Inhibition of type I and type III interferons by a secreted glycoprotein from Yaba-like disease virus.

abstract：:There are two competing hypotheses for the origin of megaliths in Europe. The conventional view from the late 19th and early 20th centuries was of a single-source diffusion of megaliths in Europe from the Near East through the Mediterranean and along the Atlantic coast. Following early radiocarbon dating in the 1970s,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schulz Paulsson B

更新日期：2019-02-26 00:00:00

abstract：:The U.S. case against Iran is based on Iran's deceptions regarding nuclear weapons development. This case is buttressed by assertions that a state so petroleum-rich cannot need nuclear power to preserve exports, as Iran claims. The U.S. infers, therefore, that Iran's entire nuclear technology program must pertain to w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stern R

更新日期：2007-01-02 00:00:00

abstract：:For many years, the Neanderthals have been recognized as a distinctive extinct hominid group that occupied Europe and western Asia between about 200,000 and 30,000 years ago. It is still debated, however, whether these hominids belong in their own species, Homo neanderthalensis, or represent an extinct variant of Homo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schwartz JH,Tattersall I

更新日期：1996-10-01 00:00:00

abstract：:A high proportion of lymphocytes from F/St mice produce infectious xenotropic murine leukemia virus (X-MuLV) and express high levels of cell surface antigens, termed XenCSA, related to the major glycoprotein of X-MuLV. In crosses of F/St with AKR, the high-virus phenotype of F/St was found to be recessive and was show...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yetter RA,Hartley JW,Morse HC 3rd

更新日期：1983-01-01 00:00:00

abstract：:The error frequency of in vitro DNA synthesis using a natural DNA template has been measured with a biological assay for nucleotide substitutions. phiX174 DNA containing an amber mutation was copied in vitro by Escherichia coli DNA polymerase I, and the reversion frequency of the progeny DNA was determined by transfec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weymouth LA,Loeb LA

更新日期：1978-04-01 00:00:00

abstract：:The deadly neurotoxin tetrodotoxin (TTX) is found in a variety of animal phyla and, because of its toxicity, is most often assumed to deter predation. On the tropical Pacific island of Guam, we found an undescribed flatworm (planocerid sp. 1) that contains high levels of TTX and its analogs. Through ecological experim...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ritson-Williams R,Yotsu-Yamashita M,Paul VJ

更新日期：2006-02-28 00:00:00

abstract：:Electrical coupling between pyramidal cell axons, and between interneuron dendrites, have both been described in the hippocampus. What are the functional roles of the two types of coupling? Interneuron gap junctions enhance synchrony of gamma oscillations (25-70 Hz) in isolated interneuron networks and also in network...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Traub RD,Pais I,Bibbig A,LeBeau FE,Buhl EH,Hormuzdi SG,Monyer H,Whittington MA

更新日期：2003-02-04 00:00:00

abstract：:Diffuse large B cell lymphomas (DLBCLs) often express BCL6, a transcriptional repressor required for the formation of normal germinal centers. In a subset of DLBCLs, BCL6 is deregulated by chromosomal translocations or aberrant somatic hypermutation; in other tumors, BCL6 expression may simply reflect germinal center ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Polo JM,Juszczynski P,Monti S,Cerchietti L,Ye K,Greally JM,Shipp M,Melnick A

更新日期：2007-02-27 00:00:00

abstract：:In a microarray-based gene profiling analysis of Müller glia-derived retinal stem cells in light-damaged retinas from adult zebrafish, we found that 2 genes required for regeneration of fin and heart tissues in zebrafish, hspd1 (heat shock 60-kDa protein 1) and mps1 (monopolar spindle 1), were up-regulated. Expression...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Qin Z,Barthel LK,Raymond PA

更新日期：2009-06-09 00:00:00

abstract：:The hammerhead ribozyme, as engineered by J. Haseloff and W. L. Gerlach [(1988) Nature (London) 334, 585-591], is an RNA molecule containing two regions of conserved nucleotides, a double helix, called helix II, which connects the two conserved regions, and flanking arms of variable sequence, which hybridize the riboz...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McCall MJ,Hendry P,Jennings PA

更新日期：1992-07-01 00:00:00

abstract：:The catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) is a classical nonhomologous end-joining (cNHEJ) factor. Loss of DNA-PKcs diminished mature B cell class switch recombination (CSR) to other isotypes, but not IgG1. Here, we show that expression of the kinase-dead DNA-PKcs (DNA-PKcsKD/KD ) severely compr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Crowe JL,Shao Z,Wang XS,Wei PC,Jiang W,Lee BJ,Estes VM,Alt FW,Zha S

更新日期：2018-08-21 00:00:00

abstract：:The effects of three anti-inflammatory drugs, which interfere with arachidonic acid transformation by three different enzymes, have been compared by using a simple model of tissue damage and foreign body rejection. In groups of control rats, subcutaneously implanted polyester sponges were rejected after a mean of 12 d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Higgs GA,Mugridge KG,Moncada S,Vane JR

更新日期：1984-05-01 00:00:00

abstract：:Mucolipidosis type IV is an autosomal recessive lysosomal storage disease of unknown etiology that causes severe neurological and ophthalmological abnormalities. In an attempt to obtain insight into the nature of the metabolic abnormality in this disorder, we prospectively evaluated 15 consecutive patients, aged 2 to ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schiffmann R,Dwyer NK,Lubensky IA,Tsokos M,Sutliff VE,Latimer JS,Frei KP,Brady RO,Barton NW,Blanchette-Mackie EJ,Goldin E

更新日期：1998-02-03 00:00:00

abstract：:Expression cloning of cDNAs was first described a decade ago and was based on transient expression of cDNA libraries in COS cells. In contrast to transient transfection of plasmids, retroviral gene transfer delivers genes stably into a wide range of target cells. We utilize a simple packaging system for production of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kitamura T,Onishi M,Kinoshita S,Shibuya A,Miyajima A,Nolan GP

更新日期：1995-09-26 00:00:00

abstract：:The persistent tetrodotoxin (TTX)-sensitive sodium current, detected in neurons of many regions of mammalian brains, is associated with many essential neuronal activities, including boosting of excitatory synaptic inputs, acceleration of firing rates, and promotion of oscillatory neuronal activities. However, the orig...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu Z,Song W,Dong K

更新日期：2004-08-10 00:00:00

abstract：:The replication of simian virus 40 (SV40) DNA is dependent upon a single viral protein [tumor (T) antigen] and multiple cellular proteins. To define the required cellular proteins, we have made use of a cell-free system that supports the replication of plasmid DNA molecules containing the SV40 origin of replication. W...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Virshup DM,Kelly TJ

更新日期：1989-05-01 00:00:00

abstract：:Recent advances in cell-free expression protocols have opened a new avenue toward high-resolution structural investigations of membrane proteins by x-ray crystallography and NMR spectroscopy. One of the biggest challenges for liquid-state NMR-based structural investigations of membrane proteins is the significant peak...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reckel S,Sobhanifar S,Schneider B,Junge F,Schwarz D,Durst F,Löhr F,Güntert P,Bernhard F,Dötsch V

更新日期：2008-06-17 00:00:00

abstract：:To facilitate genetic analysis of the human pathogenic parvovirus B19, we constructed a hybrid B19 viral genome in which the defective B19 inverted terminal repeats were replaced with the full-length inverted terminal repeats from a nonpathogenic human parvovirus, the adeno-associated virus 2 (AAV). The hybrid AAV-B19...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Srivastava CH,Samulski RJ,Lu L,Larsen SH,Srivastava A

更新日期：1989-10-01 00:00:00

abstract：:Most higher eukaryotic tubulins are separated into alpha- and beta-tubulin when electrophoresed in NaDodSO4- denaturing gels, while many lower eukaryotic tubulins are poorly resolved under these conditions, which include a stacking gel (pH 6.80) and a separating gel (pH 8.80). By lowering the pH of the separating gel ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Suprenant KA,Hays E,LeCluyse E,Dentler WL

更新日期：1985-10-01 00:00:00

abstract：:Sensory information from the external world is inherently ambiguous, necessitating prior experience as a constraint on perception. Prolonged experience (adaptation) induces perception of ambiguous morph faces as a category different from the adapted category, suggesting sensitivity in underlying neural codes to differ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Furl N,van Rijsbergen NJ,Treves A,Friston KJ,Dolan RJ

更新日期：2007-08-14 00:00:00

abstract：:HIV infection leads to a state of chronic immune activation and progressive deterioration in immune function, manifested most recognizably by the progressive depletion of CD4+ T cells. A substantial percentage of natural killer (NK) cells from patients with HIV infection are activated and express the natural cytotoxic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vieillard V,Strominger JL,Debré P

更新日期：2005-08-02 00:00:00

abstract：:Cancer vaccines genetically engineered to produce interleukin 2 have been investigated intensively in a series of animal models and are at the point of entering into clinical trials. In this study we demonstrate a strong correlation between the rate of interleukin 2 production and the protection efficiency of murine S...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schmidt W,Schweighoffer T,Herbst E,Maass G,Berger M,Schilcher F,Schaffner G,Birnstiel ML

更新日期：1995-05-09 00:00:00

abstract：:The synthetic polypeptide antigen poly(LTyr, LGlu)-poly(DLAl)- -poly(LLys)[T,G)-A- -L] was covalently linked to N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP), which is the minimal adjuvant-active structure that can substitute for Mycobacteria in complete Freund's adjuvant. When injected in aqueous solution into mice, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mozes E,Sela M,Chedid L

更新日期：1980-08-01 00:00:00

abstract：:IL-17-producing CD4(+) T helper (Th17) cells have recently been defined as a unique subset of proinflammatory helper cells whose development depends on signaling initiated by IL-6 and TGF-beta, autocrine activity of IL-21, activation of STAT3, and induction of the orphan nuclear receptor RORgammat. The maintenance, ex...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Voo KS,Wang YH,Santori FR,Boggiano C,Wang YH,Arima K,Bover L,Hanabuchi S,Khalili J,Marinova E,Zheng B,Littman DR,Liu YJ

更新日期：2009-03-24 00:00:00

abstract：:Normal vision requires the precise control of vascular growth to maintain corneal transparency. Here we provide evidence for a unique mechanism by which the Forkhead box transcription factor FoxC1 regulates corneal vascular development. Murine Foxc1 is essential for development of the ocular anterior segment, and in h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seo S,Singh HP,Lacal PM,Sasman A,Fatima A,Liu T,Schultz KM,Losordo DW,Lehmann OJ,Kume T

更新日期：2012-02-07 00:00:00

abstract：:Avian leukosis virus subgroup J (ALV-J) is an important concern for the poultry industry. Replication of ALV-J depends on a functional cellular receptor, the chicken Na+/H+ exchanger type 1 (chNHE1). Tryptophan residue number 38 of chNHE1 (W38) in the extracellular portion of this molecule is a critical amino acid for...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koslová A,Trefil P,Mucksová J,Reinišová M,Plachý J,Kalina J,Kučerová D,Geryk J,Krchlíková V,Lejčková B,Hejnar J

更新日期：2020-01-28 00:00:00

abstract：:Social interactions are fundamental for human behavior, but the quantification of their neural underpinnings remains challenging. Here, we used hyperscanning functional MRI (fMRI) to study information flow between brains of human dyads during real-time social interaction in a joint attention paradigm. In a hardware se...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bilek E,Ruf M,Schäfer A,Akdeniz C,Calhoun VD,Schmahl C,Demanuele C,Tost H,Kirsch P,Meyer-Lindenberg A

更新日期：2015-04-21 00:00:00

abstract：:Four major neutralizing regions of the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein were identified and characterized with a panel of 80 HIV-1 antibody-positive human sera. Levels of neutralizing antibodies against the HIV-1 strains IIIB, SF2, and RF were compared with reactivity in ELISAs against...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Broliden PA,von Gegerfelt A,Clapham P,Rosen J,Fenyö EM,Wahren B,Broliden K

更新日期：1992-01-15 00:00:00

abstract：:Learning the properties of an image associated with human gaze placement is important both for understanding how biological systems explore the environment and for computer vision applications. There is a large literature on quantitative eye movement models that seeks to predict fixations from images (sometimes termed...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kümmerer M,Wallis TS,Bethge M

更新日期：2015-12-29 00:00:00

abstract：:NKp46 is a cell surface receptor expressed on natural killer (NK) cells, on a minute subset of T cells, and on a population of innate lymphoid cells that produce IL-22 and express the transcription factor retinoid-related orphan receptor (ROR)-γt, referred to as NK cell receptor (NKR)(+)ROR-γt(+) cells. Here we descri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Narni-Mancinelli E,Chaix J,Fenis A,Kerdiles YM,Yessaad N,Reynders A,Gregoire C,Luche H,Ugolini S,Tomasello E,Walzer T,Vivier E

更新日期：2011-11-08 00:00:00