Spontaneous retinopathy in HLA-A29 transgenic mice.

abstract：:Dopamine supersensitivity occurs in schizophrenia and other psychoses, and after hippocampal lesions, antipsychotics, ethanol, amphetamine, phencyclidine, gene knockouts of Dbh (dopamine beta-hydroxylase), Drd4 receptors, Gprk6 (G protein-coupled receptor kinase 6), Comt (catechol-O-methyltransferase), or Th-/-, DbhTh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seeman P,Weinshenker D,Quirion R,Srivastava LK,Bhardwaj SK,Grandy DK,Premont RT,Sotnikova TD,Boksa P,El-Ghundi M,O'dowd BF,George SR,Perreault ML,Männistö PT,Robinson S,Palmiter RD,Tallerico T

更新日期：2005-03-01 00:00:00

abstract：:Aberrations in the T cell repertoire with the emergence of oligoclonal populations have been described in patients with rheumatoid arthritis (RA). However, the extent of the repertoire perturbations as well as the underlying mechanisms are not known. We now have examined the diversity of the peripheral CD4 T cell repe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wagner UG,Koetz K,Weyand CM,Goronzy JJ

更新日期：1998-11-24 00:00:00

abstract：:Pbx-regulating protein-1 (Prep1) is a tumor suppressor, whereas myeloid ecotropic viral integration site-1 (Meis1) is an oncogene. We show that, to perform these activities in mouse embryonic fibroblasts, both proteins competitively heterodimerize with pre-B-cell leukemia homeobox-1 (Pbx1). Meis1 alone transforms Prep...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dardaei L,Longobardi E,Blasi F

更新日期：2014-03-11 00:00:00

abstract：:Infectious diseases of domesticated animals impact human well-being via food insecurity, loss of livelihoods, and human infections. While much research has focused on parasites that infect single host species, most parasites of domesticated mammals infect multiple species. The impact of multihost parasites varies acro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Farrell MJ,Davies TJ

更新日期：2019-04-16 00:00:00

abstract：:Several polypeptides contained in the coat and the core of adenovirus type 2 particles have been identified as virus gene products. They are synthesized in vitro by a cell-free protein-making system programmed by adenovirus type 2 messenger RNA that has been hybridized with and eluted from virus DNA. Fractionation by ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eron L,Westphal H

更新日期：1974-09-01 00:00:00

abstract：:The high frequency, recent origin, and geographic distribution of the CCR5-Delta 32 deletion allele together indicate that it has been intensely selected in Europe. Although the allele confers resistance against HIV-1, HIV has not existed in the human population long enough to account for this selective pressure. The ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Galvani AP,Slatkin M

更新日期：2003-12-09 00:00:00

abstract：:The avian predentary is a small skeletal structure located rostral to the paired dentaries found only in Mesozoic ornithuromorphs. The evolution and function of this enigmatic element is unknown. Skeletal tissues forming the predentary and the lower jaws in the basal ornithuromorph Yanornis martini are identified usin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bailleul AM,Li Z,O'Connor J,Zhou Z

更新日期：2019-12-03 00:00:00

abstract：:This paper reports the results of a randomized field experiment involving registered voters in the city of New Haven. Nonpartisan get-out-the-vote messages were delivered through personal canvassing shortly before the November 1998 election. We find that personal canvassing increased voter turnout by approximately 6. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gerber AS,Green DP

更新日期：1999-09-14 00:00:00

abstract：:Colloidal and sol-gel procedures have been used to prepare heterogeneous catalysts consisting of platinum metal particles with narrow size distributions and well defined shapes dispersed on high-surface-area silica supports. The overall procedure was developed in three stages. First, tetrahedral and cubic colloidal me...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee I,Morales R,Albiter MA,Zaera F

更新日期：2008-10-07 00:00:00

abstract：:Growth of 3T3-L2 fibroblasts in medium containing 5-bromo-2'-deoxyuridine prevents the spontaneous cytodifferentiation of these cells into adipose cells. Treatment of bromodeoxyuridine-suppressed cultures at confluence with 1-methyl-3-isobutylxanthine, a promoter of the adipose conversion, results in differentiation o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Russell TR

更新日期：1979-09-01 00:00:00

abstract：:Determining the principal energy-transfer pathways responsible for allosteric communication in biomolecules remains challenging, partially due to the intrinsic complexity of the systems and the lack of effective characterization methods. In this work, we introduce the eigenvector centrality metric based on mutual info...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Negre CFA,Morzan UN,Hendrickson HP,Pal R,Lisi GP,Loria JP,Rivalta I,Ho J,Batista VS

更新日期：2018-12-26 00:00:00

abstract：:The recent observation of superconductivity in [Formula: see text] has raised fundamental questions about the hierarchy of the underlying electronic structure. Calculations suggest that this system falls in the Mott-Hubbard regime, rather than the charge-transfer configuration of other nickel oxides and the supercondu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goodge BH,Li D,Lee K,Osada M,Wang BY,Sawatzky GA,Hwang HY,Kourkoutis LF

更新日期：2021-01-12 00:00:00

abstract：:The rise of inorganic-biological hybrid organisms for solar-to-chemical production has spurred mechanistic investigations into the dynamics of the biotic-abiotic interface to drive the development of next-generation systems. The model system, Moorella thermoacetica-cadmium sulfide (CdS), combines an inorganic semicond...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kornienko N,Sakimoto KK,Herlihy DM,Nguyen SC,Alivisatos AP,Harris CB,Schwartzberg A,Yang P

更新日期：2016-10-18 00:00:00

abstract：:Humans choose actions based on both habit and planning. Habitual control is computationally frugal but adapts slowly to novel circumstances, whereas planning is computationally expensive but can adapt swiftly. Current research emphasizes the competition between habits and plans for behavioral control, yet many complex...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cushman F,Morris A

更新日期：2015-11-10 00:00:00

abstract：:SgrS RNA is a model for the large class of Hfq-associated small RNAs that act to posttranscriptionally regulate bacterial mRNAs. The function of SgrS is well-characterized in nonpathogenic Escherichia coli, where it was originally shown to counteract glucose-phosphate stress by acting as a repressor of the ptsG mRNA, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Papenfort K,Podkaminski D,Hinton JC,Vogel J

更新日期：2012-03-27 00:00:00

abstract：:Efficiently regenerated single colonies from mixed multiply auxotrophic Bacillus subtilis protoplasts, fused with polyethylene glycol, reveal colonies carrying each of the parent types (biparentals) and recombinant colonies. The latter appear in high yields (up to 1% of certain recombinant classes); the yield of bipar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hotchkiss RD,Gabor MH

更新日期：1980-06-01 00:00:00

abstract：:Prions are infectious proteins that encipher biological information within their conformations; variations in these conformations dictate different prion strains. Toward elucidating the molecular language of prion protein (PrP) conformations, we produced an array of recombinant PrP amyloids with varying conformational...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Colby DW,Giles K,Legname G,Wille H,Baskakov IV,DeArmond SJ,Prusiner SB

更新日期：2009-12-01 00:00:00

abstract：:Serum levels of apolipoprotein CIII (apoCIII) are increased in type 1 diabetic patients, and when β cells are exposed to these diabetic sera, apoptosis occurs, an effect abolished by an antibody against apoCIII. We have investigated the BB rat, an animal model that develops a human-like type 1 diabetes, and found that...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Holmberg R,Refai E,Höög A,Crooke RM,Graham M,Olivecrona G,Berggren PO,Juntti-Berggren L

更新日期：2011-06-28 00:00:00

abstract：:Two genes have a synthetically lethal relationship when the silencing or inhibiting of 1 gene is only lethal in the context of a mutation or activation of the second gene. This situation offers an attractive therapeutic strategy, as inhibition of such a gene will only trigger cell death in tumor cells with an activate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Molenaar JJ,Ebus ME,Geerts D,Koster J,Lamers F,Valentijn LJ,Westerhout EM,Versteeg R,Caron HN

更新日期：2009-08-04 00:00:00

abstract：:Changes in protein function can lead to changes in the selection acting on specific residues. This can often be detected as evolutionary rate changes at the sites in question. A maximum-likelihood method for detecting evolutionary rate shifts at specific protein positions is presented. The method determines significan...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Knudsen B,Miyamoto MM

更新日期：2001-12-04 00:00:00

abstract：:As an alternative pathway of controlled cell death, necroptosis can be triggered by tumor necrosis factor via the kinases RIPK1/RIPK3 and the effector protein mixed-lineage kinase domain-like protein (MLKL). Upon activation, MLKL oligomerizes and integrates into the plasma membrane via its executioner domain. Here, we...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rübbelke M,Fiegen D,Bauer M,Binder F,Hamilton J,King J,Thamm S,Nar H,Zeeb M

更新日期：2020-12-29 00:00:00

abstract：:A recombinant plasmid containing a DNA segment complementary to rat liver albumin mRNA has been constructed, cloned, and used to examine the organization of albumin gene. The 18S fraction of total liver poly(A)-containing RNA was copied into a double-stranded cDNA by avian myeloblastosis virus reverse transcriptase an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kioussis D,Hamilton R,Hanson RW,Tilghman SM,Taylor JM

更新日期：1979-09-01 00:00:00

abstract：:Speciation involves the origin of trait differences that limit or prevent gene exchange and ultimately results in daughter populations that form monophyletic or exclusive genetic groups. However, for recently diverged populations or species between which reproductive isolation is often incomplete, gene genealogies wil...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dopman EB,Pérez L,Bogdanowicz SM,Harrison RG

更新日期：2005-10-11 00:00:00

abstract：:Directionality of signaling among brain regions provides essential information about human cognition and disease states. Assessing such effective connectivity (EC) across brain states using functional magnetic resonance imaging (fMRI) alone has proven difficult, however. We propose a novel measure of EC, termed metabo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Riedl V,Utz L,Castrillón G,Grimmer T,Rauschecker JP,Ploner M,Friston KJ,Drzezga A,Sorg C

更新日期：2016-01-12 00:00:00

abstract：:Clathrin-coated vesicles are known to be involved in the transport of proteins from the Golgi to the vacuole in plant cells. The mechanisms by which proteins are directed into this pathway are not known. Here we identify an integral membrane protein of approximately 80 kDa, extracted from clathrin-coated vesicles of d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kirsch T,Paris N,Butler JM,Beevers L,Rogers JC

更新日期：1994-04-12 00:00:00

abstract：:Highly expanded Cretaceous-Paleogene (K-Pg) boundary section from the Chicxulub peak ring, recovered by International Ocean Discovery Program (IODP)-International Continental Scientific Drilling Program (ICDP) Expedition 364, provides an unprecedented window into the immediate aftermath of the impact. Site M0077 inclu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gulick SPS,Bralower TJ,Ormö J,Hall B,Grice K,Schaefer B,Lyons S,Freeman KH,Morgan JV,Artemieva N,Kaskes P,de Graaff SJ,Whalen MT,Collins GS,Tikoo SM,Verhagen C,Christeson GL,Claeys P,Coolen MJL,Goderis S,Goto K,

更新日期：2019-09-24 00:00:00

abstract：:Tetrahymena ribozymes hold promise for repairing genetic disorders but are largely limited by their modest splicing efficiency and low production of final therapeutic proteins. Ribozyme evolution in intact living mammalian cells would greatly facilitate the discovery of new ribozyme variants with high in vivo activity...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hasegawa S,Jackson WC,Tsien RY,Rao J

更新日期：2003-12-09 00:00:00

abstract：:Cells contain numerous enzymes that use molecular oxygen for their reactions. Often, their active sites are buried deeply inside the protein, which raises the question whether there are specific access channels guiding oxygen to the site of catalysis. Choosing 12/15-lipoxygenase as a typical example for such oxygen-de...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Saam J,Ivanov I,Walther M,Holzhütter HG,Kuhn H

更新日期：2007-08-14 00:00:00

abstract：:Mononegaviruses are promising tools as oncolytic vectors and transgene delivery vectors for gene therapy and regenerative medicine. By using the Magnet proteins, which reversibly heterodimerize upon blue light illumination, photocontrollable mononegaviruses (measles and rabies viruses) were generated. The Magnet prote...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tahara M,Takishima Y,Miyamoto S,Nakatsu Y,Someya K,Sato M,Tani K,Takeda M

更新日期：2019-06-11 00:00:00

abstract：:We have detected a variant species of bovine growth hormone mRNA in bovine pituitary tissue and in a stably transfected bovine growth hormone-producing cell line. Analysis of this variant mRNA indicated that the last intervening sequence (intron D) had not been removed by splicing. Inspection of the sequence of intron...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hampson RK,Rottman FM

更新日期：1987-05-01 00:00:00