Abstract:
:Partial amino acid sequence of the Ia molecule encoded by the I-E or I-C (I-EC) subregion of the major histocompatibility complex of the mouse are presented. The Ia molecule appears to be comprised of two noncovalently associated polypeptides. The larger subunit, alpha, has an approximate molecular weight of 35,000 and the smaller subunit, beta, an approximate molecular weight of 28,000. Several interesting homology relationships (or the lack thereof) are apparent when the Ia polypeptides from the I-EC subregion are compared both with their counterparts from man and guinea pig and with the molecules encoded in the I-A subregion. Clearly the most impressive homology relationship is that seen between the alpha polypeptide from the I-EC subregion of mouse and its human counterpart. This is in striking contrast to the beta polypeptide, which bears no apparent homology to its human counterpart.
journal_name
Proc Natl Acad Sci U S Aauthors
McMillan M,Cecka JM,Murphy DB,McDevitt HO,Hood Ldoi
10.1073/pnas.74.11.5135subject
Has Abstractpub_date
1977-11-01 00:00:00pages
5135-9issue
11eissn
0027-8424issn
1091-6490journal_volume
74pub_type
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Proceedings of the National Academy of Sciences of the United States of America
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2011-11-01 00:00:00
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更新日期:2020-10-06 00:00:00
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更新日期:2012-02-28 00:00:00
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更新日期:1974-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:1980-06-01 00:00:00