Cell division cycle 6, a mitotic substrate of polo-like kinase 1, regulates chromosomal segregation mediated by cyclin-dependent kinase 1 and separase.

abstract：:The gaseous phytohormone ethylene C(2)H(4) mediates numerous aspects of growth and development. Genetic analysis has identified a number of critical elements in ethylene signaling, but how these elements interact biochemically to transduce the signal from the ethylene receptor complex at the endoplasmic reticulum (ER)...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ju C,Yoon GM,Shemansky JM,Lin DY,Ying ZI,Chang J,Garrett WM,Kessenbrock M,Groth G,Tucker ML,Cooper B,Kieber JJ,Chang C

更新日期：2012-11-20 00:00:00

abstract：:Vertically transmitted symbionts that protect their hosts against parasites and pathogens are well known from insects, yet the underlying mechanisms of symbiont-mediated defense are largely unclear. A striking example of an ecologically important defensive symbiosis involves the woodland fly Drosophila neotestacea, wh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hamilton PT,Peng F,Boulanger MJ,Perlman SJ

更新日期：2016-01-12 00:00:00

abstract：:The pleiotropic effect of the sickle gene suggests that factors in addition to polymerization of the mutant gene product might be involved in sickle disease pathobiology. We have examined rates of heme transfer to hemopexin from hemoglobin in dilute aqueous solution (0.5 mg of Hb per ml) at 37 degrees C. HbO2 S loses ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hebbel RP,Morgan WT,Eaton JW,Hedlund BE

更新日期：1988-01-01 00:00:00

abstract：:Phenylglyoxal is an arginine-specific reagent that inactivates creatine kinase (CK). Previous results suggest that modification of the dimeric enzyme at a single arginine residue per subunit causes complete inactivation accompanied by the loss of nucleotide binding; the actual site of modification was not identified. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wood TD,Guan Z,Borders CL Jr,Chen LH,Kenyon GL,McLafferty FW

更新日期：1998-03-31 00:00:00

abstract：:Immediately after adsorption, phages T4 and T5 induce a partial depolarization of the host cytoplasmic membrane. Infected bacteria respond to this phage-induced effect by a repolarization that leads to a new steady state of reduced membrane potential. The rate and extent of repolarization are adjusted to the intensity...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Labedan B,Letellier L

更新日期：1981-01-01 00:00:00

abstract：:Peroxiredoxins (Prx), a family of peroxidases that reduce intracellular peroxides with the thioredoxin system as the electron donor, are highly expressed in various cellular compartments. Among the antioxidant Prx enzymes, Prx2 is the most abundant in mammalian neurons, making it a prime candidate to defend against ox...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fang J,Nakamura T,Cho DH,Gu Z,Lipton SA

更新日期：2007-11-20 00:00:00

abstract：:Accurate real-time tracking of influenza outbreaks helps public health officials make timely and meaningful decisions that could save lives. We propose an influenza tracking model, ARGO (AutoRegression with GOogle search data), that uses publicly available online search data. In addition to having a rigorous statistic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang S,Santillana M,Kou SC

更新日期：2015-11-24 00:00:00

abstract：:The int-1 and int-2 genes were first isolated as targets for transcriptional activation by proviral insertion mutations in mammary carcinomas induced by the mouse mammary tumor virus (MMTV). Since these proto-oncogenes are not expressed at detectable levels in previously tested normal tissues from adult mice, we sough...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jakobovits A,Shackleford GM,Varmus HE,Martin GR

更新日期：1986-10-01 00:00:00

abstract：:The infectivity of cloned hepatitis B viral DNA (HBV) has been tested in chimpanzees to identify a fully functional HBV genome and to assess the risk associated with its handling. Only one of two HBV DNA sequence variants tested was shown to be infectious. "Clone purified" virus of predicted nucleotide sequence was pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Will H,Cattaneo R,Darai G,Deinhardt F,Schellekens H,Schaller H

更新日期：1985-02-01 00:00:00

abstract：:Compulsive behavior is a debilitating clinical feature of many forms of neuropsychiatric disease, including Tourette syndrome, obsessive-compulsive spectrum disorders, eating disorders, and autism. Although several studies link striatal dysfunction to compulsivity, the pathophysiology remains poorly understood. Here, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu P,Grueter BA,Britt JK,McDaniel L,Huntington PJ,Hodge R,Tran S,Mason BL,Lee C,Vong L,Lowell BB,Malenka RC,Lutter M,Pieper AA

更新日期：2013-06-25 00:00:00

abstract：:HsPKS1 from Huperzia serrata is a type III polyketide synthase (PKS) with remarkable substrate tolerance and catalytic potential. Here we present the synthesis of unnatural unique polyketide-alkaloid hybrid molecules by exploiting the enzyme reaction using precursor-directed and structure-based approaches. HsPKS1 prod...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morita H,Yamashita M,Shi SP,Wakimoto T,Kondo S,Kato R,Sugio S,Kohno T,Abe I

更新日期：2011-08-16 00:00:00

abstract：:A new type of self-assembling peptide (sapeptide) scaffolds that serve as substrates for neurite outgrowth and synapse formation is described. These peptide-based scaffolds are amenable to molecular design by using chemical or biotechnological syntheses. They can be tailored to a variety of applications. The sapeptide...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Holmes TC,de Lacalle S,Su X,Liu G,Rich A,Zhang S

更新日期：2000-06-06 00:00:00

abstract：:The thymic microenvironment involves complex cell interactions among different types of epithelial cells, macrophages, tissue histiocytes, and immature and maturing T cells. We describe the isolation of a subset of thymic epithelial cells by selective primary culture followed by cotransfection with a simian virus 40 r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mizutani S,Watt SM,Robertson D,Hussein S,Healy LE,Furley AJ,Greaves MF

更新日期：1987-07-01 00:00:00

abstract：:In confluent fibroblast monolayers, an increase in the selective uptake of free cholesterol (FC) from plasma low density lipoprotein (LDL) was accompanied by an increase in FC efflux. The rate of FC efflux was proportional to the FC content of the cell surface caveolae and to mRNA levels of caveolin, an FC-binding pro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fielding CJ,Bist A,Fielding PE

更新日期：1997-04-15 00:00:00

abstract：:Although the function of silicon (Si) in plant physiology has long been debated, its beneficial effects on plant resistance against abiotic and biotic stresses, including insect herbivory, have been well documented. In addition, the jasmonate (JA) signaling pathway plays a crucial role in mediating antiherbivore defen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ye M,Song Y,Long J,Wang R,Baerson SR,Pan Z,Zhu-Salzman K,Xie J,Cai K,Luo S,Zeng R

更新日期：2013-09-17 00:00:00

abstract：:Gene-regulatory networks are ubiquitous in nature and critical for bottom-up engineering of synthetic networks. Transcriptional repression is a fundamental function that can be tuned at the level of DNA, protein, and cooperative protein-protein interactions, necessitating high-throughput experimental approaches for in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Swank Z,Laohakunakorn N,Maerkl SJ

更新日期：2019-03-26 00:00:00

abstract：:Schiff bases of the diamines 1,3-diaminopropane, putrescine, and cadaverine and the polyamines spermidine and spermine with pyridoxal or pyridoxal phosphate occur in human urine, as shown by gas chromatographic/mass spectrometric selected ion-monitoring techniques. By use of synthetic standards, procedures were devise...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aigner-Held R,Campbell RA,Daves GD Jr

更新日期：1979-12-01 00:00:00

abstract：:Cytochrome P450(BioI) (CYP107H1) from the biotin operon of Bacillus subtilis forms a seven-carbon diacid through a multistep oxidative cleavage of a fatty acid linked to acyl carrier protein (ACP). Crystal structures of P450(BioI) in complex with three different length fatty acyl-ACP (Escherichia coli) ligands show th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cryle MJ,Schlichting I

更新日期：2008-10-14 00:00:00

abstract：:Physiological sensing of O(2) tension (partial O(2) pressure, pO(2)) plays an important role in some mammalian cellular systems, but striated muscle generally is not considered to be among them. Here we describe a molecular mechanism in skeletal muscle that acutely couples changes in pO(2) to altered calcium release t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sun QA,Hess DT,Nogueira L,Yong S,Bowles DE,Eu J,Laurita KR,Meissner G,Stamler JS

更新日期：2011-09-20 00:00:00

abstract：:The environmental backdrop to the evolution and spread of early Homo sapiens in East Africa is known mainly from isolated outcrops and distant marine sediment cores. Here we present results from new scientific drill cores from Lake Malawi, the first long and continuous, high-fidelity records of tropical climate change...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scholz CA,Johnson TC,Cohen AS,King JW,Peck JA,Overpeck JT,Talbot MR,Brown ET,Kalindekafe L,Amoako PY,Lyons RP,Shanahan TM,Castañeda IS,Heil CW,Forman SL,McHargue LR,Beuning KR,Gomez J,Pierson J

更新日期：2007-10-16 00:00:00

abstract：:Macrophage migration inhibition factor (MIF) is one of a class of lymphocyte-derived mediator substances (lymphokines) which plays a role in the mechanism of cellular immunity. A variety of other soluble factors produced by non-lymphoid cells have been shown to have effects on macrophage mobility similar to that of MI...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yoshida T,Bigazzi P,Cohen S

更新日期：1975-04-01 00:00:00

abstract：:The RIG-G gene, originally isolated from an acute promyelocytic leukemia cell line NB4, codes for a 60-kDa cytoplasmic protein that is induced by all-trans retinoic acid (ATRA) treatment along with the induction of morphological differentiation of NB4 cells. Here, we provide evidence that ectopic expression of Rig-G i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xiao S,Li D,Zhu HQ,Song MG,Pan XR,Jia PM,Peng LL,Dou AX,Chen GQ,Chen SJ,Chen Z,Tong JH

更新日期：2006-10-31 00:00:00

abstract：:Array technologies have made it straightforward to monitor simultaneously the expression pattern of thousands of genes. The challenge now is to interpret such massive data sets. The first step is to extract the fundamental patterns of gene expression inherent in the data. This paper describes the application of self-o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tamayo P,Slonim D,Mesirov J,Zhu Q,Kitareewan S,Dmitrovsky E,Lander ES,Golub TR

更新日期：1999-03-16 00:00:00

abstract：:A 37-kDa glycoprotein has been described recently, whose synthesis is dramatically increased after injury of the rat sciatic and optic nerves. Cells in the nerve sheath, distal to the site of injury, produce and secrete large amounts of this protein, so that by 3 weeks after injury, it represents 2-5% of the total sol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ignatius MJ,Gebicke-Härter PJ,Skene JH,Schilling JW,Weisgraber KH,Mahley RW,Shooter EM

更新日期：1986-02-01 00:00:00

abstract：:The c-fos protooncogene is transcriptionally activated by a wide variety of agents including serum, growth factors, and phorbol esters. This induction is rapid and transient and is mediated through a number of identified promoter elements. Growth hormone (GH) is also known to induce transcription of c-fos in a variety...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meyer DJ,Stephenson EW,Johnson L,Cochran BH,Schwartz J

更新日期：1993-07-15 00:00:00

abstract：:Voltage-gated channels maintain cellular resting potentials and generate neuronal action potentials by regulating ion flux. Here, we show that Ether-à-go-go (EAG) K+ channels also regulate intracellular signaling pathways by a mechanism that is independent of ion flux and depends on the position of the voltage sensor....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hegle AP,Marble DD,Wilson GF

更新日期：2006-02-21 00:00:00

abstract：:Topological mechanical metamaterials are artificial structures whose unusual properties are protected very much like their electronic and optical counterparts. Here, we present an experimental and theoretical study of an active metamaterial--composed of coupled gyroscopes on a lattice--that breaks time-reversal symmet...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nash LM,Kleckner D,Read A,Vitelli V,Turner AM,Irvine WT

更新日期：2015-11-24 00:00:00

abstract：:Primary prostate cancer is the most common malignancy in men but has highly variable outcomes, highlighting the need for biomarkers to determine which patients can be managed conservatively. Few large prostate oncogenome resources currently exist that combine the molecular and clinical outcome data necessary to discov...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hieronymus H,Schultz N,Gopalan A,Carver BS,Chang MT,Xiao Y,Heguy A,Huberman K,Bernstein M,Assel M,Murali R,Vickers A,Scardino PT,Sander C,Reuter V,Taylor BS,Sawyers CL

更新日期：2014-07-29 00:00:00

abstract：:Before secretory vesicles undergo exocytosis, they must recruit the proteins syntaxin-1 and synaptosomal associated protein 25 (SNAP-25) in the plasma membrane. GFP-labeled versions of both proteins cluster at sites where secretory granules have docked. Single-particle tracking shows that minority populations of both ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Knowles MK,Barg S,Wan L,Midorikawa M,Chen X,Almers W

更新日期：2010-11-30 00:00:00

abstract：:Signals propagated by receptor tyrosine kinases (RTKs) can drive cell migration and proliferation, two cellular processes that do not occur simultaneously--a phenomenon called "migration-proliferation dichotomy." We previously showed that epidermal growth factor (EGF) signaling is skewed to favor migration over prolif...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bhandari D,Lopez-Sanchez I,To A,Lo IC,Aznar N,Leyme A,Gupta V,Niesman I,Maddox AL,Garcia-Marcos M,Farquhar MG,Ghosh P

更新日期：2015-09-01 00:00:00