Abstract:
:A fundamental, yet underexplored, materials system is the interface between biological molecules and inorganic surfaces. In an elemental approach to this problem, we have systematically examined the adhesion of amino acids to a series of inorganic surfaces including metals, insulators, and semiconductors. Significant differential adhesion is observed over the full complement of amino acids, determined largely by amino acid side-chain charge. Extensive mapping of the amino acid adhesion versus materials in multiple solutions is presented, with preliminary mechanisms derived from concentration and pH dependence. These results provide an empirical basis for building peptide to inorganic surface structures, and, using this adhesion data, we design inorganic nanostructures that are shown to selectively bind to prescribed primary peptide sequences.
journal_name
Proc Natl Acad Sci U S Aauthors
Willett RL,Baldwin KW,West KW,Pfeiffer LNdoi
10.1073/pnas.0408565102keywords:
subject
Has Abstractpub_date
2005-05-31 00:00:00pages
7817-22issue
22eissn
0027-8424issn
1091-6490pii
0408565102journal_volume
102pub_type
杂志文章abstract::Sialyl Lewis x (sLe(x)) and sialyl Lewis a (sLe(a)) glycans are expressed on highly metastatic colon cancer cells. They promote extravasation of cancer cells and tumor angiogenesis via interacting with E-selectin on endothelial cells. Recently, epithelial-mesenchymal transition (EMT) has been noted as a critical pheno...
journal_title:Proceedings of the National Academy of Sciences of the United States of America
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更新日期:1982-08-01 00:00:00