Phenotypic and functional immaturity of human umbilical cord blood T lymphocytes.

Abstract:

:Successful implementation of bone marrow transplantation for hematopoietic reconstitution is limited by the lack of suitably HLA-matched donors and by the occurrence of graft-versus-host disease that frequently accompanies this procedure. Recent clinical reports have implied that the use of umbilical cord blood as a source of transplantable stem cells may solve these problems. To date, definitive experiments have not been performed to assess the immunological potential of T cells found in umbilical cord blood, which could mediate graft-versus-host disease. In the present study we have observed that umbilical cord blood contains T lymphocytes that appear to be phenotypically immature. In addition, umbilical cord blood lymphocytes appeared to be functionally immature as shown by minimal responses to stimulation with interleukin 2, phytohemagglutinin, or alloantigens. Thus, umbilical cord blood may be more suitable for allogeneic transplantation than bone marrow in that these cord blood cells may not be as capable of mediating graft-versus-host disease.

authors

Harris DT,Schumacher MJ,Locascio J,Besencon FJ,Olson GB,DeLuca D,Shenker L,Bard J,Boyse EA

doi

10.1073/pnas.89.21.10006

keywords:

subject

Has Abstract

pub_date

1992-11-01 00:00:00

pages

10006-10

issue

21

eissn

0027-8424

issn

1091-6490

journal_volume

89

pub_type

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