Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice.

abstract：:cDNAs representing the alpha subunit of polyomavirus enhancer binding protein 2 (PEBP2; also called PEA2) were isolated. The products of the cDNAs are highly homologous to that of Drosophila segmentation gene runt (run) for an N-proximal 128-amino acid region showing 66% identity. The run homology region encompasses t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ogawa E,Maruyama M,Kagoshima H,Inuzuka M,Lu J,Satake M,Shigesada K,Ito Y

更新日期：1993-07-15 00:00:00

abstract：:Using short-term cultures of hamster embryo cells, we have examined the effects of the free-radical scavenger superoxide dismutase (superoxide:superoxide oxidoreductase, EC 1.15.1.1) and the enzyme catalase (hydrogen-peroxide:hydrogenperoxide oxidoreductase, EC 1.11.1.6) on x-ray- and bleomycin-induced transformation ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Borek C,Troll W

更新日期：1983-03-01 00:00:00

abstract：:The nucleolinus is an RNA-rich compartment, closely apposed to or embedded within the nucleolus. Discovered over 150 y ago, fewer than two dozen articles have been published on the nucleolinus, probably because complex histochemical stains are required for its visualization in the great majority of cells. The nucleoli...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alliegro MA,Henry JJ,Alliegro MC

更新日期：2010-08-03 00:00:00

abstract：:The reproductive activity of Trypanosoma lewisi was strikingly enhanced and sometimes prolonged for 2 days when sublethal doses of adenine were given to rats. The drug was effective when given for 5 or 7 days in the diet and/or intraperitoneally, starting one or two days before infection through two days after infecti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Taliaferro WH,D'Alesandro PA

更新日期：1971-01-01 00:00:00

abstract：:Persephin (Pspn), a recently cloned member of the transforming growth factor-beta superfamily (TGF-beta) and glial cell line-derived neurotrophic factor (GDNF) subfamily, is distributed throughout the nervous system at extremely low levels and is thought to function as a survival factor for midbrain dopaminergic and s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tomac AC,Agulnick AD,Haughey N,Chang CF,Zhang Y,Bäckman C,Morales M,Mattson MP,Wang Y,Westphal H,Hoffer BJ

更新日期：2002-07-09 00:00:00

abstract：:In a posterior silk gland extract, covalently closed circular (ccc) DNA is in a superhelical state that supports more transcription of fibroin gene than does linear DNA. A HeLa cell extract showed neither the supercoiling activity nor the preference for the transcription of ccc DNA over linear DNA. These activities co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hirose S,Suzuki Y

更新日期：1988-02-01 00:00:00

abstract：:Dendrite morphogenesis is regulated by neuronal activity or neurotrophins, which may function by activating intrinsic signaling proteins, including Rho family GTPases. Here we report that activity- and brain-derived neurotrophic factor (BDNF)-dependent dendritic morphogenesis requires activation of geranylgeranyltrans...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhou XP,Wu KY,Liang B,Fu XQ,Luo ZG

更新日期：2008-11-04 00:00:00

abstract：:Eph receptor tyrosine kinases and their ephrin ligands regulate cell navigation during normal and oncogenic development. Signaling of Ephs is initiated in a multistep process leading to the assembly of higher-order signaling clusters that set off bidirectional signaling in interacting cells. However, the structural an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Himanen JP,Yermekbayeva L,Janes PW,Walker JR,Xu K,Atapattu L,Rajashankar KR,Mensinga A,Lackmann M,Nikolov DB,Dhe-Paganon S

更新日期：2010-06-15 00:00:00

abstract：:Cooperativity in oligonucleotide-directed sequence-specific recognition of DNA by triple helix formation can be enhanced by the addition of discrete dimerization domains. The equilibrium association constants for cooperative binding of oligonucleotides that dimerize by Watson-Crick hydrogen bonds and occupy adjacent s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Distefano MD,Dervan PB

更新日期：1993-02-15 00:00:00

abstract：:The DNA strand exchange protein RAD51 facilitates the central step in homologous recombination, a process fundamentally important for accurate repair of damaged chromosomes, restart of collapsed replication forks, and telomere maintenance. The active form of RAD51 is a nucleoprotein filament that assembles on single-s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Subramanyam S,Ismail M,Bhattacharya I,Spies M

更新日期：2016-10-11 00:00:00

abstract：:The amount of information that can be stored in working memory is limited but may be improved with practice. The basis of improved efficiency at the level of neural activity is unknown. To investigate this question, we trained monkeys to perform a working memory task that required memory for multiple stimuli. Performa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tang H,Qi XL,Riley MR,Constantinidis C

更新日期：2019-04-02 00:00:00

abstract：:The active form of vitamin D, 1alpha,25-dihydroxyvitamin D [1alpha,25(OH)2D], is synthesized from its precursor 25 hydroxyvitamin D [25(OH)D] via the catalytic action of the 25(OH)D-1alpha-hydroxylase [1alpha(OH)ase] enzyme. Many roles in cell growth and differentiation have been attributed to 1,25(OH)2D, including a ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Panda DK,Miao D,Tremblay ML,Sirois J,Farookhi R,Hendy GN,Goltzman D

更新日期：2001-06-19 00:00:00

abstract：:Interaction of syntaxin 1 with the alpha(1D) subunit of the voltage-gated L type Ca(2+) channel was investigated in the pancreatic beta cell. Coexpression of the enhanced green fluorescent protein-linked alpha(1D) subunit with the enhanced blue fluorescent protein-linked syntaxin 1 and Western blot analysis together w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang SN,Larsson O,Bränström R,Bertorello AM,Leibiger B,Leibiger IB,Moede T,Köhler M,Meister B,Berggren PO

更新日期：1999-08-31 00:00:00

abstract：:The eukaryotic proteasome mediates degradation of polyubiquitinated proteins. Here we report the single-particle cryoelectron microscopy (cryo-EM) structures of the endogenous 26S proteasome from Saccharomyces cerevisiae at 4.6- to 6.3-Å resolution. The fine features of the cryo-EM maps allow modeling of 18 subunits i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luan B,Huang X,Wu J,Mei Z,Wang Y,Xue X,Yan C,Wang J,Finley DJ,Shi Y,Wang F

更新日期：2016-03-08 00:00:00

abstract：:Biological membranes contain an extraordinary diversity of lipids. Phospholipids function as major structural elements of cellular membranes, and analysis of changes in the highly heterogeneous mixtures of lipids found in eukaryotic cells is central to understanding the complex functions in which lipids participate. P...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ivanova PT,Cerda BA,Horn DM,Cohen JS,McLafferty FW,Brown HA

更新日期：2001-06-19 00:00:00

abstract：:[14C]Naphthalene was given orally to rats with cannulated bile ducts and to germ-free rats. Bile and urine from the cannulated rats and urine from the germ-free rats contained no radioactive 1,2-dihydro-1-hydroxy-2-methylthionaphthalene and only trace amounts of radioactive naphthols or naphthol conjugates. Urine of c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bakke J,Struble C,Gustafsson JA,Gustafsson B

更新日期：1985-02-01 00:00:00

abstract：:Using the Luria-Delbrück fluctuation analysis, we have examined the lung tumor-forming ability of a series of parallel clones derived from the KHT tumor, grown to small defined sizes. From these studies, we conclude that metastatic variants arise spontaneously in the clonal lines during their growth, at an apparent ra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harris JF,Chambers AF,Hill RP,Ling V

更新日期：1982-09-01 00:00:00

abstract：:During vertebrate brain development, the onset of neuronal differentiation is under strict temporal control. In the mammalian thalamus and other brain regions, neurogenesis is regulated also in a spatially progressive manner referred to as a neurogenetic gradient, the underlying mechanism of which is unknown. Here we ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scholpp S,Delogu A,Gilthorpe J,Peukert D,Schindler S,Lumsden A

更新日期：2009-11-24 00:00:00

abstract：:We have used restriction endonuclease mapping of cell DNA to investigate the structure of the beta-globin gene in beta-thalassemias. Among 17 individuals with beta +- and beta 0-thalassemia, we observed three patients of Indian origin with beta 0-thalassemia whose DNA revealed a consistent mapping abnormality. In one ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Orkin SH,Old JM,Weatherall DJ,Nathan DG

更新日期：1979-05-01 00:00:00

abstract：:In translation, elongation factor Tu (EF-Tu) molecules deliver aminoacyl-tRNAs to the mRNA-programmed ribosome. The GTPase activity of EF-Tu is triggered by ribosome-induced conformational changes of the factor that play a pivotal role in the selection of the cognate aminoacyl-tRNAs. We present a 6.7-A cryo-electron m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Villa E,Sengupta J,Trabuco LG,LeBarron J,Baxter WT,Shaikh TR,Grassucci RA,Nissen P,Ehrenberg M,Schulten K,Frank J

更新日期：2009-01-27 00:00:00

abstract：:Large changes in solvent accessibility to aspartate transcarbamylase (aspartate carbamoyltransferase, carbamoylphosphate:L-aspartate carbamoyltransferase, EC 2.1.3.2), as monitored by tritium exchange, result from binding of substrates and substrate analogs to the catalytic subunit (c3), binding of nucleoside triphosp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lennick M,Allewell NM

更新日期：1981-11-01 00:00:00

abstract：:In Caenorhabditis elegans, pre-mRNA for the essential splicing factor U2AF65 sometimes is spliced to produce an RNA that includes an extra 216-bp internal exon, exon 3. Inclusion of exon 3 inserts an in-frame stop codon, yet this RNA is not subject to SMG-mediated RNA surveillance. To test whether exon 3 causes RNA to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： MacMorris MA,Zorio DA,Blumenthal T

更新日期：1999-03-30 00:00:00

abstract：:Gene III protein of bacteriophage f1 is inserted into the host cell membrane where it is assembled into phage particles. A truncated form of gene III protein, encoded by a recombinant plasmid and lacking the carboxyl terminus, does not remain in the membrane but instead appears to slip through it. Fusion of a hydropho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Boeke JD,Model P

更新日期：1982-09-01 00:00:00

abstract：:Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common blood disorder, presenting multiple symptoms, including hemolytic anemia. It affects 400 million people worldwide, with more than 160 single mutations reported in G6PD. The most severe mutations (about 70) are classified as class I, leading to more...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Horikoshi N,Hwang S,Gati C,Matsui T,Castillo-Orellana C,Raub AG,Garcia AA,Jabbarpour F,Batyuk A,Broweleit J,Xiang X,Chiang A,Broweleit R,Vöhringer-Martinez E,Mochly-Rosen D,Wakatsuki S

更新日期：2021-01-26 00:00:00

abstract：:All science has uncertainty. Unless that uncertainty is communicated effectively, decision makers may put too much or too little faith in it. The information that needs to be communicated depends on the decisions that people face. Are they (i) looking for a signal (e.g., whether to evacuate before a hurricane), (ii) c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fischhoff B,Davis AL

更新日期：2014-09-16 00:00:00

abstract：:We have identified new genomic alterations in the breast cancer cell line HCC1954, using high-throughput transcriptome sequencing. With 120 Mb of cDNA sequences, we were able to identify genomic rearrangement events leading to fusions or truncations of genes including MRE11 and NSD1, genes already implicated in oncoge...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhao Q,Caballero OL,Levy S,Stevenson BJ,Iseli C,de Souza SJ,Galante PA,Busam D,Leversha MA,Chadalavada K,Rogers YH,Venter JC,Simpson AJ,Strausberg RL

更新日期：2009-02-10 00:00:00

abstract：:A debate has recently surfaced concerning the degree of precommitment attained by alpha beta and gamma delta T-cell precursors prior to T-cell receptor (TCR) gene rearrangement. It has been suggested that precursors may be precommitted to rearrange either alpha or delta genes, but not both, thus giving rise to alpha b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thompson SD,Pelkonen J,Hurwitz JL

更新日期：1990-07-01 00:00:00

abstract：:Transcription is a central step in gene expression, in which the DNA template is processively read by RNA polymerase II (Pol II), synthesizing a complementary messenger RNA transcript. At each cycle, Pol II moves exactly one register along the DNA, a process known as translocation. Although X-ray crystal structures ha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Silva DA,Weiss DR,Pardo Avila F,Da LT,Levitt M,Wang D,Huang X

更新日期：2014-05-27 00:00:00

abstract：:The capacity of a so-called male recombination (MR) chromosome in Drosophila melanogaster to generate mutations at 14 X-chromosome loci specifying visible phenotypes was investigated. Appreciable increases in mutation were found at three loci y, sn, and ras. Tests of represnetative mutants generated at each locus esta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Green MM

更新日期：1977-08-01 00:00:00

abstract：:The tissue-specific expression of the chicken liver cell adhesion molecule (L-CAM) was studied by generating transgenic mice. The rat insulin II promoter was fused to a chicken L-CAM cDNA or to chicken genomic L-CAM sequences. Mice carrying the cDNA showed no expression of L-CAM. Mice carrying L-CAM genomic sequences ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Begemann M,Tan SS,Cunningham BA,Edelman GM

更新日期：1990-11-01 00:00:00