unclear. We present evidence that species interactions may be a significant factor in mediating the regional assem...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gotelli NJ,Graves GR,Rahbek C

更新日期：2010-03-16 00:00:00

abstract：:Cdc20/fizzy family proteins are involved in activation of the anaphase-promoting complex/cyclosome, which catalyzes the ubiquitin-dependent proteolysis of cell cycle regulatory proteins such as anaphase inhibitors and mitotic cyclins, leading to chromosome segregation and exit from mitosis. Previous work has shown tha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Farruggio DC,Townsley FM,Ruderman JV

更新日期：1999-06-22 00:00:00

abstract：:To characterize the region on human IgG1 responsible for its high-affinity interaction with the human Fc gamma receptor class I (Fc gamma RI), we have analyzed the binding properties of a series of genetically engineered chimeric antidinitrophenyl antibodies with identical murine antibody combining sites and hybrid Ig...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chappel MS,Isenman DE,Everett M,Xu YY,Dorrington KJ,Klein MH

更新日期：1991-10-15 00:00:00

abstract：:A highly purified fraction obtained from scrapie (263-K strain)-infected hamsters' brains by an alternative procedure without proteinase K treatment contained a protease-resistant form of the scrapie precursor protein (PrPSc) and infectivity of 9.9 +/- 0.7 log LD50/ml. Polyclonal antibodies produced against hamster sc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Safar J,Wang W,Padgett MP,Ceroni M,Piccardo P,Zopf D,Gajdusek DC,Gibbs CJ Jr

更新日期：1990-08-01 00:00:00

abstract：:Biogenesis of plant microRNAs (miRNAs) takes place in nuclear dicing bodies (D-bodies), where the ribonulease III-type enzyme Dicer-like 1 (DCL1) processes primary transcripts of miRNAs (pri-miRNAs) into miRNA/miRNA* (*, passenger strand) duplexes from either base-to-loop or loop-to-base directions. Hyponastic Leaves ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gao S,Wang J,Jiang N,Zhang S,Wang Y,Zhang J,Li N,Fang Y,Yang L,Chen S,Yan B,Huang T,Kuai B,Wang Y,Chang F,Ren G

更新日期：2020-07-21 00:00:00

abstract：:The λ exonuclease is an ATP-independent enzyme that binds to dsDNA ends and processively digests the 5'-ended strand to form 5' mononucleotides and a long 3' overhang. The crystal structure of λ exonuclease revealed a toroidal homotrimer with a central funnel-shaped channel for tracking along the DNA, and a mechanism ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang J,McCabe KA,Bell CE

更新日期：2011-07-19 00:00:00

abstract：:Complement receptors (CRs), expressed notably on myeloid and lymphoid cells, play an essential function in the elimination of complement-opsonized pathogens and apoptotic/necrotic cells. In addition, these receptors are crucial for the cross-talk between the innate and adaptive branches of the immune system. CR3 (also...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bajic G,Yatime L,Sim RB,Vorup-Jensen T,Andersen GR

更新日期：2013-10-08 00:00:00

abstract：:Epilepsy is the most common neurological disorder of young humans. Each year 150,000 children in the United States experience their first seizure. Antiepileptic drugs (AEDs), used to treat seizures in children, infants, and pregnant women, cause cognitive impairment, microcephaly, and birth defects. The cause of unwan...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bittigau P,Sifringer M,Genz K,Reith E,Pospischil D,Govindarajalu S,Dzietko M,Pesditschek S,Mai I,Dikranian K,Olney JW,Ikonomidou C

更新日期：2002-11-12 00:00:00

abstract：:The mode of action of "allogeneic supernatant" (the culture supernatant of a 24-hr mixedlymphocyte reaction), has been studied. This factor stimulates the response of spleen cell cultures depleted in thymus-derived lymphoid cells (T-cells) to antigens that elicit a thymus-dependent response. We used a limiting dilutio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hunter P,Kettman JR

更新日期：1974-02-01 00:00:00

abstract：:Characterization and functional annotation of the large number of proteins predicted from genome sequencing projects poses a major scientific challenge. Whereas several proteomics techniques have been developed to quantify the abundance of proteins, these methods provide little information regarding protein function. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Okerberg ES,Wu J,Zhang B,Samii B,Blackford K,Winn DT,Shreder KR,Burbaum JJ,Patricelli MP

更新日期：2005-04-05 00:00:00