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The receptor for immunoglobulin E on rat basophilic leukemia cells: effect of ligand binding on receptor expression.

Abstract：

:We have evaluated the effect of ligand binding on expression of the receptor for IgE on rat basophilic leukemia (RBL) cells. RBL cells were grown in the presence or absence of 131I-labeled IgE and sometimes were also surface labeled with 125I. We found that cells grown in the presence of IgE continued to accumulate receptors at the surface and thus the apparent amount of cell-associated IgE continued to increase. The results obtained suggest that, in the presence of IgE, the elimination of the receptor from the surface was halted or slowed significantly (approximately equal to 80%) while insertion into the membrane of previously synthesized receptor continued.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Furuichi K,Rivera J,Isersky C

doi

10.1073/pnas.82.5.1522

subject

Has Abstract

pub_date

1985-03-01 00:00:00

pages

1522-5

issue

5

eissn

0027-8424

issn

1091-6490

journal_volume

82

pub_type

杂志文章

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