Protective immunity and eosinophilia in IgE-deficient SJA/9 mice infected with Nippostrongylus brasiliensis and Trichinella spiralis.

abstract：:Escherichia coli lipopolysaccharide (LPS)-induced nitrate biosynthesis was studied in LPS-sensitive C3H/He and LPS-resistant C3H/HeJ mice. Intraperitoneal injection of 15 micrograms of LPS led to a temporary 5- to 6-fold increase in blood nitrate concentration in the C3H/He strain. Levels of nitrate excreted in the ur...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stuehr DJ,Marletta MA

更新日期：1985-11-01 00:00:00

abstract：:We present evidence that the JAK-STAT signal transduction pathway regulates multiple developmental processes in Drosophila. We screened for second-site mutations that suppress the phenotype of the hyperactive hopTum-1 Jak kinase, and recovered a mutation that meiotically maps to the known chromosomal position of D-Sta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yan R,Luo H,Darnell JE Jr,Dearolf CR

更新日期：1996-06-11 00:00:00

abstract：:Saccharomyces cerevisiae is one of the most important model organisms and has been a valuable asset to human civilization. However, despite its extensive use in the last 9,000 y, the existence of a seasonal cycle outside human-made environments has not yet been described. We demonstrate the role of social wasps as vec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stefanini I,Dapporto L,Legras JL,Calabretta A,Di Paola M,De Filippo C,Viola R,Capretti P,Polsinelli M,Turillazzi S,Cavalieri D

更新日期：2012-08-14 00:00:00

abstract：:We have determined the localization and orientation of two genetic probes within the human major histocompatibility complex by chromosomal in situ hybridization. Our data indicate that a cloned genomic probe cross-hybridizing to HLA-A, -B, and -C heavy chain loci is homologous to sequences located on chromosome 6 at b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morton CC,Kirsch IR,Nance WE,Evans GA,Korman AJ,Strominger JL

更新日期：1984-05-01 00:00:00

abstract：:During primate evolution, a major factor in lengthening life-span and decreasing age-specific cancer rates may have been improved protective mechanisms against oxygen radicals. We propose that one of these protective systems is plasma uric acid, the level of which increased markedly during primate evolution as a conse...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ames BN,Cathcart R,Schwiers E,Hochstein P

更新日期：1981-11-01 00:00:00

abstract：:We have tried to find out why Ascaris hemoglobin has such an exceptionally high oxygen affinity (P50 approximately 0.004 mmHg; 1 mmHg = 133 Pa). Following Kloek et al., we have synthesized the N-terminal globin domain of Ascaris hemoglobin in Escherichia coli [Kloek, A. P., Yang, J., Mathews, F. S. & Goldberg, D. (199...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： De Baere I,Perutz MF,Kiger L,Marden MC,Poyart C

更新日期：1994-02-15 00:00:00

abstract：:Epilepsy is the most common neurological disorder of young humans. Each year 150,000 children in the United States experience their first seizure. Antiepileptic drugs (AEDs), used to treat seizures in children, infants, and pregnant women, cause cognitive impairment, microcephaly, and birth defects. The cause of unwan...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bittigau P,Sifringer M,Genz K,Reith E,Pospischil D,Govindarajalu S,Dzietko M,Pesditschek S,Mai I,Dikranian K,Olney JW,Ikonomidou C

更新日期：2002-11-12 00:00:00

abstract：:Controlled maturation of ovarian follicles is necessary for fertility. Follicles are restrained at an immature stage until stimulated by FSH secreted by pituitary gonadotropes. FSH acts on granulosa cells within the immature follicle to inhibit apoptosis, promote proliferation, stimulate production of steroid and prot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hunzicker-Dunn ME,Lopez-Biladeau B,Law NC,Fiedler SE,Carr DW,Maizels ET

更新日期：2012-10-30 00:00:00

abstract：:A virus is associated with a strain of transovarially-transmitted SR-spirochetes, NSR, of Drosophila. This virus, designated spv-1, is able to infect and to multiply in another strain of SR-spirochetes, WSR, thereby eliminating the SR condition from the host flies. Spv-1 contains DNA, has a buoyant density of 1.480 in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oishi K,Poulson DF

更新日期：1970-11-01 00:00:00

abstract：:Cellular cholesterol metabolism is regulated primarily through the coordinate expression of two proteins, the low density lipoprotein (LDL) receptor and 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase (EC 1.1.1.34). We have used cDNA probes for the human genes encoding these proteins to determine the precise...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lindgren V,Luskey KL,Russell DW,Francke U

更新日期：1985-12-01 00:00:00

abstract：:Mucopolysaccharides have been isolated, fractionated, and characterized from the nuclei of cultured B16 mouse melanoma cells grown in the presence of (3-H)-glucosamine and (35-S)sulfate. Digestion of the nuclei with DNase followed by Pronase gave a mixture of complex carbohydrates from which the mucopolysaccharides we...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bhavanandan VP,Davidson EA

更新日期：1975-06-01 00:00:00

abstract：:For the emergence of early life, the formation of biopolymers such as RNA is essential. However, the addition of nucleotide monomers to existing oligonucleotides requires millimolar concentrations. Even in such optimistic settings, no polymerization of RNA longer than about 20 bases could be demonstrated. How then cou...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mast CB,Schink S,Gerland U,Braun D

更新日期：2013-05-14 00:00:00

abstract：:Protein O-mannosylation represents an evolutionarily conserved, essential posttranslational modification with immense impact on a variety of cellular processes. In humans, O-mannosylation defects result in Walker-Warburg syndrome, a severe recessive congenital muscular dystrophy associated with defects in neuronal mig...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hutzler J,Schmid M,Bernard T,Henrissat B,Strahl S

更新日期：2007-05-08 00:00:00

abstract：:A temperature-sensitive ras allele has an effective lethal phase at 29 degrees C about 12 hr after pupation and a temperature-sensitive period for lethality beginning midway through the third larval instar and ending around pupation. The mutation also alters the quantity of pteridines present in the eyes, testes, and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grigliatti T,Suzuki DT

更新日期：1970-11-01 00:00:00

abstract：:Oxidation of genomic DNA forms the guanine lesion 7,8-dihydro-8-oxoguanine (8-oxoG). When in the template base position during DNA synthesis the 8-oxoG lesion has dual coding potential by virtue of its anti- and syn-conformations, base pairing with cytosine and adenine, respectively. This impacts mutagenesis, because ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Batra VK,Shock DD,Beard WA,McKenna CE,Wilson SH

更新日期：2012-01-03 00:00:00

abstract：:Replication of the kinetoplast DNA (kDNA) minicircle of trypanosomatids initiates at a conserved 12-nt sequence, 5'-GGGGTTGGTGTA-3', termed the universal minicircle sequence (UMS). A sequence-specific single-stranded DNA-binding protein from Crithidia fasciculata binds the heavy strand of the 12-mer UMS. Whereas this ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Avrahami D,Tzfati Y,Shlomai J

更新日期：1995-11-07 00:00:00

abstract：:Tridecaptin A1 (TriA1) is a nonribosomal lipopeptide with selective antimicrobial activity against Gram-negative bacteria. Here we show that TriA1 exerts its bactericidal effect by binding to the bacterial cell-wall precursor lipid II on the inner membrane, disrupting the proton motive force. Biochemical and biophysic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cochrane SA,Findlay B,Bakhtiary A,Acedo JZ,Rodriguez-Lopez EM,Mercier P,Vederas JC

更新日期：2016-10-11 00:00:00

abstract：:Activation of protein kinase C (PKC) by phorbol ester facilitates hormonal secretion and transmitter release, and phorbol ester-induced synaptic potentiation (PESP) is a model for presynaptic facilitation. A variety of PKC isoforms are expressed in the central nervous system, but the isoform involved in the PESP has n...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Saitoh N,Hori T,Takahashi T

更新日期：2001-11-20 00:00:00

abstract：:Neuroinflammation is an important contributor to neuronal pathology and death in neurodegenerative diseases and neuronal injury. Therapeutic interventions blocking the activity of the inflammatory kinase IKKβ, a key regulator of neuroinflammatory pathways, is protective in several animal models of neurodegenerative di...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ochaba J,Fote G,Kachemov M,Thein S,Yeung SY,Lau AL,Hernandez S,Lim RG,Casale M,Neel MJ,Monuki ES,Reidling J,Housman DE,Thompson LM,Steffan JS

更新日期：2019-05-28 00:00:00

abstract：:The RuvB protein is induced in Escherichia coli as part of the SOS response to DNA damage. It is required for genetic recombination and the postreplication repair of DNA. In vitro, the RuvB protein promotes the branch migration of Holliday junctions and has a DNA helicase activity in reactions that require ATP hydroly...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stasiak A,Tsaneva IR,West SC,Benson CJ,Yu X,Egelman EH

更新日期：1994-08-02 00:00:00

abstract：:A novel type I transmembrane protein of COPI-coated vesicles, p23, has been demonstrated to be localized mainly to the Golgi complex. This protein and p24, another member of the p24 family, have been shown to bind coatomer via their short cytoplasmic tails. Here we demonstrate that p23 continuously cycles through the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nickel W,Sohn K,Bünning C,Wieland FT

更新日期：1997-10-14 00:00:00

abstract：:Bordetella dermonecrotizing toxin causes assembly of actin stress fibers and focal adhesions in some cultured cells and induces mobility shifts of the small GTP-binding protein Rho on electrophoresis. We attempted to clarify the molecular basis of the toxin action on Rho. Analysis of the amino acid sequence of toxin-t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Horiguchi Y,Inoue N,Masuda M,Kashimoto T,Katahira J,Sugimoto N,Matsuda M

更新日期：1997-10-14 00:00:00

abstract：:In vitro recombination of cloned H-2 genes resulted in two allogeneically novel mouse transplantation antigens in which the C2 domains of H-2Ld and H-2Dd were exchanged. These genes were introduced into mouse L cells by DNA-mediated gene transfer. We have used these transformed fibroblast lines, expressing recombinant...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ozato K,Evans GA,Shykind B,Margulies DH,Seidman JG

更新日期：1983-04-01 00:00:00

abstract：:Coiled-coil motifs are ubiquitous mediators of specific protein-protein interactions through the formation of interlocking hydrophobic seams between alpha-helical chains. Residues that form these seams occur at the first (a) and fourth (d) positions of a characteristic 7-aa repeat and are primarily aliphatic. The pote...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu J,Yong W,Deng Y,Kallenbach NR,Lu M

更新日期：2004-11-16 00:00:00

abstract：:Type I and type III IFNs bind to different cell-surface receptors but induce identical signal transduction pathways, leading to the expression of antiviral host effector molecules. Despite the fact that type III IFN (IFN-λ) has been shown to predominantly act on mucosal organs, in vivo infection studies have failed to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pott J,Mahlakõiv T,Mordstein M,Duerr CU,Michiels T,Stockinger S,Staeheli P,Hornef MW

更新日期：2011-05-10 00:00:00

abstract：:A patterning method termed "RIPPLE" (reactive interface patterning promoted by lithographic electrochemistry) is applied to the fabrication of arrays of dielectric and metallic optical elements. This method uses cyclic voltammetry to impart patterns onto the working electrode of a standard three-electrode electrochemi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kempa TJ,Bediako DK,Kim SK,Park HG,Nocera DG

更新日期：2015-04-28 00:00:00

abstract：:Pulmonary pathologies including adult respiratory distress syndrome are characterized by disruption of pulmonary integrity and edema compromising respiratory function. Sphingosine 1-phosphate (S1P) is a lipid mediator synthesized and/or stored in mast cells, platelets, and epithelial cells, with production up-regulate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gon Y,Wood MR,Kiosses WB,Jo E,Sanna MG,Chun J,Rosen H

更新日期：2005-06-28 00:00:00

abstract：:This paper is a theoretical study of dynamic self assembly in a system of millimeter-sized magnetized disks floating at a liquid-air interface and spinning under the influence of a rotating magnetic field. Equations of motions are derived that account for the hydrodynamic and magnetic forces acting in the system. Nume...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grzybowski BA,Stone HA,Whitesides GM

更新日期：2002-04-02 00:00:00

abstract：:Two types of proteins that hydrolyze inorganic pyrophosphate (PPi), very different in both amino acid sequence and structure, have been characterized to date: soluble and membrane-bound proton-pumping pyrophosphatases (sPPases and H(+)-PPases, respectively). sPPases are ubiquitous proteins that hydrolyze PPi releasing...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Perez-Castineira JR,Lopez-Marques RL,Villalba JM,Losada M,Serrano A

更新日期：2002-12-10 00:00:00

abstract：:C.B-17 severe combined immunodeficient (scid) mice carry the scid mutation and are severely deficient in both T cell- and B cell-mediated immunity, apparently as a result of defective V(D)J joining of the immunoglobulin and T-cell receptor gene elements. In the present studies, we have defined the tissue, cellular, an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Biedermann KA,Sun JR,Giaccia AJ,Tosto LM,Brown JM

更新日期：1991-02-15 00:00:00