Inhibition of GCN2 sensitizes ASNS-low cancer cells to asparaginase by disrupting the amino acid response.

abstract：:Reduced serum testosterone (T), or hypogonadism, affects millions of men and is associated with many pathologies, including infertility, cardiovascular diseases, metabolic syndrome, and decreased libido and sexual function. Administering T-replacement therapy (TRT) reverses many of the symptoms associated with low T l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li L,Li Y,Sottas C,Culty M,Fan J,Hu Y,Cheung G,Chemes HE,Papadopoulos V

更新日期：2019-11-12 00:00:00

abstract：:Myocytes in the atria contain a prohormone that gives rise to atrial natriuretic peptides (ANP), which have intrinsic hemodynamic regulatory activity. Little is known about mechanisms regulating ANP release. In rats with indwelling catheters, acute blood volume expansion with 5% (wt/vol) dextrose increases the amount ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zamir N,Haass M,Dave JR,Zukowska-Grojec Z

更新日期：1987-01-01 00:00:00

abstract：:Type I (IFN-alpha/beta) and type III (IFN-lambdas) IFNs are important components of the host antiviral response. Although type III IFNs possess intrinsic antiviral activity similar to that of type I IFNs, they signal through a specific unique receptor complex, and their functional importance for antiviral resistance i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huang J,Smirnov SV,Lewis-Antes A,Balan M,Li W,Tang S,Silke GV,Pütz MM,Smith GL,Kotenko SV

更新日期：2007-06-05 00:00:00

abstract：:The effects of epinephrine (as low as 0.1 muM) on guanosine 3':5'-cyclic monophosphate (cGMP) and adenosine 3':5'-cyclic monophosphate (cAMP) in isolated fat cells were examined. Epinephrine increased both cGMP and cAMP levels, with the elevation of cAMP preceding the rise of cGMP. Maximal elevation was obtained with ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Asakawa T,Ruiz J,Ho RJ

更新日期：1978-06-01 00:00:00

abstract：:A DNA fragment homologous to U6 small nuclear RNA was isolated from a human genomic library and sequenced. The immediate 5'-flanking region of the U6 DNA clone had significant homology with a potential mouse U6 gene, including a "TATA box" at a position 26-29 nucleotides upstream from the transcription start site. Alt...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kunkel GR,Maser RL,Calvet JP,Pederson T

更新日期：1986-11-01 00:00:00

abstract：:According to the Dobzhansky-Muller model, hybrid sterility is a consequence of the independent evolution of related taxa resulting in incompatible genomic interactions of their hybrids. The model implies that the incompatibilities evolve randomly, unless a particular gene or nongenic sequence diverges much faster than...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bhattacharyya T,Gregorova S,Mihola O,Anger M,Sebestova J,Denny P,Simecek P,Forejt J

更新日期：2013-02-05 00:00:00

abstract：:We have studied the effects of recombinant (r) interleukin 7 (IL-7) on growth and differentiation of marrow pro-B-lymphocyte clones (CB/Bm7, LyD9, LyB9), marrow pro-T-lymphocyte clones (C4-77/3, C4-86/18, C4-95/16), and fetal thymocyte clones (FTH5, FTA2, FTD5) in the presence or absence of the bone marrow stroma clon...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takeda S,Gillis S,Palacios R

更新日期：1989-03-01 00:00:00

abstract：:In the cytoplasm of well-spread cultured normal fibroblasts, actin is organized into a network of cables that run the length of the cell just inside the adherent cell membrane. A diffuse matrix replaces the cables in fibroblasts that have become tumorigenic as a result of oncogenic transformation. We have found a simi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kopelovich L,Conlon S,Pollack R

更新日期：1977-07-01 00:00:00

abstract：:Model compositions of Earth, Venus, and Mercury are calculated from the premise that planets and chondrites underwent four identical fractionation processes in the solar nebula. Because elements of similar properties stay together in these processes, five constraints suffice to define the composition of a planet: mass...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morgan JW,Anders E

更新日期：1980-12-01 00:00:00

abstract：:Ultrashort light pulses can selectively excite charges, spins, and phonons in materials, providing a powerful approach for manipulating their properties. Here we use femtosecond laser pulses to coherently manipulate the electron and phonon distributions, and their couplings, in the charge-density wave (CDW) material 1...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang Y,Shi X,You W,Tao Z,Zhong Y,Cheenicode Kabeer F,Maldonado P,Oppeneer PM,Bauer M,Rossnagel K,Kapteyn H,Murnane M

更新日期：2020-04-21 00:00:00

abstract：:Depending on the cellular context, BCL2-like proteins promote mitochondrial fusion or fission. What determines which of these two opposing processes they promote has so far been unknown. Furthermore, the mechanisms through which BCL2-like proteins affect mitochondrial dynamics remain to be fully understood. The BCL2-l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lu Y,Rolland SG,Conradt B

更新日期：2011-10-11 00:00:00

abstract：:Understanding the molecular determinants of specificity in protein-protein interaction is an outstanding challenge of postgenome biology. The availability of large protein databases generated from sequences of hundreds of bacterial genomes enables various statistical approaches to this problem. In this context covaria...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weigt M,White RA,Szurmant H,Hoch JA,Hwa T

更新日期：2009-01-06 00:00:00

abstract：:rap1/Krev-1 is a p21ras-related GTP-binding protein that has been implicated in the reversion of the ras-transformed cell phenotype. We have identified a GTPase-activating protein (GAP) specific for rap in plasma membranes isolated from differentiated HL60 cells. The rap GAP activity remained quantitatively associated...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Polakis PG,Rubinfeld B,Evans T,McCormick F

更新日期：1991-01-01 00:00:00

abstract：:Optimization of hydride transfer (HT) catalysts to enhance rates and selectivities of (photo)electroreduction reactions could be a crucial component of a sustainable chemical industry. Here, we analyze how ring functionalization of the adsorbed transient intermediate 2-pyridinide (2-PyH-*)-predicted to form in situ fr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu S,Carter EA

更新日期：2019-11-12 00:00:00

abstract：:Vertebrae are derived from the sclerotomal moities of the somites. Sclerotomal cells migrate ventrally to surround the notochord, where they form the vertebral body, and dorsolaterally to form the neural arch, which is dorsally closed by the spinous process. Precursor cells of the spinous process as well as superficia...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Monsoro-Burq AH,Bontoux M,Teillet MA,Le Douarin NM

更新日期：1994-10-25 00:00:00

abstract：:Epithelial barrier disruption is a major cause of inflammatory bowel disease (IBD); however, the cellular and molecular regulation of intestinal epithelial homeostasis remains largely undefined. Here, we show that the C-type lectin receptor LSECtin (Clec4g) on macrophages is required for protection against dextran sul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang Z,Li Q,Wang X,Jiang X,Zhao D,Lin X,He F,Tang L

更新日期：2018-10-23 00:00:00

abstract：:Underacetylation of histone H4 is thought to be involved in the molecular mechanism of mammalian X chromosome inactivation, which is an important model system for large-scale genetic control in eukaryotes. However, it has not been established whether histone underacetylation plays a critical role in the multistep inac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wakefield MJ,Keohane AM,Turner BM,Graves JA

更新日期：1997-09-02 00:00:00

abstract：:Human skin and lung mast cells and rodent peritoneal mast cells contain a carboxypeptidase in their secretory granules. We have screened human lung cDNA libraries with a mouse mast cell carboxypeptidase A (MC-CPA) cDNA probe to isolate a near-full-length cDNA that encodes human MC-CPA. The 5' end of the human MC-CPA t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reynolds DS,Gurley DS,Stevens RL,Sugarbaker DJ,Austen KF,Serafin WE

更新日期：1989-12-01 00:00:00

abstract：:The Mauer mandible, holotype of Homo heidelbergensis, was found in 1907 in fluvial sands deposited by the Neckar River 10 km southeast of Heidelberg, Germany. The fossil is an important key to understanding early human occupation of Europe north of the Alps. Given the associated mammal fauna and the geological context...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wagner GA,Krbetschek M,Degering D,Bahain JJ,Shao Q,Falguères C,Voinchet P,Dolo JM,Garcia T,Rightmire GP

更新日期：2010-11-16 00:00:00

abstract：:Modeling studies of terrestrial extrasolar planetary climates are now including the effects of ocean circulation due to a recognition of the importance of oceans for climate; indeed, the peak equator-pole ocean heat transport on Earth peaks at almost half that of the atmosphere. However, such studies have made the ass...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cullum J,Stevens DP,Joshi MM

更新日期：2016-04-19 00:00:00

abstract：:The accumulation of metal ions and amyloid-β (Aβ) aggregates found in the brain of patients with Alzheimer's disease (AD) has been suggested to be involved in AD pathogenesis. To investigate metal-Aβ-associated pathways in AD, development of chemical tools to target metal-Aβ species is desired. Only a few efforts, how...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Choi JS,Braymer JJ,Nanga RP,Ramamoorthy A,Lim MH

更新日期：2010-12-21 00:00:00

abstract：:Volcanic eruptions caused major weather and climatic changes on timescales ranging from hours to centuries in the past. Volcanic particles are injected in the atmosphere both as primary particles rapidly deposited due to their large sizes on time scales of minutes to a few weeks in the troposphere, and secondary parti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Boulon J,Sellegri K,Hervo M,Laj P

更新日期：2011-07-26 00:00:00

abstract：:The structure and the expression of 11 cellular oncogenes (protooncogenes) were analyzed in primary cells from 20 acute lymphocytic (ALL) and 31 acute myelogenous (AML) leukemia patients. Neoplastic cells, obtained prior to initiation of therapy, were purified and classified, on the basis of both surface antigen patte...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mavilio F,Sposi NM,Petrini M,Bottero L,Marinucci M,De Rossi G,Amadori S,Mandelli F,Peschle C

更新日期：1986-06-01 00:00:00

abstract：:The concepts of source and quantum action principle are used to produce the phonon Green's function appropriate for an initial phonon vacuum state. An application to the Mossbauer effect is presented. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schwinger J

更新日期：1991-08-01 00:00:00

abstract：:The basolateral membranes of Aplysia californica foregut absorptive cells contain both Cl(-)-stimulated ATPase and ATP-dependent Cl- transport activities, and each was inhibited by orthovanadate. Both of these orthovanadate-sensitive activities were reconstituted into proteoliposomes. The reaction sequence kinetics we...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gerencser GA,Zelezna B

更新日期：1993-09-01 00:00:00

abstract：:In some countries across the globe, tropical forest cover is increasing. The national-scale reforestation of Vietnam since 1992 is assumed to contribute to this recovery. It is achieved, however, by the displacement of forest extraction to other countries on the order of 49 (34-70) M m(3), or approximately 39% of the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meyfroidt P,Lambin EF

更新日期：2009-09-22 00:00:00

abstract：:The fossil record of land plants is an obvious source of information on the dynamics of mass extinctions in the geological past. In conjunction with the end-Permian ecological crisis, approximately 250 million years ago, palynological data from East Greenland reveal some unanticipated patterns. We document the signifi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Looy CV,Twitchett RJ,Dilcher DL,Van Konijnenburg-Van Cittert JH,Visscher H

更新日期：2001-07-03 00:00:00

abstract：:Origins of DNA replication in Schizosaccharomyces pombe lack a specific consensus sequence analogous to the Saccharomyces cerevisiae autonomously replicating sequence (ARS) consensus, raising the question of how they are recognized by the replication machinery. Because all well characterized S. pombe origins are locat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dai J,Chuang RY,Kelly TJ

更新日期：2005-01-11 00:00:00

abstract：:The convulsant agent methionine sulfoximine inhibits brain glutamine synthetase irreversibly and the inhibitor becomes bound to the active site of the enzyme as methionine sulfoximine phosphate. Only one of the four isomers of methionine sulfoximine, L-methionine-S-sulfoximine, inhibits glutamine synthetase. In the pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rowe WB,Meister A

更新日期：1970-06-01 00:00:00

abstract：:The relative abundance of individual proteins shared among clones of lymphocytes provides a meaningful basis for cellular classification. Twelve clones of T cells (obtained by limiting dilution) were analyzed by two-dimensional gel electrophoresis for polypeptide content and then evaluated by the computational techniq...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lefkovits I,Kuhn L,Valiron O,Merle A,Kettman J

更新日期：1988-05-01 00:00:00