Structural basis for mutation-induced destabilization of profilin 1 in ALS.

abstract：:Adult rats were trained to detect the occurrence of a two-element sound sequence in a background of nine other nontarget sound pairs. Training resulted in a modest, enduring, static expansion of the cortical areas of representation of both target stimulus sounds. More importantly, once the initial stimulus A in the ta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhou X,de Villers-Sidani E,Panizzutti R,Merzenich MM

更新日期：2010-08-17 00:00:00

abstract：:Asymmetric cell division (ACD) is believed to be a physiological event that occurs during development and tissue homeostasis in a large variety of organisms. ACD produces two unequal daughter cells, one of which resembles a multipotent stem and/or progenitor cell, whereas the other has potential for differentiation. A...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Izumi H,Kaneko Y

更新日期：2012-10-30 00:00:00

abstract：:Chronic stress is known to promote inflammatory bowel disease (IBD), but the underlying mechanism remains largely unresolved. Here, we found chronic stress to sensitize mice to dextran sulfate sodium (DSS)-induced colitis; to increase the infiltration of B cells, neutrophils, and proinflammatory ly6Chi macrophages in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gao X,Cao Q,Cheng Y,Zhao D,Wang Z,Yang H,Wu Q,You L,Wang Y,Lin Y,Li X,Wang Y,Bian JS,Sun D,Kong L,Birnbaumer L,Yang Y

更新日期：2018-03-27 00:00:00

abstract：:In organisms from insects to vertebrates, Toll-like receptors (TLRs) are primary pathogen detectors that activate downstream pathways, specifically those that direct expression of innate immune effector genes. TLRs also have roles in development in many species. The sea anemone Nematostella vectensis is a useful cnida...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brennan JJ,Messerschmidt JL,Williams LM,Matthews BJ,Reynoso M,Gilmore TD

更新日期：2017-11-21 00:00:00

abstract：:A readily accessible new class of near infrared (NIR) molecular probes has been synthesized and evaluated. Specific fluorophores in this unique xanthene based regioisomeric seminaphthofluorone dye series exhibit a combination of desirable characteristics including (i) low molecular weight (339 amu), (ii) aqueous solub...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang Y,Lowry M,Xu X,Escobedo JO,Sibrian-Vazquez M,Wong L,Schowalter CM,Jensen TJ,Fronczek FR,Warner IM,Strongin RM

更新日期：2008-07-01 00:00:00

abstract：:Posttranslational modifications (PTMs) are important physiological means to regulate the activities and structures of central regulatory proteins in health and disease. Small GTPases have been recognized as important molecules that are targeted by PTMs during infections of mammalian cells by bacterial pathogens. The e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barthelmes K,Ramcke E,Kang HS,Sattler M,Itzen A

更新日期：2020-03-17 00:00:00

abstract：:Utilizing [3H]phorbol dibutyrate [P(Bu)2], we have developed an assay for high-affinity phorbol ester receptors in intact rat embryo fibroblasts. At 37 degrees C, binding of [3H]P(Bu)2 reached a maximum within 10 min and was rapidly reversible. The tumor promoters 12-O-tetradecanoyl-phorbol 13-acetate, teleocidin B, a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Horowitz AD,Greenebaum E,Weinstein IB

更新日期：1981-04-01 00:00:00

abstract：:The c-myc oncogene has been implicated in a wide spectrum of B-cell neoplasias. In normal cells, the level of expression of the c-myc gene correlates with growth status. In the present study, we examined the effect of receptor-mediated inhibition of growth on c-myc expression in a B-cell lymphoma. The murine lymphoma ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McCormack JE,Pepe VH,Kent RB,Dean M,Marshak-Rothstein A,Sonenshein GE

更新日期：1984-09-01 00:00:00

abstract：:Concern for the suffering of others is central to moral decision making. How humans evaluate others' suffering, relative to their own suffering, is unknown. We investigated this question by inviting subjects to trade off profits for themselves against pain experienced either by themselves or an anonymous other person....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Crockett MJ,Kurth-Nelson Z,Siegel JZ,Dayan P,Dolan RJ

更新日期：2014-12-02 00:00:00

abstract：:On illuminating chloroplasts with "short-wavelength" monochromatic light that supports oxygen evolution, spectral evidence was obtained for a new photoreactive chloroplast component, provisionally designated C550, which shows a reversible decrease of absorbance with a maximum at 550 mmu. The light-induced absorbance c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Knaff DB,Arnon DI

更新日期：1969-07-01 00:00:00

abstract：:A 1,942-base-pair DNA segment encoding the structural gene for diphtheria toxin was sequenced, and the primary structure of the toxin was deduced. Restriction enzyme fragments corresponding to nontoxic or hypotoxic peptides of the toxin were isolated from corynebacteriophage beta and cloned into Escherichia coli on pl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Greenfield L,Bjorn MJ,Horn G,Fong D,Buck GA,Collier RJ,Kaplan DA

更新日期：1983-11-01 00:00:00

abstract：:Rod-like colloids distort fluid interfaces and interact by capillarity. We explore this interaction at the free surface of aligned nematic liquid crystal films. Naive comparison of capillary and elastic energies suggests that particle assembly would be determined solely by surface tension. Here, we demonstrate that, u...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu IB,Gharbi MA,Ngo VL,Kamien RD,Yang S,Stebe KJ

更新日期：2015-05-19 00:00:00

abstract：:LMB-7 [B3(Fv)-PE38] is a single-chain immunotoxin constructed from the murine monoclonal antibody B3 and a truncated from of Pseudomonas exotoxin PE38. Antibody B3 recognizes a carbohydrate epitope found on solid tumors that frequently invade the intrathecal space and cause neoplastic meningitis. We tested the therape...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pastan IH,Archer GE,McLendon RE,Friedman HS,Fuchs HE,Wang QC,Pai LH,Herndon J,Bigner DD

更新日期：1995-03-28 00:00:00

abstract：:A powerful way to deal with a complex system is to build a coarse-grained model capable of catching its main physical features, while being computationally affordable. Inevitably, such coarse-grained models introduce a set of phenomenological parameters, which are often not easily deducible from the underlying atomist...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Invernizzi M,Valsson O,Parrinello M

更新日期：2017-03-28 00:00:00

abstract：:A fundamental, yet underexplored, materials system is the interface between biological molecules and inorganic surfaces. In an elemental approach to this problem, we have systematically examined the adhesion of amino acids to a series of inorganic surfaces including metals, insulators, and semiconductors. Significant ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Willett RL,Baldwin KW,West KW,Pfeiffer LN

更新日期：2005-05-31 00:00:00

abstract：:Atmospheric oxidation of natural and anthropogenic volatile organic compounds (VOCs) leads to secondary organic aerosol (SOA), which constitutes a major and often dominant component of atmospheric fine particulate matter (PM2.5). Recent work demonstrates that rapid autoxidation of organic peroxy radicals (RO2) formed ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pye HOT,D'Ambro EL,Lee BH,Schobesberger S,Takeuchi M,Zhao Y,Lopez-Hilfiker F,Liu J,Shilling JE,Xing J,Mathur R,Middlebrook AM,Liao J,Welti A,Graus M,Warneke C,de Gouw JA,Holloway JS,Ryerson TB,Pollack IB,Thornton

更新日期：2019-04-02 00:00:00

abstract：:As sensors, wireless communication devices, personal health monitoring systems, and autonomous microelectromechanical systems (MEMS) become distributed and smaller, there is an increasing demand for miniaturized integrated power sources. Although thin-film batteries are well-suited for on-chip integration, their energ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ning H,Pikul JH,Zhang R,Li X,Xu S,Wang J,Rogers JA,King WP,Braun PV

更新日期：2015-05-26 00:00:00

abstract：:NFATc (a member of the family of nuclear factors of activated T cells) is a transcriptional factor responsible for the Ca(2+)-inducible activation of cytokine genes during the immune response. In resting T cells, NFATc is retained in the cytoplasm by a mechanism that depends on multiple phosphorylations in an N-termin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Park S,Uesugi M,Verdine GL

更新日期：2000-06-20 00:00:00

abstract：:Located within the brain's ventricles, the choroid plexus produces cerebrospinal fluid and forms an important barrier between the central nervous system and the blood. For unknown reasons, the choroid plexus produces high levels of the protein klotho. Here, we show that these levels naturally decline with aging. Deple...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhu L,Stein LR,Kim D,Ho K,Yu GQ,Zhan L,Larsson TE,Mucke L

更新日期：2018-11-27 00:00:00

abstract：:In order to retain in an in situ system the control mechanisms involved in synthesis of bacteriophage T4 DNA, infected cells were made permeable to nucleotides by plasmolysis with concentrated sucrose. Such preparations use exogenous deoxyribonucleotides to synthesize T4 phage DNA. As has been observed with in vivo st...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wovcha MG,Tomich PK,Chiu CS,Greenberg GR

更新日期：1973-08-01 00:00:00

abstract：:The 369-residue glycoprotein D (gD) is the entry, receptor-binding protein of herpes simplex virus 1. The common receptors for viral entry are nectin-1, HveA, and a specific O-linked sulfated proteoglycan. The major receptor-binding sites of gD are at the N terminus, whereas the domain required for fusion of viral env...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhou G,Roizman B

更新日期：2007-03-06 00:00:00

abstract：:The replication initiator protein of plasmid R6K preferentially repressed transcription initiated in vitro from the promoter of the initiator protein cistron. DNase I protection experiments revealed that the sequences in the region of the promoter recognized by the initiator protein partially overlapped the sequences ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kelley W,Bastia D

更新日期：1985-05-01 00:00:00

abstract：:The cAMP-dependent protein kinase (PKA) has been shown to play an important role in long-term potentiation (LTP) in the hippocampus, but little is known about the function of PKA in long-term depression (LTD). We have combined pharmacologic and genetic approaches to demonstrate that PKA activity is required for both h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brandon EP,Zhuo M,Huang YY,Qi M,Gerhold KA,Burton KA,Kandel ER,McKnight GS,Idzerda RL

更新日期：1995-09-12 00:00:00

abstract：:Molecular junctions are essentially modified electrodes familiar to electrochemists where the electrolyte is replaced by a conducting "contact." It is generally hypothesized that changing molecular structure will alter system energy levels leading to a change in the transport barrier. Here, we show the conductance of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sayed SY,Fereiro JA,Yan H,McCreery RL,Bergren AJ

更新日期：2012-07-17 00:00:00

abstract：:T helper 17 (TH17) cells represent a discrete TH cell subset instrumental in the immune response to extracellular bacteria and fungi. However, TH17 cells are considered to be detrimentally involved in autoimmune diseases like multiple sclerosis (MS). In contrast to TH17 cells, regulatory T (Treg) cells were shown to b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ulges A,Witsch EJ,Pramanik G,Klein M,Birkner K,Bühler U,Wasser B,Luessi F,Stergiou N,Dietzen S,Brühl TJ,Bohn T,Bündgen G,Kunz H,Waisman A,Schild H,Schmitt E,Zipp F,Bopp T

更新日期：2016-09-06 00:00:00

abstract：:Polyclonal antibodies reactive with a cleavage site in human proinsulin (HPI) (C-peptide-A-chain junction) have been raised (rabbit, guinea pig) using a synthetic peptide antigen coupled with keyhole limpet hemocyanin. These antisera recognize native HPI and des-31,32-HPI equally well but react 20-50 times less well w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Steiner DF,Michael J,Houghten R,Mathieu M,Gardner PR,Ravazzola M,Orci L

更新日期：1987-09-01 00:00:00

abstract：:We examined the MLL genomic translocation breakpoint in acute myeloid leukemia of infant twins. Southern blot analysis in both cases showed two identical MLL gene rearrangements indicating chromosomal translocation. The rearrangements were detectable in the second twin before signs of clinical disease and the intensit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Megonigal MD,Rappaport EF,Jones DH,Williams TM,Lovett BD,Kelly KM,Lerou PH,Moulton T,Budarf ML,Felix CA

更新日期：1998-05-26 00:00:00

abstract：:Acetyl-CoA carboxylase 1 (ACC1) catalyzes the formation of malonyl-CoA, the C2 donor for de novo synthesis of long-chain fatty acids. We have identified 64 exons, including 7 alternatively spliced minor exons (1A, 1B, 1C, 3, 5A', 5A, and 5B) in human ACC1 gene ( approximately 330 kb). The gene is regulated by three pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mao J,Chirala SS,Wakil SJ

更新日期：2003-06-24 00:00:00

abstract：:Gel-forming mucins, the primary macromolecular components of airway mucus, facilitate airway clearance by mucociliary transport. In cystic fibrosis (CF) altered mucus properties impair mucociliary transport. Airways primarily secrete two closely related gel-forming mucins, MUC5B and MUC5AC. However, their morphologic ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ostedgaard LS,Moninger TO,McMenimen JD,Sawin NM,Parker CP,Thornell IM,Powers LS,Gansemer ND,Bouzek DC,Cook DP,Meyerholz DK,Abou Alaiwa MH,Stoltz DA,Welsh MJ

更新日期：2017-06-27 00:00:00

abstract：:Neuropathic pain afflicts millions of individuals and represents a major health problem for which there is limited effective and safe therapy. Emerging literature links altered sphingolipid metabolism to nociceptive processing. However, the neuropharmacology of sphingolipid signaling in the central nervous system in t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen Z,Doyle TM,Luongo L,Largent-Milnes TM,Giancotti LA,Kolar G,Squillace S,Boccella S,Walker JK,Pendleton A,Spiegel S,Neumann WL,Vanderah TW,Salvemini D

更新日期：2019-05-21 00:00:00