Abstract:
:The epidermal changes that occur in human cutaneous immune responses have been investigated in the tuberculin reaction and in the lesions of tuberculoid and lepromatous leprosy and cutaneous leishmaniasis. In each situation, there was a dermal accumulation of monocytes and T cells, and the epidermis exhibited thickening. In the tuberculin response, the thickness of the epidermis sometimes doubled in 48-72 hr, and this was attributed to increases in both size and number of keratinocytes. In addition, the phenotype of the keratinocytes changed from Ia- to Ia+. Similar changes in keratinocyte Ia-antigen expression occurred in the epidermis overlying untreated tuberculoid leprosy and cutaneous leishmaniasis lesions, but not in lepromatous leprosy. We suggest that one or more epidermal growth factors may be generated in the course of a delayed immune reaction in the dermis.
journal_name
Proc Natl Acad Sci U S Aauthors
Kaplan G,Witmer MD,Nath I,Steinman RM,Laal S,Prasad HK,Sarno EN,Elvers U,Cohn ZAdoi
10.1073/pnas.83.10.3469subject
Has Abstractpub_date
1986-05-01 00:00:00pages
3469-73issue
10eissn
0027-8424issn
1091-6490journal_volume
83pub_type
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