Expression and nucleotide sequence of a plasmid-determined divalent cation efflux system from Alcaligenes eutrophus.

abstract：:The RuvC protein of Escherichia coli catalyzes the resolution of recombination intermediates during genetic recombination and the recombinational repair of damaged DNA. Resolution involves specific recognition of the Holliday structure to form a complex that exhibits twofold symmetry with the DNA in an open configurat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bennett RJ,West SC

更新日期：1996-10-29 00:00:00

abstract：:In maturing T lineage cells, the helix-loop-helix protein E47 has been shown to enforce a critical proliferation and developmental checkpoint commonly referred to as beta selection. To examine how E47 regulates cellular expansion and developmental progression, we have used an E2A-deficient lymphoma cell line and DNA m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schwartz R,Engel I,Fallahi-Sichani M,Petrie HT,Murre C

更新日期：2006-06-27 00:00:00

abstract：:The WWOX gene is a recently cloned tumor suppressor gene that spans the FRA16D fragile region. Wwox protein contains two WW domains that are generally known to mediate protein-protein interaction. Here we show that Wwox physically interacts via its first WW domain with the p53 homolog, p73. The tyrosine kinase, Src, p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aqeilan RI,Pekarsky Y,Herrero JJ,Palamarchuk A,Letofsky J,Druck T,Trapasso F,Han SY,Melino G,Huebner K,Croce CM

更新日期：2004-03-30 00:00:00

abstract：:During cytokinesis, a cleavage furrow generated by actomyosin ring contraction is restructured into the midbody, a platform for the assembly of the abscission machinery that controls the final separation of daughter cells. The polymerization state of F-actin is important during assembly, ingression, disassembly, and c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Terry SJ,Donà F,Osenberg P,Carlton JG,Eggert US

更新日期：2018-02-27 00:00:00

abstract：:Circadian rhythms describe biological phenomena that oscillate with an approximately 24-hour cycle. These rhythms include blood pressure, body temperature, hormone levels, the number of immune cells in blood, and the sleep-wake cycle. In this paper, we will focus on common genes between species that are responsible fo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ishida N,Kaneko M,Allada R

更新日期：1999-08-03 00:00:00

abstract：:It recently has been shown that epithelial Na(+) channels are controlled by a receptor for intracellular Na(+), a G protein (G(o)), and a ubiquitin-protein ligase (Nedd4). Furthermore, mutations in the epithelial Na(+) channel that underlie the autosomal dominant form of hypertension known as Liddle's syndrome inhibit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ishibashi H,Dinudom A,Harvey KF,Kumar S,Young JA,Cook DI

更新日期：1999-08-17 00:00:00

abstract：:Phytosulfokine-alpha [PSK-alpha, Tyr(SO(3)H)-Ile-Tyr(SO(3)H)-Thr-Gln], a sulfated mitogenic peptide found in plants, strongly promotes proliferation of plant cells in culture at very low concentrations. Oryza sativa PSK (OsPSK) cDNA encoding a PSK-alpha precursor has been isolated. The cDNA is 725 base pairs long, and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang H,Matsubayashi Y,Nakamura K,Sakagami Y

更新日期：1999-11-09 00:00:00

abstract：:Tropical forest degradation emits carbon at a rate of approximately 0.5 Pgxy(-1), reduces biodiversity, and facilitates forest clearance. Understanding degradation drivers and patterns is therefore crucial to managing forests to mitigate climate change and reduce biodiversity loss. Putative patterns of degradation aff...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ahrends A,Burgess ND,Milledge SA,Bulling MT,Fisher B,Smart JC,Clarke GP,Mhoro BE,Lewis SL

更新日期：2010-08-17 00:00:00

abstract：:A23187 is a carboxylic antibiotic that selectively transfers calcium, magnesium, and other divalent cations across biologic membranes. This ionophore was found to produce morphologic blast transformation, DNA synthesis, and mitosis in human lymphocytes. Several hours of ionophore-cell contact were necessary to produce...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luckasen JR,White JG,Kersey JH

更新日期：1974-12-01 00:00:00

abstract：:Cerebral arteriovenous malformations (AVMs) are common vascular malformations, which may result in hemorrhagic strokes and neurological deficits. Bone morphogenetic protein (BMP) and Notch signaling are both involved in the development of cerebral AVMs, but the cross-talk between the two signaling pathways is poorly u...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yao Y,Yao J,Radparvar M,Blazquez-Medela AM,Guihard PJ,Jumabay M,Boström KI

更新日期：2013-11-19 00:00:00

abstract：:Small ubiquitin-like modifier (SUMO) modification is emerging as an important control in transcription regulation. Here, we show that CREB-binding protein (CBP), a versatile transcriptional coactivator for numerous transcription factors in response to diverse signaling events, can be modified by SUMO-1 at lysine resid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kuo HY,Chang CC,Jeng JC,Hu HM,Lin DY,Maul GG,Kwok RP,Shih HM

更新日期：2005-11-22 00:00:00

abstract：:Histone modifications are regarded as the most indispensible phenomena in epigenetics. Of these modifications, lysine methylation is of the greatest complexity and importance as site- and state-specific lysine methylation exerts a plethora of effects on chromatin structure and gene transcription. Notably, paramecium b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wei H,Zhou MM

更新日期：2010-10-26 00:00:00

abstract：:Mechanisms for controlling symbiont populations are critical for maintaining the associations that exist between a host and its microbial partners. We describe here the transcriptional, metabolic, and ultrastructural characteristics of a diel rhythm that occurs in the symbiosis between the squid Euprymna scolopes and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wier AM,Nyholm SV,Mandel MJ,Massengo-Tiassé RP,Schaefer AL,Koroleva I,Splinter-Bondurant S,Brown B,Manzella L,Snir E,Almabrazi H,Scheetz TE,Bonaldo Mde F,Casavant TL,Soares MB,Cronan JE,Reed JL,Ruby EG,McFall-Ngai MJ

更新日期：2010-02-02 00:00:00

abstract：:Mechanical robustness of the cell under different modes of stress and deformation is essential to its survival and function. Under tension, mechanical rigidity is provided by the cytoskeletal network; with increasing stress, this network stiffens, providing increased resistance to deformation. However, a cell must als...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhou EH,Trepat X,Park CY,Lenormand G,Oliver MN,Mijailovich SM,Hardin C,Weitz DA,Butler JP,Fredberg JJ

更新日期：2009-06-30 00:00:00

abstract：:A study was undertaken to elucidate the molecular mechanisms by which glucocorticoids induce cleft palate in mice. It was hypothesized that a compound such as triamcinolone acetonide inhibits mRNA synthesis; that this results later in depressed protein synthesis; and that the latter is ultimately responsible for slowe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zimmerman EF,Andrew F,Kalter H

更新日期：1970-10-01 00:00:00

abstract：:Purified RNA polymerase II (pol II) from the yeast Saccharomyces cerevisiae pauses without releasing at many locations during in vitro transcription. Pausing can be induced by intrinsic DNA sequence as well as by specific DNA bound proteins such as the RNA pol I termination factor, Reb1p, or lac repressor. Addition of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lang WH,Platt T,Reeder RH

更新日期：1998-04-28 00:00:00

abstract：:We describe a Kappa-on-Heavy (KoH) mouse that produces a class of highly diverse, fully human, antibody-like agents. This mouse was made by replacing the germline variable sequences of both the Ig heavy-chain (IgH) and Ig kappa (IgK) loci with the human IgK germline variable sequences, producing antibody-like molecule...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Macdonald LE,Meagher KA,Franklin MC,Levenkova N,Hansen J,Badithe AT,Zhong M,Krueger P,Rafique A,Tu N,Shevchuk J,Wadhwa S,Ehrlich G,Bautista J,Grant C,Esau L,Poueymirou WT,Auerbach W,Morton L,Babb R,Chen G,Huang

更新日期：2020-01-07 00:00:00

abstract：:The binding of killer cell Ig-like Receptors (KIR) to their Class I MHC ligands was shown previously to be characterized by extremely rapid association and dissociation rate constants. During experiments to investigate the biochemistry of receptor-ligand binding in more detail, the kinetic parameters of the interactio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Valés-Gómez M,Erskine RA,Deacon MP,Strominger JL,Reyburn HT

更新日期：2001-02-13 00:00:00

abstract：:Fish in schooling formations navigate complex flow fields replete with mechanical energy in the vortex wakes of their companions. Their schooling behavior has been associated with evolutionary advantages including energy savings, yet the underlying physical mechanisms remain unknown. We show that fish can improve thei...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Verma S,Novati G,Koumoutsakos P

更新日期：2018-06-05 00:00:00

abstract：:Recombinational repair of double-stranded DNA gaps was investigated in Ustilago maydis. The experimental system was designed for analysis of repair of an autonomously replicating plasmid containing a cloned gene disabled by an internal deletion. It was discovered that crossing over rarely accompanied gap repair. The s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ferguson DO,Holloman WK

更新日期：1996-05-28 00:00:00

abstract：:Clinical and experimental observations indicate a role for VEGF secreted by the retinal pigment epithelium (RPE) in the maintenance of the choriocapillaris (CC). VEGF in mice is produced as three isoforms, VEGF120, VEGF164, and VEGF188, that differ in their ability to bind heparan sulfate proteoglycan. RPE normally pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Saint-Geniez M,Kurihara T,Sekiyama E,Maldonado AE,D'Amore PA

更新日期：2009-11-03 00:00:00

abstract：:The essential eukaryotic pre-mRNA splicing factor U2AF (U2 small nuclear ribonucleoprotein auxiliary factor) is required to specify the 3' splice at an early step in spliceosome assembly. U2AF binds site-specifically to the intron polypyrimidine tract and recruits U2 small nuclear ribonucleoprotein to the branch site....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rudner DZ,Kanaar R,Breger KS,Rio DC

更新日期：1996-09-17 00:00:00

abstract：:Stearic acid is toxic for T lymphocytes in vitro but has little effect on B lymphocytes. To investigate the molecular basis for this difference, purified murine T and B lymphocytes were compared for their abilities to incorporate and metabolize stearic acid. Unstimulated T and B cells incorporated identical amounts of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Buttke TM,Van Cleave S,Steelman L,McCubrey JA

更新日期：1989-08-01 00:00:00

abstract：:The pleiotropic activities of interferons (IFNs) are mediated primarily through the transcriptional regulation of many downstream effector genes. The mRNA profiles from IFN-alpha, -beta, or -gamma treatments of the human fibrosarcoma cell line, HT1080, were determined by using oligonucleotide arrays with probe sets co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Der SD,Zhou A,Williams BR,Silverman RH

更新日期：1998-12-22 00:00:00

abstract：:The single-pass transmembrane domains (TMDs) of the syndecan family of cell surface adhesion molecules have been implicated in functional protein-protein interactions. Although each paralog contains a conserved GxxxG dimerization motif, we show here that the syndecan-1 TMD dimerizes weakly, the syndecan-3 and syndecan...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dews IC,Mackenzie KR

更新日期：2007-12-26 00:00:00

abstract：:In previous studies we showed that 5 days of treatment with granulocyte colony-stimulating factor (G-CSF) and stem cell factor (SCF) mobilized murine repopulating cells to the peripheral blood (PB) and that these cells could be efficiently transduced with retroviral vectors. We also found that, 7-14 days after cytokin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dunbar CE,Seidel NE,Doren S,Sellers S,Cline AP,Metzger ME,Agricola BA,Donahue RE,Bodine DM

更新日期：1996-10-15 00:00:00

abstract：:A detailed phenomenology of low energy excitations is a crucial starting point for microscopic understanding of complex materials, such as the cuprate high-temperature superconductors. Because of its unique momentum-space discrimination, angle-resolved photoemission spectroscopy (ARPES) is ideally suited for this task...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vishik IM,Hashimoto M,He RH,Lee WS,Schmitt F,Lu D,Moore RG,Zhang C,Meevasana W,Sasagawa T,Uchida S,Fujita K,Ishida S,Ishikado M,Yoshida Y,Eisaki H,Hussain Z,Devereaux TP,Shen ZX

更新日期：2012-11-06 00:00:00

abstract：:Activation of p53 tumor suppressor by antagonizing its negative regulator murine double minute (MDM)2 has been considered an attractive strategy for cancer therapy and several classes of p53-MDM2 binding inhibitors have been developed. However, these compounds do not inhibit the p53-MDMX interaction, and their effecti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Graves B,Thompson T,Xia M,Janson C,Lukacs C,Deo D,Di Lello P,Fry D,Garvie C,Huang KS,Gao L,Tovar C,Lovey A,Wanner J,Vassilev LT

更新日期：2012-07-17 00:00:00

abstract：:Some spectinomycin-resistant mutants of Escherichia coli are cold-sensitive. They are unable to assemble both 30S and 50S ribosomal subunits at low temperatures. They accumulate two kinds of incomplete particles, related to 30S and 50S subunits respectively. A single mutation, causing an alteration in a 30S ribosomal ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nashimoto H,Nomura M

更新日期：1970-11-01 00:00:00

abstract：:Energy-storing artificial-photosynthetic systems for CO2 reduction must derive the reducing equivalents from a renewable source rather than from sacrificial donors. To this end, a homogeneous, integrated chromophore/two-catalyst system is described that is thermodynamically capable of photochemically driving the energ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： La Porte NT,Moravec DB,Hopkins MD

更新日期：2014-07-08 00:00:00