Junctional adhesion molecule-A-deficient polymorphonuclear cells show reduced diapedesis in peritonitis and heart ischemia-reperfusion injury.

abstract：:Water freezing on solid surfaces is ubiquitous in nature. Even though icing/frosting impairs the performance and safety in many processes, its mechanism remains inadequately understood. Changing atmospheric conditions, surface properties, the complexity of icing physics, and the unorthodox behavior of water are the pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jung S,Tiwari MK,Poulikakos D

更新日期：2012-10-02 00:00:00

abstract：:Transcription factor TFIID consists of TATA binding protein (TBP) and at least eight TBP-associated factors (TAFs). As TAFs are required for activated but not basal transcription, we have proposed that TAFs act as coactivators to mediate signals between activators and the basal transcription machinery. Here we report ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Klemm RD,Goodrich JA,Zhou S,Tjian R

更新日期：1995-06-20 00:00:00

abstract：:Emotional signals are crucial for sharing important information, with conspecifics, for example, to warn humans of danger. Humans use a range of different cues to communicate to others how they feel, including facial, vocal, and gestural signals. We examined the recognition of nonverbal emotional vocalizations, such a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sauter DA,Eisner F,Ekman P,Scott SK

更新日期：2010-02-09 00:00:00

abstract：:Scientific and engineering innovation is vital for American competitiveness, quality of life, and national security. However, too few American students, especially women, pursue these fields. Although this problem has attracted enormous attention, rigorously tested interventions outside artificial laboratory settings ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dennehy TC,Dasgupta N

更新日期：2017-06-06 00:00:00

abstract：:Phosphatidylinositol 3-kinases (PI 3-kinases) have been implicated in membrane trafficking in the secretory and endocytic pathways of yeast and mammalian cells, but the molecular mechanisms by which these lipid kinases operate are not known. Here we identify a protein of 170 kDa that is rapidly released from cell memb...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Patki V,Virbasius J,Lane WS,Toh BH,Shpetner HS,Corvera S

更新日期：1997-07-08 00:00:00

abstract：:The canonical function of the human telomerase protein (hTERT) is to synthesize telomeric DNA, but it has other biological activities, including enhancing cell proliferation, decreasing apoptosis, regulating DNA damage responses, and increasing cellular proliferative lifespan. The mechanistic relationships among these...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mukherjee S,Firpo EJ,Wang Y,Roberts JM

更新日期：2011-12-13 00:00:00

abstract：:Prions are thought to consist mainly or entirely of misfolded PrP, a constitutively expressed host protein. Prions associated with the same PrP sequence may occur in the form of different strains; the strain phenotype is believed to be encoded by the conformation of the PrP. Some cell lines can be persistently infecte...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mahal SP,Baker CA,Demczyk CA,Smith EW,Julius C,Weissmann C

更新日期：2007-12-26 00:00:00

abstract：:In 2012, an unusual outbreak of urban malaria was reported from Djibouti City in the Horn of Africa and increasingly severe outbreaks have been reported annually ever since. Subsequent investigations discovered the presence of an Asian mosquito species; Anopheles stephensi, a species known to thrive in urban environme...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sinka ME,Pironon S,Massey NC,Longbottom J,Hemingway J,Moyes CL,Willis KJ

更新日期：2020-10-06 00:00:00

abstract：:Bloom syndrome (BS) is a rare cancer-predisposing disorder in which the cells of affected persons have a high frequency of somatic mutation and genomic instability. BLM, the protein altered in BS, is a RecQ DNA helicase. This report shows that BLM is found in the nucleus of normal human cells in the nuclear domain 10 ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yankiwski V,Marciniak RA,Guarente L,Neff NF

更新日期：2000-05-09 00:00:00

abstract：:We report light-induced electron paramagnetic resonance triplet spectra from samples of chloroplasts or digitonin photosystem I particles that depend upon the dark redox state of the bound acceptors of photosystem I. If the reaction centers are prepared in the redox state P-700 A X- FdB-FdA-, then upon illumination at...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Frank HA,McLean MB,Sauer K

更新日期：1979-10-01 00:00:00

abstract：:n-Type Si electrodes in MeOH solvent with 0.2 M (1-hydroxyethyl)ferrocene, 0.5 mM (1-hydroxyethyl)ferricenium, and 1.0 M LiClO(4) exhibit air mass 2 conversion efficiencies of 10.1% for optical energy into electricity. We observe open-circuit voltages of 0.53 V and short-circuit quantum efficiencies for electron flow ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gronet CM,Lewis NS,Cogan G,Gibbons J

更新日期：1983-02-01 00:00:00

abstract：:At what range can a mammalian cell sense the presence of another cell and through what medium? To approach these questions, the formation of aggregates of a 3T3 cell variant (3T3x cells) grown on solid substrates was studied. Each of the aggregates consisted of cells that, at the time of their seeding, were single and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Albrecht-Buehler G

更新日期：2005-04-05 00:00:00

abstract：:The mitochondrial contact site and cristae organizing system (MICOS) is a multisubunit protein complex that is essential for the proper architecture of the mitochondrial inner membrane. MICOS plays a key role in establishing and maintaining crista junctions, tubular or slit-like structures that connect the cristae mem...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pape JK,Stephan T,Balzarotti F,Büchner R,Lange F,Riedel D,Jakobs S,Hell SW

更新日期：2020-08-25 00:00:00

abstract：:Assessments of the importance of different routes of HIV-1 (HIV) transmission are vital for prioritization of control efforts. Lack of consistent direct data and large uncertainty in the risk of HIV transmission from HIV-contaminated injections has made quantifying the proportion of transmission caused by contaminated...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： White RG,Ben SC,Kedhar A,Orroth KK,Biraro S,Baggaley RF,Whitworth J,Korenromp EL,Ghani A,Boily MC,Hayes RJ

更新日期：2007-06-05 00:00:00

abstract：:Understanding the mechanisms of Salmonella virulence is an important challenge. The capacity of this intracellular bacterial pathogen to cause diseases depends on the expression of virulence factors including the second type III secretion system (TTSS-2), which is used to translocate into the eukaryotic cytosol a set ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Henry T,Couillault C,Rockenfeller P,Boucrot E,Dumont A,Schroeder N,Hermant A,Knodler LA,Lecine P,Steele-Mortimer O,Borg JP,Gorvel JP,Méresse S

更新日期：2006-09-05 00:00:00

abstract：:Development of therapy against infections caused by antibiotic-resistant pathogens is a major unmet need in contemporary medicine. In previous work, our group chemically modified an antimicrobial peptidomimetic motif for targeted applications against cancer and obesity. Here, we show that the modified motif per se is ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McGrath DM,Barbu EM,Driessen WH,Lasco TM,Tarrand JJ,Okhuysen PC,Kontoyiannis DP,Sidman RL,Pasqualini R,Arap W

更新日期：2013-02-26 00:00:00

abstract：:Viperin is an interferon (IFN)-inducible multifunctional protein. Recent evidence from high-throughput analyses indicates that most IFN-inducible proteins, including viperin, are intrinsically expressed in specific tissues; however, the respective intrinsic functions are unknown. Here we show that the intrinsic expres...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eom J,Kim JJ,Yoon SG,Jeong H,Son S,Lee JB,Yoo J,Seo HJ,Cho Y,Kim KS,Choi KM,Kim IY,Lee HY,Nam KT,Cresswell P,Seong JK,Seo JY

更新日期：2019-08-27 00:00:00

abstract：:The lac operon of Escherichia coli spans approximately 5300 base pairs and includes the lacZ, lacY, and lacA genes in addition to the operator, promoter, and transcription termination regions. We report here the sequence of the lacA gene and the region distal to it, confirming the sequence of thiogalactoside transacet...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hediger MA,Johnson DF,Nierlich DP,Zabin I

更新日期：1985-10-01 00:00:00

abstract：:The plant Mentzelia pumila (family Loasaceae) has leaves and stems densely covered with tiny hooked trichomes. The structures entrap and kill insects and therefore are most probably protective. But they are also maladaptive in that they incapacitate a coccinellid beetle (Hippodamia convergens) that preys upon an aphid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eisner T,Eisner M,Hoebeke ER

更新日期：1998-04-14 00:00:00

abstract：:Defining the links between cell division and DNA replication is essential for understanding normal cell cycle progression and tumorigenesis. In this report we explore the effect of phosphorylation of cell division cycle 6 (Cdc6), a DNA replication initiation factor, by polo-like kinase 1 (Plk1) on the regulation of ch...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yim H,Erikson RL

更新日期：2010-11-16 00:00:00

abstract：:Herpes simplex virus type 2 (HSV-2) DNA was treated with four restriction endonucleases (EcoRI, HincIII, Bgl II, and Xba I) and eight fragments were purified and labeled with 32P in vitro. The kinetics of renaturation of each of the fragments was measured in the presence of DNA extracted from 333-8-9, a hamster cell l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Galloway DA,Copple CD,McDougall JK

更新日期：1980-02-01 00:00:00

abstract：:Mitogen-activated protein (MAP) kinase kinase is an enzyme that activates the growth factor-regulated MAP kinase in vitro by a mechanism that involves direct phosphorylation of MAP kinase on tyrosine and threonine residues. MAP kinase kinase is stimulated by growth factor treatment of cells and has been shown to be in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ahn NG,Campbell JS,Seger R,Jensen AL,Graves LM,Krebs EG

更新日期：1993-06-01 00:00:00

abstract：:The chemokine stromal cell-derived factor 1, SDF-1, is an important regulator of leukocyte and hematopoietic precursor migration and pre-B cell proliferation. The receptor for SDF-1, CXCR4, also functions as a coreceptor for T-tropic HIV-1 entry. We find that mice deficient for CXCR4 die perinatally and display profou...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ma Q,Jones D,Borghesani PR,Segal RA,Nagasawa T,Kishimoto T,Bronson RT,Springer TA

更新日期：1998-08-04 00:00:00

abstract：:X-ray structures of bovine heart cytochrome c oxidase have suggested that the enzyme, which reduces O(2) in a process coupled with a proton pumping process, contains a proton pumping pathway (H-pathway) composed of a hydrogen bond network and a water channel located in tandem across the enzyme. The hydrogen bond netwo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shimokata K,Katayama Y,Murayama H,Suematsu M,Tsukihara T,Muramoto K,Aoyama H,Yoshikawa S,Shimada H

更新日期：2007-03-06 00:00:00

abstract：:Many complex systems are organized in the form of a network embedded in space. Important examples include the physical Internet infrastructure, road networks, flight connections, brain functional networks, and social networks. The effect of space on network topology has recently come under the spotlight because of the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Expert P,Evans TS,Blondel VD,Lambiotte R

更新日期：2011-05-10 00:00:00

abstract：:The TATA box-binding activity of transcription factor IID (TFIID) is autoinhibited by the N-terminal domain of the Drosophila TATA box-binding protein- (TBP) associated factor 230/yeast TBP-associated factor 145 subunit, which binds to the TATA box-binding domain of TBP by mimicking the TATA box structure. Here, we pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kotani T,Banno K,Ikura M,Hinnebusch AG,Nakatani Y,Kawaichi M,Kokubo T

更新日期：2000-06-20 00:00:00

abstract：:Circadian rhythms in metazoan eukaryotes are controlled by an endogenous molecular clock. It functions in many locations, including subsets of brain neurons (clock neurons) within the central nervous system. Although the molecular clock relies on transcription/translation feedback loops, posttranscriptional regulation...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen X,Rosbash M

更新日期：2016-05-24 00:00:00

abstract：:Modulation of cholesterol absorption in the intestine, the primary site of dietary cholesterol uptake in humans, can have profound clinical implications. We have undertaken a reverse genetic approach by disrupting putative cholesterol processing genes in zebrafish larvae by using morpholino (MO) antisense oligonucleot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smart EJ,De Rose RA,Farber SA

更新日期：2004-03-09 00:00:00

abstract：:Isochorismate synthase (ICS) converts chorismate to isochorismate for the biosynthesis of phylloquinone, an essential cofactor for photosynthetic electron transport. ICS is also required for salicylic acid (SA) synthesis during Arabidopsis defense. In several other species, including Populus, SA is derived primarily f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yuan Y,Chung JD,Fu X,Johnson VE,Ranjan P,Booth SL,Harding SA,Tsai CJ

更新日期：2009-12-22 00:00:00

abstract：:Ligand-specific molecular switches composed of RNA were created by coupling preexisting catalytic and receptor domains via structural bridges. Binding of ligand to the receptor triggers a conformational change within the bridge, and this structural reorganization dictates the activity of the adjoining ribozyme. The mo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Soukup GA,Breaker RR

更新日期：1999-03-30 00:00:00