Species differences in the temporal pattern of Drosophila urate oxidase gene expression are attributed to trans-acting regulatory changes.

abstract：:Glycan-protein interactions are emerging as important modulators of membrane protein organization and dynamics, regulating multiple cellular functions. In particular, it has been postulated that glycan-mediated interactions regulate surface residence time of glycoproteins and endocytosis. How this precisely occurs is ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Torreno-Pina JA,Castro BM,Manzo C,Buschow SI,Cambi A,Garcia-Parajo MF

更新日期：2014-07-29 00:00:00

abstract：:The pleiotropic activities of interferons (IFNs) are mediated primarily through the transcriptional regulation of many downstream effector genes. The mRNA profiles from IFN-alpha, -beta, or -gamma treatments of the human fibrosarcoma cell line, HT1080, were determined by using oligonucleotide arrays with probe sets co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Der SD,Zhou A,Williams BR,Silverman RH

更新日期：1998-12-22 00:00:00

abstract：:General optimization results from physics indicate that maximum efficiency of a process, in the sense of minimum overall entropy production, is achieved when the rate of entropy production is constant over time, however not in ordinary clock time but on an, in general varying, "eigen time" scale, intrinsic to the syst...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Andresen B,Shiner JS,Uehlinger DE

更新日期：2002-04-30 00:00:00

abstract：:Familial multiple system tauopathy with presenile dementia (MSTD) is a neurodegenerative disease with an abundant filamentous tau protein pathology. It belongs to the group of familial frontotemporal dementias with Parkinsonism linked to chromosome 17 (FTDP-17), a major class of inherited dementing disorders whose gen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spillantini MG,Murrell JR,Goedert M,Farlow MR,Klug A,Ghetti B

更新日期：1998-06-23 00:00:00

abstract：:The dynamic responses of the hearing organ to acoustic overstimulation were investigated using the guinea pig isolated temporal bone preparation. The organ was loaded with the fluorescent Ca2+ indicator Fluo-3, and the cochlear electric responses to low-level tones were recorded through a microelectrode in the scala m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fridberger A,Flock A,Ulfendahl M,Flock B

更新日期：1998-06-09 00:00:00

abstract：:Animal studies have shown that the brain is an insulin-responsive organ and that central nervous insulin resistance induces obesity and disturbances in glucose metabolism. In humans, insulin effects in the brain are poorly characterized. We used a magnetoencephalography approach during a two-step hyperinsulinemic eugl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tschritter O,Preissl H,Hennige AM,Stumvoll M,Porubska K,Frost R,Marx H,Klösel B,Lutzenberger W,Birbaumer N,Häring HU,Fritsche A

更新日期：2006-08-08 00:00:00

abstract：:Polycomb group proteins are essential regulators of developmental processes across animals. Despite their importance, studies on Polycomb are often restricted to classical model systems and, as such, little is known about the evolution of these important chromatin regulators. Here we focus on Polycomb Repressive Compl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gahan JM,Rentzsch F,Schnitzler CE

更新日期：2020-09-15 00:00:00

abstract：:IL-33, a cytokine of the IL-1 family, is closely associated with type II T cell responses. Here, we report an unexpected proinflammatory role of IL-33 in inflammatory arthritis. IL-33 was expressed in synovial fibroblasts from patients with rheumatoid arthritis (RA). Expression was markedly elevated in vitro by inflam...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu D,Jiang HR,Kewin P,Li Y,Mu R,Fraser AR,Pitman N,Kurowska-Stolarska M,McKenzie AN,McInnes IB,Liew FY

更新日期：2008-08-05 00:00:00

abstract：:Water-biomolecule interactions have been extensively studied in dilute solutions, crystals, and rehydrated powders, but none of these model systems may capture the behavior of water in the highly organized intracellular milieu. Because of the experimental difficulty of selectively probing the structure and dynamics of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Persson E,Halle B

更新日期：2008-04-29 00:00:00

abstract：:A convenient technique for the partial purification of large quantities of functional, poly(adenylic acid)-rich mRNA is described. The method depends upon annealing poly(adenylic acid)-rich mRNA to oligothymidylic acid-cellulose columns and its elution with buffers of low ionic strength. Biologically active rabbit glo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aviv H,Leder P

更新日期：1972-06-01 00:00:00

abstract：:Previous studies have shown that DNA methyltransferase (Dnmt) 1 is required for maintenance of bulk DNA methylation and is essential for mouse development. However, somatic disruption of DNMT1 in the human cancer cell line HCT116 was not lethal and caused only minor decreases in methylation. Here, we report the identi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Egger G,Jeong S,Escobar SG,Cortez CC,Li TW,Saito Y,Yoo CB,Jones PA,Liang G

更新日期：2006-09-19 00:00:00

abstract：:An initiation complex has been formed in high yields from E. coli ribosomes, 9S messenger RNA for rabbit hemoglobin, and N-formylmethionine-tRNA. Initiation factor IF-3 is required for the binding and puromycin is required for the release of fMet. Valyl-tRNA fails to bind to the second codon, whereas a mixture of 15 a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Noll M,Noll H,Lingrel JB

更新日期：1972-07-01 00:00:00

abstract：:The transition from a human diet based exclusively on wild plants and animals to one involving dependence on domesticated plants and animals beginning 10,000 to 11,000 y ago in Southwest Asia set into motion a series of profound health, lifestyle, social, and economic changes affecting human populations throughout mos...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Larsen CS,Knüsel CJ,Haddow SD,Pilloud MA,Milella M,Sadvari JW,Pearson J,Ruff CB,Garofalo EM,Bocaege E,Betz BJ,Dori I,Glencross B

更新日期：2019-06-25 00:00:00

abstract：:Cells of the craniofacial skeleton are derived from a common mesenchymal progenitor. The regulatory factors that control their differentiation into various cell lineages are unknown. To investigate the biological function of dentin matrix protein 1 (DMP1), an extracellular matrix gene involved in calcified tissue form...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Narayanan K,Srinivas R,Ramachandran A,Hao J,Quinn B,George A

更新日期：2001-04-10 00:00:00

abstract：:The Hawaiian Islands are renowned for some of the most spectacular species radiations in the world. Most of these radiations have been attributed to single colonization events, although the evidence supporting monophyletic origins is often poorly resolved and/or ambiguous. Without a concrete understanding of the origi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gillespie RG,Croom HB,Palumbi SR

更新日期：1994-03-15 00:00:00

abstract：:A pH-dependent transition between delocalized and trapped mixed valence states of an engineered CuA center in azurin has been investigated by UV-visible absorption and electron paramagnetic resonance spectroscopic techniques. At pH 7.0, the CuA azurin displays a typical delocalized mixed valence dinuclear [Cu(1.5).......

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hwang HJ,Lu Y

更新日期：2004-08-31 00:00:00

abstract：:Obesity is a major public health problem and is often associated with type 2 diabetes mellitus, cardiovascular disease, and metabolic syndrome. Leptin is the crucial adipostatic hormone that controls food intake and body weight through the activation of specific leptin receptors (OB-R) in the hypothalamic arcuate nucl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Couturier C,Sarkis C,Séron K,Belouzard S,Chen P,Lenain A,Corset L,Dam J,Vauthier V,Dubart A,Mallet J,Froguel P,Rouillé Y,Jockers R

更新日期：2007-12-04 00:00:00

abstract：:An acid extract of pedal ganglia of the mollusc Mytilus edulis was fractionated by high-pressure liquid chromatography with a reverse-phase column. Peak fractions with retention times of those of [Met]- and [Leu]enkephalin were subjected to binding assays in both invertebrate and vertebrate tissues. The results showed...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leung MK,Stefano GB

更新日期：1984-02-01 00:00:00

abstract：:As new disease threats arise and existing pathogens grow resistant to conventional interventions, attention increasingly focuses on the development of vaccines to induce protective immune responses. Given their admirable safety records, protein subunit vaccines are attractive for widespread immunization, but their dis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen DJ,Osterrieder N,Metzger SM,Buckles E,Doody AM,DeLisa MP,Putnam D

更新日期：2010-02-16 00:00:00

abstract：:Successful implementation of bone marrow transplantation for hematopoietic reconstitution is limited by the lack of suitably HLA-matched donors and by the occurrence of graft-versus-host disease that frequently accompanies this procedure. Recent clinical reports have implied that the use of umbilical cord blood as a s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harris DT,Schumacher MJ,Locascio J,Besencon FJ,Olson GB,DeLuca D,Shenker L,Bard J,Boyse EA

更新日期：1992-11-01 00:00:00

abstract：:A cDNA library derived from human cerebral cortex was screened for the presence of sodium channel alpha subunit-specific clones. Ligation of three overlapping clones generated a full-length cDNA clone, HBA, that provided the complete nucleotide sequence coding for a protein of 2005 amino acids. The predicted structure...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ahmed CM,Ware DH,Lee SC,Patten CD,Ferrer-Montiel AV,Schinder AF,McPherson JD,Wagner-McPherson CB,Wasmuth JJ,Evans GA

更新日期：1992-09-01 00:00:00

abstract：:The biodistribution profiles in mice of two pyrrole-imidazole polyamides were determined by PET. Pyrrole-imidazole polyamides are a class of small molecules that can be programmed to bind a broad repertoire of DNA sequences, disrupt transcription factor-DNA interfaces, and modulate gene expression pathways in cell cul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harki DA,Satyamurthy N,Stout DB,Phelps ME,Dervan PB

更新日期：2008-09-02 00:00:00

abstract：:Historical collapse of ancient states or civilizations has raised new awareness about its possible relevance to current issues of sustainability, in the context of global change. This Special Feature examines 12 case studies of societies under stress, of which seven suffered severe transformation. Outcomes were comple...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Butzer KW,Endfield GH

更新日期：2012-03-06 00:00:00

abstract：:DBA/2 mice immunized with poly(A).poly(U) complexed with methylated bovine serum albumin and emulsified in Freund's complete adjuvant were protected against challenge with Friend leukemia virus. There was no correlation between the level of antibody to the immunogen in the prechallenge serum and induced resistance to ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nahon-Merlin E,Lacour F,Friend C,Revoltella R

更新日期：1979-04-01 00:00:00

abstract：:Recent experiments have shown that spreading epithelial sheets exhibit a long-range coordination of motility forces that leads to a buildup of tension in the tissue, which may enhance cell division and the speed of wound healing. Furthermore, the edges of these epithelial sheets commonly show finger-like protrusions w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Basan M,Elgeti J,Hannezo E,Rappel WJ,Levine H

更新日期：2013-02-12 00:00:00

abstract：:The dramatic loss of Kilimanjaro's ice cover has attracted global attention. The three remaining ice fields on the plateau and the slopes are both shrinking laterally and rapidly thinning. Summit ice cover (areal extent) decreased approximately 1% per year from 1912 to 1953 and approximately 2.5% per year from 1989 to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thompson LG,Brecher HH,Mosley-Thompson E,Hardy DR,Mark BG

更新日期：2009-11-24 00:00:00

abstract：:Urate oxidase (UOxase; urate:oxygen oxidoreductase, EC 1.7.3.3), which catalyzes the oxidation of uric acid to allantoin, is present in most mammals but is absent in humans and certain primates. A cDNA clone for UOxase containing an insert of 1.3 kilobases (kb) was isolated from a lambda gt11 cDNA library prepared fro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reddy PG,Nemali MR,Reddy MK,Reddy MN,Yuan PM,Yuen S,Laffler TG,Shiroza T,Kuramitsu HK,Usuda N

更新日期：1988-12-01 00:00:00

abstract：:Resistance to cobalt, zinc, and cadmium specified by the czc determinant on plasmid pMOL30 in Alcaligenes eutrophus results from a cation efflux system. Five membrane-bound polypeptides that were expressed in Escherichia coli from this determinant under the control of a phage T7 promoter were assigned to four open rea...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nies DH,Nies A,Chu L,Silver S

更新日期：1989-10-01 00:00:00

abstract：:An inductive interaction between the sevenless (sev) transmembrane tyrosine kinase receptor and the bride of sevenless (boss) transmembrane ligand is required for the development of the R7 photoreceptor neuron in the compound eye of Drosophila melanogaster. The boss protein is proposed to contain a large N-terminal ex...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hart AC,Harrison SD,Van Vactor DL Jr,Rubin GM,Zipursky SL

更新日期：1993-06-01 00:00:00

abstract：:We have used DNase I as a probe to examine the chromatin structure of mouse immunoglobulin kappa light chain genes in rearranged and unrearranged chromosomes--i.e., in nuclei from myeloma cells and from brain and liver cells. Tissue-specific DNase I-hypersensitive sites are observed 0.7 and 1.7 kilobases upstream from...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chung SY,Folsom V,Wooley J

更新日期：1983-05-01 00:00:00