Identification of in vivo expressed vaccine candidate antigens from Staphylococcus aureus.

abstract：:The glycine receptor (GlyR) is a pentameric ligand-gated ion channel (pLGIC) mediating inhibitory transmission in the nervous system. Its transmembrane domain (TMD) is the target of allosteric modulators such as general anesthetics and ethanol and is a major locus for hyperekplexic congenital mutations altering the al...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Moraga-Cid G,Sauguet L,Huon C,Malherbe L,Girard-Blanc C,Petres S,Murail S,Taly A,Baaden M,Delarue M,Corringer PJ

更新日期：2015-03-03 00:00:00

abstract：:Mechanoelectrical transduction in the inner ear is a biophysical process underlying the senses of hearing and balance. The key players involved in this process are mechanosensitive ion channels. They are located in the stereocilia of hair cells and opened by the tension in specialized molecular springs, the tip links,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gianoli F,Risler T,Kozlov AS

更新日期：2017-12-19 00:00:00

abstract：:Immunoreactive and bioreactive corticotropin (ACTH-like) activities have been detected in the median eminence and remaining medial basal hypothalamus of both normal and hypophysectomized adult male rats: bioreactive ACTH (pg/100 mug of protein) 1028 in median eminence and 1289 in medial basal hypothalamus; immunoreact...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Krieger DT,Liotta A,Brownstein MJ

更新日期：1977-02-01 00:00:00

abstract：:Electronic nematicity, a correlated state that spontaneously breaks rotational symmetry, is observed in several layered quantum materials. In contrast to their liquid-crystal counterparts, the nematic director cannot usually point in an arbitrary direction (XY nematics), but is locked by the crystal to discrete direct...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ishida K,Tsujii M,Hosoi S,Mizukami Y,Ishida S,Iyo A,Eisaki H,Wolf T,Grube K,V Löhneysen H,Fernandes RM,Shibauchi T

更新日期：2020-03-24 00:00:00

abstract：:The field of perceptual learning has identified changes in perceptual templates as a powerful mechanism mediating the learning of statistical regularities in our environment. By measuring threshold-vs.-contrast curves using an orientation identification task under varying levels of external noise, the perceptual templ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bejjanki VR,Zhang R,Li R,Pouget A,Green CS,Lu ZL,Bavelier D

更新日期：2014-11-25 00:00:00

abstract：:Loss of function of CDKN2A/B, also known as INK4/ARF [encoding p16INK4A, p15INK4B, and p14ARF (mouse p19Arf)], confers susceptibility to cancers, whereas its up-regulation during organismal aging provokes cellular senescence and tissue degenerative disorders. To better understand the transcriptional regulation of p16 ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang Y,Hyle J,Wright S,Shao Y,Zhao X,Zhang H,Li C

更新日期：2019-12-09 00:00:00

abstract：:Let t --> gamma(t), 0

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stein EM,Wainger S

更新日期：1976-12-01 00:00:00

abstract：:The infectivity of cloned hepatitis B viral DNA (HBV) has been tested in chimpanzees to identify a fully functional HBV genome and to assess the risk associated with its handling. Only one of two HBV DNA sequence variants tested was shown to be infectious. "Clone purified" virus of predicted nucleotide sequence was pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Will H,Cattaneo R,Darai G,Deinhardt F,Schellekens H,Schaller H

更新日期：1985-02-01 00:00:00

abstract：:The apparatus of photosynthetic energy conversion in chloroplasts is quite well characterized with respect to structure and function. Light-driven electron transport in the thylakoid membrane is coupled to synthesis of ATP, used to drive energy-dependent metabolic processes in the stroma and the outer surface of the t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spetea C,Hundal T,Lundin B,Heddad M,Adamska I,Andersson B

更新日期：2004-02-03 00:00:00

abstract：:Mitochondrial function and ambulatory activity were monitored after feeding old rats acetyl-L-carnitine (ALCAR). Young (3-5 mo) and old (22-28 mo) rats were given a 1.5% (wt/vol) solution of ALCAR in their drinking water for 1 mo, were sacrificed, and their liver parenchymal cells were isolated. ALCAR supplementation ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hagen TM,Ingersoll RT,Wehr CM,Lykkesfeldt J,Vinarsky V,Bartholomew JC,Song MH,Ames BN

更新日期：1998-08-04 00:00:00

abstract：:Wnt signaling is required for the maintenance of intestinal stem cells and self-renewal of the intestinal epithelium. Intestinal cancers are frequently associated with mutations that activate the Wnt pathway. The role of Wnt signaling on differentiation of lineage-specific precursors in the intestine is not well chara...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang Y,Giel-Moloney M,Rindi G,Leiter AB

更新日期：2007-07-03 00:00:00

abstract：:We studied the surface delivery pathways followed by newly synthesized plasma membrane proteins in intestinal cells. To this end, we developed an assay and characterized an epithelial cell line (SK-CO-15) derived from human colon adenocarcinoma. Polarized confluent monolayers (2000 omega.cm2), grown on polycarbonate f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Le Bivic A,Real FX,Rodriguez-Boulan E

更新日期：1989-12-01 00:00:00

abstract：:The substance P (SP)-preferring receptor neurokinin-1 receptor (NK-1R) has two forms: a full-length receptor consisting of 407 aa and a truncated receptor consisting of 311 aa. These two receptors differ in the length of the C terminus of NK-1R. We studied the undifferentiated and phorbol myristate acetate (PMA)-diffe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lai JP,Ho WZ,Kilpatrick LE,Wang X,Tuluc F,Korchak HM,Douglas SD

更新日期：2006-05-16 00:00:00

abstract：:Glycosylation is one of the most common posttranslational modifications to occur in protein biosynthesis, yet its effect on the thermodynamics and kinetics of proteins is poorly understood. A minimalist model based on the native protein topology, in which each amino acid and sugar ring was represented by a single bead...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shental-Bechor D,Levy Y

更新日期：2008-06-17 00:00:00

abstract：:Electron spectroscopic imaging, a new technique that permits the quantitative detection of the spatial distributions of atomic elements at high resolution, has been applied to the epiphyseal zone of hypertrophy in the mouse for the visualization of calcium, phosphorus, and sulfur. Longitudinally sectioned epiphyseal g...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arsenault AL,Ottensmeyer FP

更新日期：1983-03-01 00:00:00

abstract：:The cat tongue is covered in sharp, rear-facing spines called papillae, the precise function of which is a mystery. In this combined experimental and theoretical study, we use high-speed film, grooming force measurements, and computed tomography (CT) scanning to elucidate the mechanism by which papillae are used to gr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Noel AC,Hu DL

更新日期：2018-12-04 00:00:00

abstract：:Type I interferons (IFNs) are helical cytokines that have diverse biological activities despite the fact that they appear to interact with the same receptor system. To achieve a better understanding of the structural basis for the different activities of alpha and beta IFNs, we have determined the crystal structure of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Karpusas M,Nolte M,Benton CB,Meier W,Lipscomb WN,Goelz S

更新日期：1997-10-28 00:00:00

abstract：:Netrin-1 is critical for axonal pathfinding which shares similarities with formation of vascular network. Here we report that netrin-1 induction of angiogenesis is mediated by an increase in endothelial nitric oxide (NO*) production, which occurs via a DCC-dependent, ERK1/2-eNOS feed-forward mechanism. Exposure of mat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nguyen A,Cai H

更新日期：2006-04-25 00:00:00

abstract：:The exopolysaccharide alginate is a major virulence factor in the pathogenicity of Pseudomonas aeruginosa infecting the lungs of cystic fibrosis (CF) patients. Alginate synthesis by P. aeruginosa is believed to occur in response to environmental signals present in the CF lung. Transcription of a critical alginate bios...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roychoudhury S,Sakai K,Chakrabarty AM

更新日期：1992-04-01 00:00:00

abstract：:Mood disorders cause much suffering and are the single greatest cause of lost productivity worldwide. Although multiple medications, along with behavioral therapies, have proven effective for some individuals, millions of people lack an effective therapeutic option. A common serotonin (5-HT) transporter (5-HTT/SERT, S...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baganz NL,Horton RE,Calderon AS,Owens WA,Munn JL,Watts LT,Koldzic-Zivanovic N,Jeske NA,Koek W,Toney GM,Daws LC

更新日期：2008-12-02 00:00:00

abstract：:Temporal patterning of biological variables, in the form of oscillations and rhythms on many time scales, is ubiquitous. Altering the temporal pattern of an input variable greatly affects the output of many biological processes. We develop here a conceptual framework for a quantitative understanding of such pattern de...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brezina V,Orekhova IV,Weiss KR

更新日期：1997-09-16 00:00:00

abstract：:A class II (B) general transcription factor of 34 kDa has been purified from HeLa cells to apparent homogeneity. This factor appears to be transcription factor IIB (TFIIB), since it binds in vitro to template-committed preinitiation complexes formed between a template containing the TATA box/cap-site elements of the a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Moncollin V,Fischer L,Cavallini B,Egly JM,Chambon P

更新日期：1992-01-01 00:00:00

abstract：:Diffuse large B cell lymphomas (DLBCLs) often express BCL6, a transcriptional repressor required for the formation of normal germinal centers. In a subset of DLBCLs, BCL6 is deregulated by chromosomal translocations or aberrant somatic hypermutation; in other tumors, BCL6 expression may simply reflect germinal center ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Polo JM,Juszczynski P,Monti S,Cerchietti L,Ye K,Greally JM,Shipp M,Melnick A

更新日期：2007-02-27 00:00:00

abstract：:Prions are thought to replicate in an autocatalytic process that converts cellular prion protein (PrP(C)) to the disease-associated misfolded PrP isoform (PrP(Sc)). Our study scrutinizes this hypothesis by in vitro protein misfolding cyclic amplification (PMCA). In serial transmission PMCA experiments, PrP(Sc) was ino...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bieschke J,Weber P,Sarafoff N,Beekes M,Giese A,Kretzschmar H

更新日期：2004-08-17 00:00:00

abstract：:Mumps virus (MuV) is a highly contagious pathogen, and despite extensive vaccination campaigns, outbreaks continue to occur worldwide. The virus has a negative-sense, single-stranded RNA genome that is encapsidated by the nucleocapsid protein (N) to form the nucleocapsid (NC). NC serves as the template for both transc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cox R,Pickar A,Qiu S,Tsao J,Rodenburg C,Dokland T,Elson A,He B,Luo M

更新日期：2014-10-21 00:00:00

abstract：:The land plants and their immediate green algal ancestors, the charophytes, form the Streptophyta. There is evidence that both the chloroplast DNA (cpDNA) and mitochondrial DNA (mtDNA) underwent substantial changes in their architecture (intron insertions, gene losses, scrambling in gene order, and genome expansion in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Turmel M,Otis C,Lemieux C

更新日期：2002-08-20 00:00:00

abstract：:Game theory describes strategic interactions where success of players' actions depends on those of coplayers. In humans, substantial progress has been made at the neural level in characterizing the dopaminergic and frontostriatal mechanisms mediating such behavior. Here we combined computational modeling of strategic ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Set E,Saez I,Zhu L,Houser DE,Myung N,Zhong S,Ebstein RP,Chew SH,Hsu M

更新日期：2014-07-01 00:00:00

abstract：:Rad51 is a highly conserved eukaryotic homolog of the prokaryotic recombination protein RecA, which has been shown to function in both recombinational repair of DNA damage and meiotic recombination in yeast. In primary murine B cells cultured with lipopolysaccharide (LPS) to stimulate heavy chain class switch recombin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li MJ,Peakman MC,Golub EI,Reddy G,Ward DC,Radding CM,Maizels N

更新日期：1996-09-17 00:00:00

abstract：:The core protein of a small chondroitin/dermatan sulfate proteoglycan expressed by human fibroblasts and present in extracellular matrices in association with collagen has been cloned from a lambda gt11 fibroblast cDNA library. cDNA clones were isolated by use of antibodies specific for the intact proteoglycan and ant...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Krusius T,Ruoslahti E

更新日期：1986-10-01 00:00:00

abstract：:Many physical and chemical properties of the light rare-earths and actinides are governed by the active role of f electrons, and despite intensive efforts the details of the mechanisms of phase stability and transformation are not fully understood. A prominent example which has attracted a lot of interest, both experi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Krisch M,Farber DL,Xu R,Antonangeli D,Aracne CM,Beraud A,Chiang TC,Zarestky J,Kim DY,Isaev EI,Ahuja R,Johansson B

更新日期：2011-06-07 00:00:00