Klotho controls the brain-immune system interface in the choroid plexus.

abstract：:Serotonin (5-hydroxytryptamine; 0.5 microM and above) stimulated the synthesis of prostacyclin (as measured by radioimmunoassay of 6-ketoprostaglandin F1 alpha) by bovine aortic smooth muscle cells in culture. This effect was structurally specific; a similar response was not elicited by the other indoles (tryptophan, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Coughlin SR,Moskowitz MA,Antoniades HN,Levine L

更新日期：1981-11-01 00:00:00

abstract：:Neuronal remodeling is a fundamental process by which the brain responds to environmental influences, e.g., during stress. In the hippocampus, chronic stress causes retraction of dendrites in CA3 pyramidal neurons. We have recently identified the glycoprotein M6a as a stress-responsive gene in the hippocampal formatio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alfonso J,Fernández ME,Cooper B,Flugge G,Frasch AC

更新日期：2005-11-22 00:00:00

abstract：:Tephritid fruit flies belonging to the Rhagoletis pomonella sibling species complex are controversial because they have been proposed to diverge in sympatry (in the absence of geographic isolation) by shifting and adapting to new host plants. Here, we report evidence suggesting a surprising source of genetic variation...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Feder JL,Berlocher SH,Roethele JB,Dambroski H,Smith JJ,Perry WL,Gavrilovic V,Filchak KE,Rull J,Aluja M

更新日期：2003-09-02 00:00:00

abstract：:Regulation of translation is critical for maintaining cellular protein levels, and thus protein homeostasis. The conserved RNA-binding protein CsrA (also called RsmA; for carbon storage regulator and regulator of secondary metabolism, respectively; hereafter called CsrA) represents a well-characterized example of regu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Altegoer F,Rensing SA,Bange G

更新日期：2016-09-06 00:00:00

abstract：:Growth hormone receptor (GHR) has been demonstrated to be nuclear localized both in vivo and in vitro, but the significance of this observation has remained elusive. Here we show that nuclear GHR is strongly correlated with proliferative status in vivo by using a liver regeneration model. In vitro, nuclear translocati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Conway-Campbell BL,Wooh JW,Brooks AJ,Gordon D,Brown RJ,Lichanska AM,Chin HS,Barton CL,Boyle GM,Parsons PG,Jans DA,Waters MJ

更新日期：2007-08-14 00:00:00

abstract：:General control nonderepressible 2 (GCN2) plays a major role in the cellular response to amino acid limitation. Although maintenance of amino acid homeostasis is critical for tumor growth, the contribution of GCN2 to cancer cell survival and proliferation is poorly understood. In this study, we generated GCN2 inhibito...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakamura A,Nambu T,Ebara S,Hasegawa Y,Toyoshima K,Tsuchiya Y,Tomita D,Fujimoto J,Kurasawa O,Takahara C,Ando A,Nishigaki R,Satomi Y,Hata A,Hara T

更新日期：2018-08-14 00:00:00

abstract：:By immunoaffinity column chromatography, we have purified two RNA polymerase complexes, the transcriptase and replicase, from vesicular stomatitis virus-infected baby hamster kidney cells. The transcriptase is a multiprotein complex, containing the virus-encoded RNA polymerase L and P proteins, and two cellular protei...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Qanungo KR,Shaji D,Mathur M,Banerjee AK

更新日期：2004-04-20 00:00:00

abstract：:Murine hematopoietic blast colony-forming cells (BL-CFCs) are able to generate up to 30,000 progeny blast cells within 10 d in agar cultures. Contained in these populations are large numbers of lineage-committed progenitor cells in the granulocytic and macrophage lineages. Sequential analyses of blast colonies reveale...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Metcalf D,Ng A,Mifsud S,Di Rago L

更新日期：2010-09-14 00:00:00

abstract：:Confronted with an object of perception, an individual will spontaneously try to identify unambiguously and consistently all its parts; except in rare instances of "illusory phenomena," he will immediately succeed. This elementary fact is formalized in a law of visual perception. It is used to define sets of stable st...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shiman LG

更新日期：1978-04-01 00:00:00

abstract：:The rugged folding-energy landscapes of RNAs often display many competing minima. How do RNAs discriminate among competing conformations in their search for the native state? By using optical tweezers, we show that the folding-energy landscape can be manipulated to control the fate of an RNA: individual RNA molecules ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li PT,Bustamante C,Tinoco I Jr

更新日期：2007-04-24 00:00:00

abstract：:NAD+ glycohydrolase activity is found at high levels in submitochondrial particles. It leads to the reaction products ADP-ribose, nicotinamide, and small amounts of 5'-AMP. Furthermore, submitochondrial particles catalyze the exchange reaction: [adenosine-14C]ADP-ribose + NAD+ in equilibrium [adenosine-14C]-NAD+ + ADP...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Richter C,Winterhalter KH,Baumhüter S,Lötscher HR,Moser B

更新日期：1983-06-01 00:00:00

abstract：:The secreted nodulation-signaling protein NodO was purified from the supernatant of cultures of Rhizobium leguminosarum biovar viciae. The native protein has a M(r) of approximately 67,000, suggesting that it exists as a dimer since the DNA sequence predicts a M(r) of 30,002. Pure NodO protein had no protease, pectina...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sutton JM,Lea EJ,Downie JA

更新日期：1994-10-11 00:00:00

abstract：:We report the successful infection of two rabbit T-cell lines and one rabbit macrophage line with human immunodeficiency virus 1 (HIV-1). One T-cell line was a herpesvirus ateles transformant, the other T-cell line was a human T-cell leukemia virus I transformant, and the macrophage line was a simian virus 40 transfor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kulaga H,Folks TM,Rutledge R,Kindt TJ

更新日期：1988-06-01 00:00:00

abstract：:We report a measurement of the transverse momentum correlation between two photons by detecting only one of them. Our method uses two identical sources in an arrangement in which the phenomenon of induced coherence without induced emission is observed. In this way, we produce an interference pattern in the superpositi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hochrainer A,Lahiri M,Lapkiewicz R,Lemos GB,Zeilinger A

更新日期：2017-02-14 00:00:00

abstract：:The colligative properties of ATP and catecholamines demonstrated in vitro are thought to be responsible for the extraordinary accumulation of solutes inside chromaffin cell secretory vesicles, although this has yet to be demonstrated in living cells. Because functional cells cannot be deprived of ATP, we have knocked...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Estévez-Herrera J,Domínguez N,Pardo MR,González-Santana A,Westhead EW,Borges R,Machado JD

更新日期：2016-07-12 00:00:00

abstract：:A new ribonuclease, RNase BN, has been identified and partially purified from a strain of Escherichia coli lacking RNase II and RNase D by using the artificial tRNA precursor tRNA-C-[14C]U as substrate. This enzyme is present in E. coli B but absent from the tRNA processing mutant strain BN which is unable to process ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Asha PK,Blouin RT,Zaniewski R,Deutscher MP

更新日期：1983-06-01 00:00:00

abstract：:Children who are treated for congenital cataracts later exhibit impairments in configural face analysis. This has been explained in terms of a critical period for the acquisition of normal face processing. Here, we consider a more parsimonious account according to which deficits in configural analysis result from the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vogelsang L,Gilad-Gutnick S,Ehrenberg E,Yonas A,Diamond S,Held R,Sinha P

更新日期：2018-10-30 00:00:00

abstract：:Senescence is controlled by time-evolving networks that describe the temporal transition of interactions among senescence regulators. Here, we present time-evolving networks for NAM/ATAF/CUC (NAC) transcription factors in Arabidopsis during leaf aging. The most evident characteristic of these time-dependent networks w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim HJ,Park JH,Kim J,Kim JJ,Hong S,Kim J,Kim JH,Woo HR,Hyeon C,Lim PO,Nam HG,Hwang D

更新日期：2018-05-22 00:00:00

abstract：:Studies have shown that hemophilia B (Christmas disease; factor IX deficiency) results from many different mutations in the factor IX gene, of which greater than 95% are single nucleotide substitutions. This study has identified a previously unreported form of hemophilia B in a patient who was a somatic mosaic for a g...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Taylor SA,Deugau KV,Lillicrap DP

更新日期：1991-01-01 00:00:00

abstract：:This article discusses some of the similarities between work being done by economists and by physicists seeking to contribute to economics. We also mention some of the differences in the approaches taken and seek to justify these different approaches by developing the argument that by approaching the same problem from...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stanley HE,Amaral LA,Buldyrev SV,Gopikrishnan P,Plerou V,Salinger MA

更新日期：2002-02-19 00:00:00

abstract：:Chromosome 14 allelic loss is common in nasopharyngeal carcinoma (NPC) and may reflect essential tumor suppressor gene loss in tumorigenesis. An intact chromosome 14 was transferred to an NPC cell line using a microcell-mediated chromosome transfer approach. Microcell hybrids (MCHs) containing intact exogenously trans...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheung AK,Lung HL,Ko JM,Cheng Y,Stanbridge EJ,Zabarovsky ER,Nicholls JM,Chua D,Tsao SW,Guan XY,Lung ML

更新日期：2009-08-25 00:00:00

abstract：:Ontogenetic changes in the protein phosphorylation/dephosphorylation systems in rat brain were investigated. It was found that the activity level of phospholipid-sensitive Ca2+-dependent protein kinase (PL-Ca-PK) in the particulate fraction of grey and white matter and the soluble fraction of grey matter increased rap...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Turner RS,Raynor RL,Mazzei GJ,Girard PR,Kuo JF

更新日期：1984-05-01 00:00:00

abstract：:The best-studied cytoskeletal system is the inner surface of the erythrocyte membrane, which provides an erythrocyte with the structural support needed to be stable yet flexible as it passes through the circulation. Current structural models predict that the spectrin-actin-based cytoskeletal network is attached to the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stefanovic M,Markham NO,Parry EM,Garrett-Beal LJ,Cline AP,Gallagher PG,Low PS,Bodine DM

更新日期：2007-08-28 00:00:00

abstract：:Coordinated near-threshold depolarized states in cortical and striatal neurons may contribute to form functionally segregated channels of information processing. Recent anatomical studies have identified pathways that could support spiraling interactions across corticostriatal channels, but a functional outcome of suc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kasanetz F,Riquelme LA,Della-Maggiore V,O'Donnell P,Murer MG

更新日期：2008-06-10 00:00:00

abstract：:Progesterone is involved in the development and progression of breast cancers, and progesterone receptors (PR) are important markers of hormone dependence and disease prognosis. We have used a human PR cDNA probe, genomic DNA blotting of a series of Chinese hamster-human cell hybrids, and in situ hybridization to map ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Law ML,Kao FT,Wei Q,Hartz JA,Greene GL,Zarucki-Schulz T,Conneely OM,Jones C,Puck TT,O'Malley BW

更新日期：1987-05-01 00:00:00

abstract：:Preclinical animal models have largely ignored the immune-suppressive mechanisms that are important in human cancers. The identification and use of such models should allow better predictions of successful human responses to immunotherapy. As a model for changes induced in nonmalignant cells by cancer, we examined T-c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gorgun G,Ramsay AG,Holderried TA,Zahrieh D,Le Dieu R,Liu F,Quackenbush J,Croce CM,Gribben JG

更新日期：2009-04-14 00:00:00

abstract：:The sporulation of Saccharomyces cerevisiae in the presence of [2-13C]acetate was studied by 13C NMR spectroscopy. The fate of 13C label was analyzed in vivo and in cell extracts. During the first 4 hr of sporulation the major metabolite produced from [2-13C]acetate utilization was glutamate. From the labeling pattern...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dickinson JR,Dawes IW,Boyd AS,Baxter RL

更新日期：1983-10-01 00:00:00

abstract：:The extracellular matrix (ECM) is an intricate network composed of an array of macromolecules capable of regulating the functional responsiveness of cells. Its composition greatly varies among different types of tissue, and dysregulation of its metabolism may contribute to vascular remodeling during the pathogenesis o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roth M,Eickelberg O,Kohler E,Erne P,Block LH

更新日期：1996-05-28 00:00:00

abstract：:A perversion in an otherwise uniform helical structure, such as a climbing plant tendril, refers to a kink that connects two helices with opposite chiralities. Such singularity structures are widely seen in natural and artificial mechanical systems, and they provide the fundamental mechanism of helical symmetry breaki...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu S,Yao Z,Chiou K,Stupp SI,Olvera de la Cruz M

更新日期：2016-06-28 00:00:00

abstract：:Modified bovine leukemia virus (BLV) glycoproteins were expressed by using vaccinia virus recombinants, and their fusogenic capacities were examined by a syncytia-formation assay. This analysis indicates that (i) both BLV envelope glycoproteins gp51 and gp30 are necessary for cell fusion; (ii) insertion of the N-termi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vonèche V,Portetelle D,Kettmann R,Willems L,Limbach K,Paoletti E,Ruysschaert JM,Burny A,Brasseur R

更新日期：1992-05-01 00:00:00