Capping protein regulates actin dynamics during cytokinetic midbody maturation.

abstract：:Chloroplast retrograde signaling networks are vital for chloroplast biogenesis, operation, and signaling, including excess light and drought stress signaling. To date, retrograde signaling has been considered in the context of land plant adaptation, but not regarding the origin and evolution of signaling cascades link...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhao C,Wang Y,Chan KX,Marchant DB,Franks PJ,Randall D,Tee EE,Chen G,Ramesh S,Phua SY,Zhang B,Hills A,Dai F,Xue D,Gilliham M,Tyerman S,Nevo E,Wu F,Zhang G,Wong GK,Leebens-Mack JH,Melkonian M,Blatt MR,Soltis P

更新日期：2019-03-12 00:00:00

abstract：:The excitatory neurotransmitter, glutamate, activates N-methyl-d-aspartate (NMDA) receptors to induce long-lasting synaptic changes through alterations in gene expression. It is believed that these long-lasting changes contribute to learning and memory, drug tolerance, and ischemic preconditioning. To identify NMDA-in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hong SJ,Li H,Becker KG,Dawson VL,Dawson TM

更新日期：2004-02-17 00:00:00

abstract：:Incorporation of 2-acyl spin-labeled lecithin into the phosphatidylcholine protein from bovine liver results in an immobilization of the spin-label at the methyl and the carboxyl terminal end of the acyl chain. The nitroxide group on the protein-bound lecithin molecule is not accessible to ascorbate. This suggests tha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Devaux PF,Moonen P,Bienvenue A,Wirtz KW

更新日期：1977-05-01 00:00:00

abstract：:Serotonin (5-hydroxytryptamine; 0.5 microM and above) stimulated the synthesis of prostacyclin (as measured by radioimmunoassay of 6-ketoprostaglandin F1 alpha) by bovine aortic smooth muscle cells in culture. This effect was structurally specific; a similar response was not elicited by the other indoles (tryptophan, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Coughlin SR,Moskowitz MA,Antoniades HN,Levine L

更新日期：1981-11-01 00:00:00

abstract：:Chemoresistance of cisplatin therapy is related to extensive repair of cisplatin-modified DNA in the nucleus by the nucleotide excision repair (NER). Delivering cisplatin to the mitochondria to attack mitochondrial genome lacking NER machinery can lead to a rationally designed therapy for metastatic, chemoresistant ca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marrache S,Pathak RK,Dhar S

更新日期：2014-07-22 00:00:00

abstract：:In 1944, Freeman Dyson conjectured the existence of a "crank" function for partitions that would provide a combinatorial proof of Ramanujan's congruence modulo 11. Forty years later, Andrews and Garvan successfully found such a function and proved the celebrated result that the crank simultaneously "explains" the thre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mahlburg K

更新日期：2005-10-25 00:00:00

abstract：:Whereas the neurodegeneration associated with various polyglutamine (polyQ) diseases has prompted extensive studies of polyQ-induced cell death, the neuronal loss that typically appears during late stages of the diseases may not account for the preceding movement and mental disorders. The cellular basis for polyQ-indu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee SB,Bagley JA,Lee HY,Jan LY,Jan YN

更新日期：2011-10-04 00:00:00

abstract：:A key energy-saving adaptation to chronic hypoxia that enables cardiomyocytes to withstand severe ischemic insults is hibernation, i.e., a reversible arrest of contractile function. Whereas hibernating cardiomyocytes represent the critical reserve of dysfunctional cells that can be potentially rescued, a lack of a sui...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： May D,Gilon D,Djonov V,Itin A,Lazarus A,Gordon O,Rosenberger C,Keshet E

更新日期：2008-01-08 00:00:00

abstract：:Intrinsically disordered proteins (IDPs) are characterized by a lack of defined structure. Instead, they populate ensembles of rapidly interconverting conformations with marginal structural stabilities. Changes in solution conditions such as temperature and crowding agents consequently affect IDPs more than their fold...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wicky BIM,Shammas SL,Clarke J

更新日期：2017-09-12 00:00:00

abstract：:The configuration of the heme-carbonyl group upon binding of carbon monoxide to sperm whale myoglobin (Mb) in crystals is evaluated on the basis of infrared spectroscopic methods. Multiplets of the totally symmetric C-O stretching mode are observed for the heme-bound ligand near 1933, 1944, and 1967 cm-1, correspondin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Makinen MW,Houtchens RA,Caughey WS

更新日期：1979-12-01 00:00:00

abstract：:X-ray grating interferometry is a coherent imaging technique that bears tremendous potential for three-dimensional tomographic imaging of soft biological tissue and other specimens whose details exhibit very weak absorption contrast. It is intrinsically trimodal, delivering phase contrast, absorption contrast, and sca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zanette I,Bech M,Rack A,Le Duc G,Tafforeau P,David C,Mohr J,Pfeiffer F,Weitkamp T

更新日期：2012-06-26 00:00:00

abstract：:The Hsp90 chaperone buffers development against a wide range of morphological changes in many organisms and in Drosophila masks the effects of hidden genetic variation. Theory predicts that genetic and nongenetic buffering will share common mechanisms. For example, it is argued that Hsp90 genetic buffering evolved sol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Milton CC,Huynh B,Batterham P,Rutherford SL,Hoffmann AA

更新日期：2003-11-11 00:00:00

abstract：:Delta5 and Delta6 fatty acid desaturases are critical enzymes in the pathways for the biosynthesis of the polyunsaturated fatty acids arachidonic, eicosapentaenoic, and docosahexaenoic acids. They are encoded by distinct genes in mammals and Caenorhabditis elegans. This paper describes a cDNA isolated from zebrafish (...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hastings N,Agaba M,Tocher DR,Leaver MJ,Dick JR,Sargent JR,Teale AJ

更新日期：2001-12-04 00:00:00

abstract：:Neural crest cell derivatives have been suggested to be involved in thymus development. We established nonlymphoid thymic stromal cell cultures capable of supporting T-cell differentiation. In these nonlymphoid cell cultures, we identified cells with phenotypic and biochemical markers specific for neuronal cells. Neur...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Screpanti I,Meco D,Scarpa S,Morrone S,Frati L,Gulino A,Modesti A

更新日期：1992-04-15 00:00:00

abstract：:We describe a model for early onset preeclampsia (EOPE) that uses induced pluripotent stem cells (iPSCs) generated from umbilical cords of EOPE and control (CTL) pregnancies. These iPSCs were then converted to placental trophoblast (TB) representative of early pregnancy. Marker gene analysis indicated that both sets o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sheridan MA,Yang Y,Jain A,Lyons AS,Yang P,Brahmasani SR,Dai A,Tian Y,Ellersieck MR,Tuteja G,Schust DJ,Schulz LC,Ezashi T,Roberts RM

更新日期：2019-03-05 00:00:00

abstract：:Go is a specific class ("other") of signal-transducing heterotrimeric GTP-binding proteins (G proteins) that is expressed in high levels in mammalian brain. We have cloned two different rat cDNAs encoding the alpha subunit of Go (Go alpha-1 and Go alpha-2) and a human Go alpha chromosomal gene. The human Go alpha gene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsukamoto T,Toyama R,Itoh H,Kozasa T,Matsuoka M,Kaziro Y

更新日期：1991-04-15 00:00:00

abstract：:Criegee intermediates are thought to play a role in atmospheric chemistry, in particular, the oxidation of SO2, which produces SO3 and subsequently H2SO4, an important constituent of aerosols and acid rain. However, the impact of such oxidation reactions is affected by the reactions of Criegee intermediates with water...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huang HL,Chao W,Lin JJ

更新日期：2015-09-01 00:00:00

abstract：:Nuclear factor of activated T cells (NFAT) proteins are Ca(2+)-regulated transcription factors that control gene expression in many cell types. NFAT proteins are heavily phosphorylated and reside in the cytoplasm of resting cells; when cells are stimulated by a rise in intracellular Ca(2+), NFAT proteins are dephospho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sharma S,Findlay GM,Bandukwala HS,Oberdoerffer S,Baust B,Li Z,Schmidt V,Hogan PG,Sacks DB,Rao A

更新日期：2011-07-12 00:00:00

abstract：:The immunophilin FK506 binding protein 12 (FKBP12) is associated with and modulates the ryanodine receptor calcium release channel of skeletal muscle. Ryanodine receptor has amino acid homology and functional similarity with another intracellular Ca2+ release channel, the inositol 1,4,5-trisphosphate receptor (IP3R). ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cameron AM,Steiner JP,Sabatini DM,Kaplin AI,Walensky LD,Snyder SH

更新日期：1995-02-28 00:00:00

abstract：:The way general anesthetics cause their clinically useful effects on the nervous system is not known. Since the principal determinant of the potency of these agents is their solubility in oil, the role of chemical structure in affecting anesthetic targets has been obscured. In this work, we use an intense beam of ligh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Campbell DB,Nash HA

更新日期：1994-03-15 00:00:00

abstract：:The activities of cytosolic 3-hydroxy-3-methylglutaryl coenzyme A synthase [3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acylating), EC 4.1.3.5] and microsomal 3-hydroxy-3-methylglutaryl coenzyme A reductase[mevalonate:NADP+ oxidoreductase (CoA-acylating), EC 1.1.1.34], two sequential enzymes in the chole...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Balasubramaniam S,Goldstein JL,Brown MS

更新日期：1977-04-01 00:00:00

abstract：:Two-dimensional electron gases (2DEGs) are at the base of current nanoelectronics because of their exceptional mobilities. Often the accumulation layer forms at polar interfaces with longitudinal optical (LO) modes. In most cases, the many-body screening of the quasi-2DEGs dramatically reduces the Fröhlich scattering ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen Z,Sjakste J,Dong J,Taleb-Ibrahimi A,Rueff JP,Shukla A,Peretti J,Papalazarou E,Marsi M,Perfetti L

更新日期：2020-09-08 00:00:00

abstract：:To improve the efficacy of plasminogen activators, we produced a monoclonal antibody (RWR) that inhibits human alpha 2-antiplasmin (alpha 2AP). In addition to inhibiting alpha 2AP in plasma, RWR binds to and inhibits fibrin cross-linked alpha 2AP and reproduces the "spontaneous" clot lysis that is the hallmark of huma...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reed GL 3rd,Matsueda GR,Haber E

更新日期：1990-02-01 00:00:00

abstract：:We previously isolated a mutant of Escherichia coli that is preferentially affected in the synthesis of rRNA and has a mutation in the gene (accD) encoding a subunit of acetyl-CoA carboxylase. Using this mutant and other mutants of the pathway for fatty acid and phospholipid biosynthesis as well as cerulenin, a specif...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seyfzadeh M,Keener J,Nomura M

更新日期：1993-12-01 00:00:00

abstract：:Long QT syndrome (LQT) is an autosomal dominant disorder that can cause sudden death from cardiac arrhythmias. We recently discovered that mutations in HERG, a K+-channel gene, cause chromosome 7-linked LQT. Heterologous expression of HERG in Xenopus oocytes revealed that HERG current was similar to a well-characteriz...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sanguinetti MC,Curran ME,Spector PS,Keating MT

更新日期：1996-03-05 00:00:00

abstract：:The minimal size of the recombination site required for efficient FLP recombinase-catalyzed recombination in vitro is no more than 28 base pairs, which includes parts of two 13-base-pair inverted repeats and all of an 8-base-pair spacer. The FLP recombinase cleaves the DNA at the boundaries of the spacer, becomes cova...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Senecoff JF,Bruckner RC,Cox MM

更新日期：1985-11-01 00:00:00

abstract：:We have developed an in vitro transcription system that uses nuclei isolated from Lemna gibba G-3. The in vitro transcripts include sequences homologous to hybridization probes for the small subunit of ribulose-1,5-bisphosphate carboxylase [3-phospho-D-glycerate carboxy-lyase (dimerizing), EC 4.1.1.39], the light-harv...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Silverthorne J,Tobin EM

更新日期：1984-02-01 00:00:00

abstract：:Microsomal NADPH-cytochrome P450 reductase (CPR) is one of only two mammalian enzymes known to contain both FAD and FMN, the other being nitric-oxide synthase. CPR is a membrane-bound protein and catalyzes electron transfer from NADPH to all known microsomal cytochromes P450. The structure of rat liver CPR, expressed ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang M,Roberts DL,Paschke R,Shea TM,Masters BS,Kim JJ

更新日期：1997-08-05 00:00:00

abstract：:Numerous international bodies have advocated the development of strategies to achieve the sustainability of marine environments. Typically, such strategies are based on information from expert groups about causes of degradation and policy options to address them, but these strategies rarely take into account assessed ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gelcich S,Buckley P,Pinnegar JK,Chilvers J,Lorenzoni I,Terry G,Guerrero M,Castilla JC,Valdebenito A,Duarte CM

更新日期：2014-10-21 00:00:00

abstract：:The mouse mammary tumor virus (MMTV) promoter is regulated by steroid hormones through a hormone-responsive region that is organized in a positioned nucleosome. Hormone induction leads to a structural change of this nucleosome which makes its DNA more sensitive to cleavage by DNase I and enables simultaneous binding o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bartsch J,Truss M,Bode J,Beato M

更新日期：1996-10-01 00:00:00