Abstract:
:Sprouty proteins act as intracellular inhibitors of receptor tyrosine kinase signaling. Here we show that the mammalian Sprouty2 protein contains an iron-sulfur complex that can exist in an oxidized, reduced, or nitrosylated state. Purified Sprouty2 assembles into large monodisperse spheres containing approximately 24 polypeptides per particle. Biochemical experiments indicate that the charge state of the iron within Sprouty2 particles may be insulated from ambient intracellular redox. These features offer the possibility that Sprouty2 particles are capable of receiving, maintaining, and dissipating electrical charge in a manner formally equivalent to a battery.
journal_name
Proc Natl Acad Sci U S Aauthors
Wu X,Alexander PB,He Y,Kikkawa M,Vogel PD,McKnight SLdoi
10.1073/pnas.0506714102keywords:
subject
Has Abstractpub_date
2005-09-27 00:00:00pages
14058-62issue
39eissn
0027-8424issn
1091-6490pii
0506714102journal_volume
102pub_type
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