Mercury offloaded in Northern elephant seal hair affects coastal seawater surrounding rookery.

abstract：:Cardiolipin is important for bacterial and mitochondrial stability and function. The final step in cardiolipin biosynthesis is catalyzed by cardiolipin synthase and differs mechanistically between prokaryotes and eukaryotes. To study the importance of cardiolipin synthesis for mitochondrial integrity, membrane protein...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Serricchio M,Bütikofer P

更新日期：2012-04-17 00:00:00

abstract：:The electronic absorption spectra of oxidized and reduced spinach ferredoxins have been measured between 1200 and 600 nm at low temperature in D(2)O/ethylene glycol glasses. Relatively weak absorption bands are observed at 720, 820, and 920 nm in oxidized ferredoxin, and at 652, 820, and 920 nm in reduced ferredoxin. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rawlings J,Siiman O,Gray HB

更新日期：1974-01-01 00:00:00

abstract：:Wild-type newborn mice are characterized by the ability of certain liver-specific genes encoding various enzymes and mapping on different chromosomes to respond to glucocorticoid induction. Newborn mice homozygous for deletions at and around the albino locus on chromosome 7 fail to develop this competence for hormone-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： DeFranco D,Bali D,Torres R,DePinho RA,Erickson RP,Gluecksohn-Waelsch S

更新日期：1991-07-01 00:00:00

abstract：:Smallpox has played an unparalleled role in human history and remains a significant potential threat to public health. Despite the historical significance of this disease, we know little about the underlying pathophysiology or the virulence mechanisms of the causative agent, variola virus. To improve our understanding...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rubins KH,Hensley LE,Jahrling PB,Whitney AR,Geisbert TW,Huggins JW,Owen A,Leduc JW,Brown PO,Relman DA

更新日期：2004-10-19 00:00:00

abstract：:We describe the mechanical separation of the two complementary strands of a single molecule of bacteriophage lambda DNA. The 3' and 5' extremities on one end of the molecule are pulled progressively apart, and this leads to the opening of the double helix. The typical forces along the opening are in the range of 10-15...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Essevaz-Roulet B,Bockelmann U,Heslot F

更新日期：1997-10-28 00:00:00

abstract：:Signaling lymphocytic activation molecule family 3 (SLAMF3/Ly9) is a coregulatory molecule implicated in T-cell activation and differentiation. Systemic lupus erythematosus (SLE) is characterized by aberrant T-cell activation and compromised IL-2 production, leading to abnormal regulatory T-cell (Treg) development/fun...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Comte D,Karampetsou MP,Kis-Toth K,Yoshida N,Bradley SJ,Mizui M,Kono M,Solomon JR,Kyttaris VC,Tsokos GC

更新日期：2016-08-16 00:00:00

abstract：:Transgenic crops producing Bacillus thuringiensis (Bt) toxins kill some key insect pests and thus can reduce reliance on insecticides. Widespread planting of such Bt crops increased concerns that their usefulness would be cut short by rapid evolution of resistance to Bt toxins by pests. Pink bollworm (Pectinophora gos...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tabashnik BE,Dennehy TJ,Carrière Y

更新日期：2005-10-25 00:00:00

abstract：:Rabbit chondrocyte cultures on plastic dishes are capable of depositing a cartilaginous matrix, although the matrix does not calcify unless high levels of phosphate are added to the medium. In the present study, we cultivated a pelleted mass of rabbit growth-plate chondrocytes in the presence of Eagle's minimum essent...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kato Y,Iwamoto M,Koike T,Suzuki F,Takano Y

更新日期：1988-12-01 00:00:00

abstract：:Bacteriophage lambda encodes a number of genes involved in the recombinational repair of DNA double-strand breaks. The product of one of these genes, rap, has been purified. Truncated Rap proteins that copurify with the full-length form are derived, at least in part, from a rho-dependent transcription terminator locat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sharples GJ,Corbett LM,Graham IR

更新日期：1998-11-10 00:00:00

abstract：:A single mutation altering the transmembrane domain of the receptor-like p185 protein encoded by the rat neu gene converts the normal neu gene into a potent oncogene. The biochemical consequences of this mutation were studied by examining phosphorylation of the normal and transforming p185 molecules in membrane prepar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bargmann CI,Weinberg RA

更新日期：1988-08-01 00:00:00

abstract：:Discrete state models are a common tool of modeling in many areas. E.g., Markov state models as a particular representative of this model family became one of the major instruments for analysis and understanding of processes in molecular dynamics (MD). Here we extend the scope of discrete state models to the case of s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gerber S,Horenko I

更新日期：2014-10-14 00:00:00

abstract：:Homeostasis of intravascular volume, Na(+), Cl(-), and K(+) is interdependent and determined by the coordinated activities of structurally diverse mediators in the distal nephron and the distal colon. The behavior of these flux pathways is regulated by the renin-angiotensin-aldosterone system; however, the mechanisms ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ring AM,Cheng SX,Leng Q,Kahle KT,Rinehart J,Lalioti MD,Volkman HM,Wilson FH,Hebert SC,Lifton RP

更新日期：2007-03-06 00:00:00

abstract：:Blood viscosity decreases with shear stress, a property essential for an efficient perfusion of the vascular tree. Shear thinning is intimately related to the dynamics and mutual interactions of RBCs, the major component of blood. Because of the lack of knowledge about the behavior of RBCs under physiological conditio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lanotte L,Mauer J,Mendez S,Fedosov DA,Fromental JM,Claveria V,Nicoud F,Gompper G,Abkarian M

更新日期：2016-11-22 00:00:00

abstract：:Guanine nucleotide-binding regulatory protein (G protein)-coupled receptor kinases (GRKs) constitute a family of serine/threonine kinases that play a major role in the agonist-induced phosphorylation and desensitization of G-protein-coupled receptors. Herein we describe the generation of monoclonal antibodies (mAbs) t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oppermann M,Diversé-Pierluissi M,Drazner MH,Dyer SL,Freedman NJ,Peppel KC,Lefkowitz RJ

更新日期：1996-07-23 00:00:00

abstract：:The retinoblastoma gene product (the RB protein) is phosphorylated in a cell cycle-dependent manner and this modification is believed to be important for cells to progress through the cell cycle. We found that purified cdk2 (cyclin-dependent kinase/cell division kinase 2) can phosphorylate the RB protein in vitro at t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Akiyama T,Ohuchi T,Sumida S,Matsumoto K,Toyoshima K

更新日期：1992-09-01 00:00:00

abstract：:For many years, the Neanderthals have been recognized as a distinctive extinct hominid group that occupied Europe and western Asia between about 200,000 and 30,000 years ago. It is still debated, however, whether these hominids belong in their own species, Homo neanderthalensis, or represent an extinct variant of Homo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schwartz JH,Tattersall I

更新日期：1996-10-01 00:00:00

abstract：:Regulation of gene expression is usually separated into cis and trans components. The separation may become artificial if much of the variation in expression is under multigenic and epistatic (e.g., cis-by-trans) control. There is hence a need to quantify the relative contribution of cis, trans, and cis-by-trans effec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang HY,Fu Y,McPeek MS,Lu X,Nuzhdin S,Xu A,Lu J,Wu ML,Wu CI

更新日期：2008-04-29 00:00:00

abstract：:RNA interference, mediated by small interfering RNAs (siRNAs), is a conserved regulatory process that has evolved as an antiviral defense mechanism in plants and animals. It is not known whether host cells also use siRNAs as an antibacterial defense mechanism in eukaryotes. Here, we report the discovery of an endogeno...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Katiyar-Agarwal S,Morgan R,Dahlbeck D,Borsani O,Villegas A Jr,Zhu JK,Staskawicz BJ,Jin H

更新日期：2006-11-21 00:00:00

abstract：:The six members of the contactin (CNTN) family of neural cell adhesion molecules are involved in the formation and maintenance of the central nervous system (CNS) and have been linked to mental retardation and neuropsychiatric disorders such as autism. Five of the six CNTNs bind to the homologous receptor protein tyro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lamprianou S,Chatzopoulou E,Thomas JL,Bouyain S,Harroch S

更新日期：2011-10-18 00:00:00

abstract：:Synaptic loss is the cardinal feature linking neuropathology to cognitive decline in Alzheimer's disease (AD). However, the mechanism of synaptic damage remains incompletely understood. Here, using FRET-based glutamate sensor imaging, we show that amyloid-β peptide (Aβ) engages α7 nicotinic acetylcholine receptors to ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Talantova M,Sanz-Blasco S,Zhang X,Xia P,Akhtar MW,Okamoto S,Dziewczapolski G,Nakamura T,Cao G,Pratt AE,Kang YJ,Tu S,Molokanova E,McKercher SR,Hires SA,Sason H,Stouffer DG,Buczynski MW,Solomon JP,Michael S,Powers E

更新日期：2013-07-02 00:00:00

abstract：:Blood oxygen level-dependent functional MRI (fMRI) constitutes a powerful neuroimaging technology to map brain-wide functions in response to specific sensory or cognitive tasks. However, fMRI mapping of the vestibular system, which is pivotal for our sense of balance, poses significant challenges. Physical constraints...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leong ATL,Gu Y,Chan YS,Zheng H,Dong CM,Chan RW,Wang X,Liu Y,Tan LH,Wu EX

更新日期：2019-05-14 00:00:00

abstract：:Humans who have inherited the class I major histocompatibility allele HLA-A29 have a markedly increased relative risk of developing the eye disease termed birdshot chorioretinopathy. This disease affecting adults is characterized by symmetrically scattered, small, cream-colored spots in the fundus associated with reti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Szpak Y,Vieville JC,Tabary T,Naud MC,Chopin M,Edelson C,Cohen JH,Dausset J,de Kozak Y,Pla M

更新日期：2001-02-27 00:00:00

abstract：:The kainate receptor (KAR), a subtype of glutamate receptor, mediates excitatory synaptic responses at a subset of glutamatergic synapses. However, the molecular mechanisms underlying the trafficking of its different subunits are poorly understood. Here we use the CA1 hippocampal pyramidal cell, which lacks KAR-mediat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sheng N,Shi YS,Nicoll RA

更新日期：2017-01-31 00:00:00

abstract：:Pseudohypoparathyroidism type Ia (PHP-Ia) results from the loss of one allele of G(salpha), causing resistance to parathyroid hormone and other hormones that transduce signals via G(s). Most G(salpha)mutations cause the complete loss of protein expression, but some cause loss of function only, and these have provided ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Makita N,Sato J,Rondard P,Fukamachi H,Yuasa Y,Aldred MA,Hashimoto M,Fujita T,Iiri T

更新日期：2007-10-30 00:00:00

abstract：:Vertebrate remains recovered from a limestone fissure filling on Antigua, Lesser Antilles, are associated with radiocarbon dates ranging from 4300 to 2500 yr B.P., contemporaneous with the earliest aboriginal human occupation of the island. Nine taxa of lizards, snakes, birds, bats, and rodents (one-third of the total...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Steadman DW,Pregill GK,Olson SL

更新日期：1984-07-01 00:00:00

abstract：:Protein framework alterations in heritable Cu, Zn superoxide dismutase (SOD) mutants cause misassembly and aggregation in cells affected by the motor neuron disease ALS. However, the mechanistic relationship between superoxide dismutase 1 (SOD1) mutations and human disease is controversial, with many hypotheses postul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pratt AJ,Shin DS,Merz GE,Rambo RP,Lancaster WA,Dyer KN,Borbat PP,Poole FL 2nd,Adams MW,Freed JH,Crane BR,Tainer JA,Getzoff ED

更新日期：2014-10-28 00:00:00

abstract：:This article presents an agent-based computational model of civil violence. Two variants of the civil violence model are presented. In the first a central authority seeks to suppress decentralized rebellion. In the second a central authority seeks to suppress communal violence between two warring ethnic groups. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Epstein JM

更新日期：2002-05-14 00:00:00

abstract：:An evolutionary framework for viewing the formation, the stability, the organizational structure, and the social dynamics of biological families is developed. This framework is based upon three conceptual pillars: ecological constraints theory, inclusive fitness theory, and reproductive skew theory. I offer a set of 1...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Emlen ST

更新日期：1995-08-29 00:00:00

abstract：:Protecting hydrologic connectivity of freshwater ecosystems is fundamental to ensuring species persistence, ecosystem integrity, and human well-being. More frequent and severe droughts associated with climate change are poised to significantly alter flow intermittence patterns and hydrologic connectivity in dryland st...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jaeger KL,Olden JD,Pelland NA

更新日期：2014-09-23 00:00:00

abstract：:Better understanding myelination of peripheral nerves would benefit patients affected by peripheral neuropathies, including Charcot-Marie-Tooth disease. Little is known about the role the Golgi compartment plays in Schwann cell (SC) functions. Here, we studied the role of Golgi in myelination of peripheral nerves in m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baba T,Alvarez-Prats A,Kim YJ,Abebe D,Wilson S,Aldworth Z,Stopfer MA,Heuser J,Balla T

更新日期：2020-11-10 00:00:00