Histone underacetylation is an ancient component of mammalian X chromosome inactivation.

abstract：:The timing of human colonization of East Polynesia, a vast area lying between Hawai'i, Rapa Nui, and New Zealand, is much debated and the underlying causes of this great migration have been enigmatic. Our study generates evidence for human dispersal into eastern Polynesia from islands to the west from around AD 900 an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sear DA,Allen MS,Hassall JD,Maloney AE,Langdon PG,Morrison AE,Henderson ACG,Mackay H,Croudace IW,Clarke C,Sachs JP,Macdonald G,Chiverrell RC,Leng MJ,Cisneros-Dozal LM,Fonville T,Pearson E

更新日期：2020-04-21 00:00:00

abstract：:The prefrontal cortex continues to mature after puberty and into early adulthood, mirroring the time course of maturation of cognitive abilities. However, the way in which prefrontal activity changes during peri- and postpubertal cortical maturation is largely unknown. To address this question, we evaluated the develo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhou X,Zhu D,Katsuki F,Qi XL,Lees CJ,Bennett AJ,Salinas E,Stanford TR,Constantinidis C

更新日期：2014-03-11 00:00:00

abstract：:Many physical and chemical properties of the light rare-earths and actinides are governed by the active role of f electrons, and despite intensive efforts the details of the mechanisms of phase stability and transformation are not fully understood. A prominent example which has attracted a lot of interest, both experi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Krisch M,Farber DL,Xu R,Antonangeli D,Aracne CM,Beraud A,Chiang TC,Zarestky J,Kim DY,Isaev EI,Ahuja R,Johansson B

更新日期：2011-06-07 00:00:00

abstract：:The suprachiasmatic nucleus (SCN) is the principal circadian pacemaker of mammals, coordinating daily rhythms of behavior and metabolism. Circadian timekeeping in SCN neurons revolves around transcriptional/posttranslational feedback loops, in which Period (Per) and Cryptochrome (Cry) genes are negatively regulated by...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maywood ES,Chesham JE,O'Brien JA,Hastings MH

更新日期：2011-08-23 00:00:00

abstract：:Break-induced replication (BIR) refers to recombination-dependent DNA synthesis initiated from one end of a DNA double-strand break and can extend for more than 100 kb. BIR initiates by Rad51-catalyzed strand invasion, but the mechanism for DNA synthesis is not known. Here, we used BrdU incorporation to track DNA synt...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Donnianni RA,Symington LS

更新日期：2013-08-13 00:00:00

abstract：:High titered IgE, IgG, and IgM antibody responses to the major antigenic determinant of penicillin, the benzylpenicilloyl hapten, were elicited by the intraperitoneal injection of the hapten coupled to keyhole limpet hemocyanin mixed with the appropriate adjuvant. However, treatment of such mice with the benzylpenicil...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chiorazzi N,Eshhar Z,Katz DH

更新日期：1976-06-01 00:00:00

abstract：:Complement-stimulated granulocytes adhere to and induce significant 51Cr release from endothelial cells in vitro. Platelets were stimulated to undergo release, and these release products significantly enhanced granulocyte-endothelial cell adherence and granulocyte-induced 51Cr release from endothelial cells. Platelet ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Boogaerts MA,Yamada O,Jacob HS,Moldow CF

更新日期：1982-11-01 00:00:00

abstract：:A recently discovered family of natural anion channelrhodopsins (ACRs) have the highest conductance among channelrhodopsins and exhibit exclusive anion selectivity, which make them efficient inhibitory tools for optogenetics. We report analysis of flash-induced absorption changes in purified wild-type and mutant ACRs,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sineshchekov OA,Li H,Govorunova EG,Spudich JL

更新日期：2016-04-05 00:00:00

abstract：:We report light-induced electron paramagnetic resonance triplet spectra from samples of chloroplasts or digitonin photosystem I particles that depend upon the dark redox state of the bound acceptors of photosystem I. If the reaction centers are prepared in the redox state P-700 A X- FdB-FdA-, then upon illumination at...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Frank HA,McLean MB,Sauer K

更新日期：1979-10-01 00:00:00

abstract：:The insect gut microbiota plays crucial roles in modulating the interactions between the host and intestinal pathogens. Unlike viruses, bacteria, and parasites, which need to be ingested to cause disease, entomopathogenic fungi infect insects through the cuticle and proliferate in the hemolymph. However, interactions ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wei G,Lai Y,Wang G,Chen H,Li F,Wang S

更新日期：2017-06-06 00:00:00

abstract：:Small GTP-binding proteins play a critical role in the regulation of a range of cellular processes--including growth, differentiation, and intracellular transportation. Previously, we isolated a gene, rgp1, encoding a small GTP-binding protein, by differential screening of a rice cDNA library with probe DNAs from rice...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sano H,Ohashi Y

更新日期：1995-05-09 00:00:00

abstract：:A method using PCR amplification and primer extension with fluorescent oligonucleotides was developed to analyze T-cell repertoires. The sizes of the hypervariable CDR3-like regions of the murine T-cell antigen receptor beta chains were measured for all possible V beta-J beta combinations. This analysis shows that bet...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pannetier C,Cochet M,Darche S,Casrouge A,Zöller M,Kourilsky P

更新日期：1993-05-01 00:00:00

abstract：:The rate of derepressed synthesis of a membrane protein required for lactose transport (M protein) by Escherichia coli is increased in response to increased gene dosage to the same extent as the rates of synthesis of beta-galactosidase and galactoside acetylase. However, elevated gene dosage does not increase beta-gal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fox CF

更新日期：1969-07-01 00:00:00

abstract：:The oligodendrocyte (Od), a glial cell that produces myelin in the central nervous system, may be a target for autoreactive T cells in autoimmune demyelinating processes, although not expressing major histocompatibility complex (MHC) products. To analyze Od-T-cell interactions, we selected from normal SJL/J mouse sple...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jewtoukoff V,Lebar R,Bach MA

更新日期：1989-04-01 00:00:00

abstract：:The folding energetics of the mono-N-glycosylated adhesion domain of the human immune cell receptor cluster of differentiation 2 (hCD2ad) were studied systematically to understand the influence of the N-glycan on the folding energy landscape. Fully elaborated N-glycan structures accelerate folding by 4-fold and stabil...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hanson SR,Culyba EK,Hsu TL,Wong CH,Kelly JW,Powers ET

更新日期：2009-03-03 00:00:00

abstract：:Toll-like receptor 4 (TLR4), the principal signaling receptor for lipopolysaccharide (LPS) in mammals, requires the binding of MD-2 to its extracellular domain for maximal responsiveness. MD-2 contains a leader sequence but lacks a transmembrane domain, and we asked whether it is secreted into the medium as an active ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Visintin A,Mazzoni A,Spitzer JA,Segal DM

更新日期：2001-10-09 00:00:00

abstract：:Light emission produced by the reversible collapse of a cavity in a dielectric medium is given an initial, simplified treatment. The agreement between planar and spherical shapes indicates the volume nature of the effect. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schwinger J

更新日期：1993-02-01 00:00:00

abstract：:The migration of lymphocytes into inflammatory tissue requires the migrating cell to overcome mechanical forces produced by blood flow. A generally accepted hypothesis is that these forces are overcome by a multistep sequence of adhesive interactions between lymphocytes and endothelial cells. This hypothesis has been ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Secomb TW,Konerding MA,West CA,Su M,Young AJ,Mentzer SJ

更新日期：2003-06-10 00:00:00

abstract：:The functional unit molecular size of the intestinal brush border membrane-bound Na+/glucose cotransporter was determined by radiation inactivation. Purified brush border membrane vesicles preserved in cryoprotectant buffer were irradiated (-135 degrees C) with high-energy electrons from a 13-MeV (1 eV = 1.602 x 10(-1...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stevens BR,Fernandez A,Hirayama B,Wright EM,Kempner ES

更新日期：1990-02-01 00:00:00

abstract：:The human Bernard-Soulier syndrome is an autosomal recessive disorder of platelet dysfunction presenting with mild thrombocytopenia, circulating "giant" platelets and a bleeding phenotype. The bleeding in patients with the Bernard-Soulier syndrome is disproportionately more severe than suggested by the reduced platele...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ware J,Russell S,Ruggeri ZM

更新日期：2000-03-14 00:00:00

abstract：:Murine-virus-infected erythroleukemia cells cultured in a medium with dimethylsulfoxide or N,N-dimethylformamide are induced to differentiate to erythroid cells. A number of highly polar compounds have a similar effect in inducing erythroid differentiation of the virus-infected cells, as assayed by the appearance of h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tanaka M,Levy J,Terada M,Breslow R,Rifkind RA,Marks PA

更新日期：1975-03-01 00:00:00

abstract：:Flagellar polypeptides of Chlamydomonas reinhardtii were analyzed in two-dimensions by isoelectric focusing and electrophoresis in the presence of sodium dodecyl sulfate. In addition to flagellar tubulin, over 130 polypeptides were resolved and 100 of these were identified as axonemal components in wild-type organisms...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Piperno G,Huang B,Luck DJ

更新日期：1977-04-01 00:00:00

abstract：:We obtain a classification of the irreducible (nonunitary) representations of a connected semisimple Lie group G, in terms of their restriction to a maximal compact subgroup K of G. (A classification in terms of analytic properties of the representations has been given by R. P. Langlands [(1973), mimeographed notes, I...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vogan DA

更新日期：1977-07-01 00:00:00

abstract：:Global supply chains play a critical role in many of the most pressing environmental stresses and social struggles identified by the United Nations' Sustainable Development Goals (SDGs). Responding to calls from the global community, companies are adopting a variety of voluntary practices to improve the environmental ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thorlakson T,de Zegher JF,Lambin EF

更新日期：2018-02-27 00:00:00

abstract：:Society places value on the multiple functions of ecosystems from soil fertility to erosion control to wildlife-carrying capacity, and these functions are potentially threatened by ongoing biodiversity losses. Recent empirically based models using individual species' traits suggest that higher species richness is requ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zavaleta ES,Pasari JR,Hulvey KB,Tilman GD

更新日期：2010-01-26 00:00:00

abstract：:Siphoviridae is the most abundant viral family on earth which infects bacteria as well as archaea. All known siphophages infecting gram+ Lactococcus lactis possess a baseplate at the tip of their tail involved in host recognition and attachment. Here, we report analysis of the p2 phage baseplate structure by X-ray cry...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sciara G,Bebeacua C,Bron P,Tremblay D,Ortiz-Lombardia M,Lichière J,van Heel M,Campanacci V,Moineau S,Cambillau C

更新日期：2010-04-13 00:00:00

abstract：:The availability of gene-targeted mice deficient in the urokinase-type plasminogen activator (uPA), urokinase receptor (uPAR), tissue-type plasminogen activator (tPA), and plasminogen permits a critical, genetic-based analysis of the physiological and pathological roles of the two mammalian plasminogen activators. We ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bugge TH,Flick MJ,Danton MJ,Daugherty CC,Romer J,Dano K,Carmeliet P,Collen D,Degen JL

更新日期：1996-06-11 00:00:00

abstract：:The extracellular hemoglobin of Ascaris has an extremely high oxygen affinity (P50 = 0.004 mmHg). It consists of eight identical subunits of molecular weight 40,600. Their sequence, determined by protein chemistry, shows two tandemly linked globin-like sequences and an 18-residue C-terminal extension. Two N-linked gly...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： De Baere I,Liu L,Moens L,Van Beeumen J,Gielens C,Richelle J,Trotman C,Finch J,Gerstein M,Perutz M

更新日期：1992-05-15 00:00:00

abstract：:Herpesvirus entry into cells requires the coordinated action of multiple virus envelope glycoproteins, including gH, gL, and gB. For EBV, the gp42 protein assembles into complexes with gHgL heterodimers and binds HLA class II to activate gB-mediated membrane fusion with B cells. EBV tropism is dictated by gp42 levels ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sathiyamoorthy K,Jiang J,Möhl BS,Chen J,Zhou ZH,Longnecker R,Jardetzky TS

更新日期：2017-10-10 00:00:00

abstract：:The later stages of cochlear differentiation and the developmental onset of hearing require thyroid hormone. Although thyroid hormone receptors (TRs) are a prerequisite for this process, it is likely that other factors modify TR activity during cochlear development. The mouse cochlea expresses type 2 deiodinase (D2), ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ng L,Goodyear RJ,Woods CA,Schneider MJ,Diamond E,Richardson GP,Kelley MW,Germain DL,Galton VA,Forrest D

更新日期：2004-03-09 00:00:00