Arachidonate lipoxygenases as essential regulators of cell survival and apoptosis.

abstract：:In the United States, the iconic groundfish fishery for Gulf of Maine cod has endured several dramatic reductions in annual catch limits and been federally declared an economic disaster. Using a repeated cross-sectional survey of fishing captains to assess potential social impacts of the fishery failure, we found that...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scyphers SB,Picou JS,Grabowski JH

更新日期：2019-11-12 00:00:00

abstract：:The dynamics of excited-state double proton transfer of model DNA base pairs, 7-azaindole dimers, is reported using femtosecond fluorescence spectroscopy. To elucidate the nature of the transfer in the condensed phase, here we examine variation of solvent polarity and viscosity, solute concentration, and isotopic frac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kwon OH,Zewail AH

更新日期：2007-05-22 00:00:00

abstract：:The cDNA of the gene pds from tomato, encoding the carotenoid biosynthesis enzyme phytoene desaturase, was cloned, and its nucleotide sequence was determined. Cells of Escherichia coli that expressed the tomato pds gene could convert phytoene to zeta-carotene. This result suggests that one polypeptide, the product of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pecker I,Chamovitz D,Linden H,Sandmann G,Hirschberg J

更新日期：1992-06-01 00:00:00

abstract：:Under typical conditions, medial prefrontal cortex (mPFC) connections with the amygdala are immature during childhood and become adult-like during adolescence. Rodent models show that maternal deprivation accelerates this development, prompting examination of human amygdala-mPFC phenotypes following maternal deprivati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gee DG,Gabard-Durnam LJ,Flannery J,Goff B,Humphreys KL,Telzer EH,Hare TA,Bookheimer SY,Tottenham N

更新日期：2013-09-24 00:00:00

abstract：:Elastin peptides prepared by alcoholic potassium hydroxide degradation of highly purified fibrous elastin from bovine ligamentum nuchae (kappa-elastin) were shown to act on the ion channels of human monocytes, aorta smooth muscle cells, and skin fibroblasts. In small amounts (between 0.1 and 1 microgram/ml), elastin p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jacob MP,Fülöp T Jr,Foris G,Robert L

更新日期：1987-02-01 00:00:00

abstract：:In our 3D NOESY-[(1)H,(15)N,(1)H]-ZQ-TROSY experiment, the TROSY principle (transverse relaxation-optimized spectroscopy) is used in three-dimensional (3D) (15)N-resolved nuclear Overhauser enhancement spectroscopy (NOESY), which enables resonance assignments by sequential nuclear Overhauser effects and the collection...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pervushin KV,Wider G,Riek R,Wüthrich K

更新日期：1999-08-17 00:00:00

abstract：:A TL+ leukemia of a (B6 X A)F1 hybrid mouse (H-2b/H-2a) was previously subjected to immunoselection against H-2a by passage in (B6 X A.SW)F1 mice (H-2b/H-2s). A variant leukemia line was obtained that serologically lacked not only the H-2a phenotype but also the TL phenotype determined by the linked cis Tlaa allele of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shen FW,Chaganti RS,Doucette LA,Litman GW,Steinmetz M,Hood L,Boyse EA

更新日期：1984-10-01 00:00:00

abstract：:The anticancer peptide PNC-27, which contains an HDM-2-binding domain corresponding to residues 12-26 of p53 and a transmembrane-penetrating domain, has been found to kill cancer cells (but not normal cells) by inducing membranolysis. We find that our previously determined 3D structure of the p53 residues of PNC-27 is...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sarafraz-Yazdi E,Bowne WB,Adler V,Sookraj KA,Wu V,Shteyler V,Patel H,Oxbury W,Brandt-Rauf P,Zenilman ME,Michl J,Pincus MR

更新日期：2010-02-02 00:00:00

abstract：:We report here that component members of the keratin intermediate filament (IF) type I and type II gene families of sheep are closely linked but apparently the two families are not. Nine genes, accounting for up to half of the keratin IF gene repertoire, were mapped in four cosmid clones and the linkage between the ge...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Powell BC,Cam GR,Fietz MJ,Rogers GE

更新日期：1986-07-01 00:00:00

abstract：:Scientific cinematography using ultrafast optical imaging is a common tool to study motion. In opaque organisms or structures, X-ray radiography captures sequences of 2D projections to visualize morphological dynamics, but for many applications full four-dimensional (4D) spatiotemporal information is highly desirable....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： dos Santos Rolo T,Ershov A,van de Kamp T,Baumbach T

更新日期：2014-03-18 00:00:00

abstract：:The need to assess subtle, potentially exploitable changes in serial structure is paramount in the analysis of financial data. Herein, we demonstrate the utility of approximate entropy (ApEn), a model-independent measure of sequential irregularity, toward this goal, by several distinct applications. We consider both e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pincus S,Kalman RE

更新日期：2004-09-21 00:00:00

abstract：:The embryonic sites in which progenitors of the hematopoietic lineages first emerge are ideal regions to characterize both the cells and environment needed to initiate blood cell development. For a number of years both the murine yolk sac and embryo have been recognized to contain progenitors of B lymphocytes. However...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cumano A,Furlonger C,Paige CJ

更新日期：1993-07-15 00:00:00

abstract：:Sympathetic activation of β-adrenoreceptors (β-AR) represents a hallmark in the development of heart failure (HF). However, little is known about the underlying mechanisms of gene regulation. In human ventricular myocardium from patients with end-stage HF, we found high levels of phosphorylated histone 3 at serine-28 ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Saadatmand AR,Sramek V,Weber S,Finke D,Dewenter M,Sticht C,Gretz N,Wüstemann T,Hagenmueller M,Kuenzel SR,Meyer-Roxlau S,Kramer M,Sossalla S,Lehmann LH,Kämmerer S,Backs J,El-Armouche A

更新日期：2019-10-29 00:00:00

abstract：:Activating region I of GAL4 protein is a stretch of amino acids, positioned adjacent to the DNA-binding region, that activates transcription in yeast and, as we show here, in mammalian cells. Here we describe mutations located throughout a 65-amino acid region that increase the activation function of region I. Most of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gill G,Sadowski I,Ptashne M

更新日期：1990-03-01 00:00:00

abstract：:An expression vector containing the murine c-ets-2 protooncogene cDNA was introduced into NIH 3T3 cells by DNA transfection. The cells transfected with this construct showed foci of densely growing, morphologically altered cells, when grown either in low-serum (0.05%) or in serum-free medium. The c-ets-2-derived foci ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seth A,Watson DK,Blair DG,Papas TS

更新日期：1989-10-01 00:00:00

abstract：:Although much of the brain's functional organization is genetically predetermined, it appears that some noninnate functions can come to depend on dedicated and segregated neural tissue. In this paper, we describe a series of experiments that have investigated the neural development and organization of one such noninna...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Polk TA,Farah MJ

更新日期：1998-02-03 00:00:00

abstract：:Cactus, a Drosophila homologue of I kappa B, binds to and inhibits Dorsal, a homologue of the p50 and p65 components of NF-kappa B. We describe experiments in yeast with various Dorsal and Cactus derivatives showing that Cactus blocks the DNA binding and nuclear localization functions of Dorsal. In contrast, Dorsal's ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lehming N,McGuire S,Brickman JM,Ptashne M

更新日期：1995-10-24 00:00:00

abstract：:Regulation of cardiac contraction by neurotransmitters and hormones is often correlated with regulation of the L-type Ca2(+)-channel current (ICa) through the opposite actions of two second messengers, cyclic AMP and cyclic GMP. While cyclic AMP stimulation of ICa is mediated by the activation of cyclic AMP-dependent ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Méry PF,Lohmann SM,Walter U,Fischmeister R

更新日期：1991-02-15 00:00:00

abstract：:Controversy remains over whether the cancer stem cell (CSC) theory applies to all tumors. To determine whether cells within a highly aggressive solid tumor are stochastically or hierarchically organized, we combined a reporter system where the nucleostemin (NS) promoter drives GFP expression (termed NS-GFP) with a mou...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tamase A,Muraguchi T,Naka K,Tanaka S,Kinoshita M,Hoshii T,Ohmura M,Shugo H,Ooshio T,Nakada M,Sawamoto K,Onodera M,Matsumoto K,Oshima M,Asano M,Saya H,Okano H,Suda T,Hamada J,Hirao A

更新日期：2009-10-06 00:00:00

abstract：:In Gram-negative bacteria, the outer membrane contains primarily β-barrel transmembrane proteins and lipoproteins. The insertion and assembly of β-barrel outer-membrane proteins (OMPs) is mediated by the β-barrel assembly machinery (BAM) complex, the core component of which is the 16-stranded transmembrane β-barrel Ba...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lundquist K,Bakelar J,Noinaj N,Gumbart JC

更新日期：2018-08-21 00:00:00

abstract：:Inelastic electron tunneling spectra of nucleosides and nucleotides are presented which show that detailed information on the vibrational spectra of these molecules can be obtained from a few micrograms of material. A series of studies on adenine derivatives demonstrates that unambiguous identification of a large numb...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Clark JM,Coleman RV

更新日期：1976-05-01 00:00:00

abstract：:In the recently halted HIV type 1 (HIV-1) vaccine STEP trial, individuals that were seropositive for adenovirus serotype 5 (Ad5) showed increased rates of HIV-1 infection on vaccination with an Ad5 vaccine. We propose that this was due to activation and expansion of Ad5-specific mucosal-homing memory CD4 T cells. To t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Benlahrech A,Harris J,Meiser A,Papagatsias T,Hornig J,Hayes P,Lieber A,Athanasopoulos T,Bachy V,Csomor E,Daniels R,Fisher K,Gotch F,Seymour L,Logan K,Barbagallo R,Klavinskis L,Dickson G,Patterson S

更新日期：2009-11-24 00:00:00

abstract：:The high susceptibility of human immunoglobulin D to proteolytic degradation affects its biological function, metabolism, and immunoassay. High-pressure liquid chromatography was used to investigate the mechanism and rate of limited proteolytic cleavage of IgD and also to identify, isolate, and quantify the reaction p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ishioka N,Takahashi N,Putnam FW

更新日期：1987-01-01 00:00:00

abstract：:Partial amino acid sequence of the Ia molecule encoded by the I-E or I-C (I-EC) subregion of the major histocompatibility complex of the mouse are presented. The Ia molecule appears to be comprised of two noncovalently associated polypeptides. The larger subunit, alpha, has an approximate molecular weight of 35,000 an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McMillan M,Cecka JM,Murphy DB,McDevitt HO,Hood L

更新日期：1977-11-01 00:00:00

abstract：:Exposure to green space has been associated with better physical and mental health. Although this exposure could also influence cognitive development in children, available epidemiological evidence on such an impact is scarce. This study aimed to assess the association between exposure to green space and measures of c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dadvand P,Nieuwenhuijsen MJ,Esnaola M,Forns J,Basagaña X,Alvarez-Pedrerol M,Rivas I,López-Vicente M,De Castro Pascual M,Su J,Jerrett M,Querol X,Sunyer J

更新日期：2015-06-30 00:00:00

abstract：:Many bacteria use N-acyl homoserine lactone (AHL) signals to coordinate the behavior of individual cells in a local population. The successful infection of eukaryotic hosts by bacteria seems to depend particularly on such AHL-mediated "quorum-sensing" regulation. We have used proteome analysis to show that a eukaryoti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mathesius U,Mulders S,Gao M,Teplitski M,Caetano-Anolles G,Rolfe BG,Bauer WD

更新日期：2003-02-04 00:00:00

abstract：:S-adenosyl-L-methionine (SAM)-dependent O-methyltransferases (OMTs) catalyze the methylation of hydroxycinnamic acid derivatives for the synthesis of methylated plant polyphenolics, including lignin. The distinction in the extent of methylation of lignins in angiosperms and gymnosperms, mediated by substrate-specific ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li L,Popko JL,Zhang XH,Osakabe K,Tsai CJ,Joshi CP,Chiang VL

更新日期：1997-05-13 00:00:00

abstract：:Molecular dynamics (MD) simulations provide essential information about the thermodynamics and dynamics of proteins. To construct the free-energy surface from equilibrium trajectories, it is necessary to group the individual snapshots in a meaningful way. The inherent structures (IS) are shown to provide an appropriat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rao F,Karplus M

更新日期：2010-05-18 00:00:00

abstract：:Porcine aortic endothelial cells were isolated and maintained in Dulbecco's modified Eagle's medium (DME medium)/10% citrate-treated human plasma. They were stimulated by DME medium/10% human serum to grow from a density of 10,100 +/- 500 per well to a final density of 83,000 +/- 1,800 per well over a 9-day period. On...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Clemmons DR,Isley WL,Brown MT

更新日期：1983-03-01 00:00:00

abstract：:We are presented with choices each day about how to invest our effort to achieve our goals. Critically, these decisions must frequently be made under conditions of incomplete information, where either the effort required or possible reward to be gained is uncertain. Such choices therefore require the development of po...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arulpragasam AR,Cooper JA,Nuutinen MR,Treadway MT

更新日期：2018-05-29 00:00:00