A virus associated with SR-spirochetes of Drosophila nebulosa.

abstract：:A major challenge of cancer immunotherapy is the persistence and outgrowth of subpopulations that lose expression of the target antigen. IL-15 is a potent cytokine that can promote organ-specific autoimmunity when up-regulated on tissue cells. Here we report that T cells eradicated 2-wk-old solid tumors that expressed...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu RB,Engels B,Schreiber K,Ciszewski C,Schietinger A,Schreiber H,Jabri B

更新日期：2013-05-14 00:00:00

abstract：:Intergroup conflict persists when and because individuals make costly contributions to their group's fighting capacity, but how groups organize contributions into effective collective action remains poorly understood. Here we distinguish between contributions aimed at subordinating out-groups (out-group aggression) fr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： De Dreu CK,Gross J,Méder Z,Giffin M,Prochazkova E,Krikeb J,Columbus S

更新日期：2016-09-20 00:00:00

abstract：:The 158,000 Mr protein, previously designated C5c, present in fully assembled complement (C) membrane attack complexes (MC5b-9) has been identified as a disulfide-bonded dimer of C9. This conclusion was based on the observations that: (i) a portion of the 125I-radiolabeled precursor C9 incorporated into MC5b-9 complex...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ware CF,Kolb WP

更新日期：1981-10-01 00:00:00

abstract：:Improper function of voltage-gated sodium channels (NaVs), obligatory membrane proteins for bioelectrical signaling, has been linked to a number of human pathologies. Small-molecule agents that target NaVs hold considerable promise for treatment of chronic disease. Absent a comprehensive understanding of channel struc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thomas-Tran R,Du Bois J

更新日期：2016-05-24 00:00:00

abstract：:Studies of the accelerated aging disorder Hutchinson-Gilford progeria syndrome (HGPS) can potentially reveal cellular defects associated with physiological aging. HGPS results from expression and abnormal nuclear envelope association of a farnesylated, truncated variant of prelamin A called "progerin." We surveyed the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chang W,Wang Y,Luxton GWG,Östlund C,Worman HJ,Gundersen GG

更新日期：2019-02-26 00:00:00

abstract：:We report a machine-learning strategy for design of organic structure directing agents (OSDAs) for zeolite beta. We use machine learning to replace a computationally expensive molecular dynamics evaluation of the stabilization energy of the OSDA inside zeolite beta with a neural network prediction. We train the neural...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Daeyaert F,Ye F,Deem MW

更新日期：2019-02-26 00:00:00

abstract：:p90 ribosomal S6 kinase (RSK1) is an effector of both Ras/MEK/MAPK and PI3K/PDK1 pathways. We present evidence that RSK1 drives p27 phosphorylation at T198 to increase RhoA-p27 binding and cell motility. RSK1 activation and p27pT198 both increase in early G(1). As for many kinase-substrate pairs, cellular RSK1 copreci...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Larrea MD,Hong F,Wander SA,da Silva TG,Helfman D,Lannigan D,Smith JA,Slingerland JM

更新日期：2009-06-09 00:00:00

abstract：:Epilepsy is characterized by recurrent synchronizations of neuronal activity, which are both a cardinal clinical symptom and a debilitating phenomenon. Although the temporal dynamics of epileptiform synchronizations are well described at the macroscopic level using electrophysiological approaches, less is known about ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Feldt Muldoon S,Soltesz I,Cossart R

更新日期：2013-02-26 00:00:00

abstract：:Monosynaptic excitatory connections between cerebellar granule and Purkinje cells were studied in dissociated cell cultures, and identification of the transmitter and the postsynaptic receptor at this synapse was pharmacologically investigated. The presynaptic granule cell and the postsynaptic Purkinje cell were volta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hirano T,Hagiwara S

更新日期：1988-02-01 00:00:00

abstract：:In response to environmental changes, the connections ("arrows") in gene regulatory networks determine which genes modulate their expression, but the quantitative parameters of the network ("the numbers on the arrows") are equally important in determining the resulting phenotype. What are the objectives and constraint...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chubukov V,Zuleta IA,Li H

更新日期：2012-03-27 00:00:00

abstract：:Monotremes have left a poor fossil record, and paleontology has been virtually mute during two decades of discussion about molecular clock estimates of the timing of divergence between the platypus and echidna clades. We describe evidence from high-resolution x-ray computed tomography indicating that Teinolophos, an E...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rowe T,Rich TH,Vickers-Rich P,Springer M,Woodburne MO

更新日期：2008-01-29 00:00:00

abstract：:Solid-state cross-polarization/magic-angle sample-spinning (13)C NMR spectra have been recorded on chlorophyll a-water aggregates, methyl pyrochlorophyllide a, and methyl pyropheophorbide a (derivatives that lack a phytyl chain). Spectra have also been collected under a decoupling regime in which resonances of certain...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brown CE,Spencer RB,Burger VT,Katz JJ

更新日期：1984-01-01 00:00:00

abstract：:Although proteins generally fold to their thermodynamically most stable state, some metastable proteins populate higher free energy states. Conformational changes from metastable higher free energy states to lower free energy states with greater stability can then generate the work required to perform physiologically ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chandrasekhar K,Ke H,Wang N,Goodwin T,Gierasch LM,Gershenson A,Hebert DN

更新日期：2016-06-07 00:00:00

abstract：:Junctional Adhesion Molecule-A (JAM-A) is a transmembrane adhesive protein expressed at endothelial junctions and in leukocytes. Here we report that JAM-A is required for the correct infiltration of polymorphonuclear leukocytes (PMN) into an inflamed peritoneum or in the heart upon ischemia-reperfusion injury. The def...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Corada M,Chimenti S,Cera MR,Vinci M,Salio M,Fiordaliso F,De Angelis N,Villa A,Bossi M,Staszewsky LI,Vecchi A,Parazzoli D,Motoike T,Latini R,Dejana E

更新日期：2005-07-26 00:00:00

abstract：:Cell-free DNA shed by cancer cells has been shown to be a rich source of putative tumor-specific biomarkers. Because cell-free DNA from brain and spinal cord tumors cannot usually be detected in the blood, we studied whether the cerebrospinal fluid (CSF) that bathes the CNS is enriched for tumor DNA, here termed CSF-t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang Y,Springer S,Zhang M,McMahon KW,Kinde I,Dobbyn L,Ptak J,Brem H,Chaichana K,Gallia GL,Gokaslan ZL,Groves ML,Jallo GI,Lim M,Olivi A,Quinones-Hinojosa A,Rigamonti D,Riggins GJ,Sciubba DM,Weingart JD,Wolinsky JP

更新日期：2015-08-04 00:00:00

abstract：:Fungal cell walls and fragments thereof (elicitors) induce the formation of low and high molecular weight defense compounds in plant cell suspension cultures. This induced synthesis requires a signal molecule transmitting the message between the elicitor plant cell wall receptor and gene activation. We demonstrate in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mueller MJ,Brodschelm W,Spannagl E,Zenk MH

更新日期：1993-08-15 00:00:00

abstract：:The glutathione S-transferases (GST) (glutathione transferase; EC 2.5.1.18) are a family of enzymes responsible for the metabolism of a broad range of xenobiotics and carcinogens. A cDNA clone containing the entire amino acid coding sequence of a human GST-2 subunit has been isolated using a lambda gt11 expression lib...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Board PG,Webb GC

更新日期：1987-04-01 00:00:00

abstract：:Interaction of syntaxin 1 with the alpha(1D) subunit of the voltage-gated L type Ca(2+) channel was investigated in the pancreatic beta cell. Coexpression of the enhanced green fluorescent protein-linked alpha(1D) subunit with the enhanced blue fluorescent protein-linked syntaxin 1 and Western blot analysis together w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang SN,Larsson O,Bränström R,Bertorello AM,Leibiger B,Leibiger IB,Moede T,Köhler M,Meister B,Berggren PO

更新日期：1999-08-31 00:00:00

abstract：:Matrix-assisted laser desorption/ionization (MALDI) time of flight mass spectrometry was used to detect and order DNA fragments generated by Sanger dideoxy cycle sequencing. This was accomplished by improving the sensitivity and resolution of the MALDI method using a delayed ion extraction technique (DE-MALDI). The cy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roskey MT,Juhasz P,Smirnov IP,Takach EJ,Martin SA,Haff LA

更新日期：1996-05-14 00:00:00

abstract：:Immobilization antigens of stock 51 of Paramecium tetraurelia were subjected to electrophoresis in NaDodSO(4)/polyacrylamide gels. Type A is estimated to have a molecular size of 300,000 daltons; H is estimated to be 288,000, D to be 280,000, E to be 270,000, B to be 253,000, and C to be 250,000. Poly(A)(+)RNAs have b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Preer JR,Preer LB,Rudman BM

更新日期：1981-11-01 00:00:00

abstract：:Topological mechanical metamaterials are artificial structures whose unusual properties are protected very much like their electronic and optical counterparts. Here, we present an experimental and theoretical study of an active metamaterial--composed of coupled gyroscopes on a lattice--that breaks time-reversal symmet...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nash LM,Kleckner D,Read A,Vitelli V,Turner AM,Irvine WT

更新日期：2015-11-24 00:00:00

abstract：:Rodless retina (gene symbol, r) was discovered in mice by Keeler 70 years ago and was first described in this journal as an autosomal recessive mutation leading to "the absence of the visual cells (rods), the external nuclear layer, and the external molecular layer" [Keeler, C. E. (1924) Proc. Natl. Acad. Sci. USA 10,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pittler SJ,Keeler CE,Sidman RL,Baehr W

更新日期：1993-10-15 00:00:00

abstract：:The "kindling" phenomenon is associated with long-lasting facilitation of synaptic transmission. A possible mechanism of such facilitation could involve changes in the number of synaptic contacts. However, previous attempts to demonstrate a synaptic morphological alteration that could account for the long-term effects...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Geinisman Y,Morrell F,deToledo-Morrell L

更新日期：1988-05-01 00:00:00

abstract：:Elucidation of the genetic control of rice architecture is crucial due to the global demand for high crop yields. Rice architecture is a complex trait affected by plant height, tillering, and panicle morphology. In this study, principal component analysis (PCA) on 8 typical traits related to plant architecture reveale...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yano K,Morinaka Y,Wang F,Huang P,Takehara S,Hirai T,Ito A,Koketsu E,Kawamura M,Kotake K,Yoshida S,Endo M,Tamiya G,Kitano H,Ueguchi-Tanaka M,Hirano K,Matsuoka M

更新日期：2019-10-15 00:00:00

abstract：:Hypophosphatasia is a heritable form of rickets/osteomalacia with extremely variable clinical expression. Severe forms are inherited in an autosomal recessive fashion; the mode of transmission of mild forms is uncertain. The biochemical hallmark of hypophosphatasia is deficient activity of the tissue-nonspecific isozy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Henthorn PS,Raducha M,Fedde KN,Lafferty MA,Whyte MP

更新日期：1992-10-15 00:00:00

abstract：:Lateral organ distribution at the shoot apical meristem defines specific and robust phyllotaxis patterns that have intrigued biologists and mathematicians for centuries. In silico studies have revealed that this self-organizing process can be recapitulated by modeling the polar transport of the phytohormone auxin. Phy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pinon V,Prasad K,Grigg SP,Sanchez-Perez GF,Scheres B

更新日期：2013-01-15 00:00:00

abstract：:The x-ray crystal structure of an oligomeric miniprotein has been determined to a 1.2-A resolution by means of multiwavelength anomalous diffraction phasing with selenomethionine analogs that retain the biophysical characteristics of the native peptide. Peptide 1, comprising alpha and beta secondary structure elements...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ali MH,Peisach E,Allen KN,Imperiali B

更新日期：2004-08-17 00:00:00

abstract：:Two monoclonal antibodies directed against the native beta 2 subunit of Escherichia coli tryptophan synthase [L-serine hydro-lyase (adding indoleglycerol-phosphate), EC 4.2.1.20], one recognizing the C-terminal F1 domain and the other the N-terminal F2 domain, were used to detect immunoreactive intermediates in the fo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blond S,Goldberg M

更新日期：1987-03-01 00:00:00

abstract：:Intramembrane proteolysis is a new paradigm in biology that controls signaling events throughout evolution. Hydrolysis of peptide bonds is thought to occur within the normally hydrophobic membrane environment, but insights into this unusual activity have been lacking because of difficulty in recapitulating activity in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Urban S,Wolfe MS

更新日期：2005-02-08 00:00:00

abstract：:Human genetic diversity in southern Europe is higher than in other regions of the continent. This difference has been attributed to postglacial expansions, the demic diffusion of agriculture from the Near East, and gene flow from Africa. Using SNP data from 2,099 individuals in 43 populations, we show that estimates o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Botigué LR,Henn BM,Gravel S,Maples BK,Gignoux CR,Corona E,Atzmon G,Burns E,Ostrer H,Flores C,Bertranpetit J,Comas D,Bustamante CD

更新日期：2013-07-16 00:00:00