Intramolecular vibrational dephasing obeys a power law at intermediate times.

abstract：:The reproductive activity of Trypanosoma lewisi was strikingly enhanced and sometimes prolonged for 2 days when sublethal doses of adenine were given to rats. The drug was effective when given for 5 or 7 days in the diet and/or intraperitoneally, starting one or two days before infection through two days after infecti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Taliaferro WH,D'Alesandro PA

更新日期：1971-01-01 00:00:00

abstract：:For length and area, a central fact is that the value of the length of a curve or the area of a surface, as given by the Lebesgue theory, is at least as great as that given by the classical formula, whenever the latter has meaning. This is now found not to be valid in higher dimensions. We give an example of a continu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goffman C

更新日期：1969-05-01 00:00:00

abstract：:Electromyographic recordings from individual identified ankle muscles of the 7-day chick embryo (stage 31) were used to determine the organization of motor output at a developmental stage shortly after the onset of spontaneous motility in the leg. During spontaneous motility of the embryo, the electromyographic record...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bekoff A,Stein PS,Hamburger V

更新日期：1975-04-01 00:00:00

abstract：:We report that oxytocin (Oxt) receptors (Oxtrs), on stimulation by the ligand Oxt, translocate into the nucleus of osteoblasts, implicating this process in the action of Oxt on osteoblast maturation. Sequential immunocytochemistry of intact cells or isolated nucleoplasts stripped of the outer nuclear membrane showed p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Di Benedetto A,Sun L,Zambonin CG,Tamma R,Nico B,Calvano CD,Colaianni G,Ji Y,Mori G,Grano M,Lu P,Colucci S,Yuen T,New MI,Zallone A,Zaidi M

更新日期：2014-11-18 00:00:00

abstract：:Four polyimidazoles were used in the binding and cleavage studies with poly(U). The two polydisperse polyvinylimidazoles were previously described by others, while the other two new polymers of polyethyleneimines were prepared by cationic polymerization of oxazolines. The latter had imidazole units attached to each ni...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheng L,Abhilash KG,Breslow R

更新日期：2012-08-07 00:00:00

abstract：:The transcription and processing of mitochondrial 21S rRNA in a petite strain of Saccharomyces cerevisiae has been examined by electron microscopic analysis of R-loop hybrids and by hybridization of labeled mitochondrial DNA probes to RNA transferred to diazobenzyloxymethyl paper. We have shown the presence of a large...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Merten S,Synenki RM,Locker J,Christianson T,Rabinowitz M

更新日期：1980-03-01 00:00:00

abstract：:We have evaluated the effect of ligand binding on expression of the receptor for IgE on rat basophilic leukemia (RBL) cells. RBL cells were grown in the presence or absence of 131I-labeled IgE and sometimes were also surface labeled with 125I. We found that cells grown in the presence of IgE continued to accumulate re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Furuichi K,Rivera J,Isersky C

更新日期：1985-03-01 00:00:00

abstract：:An automatic protein design procedure is used to select amino acid sequences that optimize the folding free energy function for a given protein. The only information used in designing the sequences is a set of known backbone structures for each protein, a rotamer library, and a well established classical empirical for...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jaramillo A,Wernisch L,Héry S,Wodak SJ

更新日期：2002-10-15 00:00:00

abstract：:The thrombogenicity of three highly purified proteases (thrombin, activated Factor X, and activated Factor IX) was determined quantitatively in an animal model. The minimal amounts required to produce a standard score 4 thrombus were 1.1 nmol for thrombin, 0.12 nmol for activated Factor X, and 0.018 nmol for activated...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gitel SN,Stephenson RC,Wessler S

更新日期：1977-07-01 00:00:00

abstract：:The Escherichia coli galactokinase gene (galK) was inserted into a modified early region transcription unit of simian virus 40 (SV40) contained on a bacterial plasmid. Introduction of this pSVK vector into monkey, mouse, and hamster cell lines by transfection resulted in efficient expression of the bacterial galK gene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schümperli D,Howard BH,Rosenberg M

更新日期：1982-01-01 00:00:00

abstract：:A visual scene is perceived in terms of visual objects. Similar ideas have been proposed for the analogous case of auditory scene analysis, although their hypothesized neural underpinnings have not yet been established. Here, we address this question by recording from subjects selectively listening to one of two compe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ding N,Simon JZ

更新日期：2012-07-17 00:00:00

abstract：:Recent work using culture-independent methods suggests that the lungs of cystic fibrosis (CF) patients harbor a vast array of bacteria not conventionally implicated in CF lung disease. However, sampling lung secretions in living subjects requires that expectorated specimens or collection devices pass through the oroph...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goddard AF,Staudinger BJ,Dowd SE,Joshi-Datar A,Wolcott RD,Aitken ML,Fligner CL,Singh PK

更新日期：2012-08-21 00:00:00

abstract：:Antigen receptor variable region exons are assembled during lymphocyte development from variable (V), diversity (D), and joining (J) gene segments. Each germ-line gene segment is flanked by recombination signal sequences (RSs). Recombination-activating gene endonuclease initiates V(D)J recombination by cleaving a pair...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zha S,Jiang W,Fujiwara Y,Patel H,Goff PH,Brush JW,Dubois RL,Alt FW

更新日期：2011-02-01 00:00:00

abstract：:Because neurogenesis persists in the adult mammalian brain and can be regulated by physiological and pathological events, we investigated its possible involvement in the brain's response to focal cerebral ischemia. Ischemia was induced by occlusion of the middle cerebral artery in the rat for 90 min, and proliferating...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jin K,Minami M,Lan JQ,Mao XO,Batteur S,Simon RP,Greenberg DA

更新日期：2001-04-10 00:00:00

abstract：:Very-long-baseline interferometry images of the nuclear region of the radio galaxy Cygnus A reveal a pronounced "core" and a knotty jet and counterjet. The knots are moving away from the core at apparent speeds which are subluminal for h = 1 [h = H0/100 km.s-1.Mpc-1;1 parsec (pc) = 3.09 x 10(16)m] and about c for h = ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bartel N,Sorathia B,Bietenholz MF,Carilli CL,Diamond P

更新日期：1995-12-05 00:00:00

abstract：:The early reactions in the catabolism of quinic acid in Neurospora crassa are controlled by at least four genes which are clustered on linkage group VII. Three of the loci (qa-2, qa-4, and qa-3) encode enzymes that convert quinic acid to protocatechuic acid. The fourth gene (qa-1) encodes a positive regulatory protein...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schweizer M,Case ME,Dykstra CC,Giles NH,Kushner SR

更新日期：1981-08-01 00:00:00

abstract：:Understanding the genetic networks that operate inside cells will require the dissection of interactions among network members. Here we describe a peptide aptamer isolated from a combinatorial library that distinguishes among such interactions. This aptamer binds to cyclin-dependent kinase 2 (Cdk2) and inhibits its ki...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cohen BA,Colas P,Brent R

更新日期：1998-11-24 00:00:00

abstract：:BALB/c mice immunized with myeloma proteins 315 or 460 made antibodies to the individually specific ("idiotypic") determinants of these proteins and suppressed growth of the corresponding transplanted tumor cells (MOPC-315 or MOPC-460). Stable, variant MOPC-315 tumors that produce only the light chain of protein 315 g...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lynch RG,Graff RJ,Sirisinha S,Simms ES,Eisen HN

更新日期：1972-06-01 00:00:00

abstract：:Various reconstructive procedures have been attempted to restore a cosmetically acceptable phallus that would allow normal reproductive, sexual, and urinary function in patients requiring penile reconstruction. However, these procedures are limited by a shortage of native penile tissue. We previously demonstrated that...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen KL,Eberli D,Yoo JJ,Atala A

更新日期：2010-02-23 00:00:00

abstract：:Herpes simplex virus type 2 (HSV-2) DNA was treated with four restriction endonucleases (EcoRI, HincIII, Bgl II, and Xba I) and eight fragments were purified and labeled with 32P in vitro. The kinetics of renaturation of each of the fragments was measured in the presence of DNA extracted from 333-8-9, a hamster cell l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Galloway DA,Copple CD,McDougall JK

更新日期：1980-02-01 00:00:00

abstract：:Methylmercury (MeHg) is a potent neurotoxin that is biomagnified approximately 1-10 million-fold in aquatic carnivores such as the Northern elephant seal (Mirounga angustirostris), whose excreta and molted pelage, in turn, constitute a source of environmental MeHg contamination at the base of marine food chains. The p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cossaboon JM,Ganguli PM,Flegal AR

更新日期：2015-09-29 00:00:00

abstract：:The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the DNA lesions 1-methyladenine and 3-methylcytosine, which are generated in single-stranded stretches of DNA. AlkB is an alpha-ketoglutarate- and Fe(II)-dependent dioxygenase that oxidizes the relevant methyl groups...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Duncan T,Trewick SC,Koivisto P,Bates PA,Lindahl T,Sedgwick B

更新日期：2002-12-24 00:00:00

abstract：:Disruption of latent Epstein-Barr virus (EBV) infection is induced by the key immediate-early protein BZLF1 (or Z, a member of the basic leucine-zipper family), which transactivates the viral early promoters. Viral reactivation is marked by renewed synthesis of early gene products such as EBV early antigen-diffuse (EA...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sista ND,Pagano JS,Liao W,Kenney S

更新日期：1993-05-01 00:00:00

abstract：:Creatine, a nitrogenous organic acid, replenishes cytoplasmic ATP at the expense of mitochondrial ATP via the phosphocreatine shuttle. Creatine levels are maintained by diet and endogenous synthesis from arginine and glycine. Glycine amidinotransferase (GATM) catalyzes the rate-limiting step of creatine biosynthesis: ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Turer E,McAlpine W,Wang KW,Lu T,Li X,Tang M,Zhan X,Wang T,Zhan X,Bu CH,Murray AR,Beutler B

更新日期：2017-02-14 00:00:00

abstract：:The three-dimensional structure of the N-acyl-l-homoserine lactone hydrolase (AHL lactonase) from Bacillus thuringiensis has been determined, by using single-wavelength anomalous dispersion (SAD) phasing, to 1.6-angstroms resolution. AHLs are produced by many Gram-negative bacteria as signaling molecules used in quoru...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu D,Lepore BW,Petsko GA,Thomas PW,Stone EM,Fast W,Ringe D

更新日期：2005-08-16 00:00:00

abstract：:The auditory and motor neural systems are closely intertwined, enabling people to carry out tasks such as playing a musical instrument whose mapping between action and sound is extremely sophisticated. While the dorsal auditory stream has been shown to mediate these audio-motor transformations, little is known about h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wollman I,Penhune V,Segado M,Carpentier T,Zatorre RJ

更新日期：2018-06-26 00:00:00

abstract：:We have examined whether dissociation of the histone octamer is required for elongation of RNA transcripts through arrays of nucleosome cores in vitro. Control or dimethyl suberimidate-crosslinked histone octamers were reconstituted onto supercoiled, closed circular pT207-18 DNA, which contains tandemly repeated 207-b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： O'Neill TE,Smith JG,Bradbury EM

更新日期：1993-07-01 00:00:00

abstract：:The microbiota is pivotal in the pathogenesis of inflammatory bowel disease (IBD)-associated inflammation-induced colorectal cancer (CRC), yet mechanisms for these effects remain poorly characterized. Here, we demonstrate that aberrant inflammasome-induced microbiota plays a critical role in CRC development, where mic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hu B,Elinav E,Huber S,Strowig T,Hao L,Hafemann A,Jin C,Wunderlich C,Wunderlich T,Eisenbarth SC,Flavell RA

更新日期：2013-06-11 00:00:00

abstract：:The crystal structures of Escherichia coli thymidylate kinase (TmpK) in complex with P1-(5'-adenosyl)-P5-(5'-thymidyl)pentaphosphate and P1-(5'-adenosyl)P5-[5'-(3'-azido-3'-deoxythymidine)] pentaphosphate have been solved to 2.0-A and 2.2-A resolution, respectively. The overall structure of the bacterial TmpK is very ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lavie A,Ostermann N,Brundiers R,Goody RS,Reinstein J,Konrad M,Schlichting I

更新日期：1998-11-24 00:00:00

abstract：:Interleukin (IL)-15 and its specific receptor chain, IL-15Rα, support the development of various effector cells, including NK and CD8 T cells via a mechanism called trans-presentation. Whereas the dynamic of trans-presentation has been shown to involve the recycling of IL-15Rα by presenting cells, the way responding c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tamzalit F,Barbieux I,Plet A,Heim J,Nedellec S,Morisseau S,Jacques Y,Mortier E

更新日期：2014-06-10 00:00:00