Her6 regulates the neurogenetic gradient and neuronal identity in the thalamus.

abstract：:The detailed molecular dynamics of an actual bond-breaking event in a fluctuating enzyme substrate complex is simulated. The method developed allows one to explore what type of fluctuations are involved in enzymatic reactions and to evaluate entropic contributions to enzyme catalysis. The fluctuations of the enzyme el...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Warshel A

更新日期：1984-01-01 00:00:00

abstract：:A compound of simple structure, 2,4-dichlorobenzyl thiocyanate (DCBT), is an antimitotic agent with a number of unusual properties. The drug causes an extreme reorganization of microtubules in cells in culture. Most normal microtubules disappear, and remaining tubulin-containing structures appear to be bundled or aggr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Abraham I,Dion RL,Chi DM,Gottesman MM,Hamel E

更新日期：1986-09-01 00:00:00

abstract：:We demonstrate that individual cells infected with and expressing a recombinant retrovirus carrying the Escherichia coli beta-galactosidase gene (lacZ) can be viably stained, analyzed, sorted, and cloned by fluorescence-activated cell sorting based on the levels of lacZ expressed. To accomplish this we have devised a ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nolan GP,Fiering S,Nicolas JF,Herzenberg LA

更新日期：1988-04-01 00:00:00

abstract：:Telomerase is a special reverse transcriptase that extends one strand of the telomere repeat by using a template embedded in an RNA subunit. Like other polymerases, telomerase is believed to use a pair of divalent metal ions (coordinated by a triad of aspartic acid residues) for catalyzing nucleotide addition. Here we...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lue NF,Bosoy D,Moriarty TJ,Autexier C,Altman B,Leng S

更新日期：2005-07-12 00:00:00

abstract：:T cells must respond differently to antigens of varying affinity presented at different doses. Previous attempts to map peptide MHC (pMHC) affinity onto T-cell responses have produced inconsistent patterns of responses, preventing formulations of canonical models of T-cell signaling. Here, a systematic analysis of T-c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lever M,Lim HS,Kruger P,Nguyen J,Trendel N,Abu-Shah E,Maini PK,van der Merwe PA,Dushek O

更新日期：2016-10-25 00:00:00

abstract：:The identification and targeting of key molecular drivers of melanoma and breast and lung cancer have substantially improved their therapy. However, subtypes of each of these three common, lethal solid tumors lack identified molecular drivers, and are thus not amenable to targeted therapies. Here we show that pleckstr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： de Semir D,Bezrookove V,Nosrati M,Dar AA,Wu C,Shen J,Rieken C,Venkatasubramanian M,Miller JR 3rd,Desprez PY,McAllister S,Soroceanu L,Debs RJ,Salomonis N,Schadendorf D,Cleaver JE,Kashani-Sabet M

更新日期：2018-06-19 00:00:00

abstract：:The formation of amyloid-like aggregates by expanded polyglutamine (polyGln) sequences is suspected to play a critical role in the neuropathology of Huntington's disease and other expanded CAG-repeat diseases. To probe the folding of the polyGln sequence in the aggregate, we replaced Gln-Gln pairs at different sequenc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thakur AK,Wetzel R

更新日期：2002-12-24 00:00:00

abstract：:The bryostatins are macrocyclic lactones, extracted from the marine bryozoan Bugula neritina, and have been reported to be potent antineoplastic agents. Results described here demonstrate that the bryostatins may also be useful as stimulators of normal human hematopoietic cells since they can (i) directly stimulate bo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： May WS,Sharkis SJ,Esa AH,Gebbia V,Kraft AS,Pettit GR,Sensenbrenner LL

更新日期：1987-12-01 00:00:00

abstract：:The "parallel-up" packing in cellulose Ialpha and Ibeta unit cells was experimentally demonstrated by a combination of direct-staining the reducing ends of cellulose chains and microdiffraction-tilting electron crystallographic analysis. Microdiffraction investigation of nascent bacterial cellulose microfibrils showed...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koyama M,Helbert W,Imai T,Sugiyama J,Henrissat B

更新日期：1997-08-19 00:00:00

abstract：:Whole-cell and single-channel recording techniques were used to study the action of the anticonvulsant drug MK-801 [(+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]- cyclohepten-5,10-imine maleate) on responses to excitatory amino acids in rat neocortical neurons in cell culture. MK-801 caused a progressive, long-lasting bl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huettner JE,Bean BP

更新日期：1988-02-01 00:00:00

abstract：:T-box riboswitches control transcription of downstream genes through the tRNA-binding formation of terminator or antiterminator structures. Previously reported T-boxes were described as single-specificity riboswitches that can bind specific tRNA anticodons through codon-anticodon interactions with the nucleotide tripl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Saad NY,Stamatopoulou V,Brayé M,Drainas D,Stathopoulos C,Becker HD

更新日期：2013-07-30 00:00:00

abstract：:Reduced serum testosterone (T), or hypogonadism, affects millions of men and is associated with many pathologies, including infertility, cardiovascular diseases, metabolic syndrome, and decreased libido and sexual function. Administering T-replacement therapy (TRT) reverses many of the symptoms associated with low T l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li L,Li Y,Sottas C,Culty M,Fan J,Hu Y,Cheung G,Chemes HE,Papadopoulos V

更新日期：2019-11-12 00:00:00

abstract：:In multicellular organisms, the higher order organization of chromatin during interphase and the reassembly of the nuclear envelope during mitosis are thought to involve an interaction between the nuclear lamina and chromatin. The nuclear distribution of lamins and of peripheral chromatin is highly correlated in vivo,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goldberg M,Harel A,Brandeis M,Rechsteiner T,Richmond TJ,Weiss AM,Gruenbaum Y

更新日期：1999-03-16 00:00:00

abstract：:It is generally accepted that adult human bone marrow-derived mesenchymal stromal cells (hMSCs) are default committed toward osteogenesis. Even when induced to chondrogenesis, hMSCs typically form hypertrophic cartilage that undergoes endochondral ossification. Because embryonic mesenchyme is obviously competent to ge...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Occhetta P,Pigeot S,Rasponi M,Dasen B,Mehrkens A,Ullrich T,Kramer I,Guth-Gundel S,Barbero A,Martin I

更新日期：2018-05-01 00:00:00

abstract：:Debate over the influence of postwildfire management on future fire severity is occurring in the absence of empirical studies. We used satellite data, government agency records, and aerial photography to examine a forest landscape in southwest Oregon that burned in 1987 and then was subject, in part, to salvage-loggin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thompson JR,Spies TA,Ganio LM

更新日期：2007-06-19 00:00:00

abstract：:Biocompatible gold nanoparticles designed to absorb light at wavelengths of high tissue transparency have been of particular interest for biomedical applications. The ability of such nanoparticles to convert absorbed near-infrared light to heat and induce highly localized hyperthermia has been shown to be highly effec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rastinehad AR,Anastos H,Wajswol E,Winoker JS,Sfakianos JP,Doppalapudi SK,Carrick MR,Knauer CJ,Taouli B,Lewis SC,Tewari AK,Schwartz JA,Canfield SE,George AK,West JL,Halas NJ

更新日期：2019-09-10 00:00:00

abstract：:Highly purified RNA polymerase II was found to be able to weakly recognize the initiator (Inr) present in the adenovirus IVa2 and major late promoters. The association of RNA polymerase II with the Inr was enhanced by the general transcription factors. The Inr was capable of directing the formation of a DNA-protein co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carcamo J,Buckbinder L,Reinberg D

更新日期：1991-09-15 00:00:00

abstract：:Clonal expansion of premalignant lesions is an important step in the progression to cancer. This process is commonly considered to be a consequence of sustaining a proliferative mutation. Here, we investigate whether the growth trajectory of clones can be better described by a model in which clone growth does not depe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chao DL,Eck JT,Brash DE,Maley CC,Luebeck EG

更新日期：2008-09-30 00:00:00

abstract：:A methionine-rich low complexity (LC) domain is found within a C-terminal region of the TDP43 RNA-binding protein. Self-association of this domain leads to the formation of labile cross-β polymers and liquid-like droplets. Treatment with H2O2 caused phenomena of methionine oxidation and droplet melting that were rever...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin Y,Zhou X,Kato M,Liu D,Ghaemmaghami S,Tu BP,McKnight SL

更新日期：2020-11-17 00:00:00

abstract：:We have evaluated the effect of ligand binding on expression of the receptor for IgE on rat basophilic leukemia (RBL) cells. RBL cells were grown in the presence or absence of 131I-labeled IgE and sometimes were also surface labeled with 125I. We found that cells grown in the presence of IgE continued to accumulate re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Furuichi K,Rivera J,Isersky C

更新日期：1985-03-01 00:00:00

abstract：:The anaphase-promoting complex/cyclosome (APC/C) is a multisubunit ubiquitin-protein ligase that targets for degradation cell-cycle regulatory proteins during exit from mitosis and in the G1 phase of the cell cycle. The activity of APC/C in mitosis and in G1 requires interaction with the activator proteins Cdc20 and C...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eytan E,Moshe Y,Braunstein I,Hershko A

更新日期：2006-02-14 00:00:00

abstract：:Temperate-zone species have responded to warming temperatures by shifting their distributions poleward and upslope. Thermal tolerance data suggests that tropical species may respond to warming temperatures even more strongly than temperate-zone species, but this prediction has yet to be tested. We addressed this data ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Freeman BG,Class Freeman AM

更新日期：2014-03-25 00:00:00

abstract：:Molecular beacons are FRET-based target-activatable probes. They offer control of fluorescence emission in response to specific cancer targets, thus are useful tools for in vivo cancer imaging. Photodynamic therapy (PDT) is a cell-killing process by light activation of a photosensitizer (PS) in the presence of oxygen....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zheng G,Chen J,Stefflova K,Jarvi M,Li H,Wilson BC

更新日期：2007-05-22 00:00:00

abstract：:Degradation of the most abundant membrane protein on earth, the light-harvesting complex of Photosystem II (LHC II), is highly regulated under various environmental conditions, e.g., light stress, to prevent photochemical damage to the reaction center. We identified the LHC II degrading protease in Arabidopsis thalian...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zelisko A,García-Lorenzo M,Jackowski G,Jansson S,Funk C

更新日期：2005-09-20 00:00:00

abstract：:Increased intestinal permeability has been observed in numerous human autoimmune diseases, including type-1 diabetes (T1D) and its' animal model, the BB-wor diabetic prone rat. We have recently described zonulin, a protein that regulates intercellular tight junctions. The objective of this study was to establish wheth...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Watts T,Berti I,Sapone A,Gerarduzzi T,Not T,Zielke R,Fasano A

更新日期：2005-02-22 00:00:00

abstract：:Global supply chains play a critical role in many of the most pressing environmental stresses and social struggles identified by the United Nations' Sustainable Development Goals (SDGs). Responding to calls from the global community, companies are adopting a variety of voluntary practices to improve the environmental ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thorlakson T,de Zegher JF,Lambin EF

更新日期：2018-02-27 00:00:00

abstract：:Current theoretical models of the commons assert that common-pool resources can only be managed sustainably with clearly defined boundaries around both communities and the resources that they use. In these theoretical models, open access inevitably leads to a tragedy of the commons. However, in many open-access system...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Moritz M,Behnke R,Beitl CM,Bliege Bird R,Chiaravalloti RM,Clark JK,Crabtree SA,Downey SS,Hamilton IM,Phang SC,Scholte P,Wilson JA

更新日期：2018-12-18 00:00:00

abstract：:Collectivistic cultures have been characterized as having harmonious, cooperative ingroup relationships. However, we find evidence that people in collectivistic cultures are more vigilant toward ingroup members, mindful of their possible unethical intentions. Study 1 found that Chinese participants were more vigilant ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu SS,Morris MW,Talhelm T,Yang Q

更新日期：2019-07-16 00:00:00

abstract：:The amyloid beta-protein precursor (AbetaPP) is best known as the parent molecule to the amyloid beta-peptide that accumulates in the brains of patients with Alzheimer's disease. Secreted isoforms of AbetaPP that contain the Kunitz proteinase inhibitor domain are analogous to the previously identified cell-secreted pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu F,Davis J,Miao J,Previti ML,Romanov G,Ziegler K,Van Nostrand WE

更新日期：2005-12-13 00:00:00

abstract：:C1q-like genes (C1ql1-C1ql4) encode small, secreted proteins that are expressed in differential patterns in the brain but whose receptors and functions remain unknown. BAI3 protein, in contrast, is a member of the cell-adhesion class of G protein-coupled receptors that are expressed at high levels in the brain but who...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bolliger MF,Martinelli DC,Südhof TC

更新日期：2011-02-08 00:00:00