Critical perspectives on historical collapse.

abstract：:Paraspeckles are subnuclear structures that form around nuclear paraspeckle assembly transcript 1 (NEAT1) long noncoding RNA (lncRNA). Recently, paraspeckles were shown to be functional nuclear bodies involved in stress responses and the development of specific organs. Paraspeckle formation is initiated by transcripti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kawaguchi T,Tanigawa A,Naganuma T,Ohkawa Y,Souquere S,Pierron G,Hirose T

更新日期：2015-04-07 00:00:00

abstract：:Recent work has demonstrated that Web search volume can "predict the present," meaning that it can be used to accurately track outcomes such as unemployment levels, auto and home sales, and disease prevalence in near real time. Here we show that what consumers are searching for online can also predict their collective...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goel S,Hofman JM,Lahaie S,Pennock DM,Watts DJ

更新日期：2010-10-12 00:00:00

abstract：:The number of solute-binding protein-dependent transporters in rhizobia is dramatically increased compared with the majority of other bacteria so far sequenced. This increase may be due to the high affinity of solute-binding proteins for solutes, permitting the acquisition of a broad range of growth-limiting nutrients...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mauchline TH,Fowler JE,East AK,Sartor AL,Zaheer R,Hosie AH,Poole PS,Finan TM

更新日期：2006-11-21 00:00:00

abstract：:Chorismate mutase acts at the first branch-point of aromatic amino acid biosynthesis and catalyzes the conversion of chorismate to prephenate. The results of molecular dynamics simulations of the substrate in solution and in the active site of chorismate mutase are reported. Two nonreactive conformers of chorismate ar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guo H,Cui Q,Lipscomb WN,Karplus M

更新日期：2001-07-31 00:00:00

abstract：:In classical knot theory and the theory of quantum invariants substantial effort was directed toward the search for unknotting moves on links. We solve, in this article, several classical problems concerning unknotting moves. Our approach uses a concept, Burnside groups of links, that establishes an unexpected relatio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dabkowski MK,Przytycki JH

更新日期：2004-12-14 00:00:00

abstract：:Synthetic oligonucleotide probes can be easily obtained and used, in contrast to cDNA cloning to develop probes, and thus the present study was carried out to determine whether such probes could also be useful for in situ hybridization. A 24-base synthetic oligonucleotide complementary to part of the alpha-melanocyte-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lewis ME,Sherman TG,Burke S,Akil H,Davis LG,Arentzen R,Watson SJ

更新日期：1986-08-01 00:00:00

abstract：:The peptide composition of purified Histocompatibility-2 (H-2) reactive glycoprotein fragments from two murine strains allelic at the H-2 locus (H-2(b) and H-2(d)) were compared by a cellulose thin-layer peptide mapping micro technique. Approximately 70 per cent of the theoretical maximum number of peptides produced b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shimada A,Yamane K,Nathenson SG

更新日期：1970-03-01 00:00:00

abstract：:Wnt signaling is required for the maintenance of intestinal stem cells and self-renewal of the intestinal epithelium. Intestinal cancers are frequently associated with mutations that activate the Wnt pathway. The role of Wnt signaling on differentiation of lineage-specific precursors in the intestine is not well chara...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang Y,Giel-Moloney M,Rindi G,Leiter AB

更新日期：2007-07-03 00:00:00

abstract：:Nitric oxide (NO) biology has focused on the tightly regulated enzymatic mechanism that transforms L-arginine into a family of molecules, which serve both signaling and defense functions. However, very little is known of the pathways that metabolize these molecules or turn off the signals. The paradigm is well exempli...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hausladen A,Gow AJ,Stamler JS

更新日期：1998-11-24 00:00:00

abstract：:Recent studies indicate that impairments in two cognitive domains characterize the cognitive abnormalities that appear earliest in the course of Alzheimer disease (AD). These cognitive domains pertain to memory and executive function ability; in particular, memory test scores reflecting the difference between immediat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Albert MS

更新日期：1996-11-26 00:00:00

abstract：:An important goal in biology is to predict from sequence data the high-resolution structures of proteins and the interactions that occur between them. In this paper, we describe a computational approach that can make these types of predictions for a series of coiled-coil dimers. Our method comprises a dual strategy th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Keating AE,Malashkevich VN,Tidor B,Kim PS

更新日期：2001-12-18 00:00:00

abstract：:To initiate transcription from specific promoters, the bacterial RNA polymerase (RNAP) core enzyme must associate with the initiation factor sigma, which contains determinants that allow sequence-specific interactions with promoter DNA. Most bacteria contain several sigma factors, each of which directs recognition of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yuan AH,Nickels BE,Hochschild A

更新日期：2009-04-21 00:00:00

abstract：:The Hippo signaling pathway is a master regulator of organ growth, tissue homeostasis, and tumorigenesis. The activity of the Hippo pathway is controlled by various upstream components, including Expanded (Ex), but the precise molecular mechanism of how Ex is regulated remains poorly understood. Here we identify Plent...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ma X,Guo X,Richardson HE,Xu T,Xue L

更新日期：2018-02-27 00:00:00

abstract：:The polymerization of deoxynucleoside triphosphates, catalyzed by terminal deoxynucleotidyl transferase from calf thymus gland, is strongly inhibited by various metal chelators. The reaction appears to be first order with respect to enzyme, deoxynucleoside triphosphate, and initiator, indicating that there is only one...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chang LM,Bollum FJ

更新日期：1970-04-01 00:00:00

abstract：:The intracellular signaling mechanisms regulating the generation and long-term persistence of memory T cells in vivo remain unclear. In this study, we used mouse models with conditional deletion of the key T cell receptor (TCR)-coupled adaptor molecule SH2-domain-containing phosphoprotein of 76 kDa (SLP-76), to analyz...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bushar ND,Corbo E,Schmidt M,Maltzman JS,Farber DL

更新日期：2010-01-12 00:00:00

abstract：:Flagellar polypeptides of Chlamydomonas reinhardtii were analyzed in two-dimensions by isoelectric focusing and electrophoresis in the presence of sodium dodecyl sulfate. In addition to flagellar tubulin, over 130 polypeptides were resolved and 100 of these were identified as axonemal components in wild-type organisms...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Piperno G,Huang B,Luck DJ

更新日期：1977-04-01 00:00:00

abstract：:The domestication of cultivated barley has been used as a model system for studying the origins and early spread of agrarian culture. Our previous results indicated that the Tibetan Plateau and its vicinity is one of the centers of domestication of cultivated barley. Here we reveal multiple origins of domesticated bar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dai F,Chen ZH,Wang X,Li Z,Jin G,Wu D,Cai S,Wang N,Wu F,Nevo E,Zhang G

更新日期：2014-09-16 00:00:00

abstract：:Caveolin, a 21- to 24-kDa integral membrane protein, is a principal component of caveolae membranes. Caveolin interacts directly with heterotrimeric guanine nucleotide binding proteins (G proteins) and can functionally regulate their activity. Here, an approximately 20-kDa caveolin-related protein, caveolin-2, was ide...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scherer PE,Okamoto T,Chun M,Nishimoto I,Lodish HF,Lisanti MP

更新日期：1996-01-09 00:00:00

abstract：:Mechanical robustness of the cell under different modes of stress and deformation is essential to its survival and function. Under tension, mechanical rigidity is provided by the cytoskeletal network; with increasing stress, this network stiffens, providing increased resistance to deformation. However, a cell must als...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhou EH,Trepat X,Park CY,Lenormand G,Oliver MN,Mijailovich SM,Hardin C,Weitz DA,Butler JP,Fredberg JJ

更新日期：2009-06-30 00:00:00

abstract：:Our main goal is to analyze the geometric and spectral properties of the Picard modular group with Gaussian integer entries acting on the two-dimensional complex hyperbolic space. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Francsics G,Lax PD

更新日期：2006-07-25 00:00:00

abstract：:Break-induced replication (BIR) refers to recombination-dependent DNA synthesis initiated from one end of a DNA double-strand break and can extend for more than 100 kb. BIR initiates by Rad51-catalyzed strand invasion, but the mechanism for DNA synthesis is not known. Here, we used BrdU incorporation to track DNA synt...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Donnianni RA,Symington LS

更新日期：2013-08-13 00:00:00

abstract：:The steady-state level and synthesis of a pair of polypeptides of Mr 33,000 and 35,000 in chicken embryo fibroblasts (CEF) transformed by Rous sarcoma virus (RSV) are significantly decreased relative to normal CEF; however, the decrease is more pronounced in the case of the Mr 35,000 polypeptide. These polypeptides ha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hendricks M,Weintraub H

更新日期：1981-09-01 00:00:00

abstract：:Phosphatidylcholine (PC) is the major glycerophospholipid in eukaryotic cells and is an essential component in all cellular membranes. The biochemistry of de novo PC synthesis by the Kennedy pathway is well established, but less is known about the physiological functions of PC. We identified two unrelated patients wit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Payne F,Lim K,Girousse A,Brown RJ,Kory N,Robbins A,Xue Y,Sleigh A,Cochran E,Adams C,Dev Borman A,Russel-Jones D,Gorden P,Semple RK,Saudek V,O'Rahilly S,Walther TC,Barroso I,Savage DB

更新日期：2014-06-17 00:00:00

abstract：:We address the stability of multicharged finite systems driven by Coulomb forces beyond the Rayleigh instability limit. Our exploration of the nuclear dynamics of heavily charged Morse clusters enabled us to vary the range of the pair potential and of the fissibility parameter, which results in distinct fragmentation ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Last I,Levy Y,Jortner J

更新日期：2002-07-09 00:00:00

abstract：:Although genetic analysis has demonstrated that members of the winged helix, or forkhead, family of transcription factors play pivotal roles in the regulation of cellular differentiation and proliferation, both during development and in the adult, little is known of the mechanisms underlying their regulation. Here we ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Biggs WH 3rd,Meisenhelder J,Hunter T,Cavenee WK,Arden KC

更新日期：1999-06-22 00:00:00

abstract：:The x-ray structure of rubredoxin has been refined by energy minimization. The computed structure is constrained to have standard bond lengths, bond angles, and planar trans peptide groups. Also, since most of the steric overlaps have been relieved, it has a very low energy. As judged by the root mean square (RMS) dev...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rasse D,Warme PK,Scheraga HA

更新日期：1974-09-01 00:00:00

abstract：:The hippocampus has a well-documented role for spatial navigation across species, but its role for spatial memory in nonnavigational tasks is uncertain. In particular, when monkeys are tested in tasks that do not require navigation, spatial memory seems unaffected by lesions of the hippocampus. However, the interpreta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Forcelli PA,Palchik G,Leath T,DesJardin JT,Gale K,Malkova L

更新日期：2014-03-18 00:00:00

abstract：:To determine the importance of mitochondrial reactive oxygen species toxicity in aging and senescence, we analyzed changes in mitochondrial function with age in mice with partial or complete deficiencies in the mitochondrial antioxidant enzyme manganese superoxide dismutase (MnSOD). Liver mitochondria from homozygous ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kokoszka JE,Coskun P,Esposito LA,Wallace DC

更新日期：2001-02-27 00:00:00

abstract：:Vertebrate embryogenesis and organogenesis are driven by cell biological processes, ranging from mitosis and migration to changes in cell size and polarity, but their control and causal relationships are not fully defined. Here, we use the developing limb skeleton to better define the relationships between mitosis and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li Y,Junge JA,Arnesano C,Gross GG,Miner JH,Moats R,Roberts RW,Arnold DB,Fraser SE

更新日期：2018-11-13 00:00:00

abstract：:A study of the near-infrared absorption spectra of three oxygen compounds of membrane-bound cytochrome oxidase (ferrocytochrome c:oxygen oxidoreductase; EC 1.9.3.1) shows that the formation of compound A (oxycytochrome oxidase) causes no significant infrared absorbance changes at -103 degrees. At -64 degrees, the form...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chance B,Leigh JS Jr

更新日期：1977-11-01 00:00:00