Lowering apolipoprotein CIII delays onset of type 1 diabetes.

abstract：:When the visual (striate) cortex (V1) is damaged in human subjects, cortical blindness results in the contralateral visual half field. Nevertheless, under some experimental conditions, subjects demonstrate a capacity to make visual discriminations in the blind hemifield (blindsight), even though they have no phenomena...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weiskrantz L,Barbur JL,Sahraie A

更新日期：1995-06-20 00:00:00

abstract：:Repeated within-day testing on a texture discrimination task leads to retinotopically specific decreases in performance. Although perceptual learning has been shown to be highly specific to the retinotopic location and characteristics of the trained stimulus, the specificity of perceptual deterioration has not been st...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mednick SC,Arman AC,Boynton GM

更新日期：2005-03-08 00:00:00

abstract：:The RAD6 gene of Saccharomyces cerevisiae encodes a ubiquitin-conjugating enzyme (E2) that is required for DNA repair, damage-induced mutagenesis, and sporulation. We have cloned the two human RAD6 homologs, designated HHR6A and HHR6B. The two 152-amino acid human proteins share 95% sequence identity with each other a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koken MH,Reynolds P,Jaspers-Dekker I,Prakash L,Prakash S,Bootsma D,Hoeijmakers JH

更新日期：1991-10-15 00:00:00

abstract：:PKC eta is expressed predominantly in the epithelial tissues; however, its role in the regulation of epithelial tight junctions (TJs) is unknown. We present evidence that PKC eta phosphorylates occludin on threonine residues (T403 and T404) and plays a crucial role in the assembly and/or maintenance of TJs in Caco-2 a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Suzuki T,Elias BC,Seth A,Shen L,Turner JR,Giorgianni F,Desiderio D,Guntaka R,Rao R

更新日期：2009-01-06 00:00:00

abstract：:Klotho is a circulating protein, and Klotho deficiency disturbs endothelial integrity, but the molecular mechanism is not fully clarified. We report that vascular endothelium in Klotho-deficient mice showed hyperpermeability with increased apoptosis and down-regulation of vascular endothelial (VE)-cadherin because of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kusaba T,Okigaki M,Matui A,Murakami M,Ishikawa K,Kimura T,Sonomura K,Adachi Y,Shibuya M,Shirayama T,Tanda S,Hatta T,Sasaki S,Mori Y,Matsubara H

更新日期：2010-11-09 00:00:00

abstract：:Multiple epiphyseal dysplasia (MED) is a degenerative cartilage condition shown in some cases to be caused by mutations in genes encoding cartilage oligomeric matrix protein or type IX collagen. We studied a family with autosomal dominant MED affecting predominantly the knee joints and a mild proximal myopathy. Geneti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bönnemann CG,Cox GF,Shapiro F,Wu JJ,Feener CA,Thompson TG,Anthony DC,Eyre DR,Darras BT,Kunkel LM

更新日期：2000-02-01 00:00:00

abstract：:An unbiased survey has been made of the stable, most abundant multi-protein complexes in Desulfovibrio vulgaris Hildenborough (DvH) that are larger than Mr approximately 400 k. The quaternary structures for 8 of the 16 complexes purified during this work were determined by single-particle reconstruction of negatively ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Han BG,Dong M,Liu H,Camp L,Geller J,Singer M,Hazen TC,Choi M,Witkowska HE,Ball DA,Typke D,Downing KH,Shatsky M,Brenner SE,Chandonia JM,Biggin MD,Glaeser RM

更新日期：2009-09-29 00:00:00

abstract：:The mitochondrial genome of Saccharomyces cerevisiae codes for 24 tRNAs. The nucleotide sequences of the tRNA genes suggest a unique set of rules that govern the decoding of the mitochondrial genetic code. The four codons of unmixed fmilies are recognized by single tRNAs that always have a U in the wobble position of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bonitz SG,Berlani R,Coruzzi G,Li M,Macino G,Nobrega FG,Nobrega MP,Thalenfeld BE,Tzagoloff A

更新日期：1980-06-01 00:00:00

abstract：:Historical data provide a baseline against which to judge the significance of recent ecological shifts and guide conservation strategies, especially for species decimated by pre-20th century harvesting. Northern fur seals (NFS; Callorhinus ursinus) are a common pinniped species in archaeological sites from southern Ca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Newsome SD,Etnier MA,Gifford-Gonzalez D,Phillips DL,van Tuinen M,Hadly EA,Costa DP,Kennett DJ,Guilderson TP,Koch PL

更新日期：2007-06-05 00:00:00

abstract：:The cytoskeleton provides structural integrity to cells and serves as a key component in mechanotransduction. Tensins are thought to provide a force-bearing linkage between integrins and the actin cytoskeleton; yet, direct evidence of tensin's role in mechanotransduction is lacking. We here report that local force app...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheah JS,Jacobs KA,Heinrich V,Lo SH,Yamada S

更新日期：2019-10-01 00:00:00

abstract：:CrAs was observed to possess the bulk superconductivity under high-pressure conditions. To understand the superconducting mechanism and explore the correlation between the structure and superconductivity, the high-pressure structural evolution of CrAs was investigated using the angle-dispersive X-ray diffraction (XRD)...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yu Z,Wu W,Hu Q,Zhao J,Li C,Yang K,Cheng J,Luo J,Wang L,Mao HK

更新日期：2015-12-01 00:00:00

abstract：:Interfacial zones between tissues provide specialized, transitional junctions central to normal tissue function. Regenerative medicine strategies focused on multiple cell types and/or bi/tri-layered scaffolds do not provide continuously graded interfaces, severely limiting the integration and biological performance of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Phillips JE,Burns KL,Le Doux JM,Guldberg RE,García AJ

更新日期：2008-08-26 00:00:00

abstract：:The epidermal growth factor receptor gene has been found to be amplified and rearranged in human glioblastomas in vivo. Here we present the sequence across a splice junction of aberrant epidermal growth factor receptor transcripts derived from corresponding and uniquely rearranged genes that are coamplified and coexpr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sugawa N,Ekstrand AJ,James CD,Collins VP

更新日期：1990-11-01 00:00:00

abstract：:A retinoid was isolated by a multistep procedure from the small intestines of vitamin A-deficient rats given a single dose of retinoic acid. The compound, designated 8II, was pure, as demonstrated by four high-pressure liquid chromatographic procedures. It was positively identified as 5,8-oxyretinoic acid by ultraviol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Napoli JL,McCormick AM,Schnoes HK,DeLuca HF

更新日期：1978-06-01 00:00:00

abstract：:In rats fed the liver carcinogen 2-acetylaminofluorene (AAF), the two most abundant types of DNA adduct are N-(deoxyguanosin-8-yl)-2-acetylaminofluorene and its deacetylated derivative. When plasmids carrying AAF adducts replicate in bacteria, the predominant mutations are frameshifts, whereas with deacetylated (AF) a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mah MC,Boldt J,Culp SJ,Maher VM,McCormick JJ

更新日期：1991-11-15 00:00:00

abstract：:Gram-negative bacteria possess a characteristic outer membrane, of which the lipid A constituent elicits a strong host immune response through the Toll-like receptor 4 complex, and acts as a component of the permeability barrier to prevent uptake of bactericidal compounds. Lipid A species comprise the bulk of the oute...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dovala D,Rath CM,Hu Q,Sawyer WS,Shia S,Elling RA,Knapp MS,Metzger LE 4th

更新日期：2016-10-11 00:00:00

abstract：:The Xlim-1 gene is activated in the late blastula stage of Xenopus embryogenesis in the mesoderm, and its RNA product becomes concentrated in the Spemann organizer at early gastrula stage. A major regulator of early expression of Xlim-1 is activin or an activin-like signal. We report experiments aiming to identify the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rebbert ML,Dawid IB

更新日期：1997-09-02 00:00:00

abstract：:In a previous study we demonstrated that vesicular stomatitis virus (VSV) can be used as a vector to express a soluble protein in mammalian cells. Here we have generated VSV recombinants that express four different membrane proteins: the cellular CD4 protein, a CD4-G hybrid protein containing the ectodomain of CD4 and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schnell MJ,Buonocore L,Kretzschmar E,Johnson E,Rose JK

更新日期：1996-10-15 00:00:00

abstract：:How climate change influences the dynamics of plant populations is not well understood, as few plant studies have measured responses of vital rates to climatic variables and modeled the impact on population growth. The present study used 25 y of demographic data to analyze how survival, growth, and fecundity respond t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Campbell DR

更新日期：2019-06-25 00:00:00

abstract：:Activation of P2X2 receptor channels by extracellular ATP is thought to play important roles in cochlear adaptation to elevated sound levels and protection from overstimulation. Each subunit of a trimeric P2X2 receptor is composed of intracellular N and C termini, a large extracellular domain containing the ATP bindin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： George B,Swartz KJ,Li M

更新日期：2019-11-05 00:00:00

abstract：:We use a three-dimensional, higher-order ice flow model and a realistic initial condition to simulate dynamic perturbations to the Greenland ice sheet during the last decade and to assess their contribution to sea level by 2100. Starting from our initial condition, we apply a time series of observationally constrained...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Price SF,Payne AJ,Howat IM,Smith BE

更新日期：2011-05-31 00:00:00

abstract：:Members of the transforming growth factor-β superfamily play essential roles in various aspects of embryonic development and physiological organ function. Among them, bone morphogenetic protein (BMP) 9 and BMP10 regulate embryonic vascular development by activating their endothelial receptor ALK1 (activin receptor-lik...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Somekawa S,Imagawa K,Hayashi H,Sakabe M,Ioka T,Sato GE,Inada K,Iwamoto T,Mori T,Uemura S,Nakagawa O,Saito Y

更新日期：2012-07-24 00:00:00

abstract：:Radiation leukemia virus, isolated from radiation-induced lymphomas in C57BL/Ka mice and propagated in that strain, is thymotropic and leukemogenic in vivo but replicates poorly, if at all, in mouse and mink fibroblast cultures in vitro. Comparative studies indicate that this naturally occurring virus is distinct from...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Declève A,Lieberman M,Ihle JN,Kaplan HS

更新日期：1976-12-01 00:00:00

abstract：:The multifunctional Ca2+/calmodulin-dependent protein kinase purified from rat brain cytosol undergoes an intramolecular self-phosphorylation or autophosphorylation. Autophosphorylation produces two strikingly different effects on kinase activity that are dependent on the level of ATP used in the reaction. At low but ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lou LL,Lloyd SJ,Schulman H

更新日期：1986-12-01 00:00:00

abstract：:beta-catenin has functions as both an adhesion and a signaling molecule. Disruption of these functions through mutations of the beta-catenin gene (CTNNB1) may be important in the development of colorectal tumors. We examined the entire coding sequence of beta-catenin by reverse transcriptase-PCR (RT-PCR) and direct se...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ilyas M,Tomlinson IP,Rowan A,Pignatelli M,Bodmer WF

更新日期：1997-09-16 00:00:00

abstract：:cDNA clones for the (S)-tetrahydroberberine (H4Ber) oxidase of cultured berberine-producing Coptis japonica cells were isolated by screening a C. japonica cDNA library with synthetic nucleotides that can encode the NH2-terminal sequence of this enzyme. Analyses of the nucleotide sequences of the cloned cDNA inserts re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Okada N,Koizumi N,Tanaka T,Ohkubo H,Nakanishi S,Yamada Y

更新日期：1989-01-01 00:00:00

abstract：:To elucidate the roles of IgE antibody in host responses to helminth infection, selective IgE-deficient SJA/9 mice were infected with the nematode parasites Nippostrongylus brasiliensis, which elicits remarkable potentiated IgE production, and Trichinella spiralis, which induces strong anti-Trichinella IgE antibody pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Watanabe N,Katakura K,Kobayashi A,Okumura K,Ovary Z

更新日期：1988-06-01 00:00:00

abstract：:We have cloned and identified a DNA sequence complementary to the mRNA of creatine kinase (CK) isozyme M, although the mRNA is a minor species of the total mRNA in developing myoblasts. Poly(A)+RNA from breast and thigh muscle of 5-week-old chicks was enriched for CK mRNA by a novel procedure of sucrose gradient centr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schweinfest CW,Kwiatkowski RW,Dottin RP

更新日期：1982-08-01 00:00:00

abstract：:The 5' end of a eukaryotic mRNA transcript generally has a 7-methylguanosine (m7G) cap that protects mRNA from degradation and mediates almost all other aspects of gene expression. Some RNAs in Escherichia coli, yeast, and mammals were recently found to contain an NAD+ cap. Here, we report the development of the metho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang H,Zhong H,Zhang S,Shao X,Ni M,Cai Z,Chen X,Xia Y

更新日期：2019-06-11 00:00:00

abstract：:13C-labeled precorrin-6x is biosynthesized by cell-free protein preparations from Pseudomonas denitrificans in separate experiments using delta-amino[5-13C]levulinic acid and the corresponding delta-amino[4-13C]- and delta-amino[3-13C]levulinic acid-labeled forms in conjunction with S-[methyl-13C]adenosylmethionine fo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thibaut D,Blanche F,Debussche L,Leeper FJ,Battersby AR

更新日期：1990-11-01 00:00:00