Identification and analysis of plasticity-induced late-response genes.

abstract：:The brain is assumed to be hypoactive during cardiac arrest. However, the neurophysiological state of the brain immediately following cardiac arrest has not been systematically investigated. In this study, we performed continuous electroencephalography in rats undergoing experimental cardiac arrest and analyzed change...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Borjigin J,Lee U,Liu T,Pal D,Huff S,Klarr D,Sloboda J,Hernandez J,Wang MM,Mashour GA

更新日期：2013-08-27 00:00:00

abstract：:The RAD6 gene of Saccharomyces cerevisiae encodes a ubiquitin-conjugating enzyme (E2) that is required for DNA repair, damage-induced mutagenesis, and sporulation. We have cloned the two human RAD6 homologs, designated HHR6A and HHR6B. The two 152-amino acid human proteins share 95% sequence identity with each other a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koken MH,Reynolds P,Jaspers-Dekker I,Prakash L,Prakash S,Bootsma D,Hoeijmakers JH

更新日期：1991-10-15 00:00:00

abstract：:In this paper, we report an example of the engineered expression of tetrameric β-galactosidase (β-gal) containing varying numbers of active monomers. Specifically, by combining wild-type and single-nucleotide polymorphism plasmids at varying ratios, tetrameric β-gal was expressed in vitro with one to four active monom...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li X,Jiang Y,Chong S,Walt DR

更新日期：2018-08-14 00:00:00

abstract：:Amplitude-modulated phosphorescence/microwave double-resonance (AM-PMDR) spectra are reported for complexes of methylmercury(II) cation, designated CH3Hg(II), with tryptophan and glyceraldehyde-3-phosphate dehydrogenase (GPDHase; from rabbit muscle). Wavelength shifts are observed in the AM-PMDR spectra of CH3Hg(II)-t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Davis JM,Maki AH

更新日期：1982-07-01 00:00:00

abstract：:Cyclin-dependent kinase 4/6 (CDK4/6) inhibitors are an established treatment in estrogen receptor-positive breast cancer and are currently in clinical development in melanoma, a tumor that exhibits high rates of CDK4 activation. We analyzed melanoma cells with acquired resistance to the CDK4/6 inhibitor palbociclib an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： AbuHammad S,Cullinane C,Martin C,Bacolas Z,Ward T,Chen H,Slater A,Ardley K,Kirby L,Chan KT,Brajanovski N,Smith LK,Rao AD,Lelliott EJ,Kleinschmidt M,Vergara IA,Papenfuss AT,Lau P,Ghosh P,Haupt S,Haupt Y,Sanij E,

更新日期：2019-09-03 00:00:00

abstract：:Incommensurate charge order in hole-doped oxides is intertwined with exotic phenomena such as colossal magnetoresistance, high-temperature superconductivity, and electronic nematicity. Here, we map, at atomic resolution, the nature of incommensurate charge-lattice order in a manganite using scanning transmission elect...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： El Baggari I,Savitzky BH,Admasu AS,Kim J,Cheong SW,Hovden R,Kourkoutis LF

更新日期：2018-02-13 00:00:00

abstract：:A further study is made of the intertwining operators for the representations of the simple Lie groups of real rank one. We extend and apply this to the higher rank case, obtaining various results dealing with reducibility of principal series and existence of complementary series. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Knapp AW,Stein EM

更新日期：1970-05-01 00:00:00

abstract：:We have determined the localization and orientation of two genetic probes within the human major histocompatibility complex by chromosomal in situ hybridization. Our data indicate that a cloned genomic probe cross-hybridizing to HLA-A, -B, and -C heavy chain loci is homologous to sequences located on chromosome 6 at b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morton CC,Kirsch IR,Nance WE,Evans GA,Korman AJ,Strominger JL

更新日期：1984-05-01 00:00:00

abstract：:Ehrlich and Raven formally introduced the concept of stepwise coevolution using butterfly and angiosperm interactions in an attempt to account for the impressive biological diversity of these groups. However, many biologists currently envision butterflies evolving 50 to 30 million years (Myr) after the major angiosper...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wheat CW,Vogel H,Wittstock U,Braby MF,Underwood D,Mitchell-Olds T

更新日期：2007-12-18 00:00:00

abstract：:There is a hypothesis that dangerous diseases such as bovine spongiform encephalopathy, Creutzfeldt-Jakob, Alzheimer's, fatal familial insomnia, and several others are induced by propagation of wrong or misfolded conformations of some vital proteins. If for some reason the misfolded conformations were acquired by many...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Małolepsza E,Boniecki M,Kolinski A,Piela L

更新日期：2005-05-31 00:00:00

abstract：:We have tried to find out why Ascaris hemoglobin has such an exceptionally high oxygen affinity (P50 approximately 0.004 mmHg; 1 mmHg = 133 Pa). Following Kloek et al., we have synthesized the N-terminal globin domain of Ascaris hemoglobin in Escherichia coli [Kloek, A. P., Yang, J., Mathews, F. S. & Goldberg, D. (199...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： De Baere I,Perutz MF,Kiger L,Marden MC,Poyart C

更新日期：1994-02-15 00:00:00

abstract：:Receptor-mediated endocytosis proceeds by transfer of receptor-ligand complexes from clathrin-coated pits at the cell surface to uncoated endocytic vesicles termed receptosomes (or endosomes). These vesicles have now been purified more than 37-fold based on their content of newly internalized epidermal growth factor. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dickson RB,Beguinot L,Hanover JA,Richert ND,Willingham MC,Pastan I

更新日期：1983-09-01 00:00:00

abstract：:Expression of the transcription factor FOXC2 is induced and necessary for successful epithelial-mesenchymal transition, a developmental program that when activated in cancer endows cells with metastatic potential and the properties of stem cells. As such, identifying agents that inhibit the growth of FOXC2-transformed...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bollong MJ,Pietilä M,Pearson AD,Sarkar TR,Ahmad I,Soundararajan R,Lyssiotis CA,Mani SA,Schultz PG,Lairson LL

更新日期：2017-11-14 00:00:00

abstract：:Influenza virus infections cause a wide variety of outcomes, from mild disease to 3 to 5 million cases of severe illness and ∼290,000 to 645,000 deaths annually worldwide. The molecular mechanisms underlying these disparate outcomes are currently unknown. Glycosylation within the human host plays a critical role in in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Heindel DW,Koppolu S,Zhang Y,Kasper B,Meche L,Vaiana CA,Bissel SJ,Carter CE,Kelvin AA,Elaish M,Lopez-Orozco J,Zhang B,Zhou B,Chou TW,Lashua L,Hobman TC,Ross TM,Ghedin E,Mahal LK

更新日期：2020-10-27 00:00:00

abstract：:Molecular chaperones are an essential part of the machinery that avoids protein aggregation and misfolding in vivo. However, understanding the molecular basis of how chaperones prevent such undesirable interactions requires the conformational changes within substrate proteins to be probed during chaperone action. Here...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kellner R,Hofmann H,Barducci A,Wunderlich B,Nettels D,Schuler B

更新日期：2014-09-16 00:00:00

abstract：:We used cryo-electron tomography in conjunction with single-particle averaging techniques to study the structures of frozen-hydrated envelope glycoprotein (Env) complexes on intact Moloney murine leukemia retrovirus particles. Cryo-electron tomography allows 3D imaging of viruses in toto at a resolution sufficient to ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Förster F,Medalia O,Zauberman N,Baumeister W,Fass D

更新日期：2005-03-29 00:00:00

abstract：:A major goal for developmental biologists is to define the behaviors and molecular contents of differentiating cells. We have devised a strategy for isolating cells from diverse embryonic regions and stages in the zebrafish, using computer-guided laser photoconversion of injected Kaede protein and flow cytometry. This...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brown JL,Snir M,Noushmehr H,Kirby M,Hong SK,Elkahloun AG,Feldman B

更新日期：2008-08-26 00:00:00

abstract：:Cell recognition molecules play a crucial role in the regulation of immune cells. We recently found that mast cells (MCs) express leukocyte recognition molecules, including ICAM-1 antigen, a natural ligand of LFA-1. We here report that interleukin 4 (IL-4), a pleiotropic cytokine and mast cell differentiation factor, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Valent P,Bevec D,Maurer D,Besemer J,Di Padova F,Butterfield JH,Speiser W,Majdic O,Lechner K,Bettelheim P

更新日期：1991-04-15 00:00:00

abstract：:Loss of IκB kinase (IKK) β-dependent NF-κB signaling in hematopoietic cells is associated with increased granulopoiesis. Here we identify a regulatory cytokine loop that causes neutrophilia in Ikkβ-deficient mice. TNF-α-dependent apoptosis of myeloid progenitor cells leads to the release of IL-1β, which promotes Th17 ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mankan AK,Canli O,Schwitalla S,Ziegler P,Tschopp J,Korn T,Greten FR

更新日期：2011-04-19 00:00:00

abstract：:Cognitive flexibility depends on a fast neural learning mechanism for enhancing momentary relevant over irrelevant information. A possible neural mechanism realizing this enhancement uses fast spiking interneurons (FSIs) in the striatum to train striatal projection neurons to gate relevant and suppress distracting cor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Banaie Boroujeni K,Oemisch M,Hassani SA,Womelsdorf T

更新日期：2020-07-28 00:00:00

abstract：:The mammalian hair follicle unit consists of a central follicle and a series of associated structures: sebaceous glands, arrector pili muscles, Merkel cells, and sensory nerve endings. The architecture of this multicellular structure is highly polarized with respect to the body axes. Previous work has implicated Frizz...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chang H,Nathans J

更新日期：2013-03-05 00:00:00

abstract：:Economic experiments are often used to study if humans altruistically value the welfare of others. A canonical result from public-good games is that humans vary in how they value the welfare of others, dividing into fair-minded conditional cooperators, who match the cooperation of others, and selfish noncooperators. H...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burton-Chellew MN,El Mouden C,West SA

更新日期：2016-02-02 00:00:00

abstract：:Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutations in the gene encoding MeCP2. By binding to methylated CpG dinucleotide promoter regions, MeCP2 acts as a transcriptional repressor, predicting that its absence might result in widespread aberrant gene transcription, leading to the RTT phenotype. C...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Matarazzo V,Ronnett GV

更新日期：2004-05-18 00:00:00

abstract：:Astrogenesis is repressed in the early embryonic period and occurs in the late embryonic period. A variety of external and internal signals contribute to the sequential differentiation of neural stem cells. Here, we discovered that immune-related CD93 plays a critical negative role in the regulation of astrogenesis in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liang Q,Su L,Zhang D,Jiao J

更新日期：2020-04-28 00:00:00

abstract：:During the first 2 postnatal years, cortical thickness of the human brain develops dynamically and spatially heterogeneously and likely peaks between 1 and 2 y of age. The striking development renders this period critical for later cognitive outcomes and vulnerable to early neurodevelopmental disorders. However, due t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang F,Lian C,Wu Z,Zhang H,Li T,Meng Y,Wang L,Lin W,Shen D,Li G

更新日期：2019-08-06 00:00:00

abstract：:This article extends our previous quantitative analysis of the relationship between the dynamics of the primary structure of DNA and mutagenesis associated with single-strand lesions to an analysis of the production and processing of endogenous double-strand breaks (EDSBs) and to their implications for oncogenesis. We...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vilenchik MM,Knudson AG

更新日期：2003-10-28 00:00:00

abstract：:Sprouty proteins act as intracellular inhibitors of receptor tyrosine kinase signaling. Here we show that the mammalian Sprouty2 protein contains an iron-sulfur complex that can exist in an oxidized, reduced, or nitrosylated state. Purified Sprouty2 assembles into large monodisperse spheres containing approximately 24...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu X,Alexander PB,He Y,Kikkawa M,Vogel PD,McKnight SL

更新日期：2005-09-27 00:00:00

abstract：:We provide a framework for structural multiscale geometric organization of graphs and subsets of R(n). We use diffusion semigroups to generate multiscale geometries in order to organize and represent complex structures. We show that appropriately selected eigenfunctions or scaling functions of Markov matrices, which d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Coifman RR,Lafon S,Lee AB,Maggioni M,Nadler B,Warner F,Zucker SW

更新日期：2005-05-24 00:00:00

abstract：:Although NMDA receptor (NMDAR)-dependent long-term potentiation (LTP) and long-term depression (LTD) of glutamatergic transmission are candidate mechanisms for long-term spatial memory, the precise contributions of LTP and LTD remain poorly understood. Here, we report that LTP and LTD in the hippocampal CA1 region of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ge Y,Dong Z,Bagot RC,Howland JG,Phillips AG,Wong TP,Wang YT

更新日期：2010-09-21 00:00:00

abstract：:Ig heavy chain (IgH) isotypes (e.g., IgM, IgG, and IgE) are generated as secreted/soluble antibodies (sIg) or as membrane-bound (mIg) B cell receptors (BCRs) through alternative RNA splicing. IgH isotype dictates soluble antibody function, but how mIg isotype influences B cell behavior is not well defined. We examined...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tong P,Granato A,Zuo T,Chaudhary N,Zuiani A,Han SS,Donthula R,Shrestha A,Sen D,Magee JM,Gallagher MP,van der Poel CE,Carroll MC,Wesemann DR

更新日期：2017-10-03 00:00:00