scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair.

abstract：:Structural information about rat enteroglucagon, intestinal peptides containing the pancreatic glucagon sequence, has been based previously on cDNA, immunologic, and chromatographic data. Our interests in testing the physiological actions of synthetic enteroglucagon peptides in rats required that we identify precisely...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Collie NL,Walsh JH,Wong HC,Shively JE,Davis MT,Lee TD,Reeve JR Jr

更新日期：1994-09-27 00:00:00

abstract：:Thousands of large intergenic noncoding RNAs (lincRNAs) have been identified in the mammalian genome, many of which have important roles in regulating a variety of biological processes. Here, we used a custom microarray to identify lincRNAs associated with activation of the innate immune response. A panel of 159 lincR...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li Z,Chao TC,Chang KY,Lin N,Patil VS,Shimizu C,Head SR,Burns JC,Rana TM

更新日期：2014-01-21 00:00:00

abstract：:A human craniofacial cDNA library was screened with a degenerate oligonucleotide probe based on the conserved third helix of homeobox genes. From this screening, we identified a homeobox gene, H6, which shared only 57-65% amino acid identity to previously reported homeodomains. H6 was physically mapped to the 4p16.1 r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stadler HS,Padanilam BJ,Buetow K,Murray JC,Solursh M

更新日期：1992-12-01 00:00:00

abstract：:In the antennal lobe of Drosophila, information about odors is transferred from olfactory receptor neurons (ORNs) to projection neurons (PNs), which then send axons to neurons in the lateral horn of the protocerebrum (LHNs) and to Kenyon cells (KCs) in the mushroom body. The transformation from ORN to PN responses can...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luo SX,Axel R,Abbott LF

更新日期：2010-06-08 00:00:00

abstract：:The mammalian target of rapamycin (mTOR) is a central regulator of cell growth and proliferation in response to growth factor and nutrient signaling. Consequently, this kinase is implicated in metabolic diseases including cancer and diabetes, so there is great interest in understanding the complete spectrum of mTOR-re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang BT,Ducker GS,Barczak AJ,Barbeau R,Erle DJ,Shokat KM

更新日期：2011-09-13 00:00:00

abstract：:Efforts to increase the potency of transcriptional activators are generally unsuccessful because poor expression of activators in mammalian cells limits their delivery to target promoters. Here we report that the effectiveness of chimeric activators can be dramatically improved by expressing them as noncovalent tetram...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Natesan S,Molinari E,Rivera VM,Rickles RJ,Gilman M

更新日期：1999-11-23 00:00:00

abstract：:We report potent inhibition of the Mg(II).ATP-dependent protein phosphatase, Fc.M, by the regulatory subunit dimer of type II cAMP-dependent protein kinase, RII2. The protein kinase catalytic subunit has no effect on phosphatase activity and is unable to substitute for kinase FA in the kinase FA- and Mg(II).ATP-mediat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jurgensen SR,Chock PB,Taylor S,Vandenheede JR,Merlevede W

更新日期：1985-11-01 00:00:00

abstract：:Discrete state models are a common tool of modeling in many areas. E.g., Markov state models as a particular representative of this model family became one of the major instruments for analysis and understanding of processes in molecular dynamics (MD). Here we extend the scope of discrete state models to the case of s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gerber S,Horenko I

更新日期：2014-10-14 00:00:00

abstract：:The immunoglobulin heavy-chain variable region (VH) locus in a phylogenetically primitive teleost (Elops saurus) has been characterized by a strategy that relied initially on cross-hybridization between genomic VH segments and a murine VH probe. Using a homologous (Elops) VH probe and DNA sequencing, this gene family ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Amemiya CT,Litman GW

更新日期：1990-01-01 00:00:00

abstract：:Athymic mice grafted at birth with allogeneic thymic epithelium (TE) from day 10 embryos before hematopoietic cell colonization reconstitute normal numbers of T cells and exhibit full life-long tolerance to skin grafts of the TE haplotype. Intravenous transfers of splenic cells, from these animals to adult syngeneic a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Modigliani Y,Thomas-Vaslin V,Bandeira A,Coltey M,Le Douarin NM,Coutinho A,Salaün J

更新日期：1995-08-01 00:00:00

abstract：:Receptor tyrosine kinases (RTKs) control a multitude of biological processes and are therefore subjected to multiple levels of regulation. Negative feedback is one of the mechanisms that provide an effective means to control RTK-mediated signaling. Sef has recently been identified as a specific antagonist of fibroblas...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Preger E,Ziv I,Shabtay A,Sher I,Tsang M,Dawid IB,Altuvia Y,Ron D

更新日期：2004-02-03 00:00:00

abstract：:Transient expression of either alpha or alpha + beta subunits of the high-conductance Ca2+-activated K+ (maxi-K) channel has been achieved in COS-1 cells. Expression has been studied using charybdotoxin (ChTX), a peptidyl inhibitor that binds in the pore on the alpha subunit. Although some properties of monoiodotyrosi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hanner M,Schmalhofer WA,Munujos P,Knaus HG,Kaczorowski GJ,Garcia ML

更新日期：1997-04-01 00:00:00

abstract：:Individual proteins can now often be modified with atomic precision, but there are still major obstacles to connecting proteins into larger assemblies. To direct protein assembly, ideally, peptide tags would be used, providing the minimal perturbation to protein function. However, binding to peptides is generally weak...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fierer JO,Veggiani G,Howarth M

更新日期：2014-04-01 00:00:00

abstract：:Structural protein 4.1, which has crucial interactions within the spectrin-actin lattice of the human red cell membrane skeleton, also is widely distributed at diverse intracellular sites in nucleated cells. We previously showed that 4.1 is essential for assembly of functional nuclei in vitro and that the capacity of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Krauss SW,Chen C,Penman S,Heald R

更新日期：2003-09-16 00:00:00

abstract：:A synthetic peptide composed of the first 22 amino acid residues of the Drosophila Shaker K+ channel inhibits a voltage-gated K+ channel in basolateral membrane vesicles from Necturus enterocytes reconstituted in planar phospholipid bilayers when added to the solution bathing the inner surface of this channel but not ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dubinsky WP,Mayorga-Wark O,Schultz SG

更新日期：1992-03-01 00:00:00

abstract：:Neonicotinoid insecticides control crop pests based on their action as agonists at the insect nicotinic acetylcholine receptor, which accepts chloropyridinyl- and chlorothiazolyl-analogs almost equally well. In some cases, these compounds have also been reported to enhance plant vigor and (a)biotic stress tolerance, i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ford KA,Casida JE,Chandran D,Gulevich AG,Okrent RA,Durkin KA,Sarpong R,Bunnelle EM,Wildermuth MC

更新日期：2010-10-12 00:00:00

abstract：:Genetic analysis for group selection is developed for the case of a biallelic locus (A, a) undergoing group selection of founder populations only. By contrast to R. Levins"E = E(x) models, extinction now depends on genetics at the propagule stage but acts uniformly on larger populations. Biological evidence supports t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Boorman SA

更新日期：1978-04-01 00:00:00

abstract：:The bifunctional Neurospora crassa mitochondrial tyrosyl-tRNA synthetase (CYT-18 protein) both aminoacylates mitochondrial tRNA(Tyr) and acts as a structure-stabilizing splicing cofactor for group I introns. Previous studies showed that CYT-18 has distinct tRNA(Tyr) and group I intron-binding sites, with the latter fo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Paukstelis PJ,Lambowitz AM

更新日期：2008-04-22 00:00:00

abstract：:An exciton is an electron-hole pair bound by attractive Coulomb interaction. Short-lived excitons have been detected by a variety of experimental probes in numerous contexts. An excitonic insulator, a collective state of such excitons, has been more elusive. Here, thanks to Nernst measurements in pulsed magnetic field...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang J,Nie P,Li X,Zuo H,Fauqué B,Zhu Z,Behnia K

更新日期：2020-12-01 00:00:00

abstract：:We present a theory, and its computer implementation, of how mental simulations underlie the abductions of informal algorithms and deductions from these algorithms. Three experiments tested the theory's predictions, using an environment of a single railway track and a siding. This environment is akin to a universal Tu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Khemlani SS,Mackiewicz R,Bucciarelli M,Johnson-Laird PN

更新日期：2013-10-15 00:00:00

abstract：:Subunits A and B of chloroplast glyceraldehyde-3-phosphate dehydrogenase are synthesized as higher molecular weight precursors when polyadenylylated mRNA from angiosperm seedlings is translated in vitro by wheat germ ribosomes. The in vivo levels of mRNA coding for these precursors are strongly light dependent, and th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cerff R,Kloppstech K

更新日期：1982-12-01 00:00:00

abstract：:The impact of projected global warming on crop yields has been evaluated by indirect methods using simulation models. Direct studies on the effects of observed climate change on crop growth and yield could provide more accurate information for assessing the impact of climate change on crop production. We analyzed weat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Peng S,Huang J,Sheehy JE,Laza RC,Visperas RM,Zhong X,Centeno GS,Khush GS,Cassman KG

更新日期：2004-07-06 00:00:00

abstract：:A stable free-radical polymeric derivative of prostaglandin B1 (PGBx) has been synthesized that exhibits regenerative effects on oxidative phosphorylation in aged mitochondria. The molecular weights of the most active preparations fall between 2000 and 2600. PGBx is characterized by a single-line electron spin resonan...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Polis BD,Polis E,Kwong S

更新日期：1979-04-01 00:00:00

abstract：:For the design of potent subunit vaccines, it is of paramount importance to identify all antigens immunologically recognized by a patient population infected with a pathogen. We have developed a rapid and efficient procedure to identify such commonly recognized antigens, and here we provide a comprehensive in vivo ant...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Etz H,Minh DB,Henics T,Dryla A,Winkler B,Triska C,Boyd AP,Söllner J,Schmidt W,von Ahsen U,Buschle M,Gill SR,Kolonay J,Khalak H,Fraser CM,von Gabain A,Nagy E,Meinke A

更新日期：2002-05-14 00:00:00

abstract：:An unusual cAMP signaling system mediates many of the events that prepare spermatozoa to meet the egg. Its components include the atypical, bicarbonate-stimulated, sperm adenylyl cyclase and a cAMP-dependent protein kinase (PKA) with the unique catalytic subunit termed Calpha(2) or C(s). We generated mice that lack Ca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nolan MA,Babcock DF,Wennemuth G,Brown W,Burton KA,McKnight GS

更新日期：2004-09-14 00:00:00

abstract：:CD2 (T11, sheep erythrocyte receptor) is a surface antigen of the human T-lymphocyte lineage. cDNA clones encoding CD2 have been isolated by using the purified, denatured CD2 to raise a rat antiserum. Positive clones were recognized in a phage lambda gt11 expression library prepared from the human leukemia T-cell line...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sewell WA,Brown MH,Dunne J,Owen MJ,Crumpton MJ

更新日期：1986-11-01 00:00:00

abstract：:Citrus bacterial canker (CBC) caused by Xanthomonas axonopodis pv. citri (Xac) was first documented in India and Java in the mid 19th century. Since that time, the known distribution of the disease has steadily increased. Concurrent with the dispersion of the pathogen, the diversity of described strains continues to i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li W,Song Q,Brlansky RH,Hartung JS

更新日期：2007-11-20 00:00:00

abstract：:Fungal cell walls and fragments thereof (elicitors) induce the formation of low and high molecular weight defense compounds in plant cell suspension cultures. This induced synthesis requires a signal molecule transmitting the message between the elicitor plant cell wall receptor and gene activation. We demonstrate in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mueller MJ,Brodschelm W,Spannagl E,Zenk MH

更新日期：1993-08-15 00:00:00

abstract：:Split GFPs have been widely applied for monitoring protein-protein interactions by expressing GFPs as two or more constituent parts linked to separate proteins that only fluoresce on complementing with one another. Although this complementation is typically irreversible, it has been shown previously that light acceler...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin CY,Both J,Do K,Boxer SG

更新日期：2017-03-14 00:00:00

abstract：:The DNA of functional cis-regulatory modules displays extensive sequence conservation in comparisons of genomes from modestly distant species. Patches of sequence that are several hundred base pairs in length within these modules are often seen to be 80-95% identical, although the flanking sequence cannot even be alig...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cameron RA,Chow SH,Berney K,Chiu TY,Yuan QA,Krämer A,Helguero A,Ransick A,Yun M,Davidson EH

更新日期：2005-08-16 00:00:00