Abstract:
:The x-ray structure of rubredoxin has been refined by energy minimization. The computed structure is constrained to have standard bond lengths, bond angles, and planar trans peptide groups. Also, since most of the steric overlaps have been relieved, it has a very low energy. As judged by the root mean square (RMS) deviation of the computed coordinates from those of the x-ray structure, the two are very similar. The reliability index R for the computed structure (determined from the structure factors for the calculated conformation) is 0.37, which is comparable to that for other proteins.
journal_name
Proc Natl Acad Sci U S Aauthors
Rasse D,Warme PK,Scheraga HAdoi
10.1073/pnas.71.9.3736subject
Has Abstractpub_date
1974-09-01 00:00:00pages
3736-40issue
9eissn
0027-8424issn
1091-6490journal_volume
71pub_type
杂志文章abstract::The Notch signaling pathway is essential for many aspects of development, cell fate determination, and tissue homeostasis. Notch signaling can be modulated by posttranslational modifications to the Notch receptor, which are known to alter both ligand binding and receptor activation. We have modified the ligand-binding...
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journal_title:Proceedings of the National Academy of Sciences of the United States of America
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