Casimir light: a glimpse.

abstract：:Skeletal muscle L-type Ca2+ channels respond to trains of brief depolarizations with a strong shift of the voltage dependence of channel activation toward more negative membrane potentials and slowing of channel deactivation. Increased Ca2+ entry resulting from this potentiation of channel activity may increase contra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Johnson BD,Scheuer T,Catterall WA

更新日期：1994-11-22 00:00:00

abstract：:The Tat protein coded by human immunodeficiency virus (HIV) is a strong activator of viral gene expression from the long terminal repeat (LTR). It appears that Tat-mediated trans-activation of the HIV LTR is predominantly a transcriptional event. It has been reported that Tat acts at the level of both transcriptional ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kamine J,Subramanian T,Chinnadurai G

更新日期：1991-10-01 00:00:00

abstract：:We evaluated the formation and removal of (+-)-3 alpha,4 beta-dihydroxy-1 alpha,2 alpha-epoxy-1,2,3,4- tetrahydrobenzo[c]phenanthrene (BcPHDE)-DNA adducts in two Chinese hamster ovary (CHO) cell lines. One line of repair-proficient cells (MK42) carries a stable 150-fold amplification of the dihydrofolate reductase (DH...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carothers AM,Zhen W,Mucha J,Zhang YJ,Santella RM,Grunberger D,Bohr VA

更新日期：1992-12-15 00:00:00

abstract：:The genetic code in a eukaryotic system has been expanded by the engineering of Escherichia coli tyrosyl-tRNA synthetase (TyrRS) with the Y37V and Q195C mutations (37V195C), which specifically recognize 3-iodo-L-tyrosine rather than L-tyrosine. In the present study, we determined the 3-iodo-L-tyrosine- and L-tyrosine-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kobayashi T,Sakamoto K,Takimura T,Sekine R,Kelly VP,Kamata K,Nishimura S,Yokoyama S

更新日期：2005-02-01 00:00:00

abstract：:We present a simple molecular indexing method for quantitative targeted RNA sequencing, in which mRNAs of interest are selectively captured from complex cDNA libraries and sequenced to determine their absolute concentrations. cDNA fragments are individually labeled so that each molecule can be tracked from the origina...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fu GK,Xu W,Wilhelmy J,Mindrinos MN,Davis RW,Xiao W,Fodor SP

更新日期：2014-02-04 00:00:00

abstract：:The bacterial pathogen Helicobacter pylori chronically infects the human gastric mucosa and is the leading risk factor for the development of gastric cancer. The molecular mechanisms of H. pylori-associated gastric carcinogenesis remain ill defined. In this study, we examined the possibility that H. pylori directly co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Toller IM,Neelsen KJ,Steger M,Hartung ML,Hottiger MO,Stucki M,Kalali B,Gerhard M,Sartori AA,Lopes M,Müller A

更新日期：2011-09-06 00:00:00

abstract：:As a dynamic property of folded proteins, protein compressibility provides important information about the forces that govern structural stability. We relate intrinsic compressibility to stability by using molecular dynamics to identify a molecular basis for the variation in compressibility among globular proteins. We...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dadarlat VM,Post CB

更新日期：2003-12-09 00:00:00

abstract：:Surfactant replacement therapy (SRT) involves instillation of a liquid-surfactant mixture directly into the lung airway tree. It is widely successful for treating surfactant deficiency in premature neonates who develop neonatal respiratory distress syndrome (NRDS). However, when applied to adults with acute respirator...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Filoche M,Tai CF,Grotberg JB

更新日期：2015-07-28 00:00:00

abstract：:Mobilization of the T-cell response against cancer has the potential to achieve long-lasting cures. However, it is not known how to harness antigen-presenting cells optimally to achieve an effective antitumor T-cell response. In this study, we show that anti-CD47 antibody-mediated phagocytosis of cancer by macrophages...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tseng D,Volkmer JP,Willingham SB,Contreras-Trujillo H,Fathman JW,Fernhoff NB,Seita J,Inlay MA,Weiskopf K,Miyanishi M,Weissman IL

更新日期：2013-07-02 00:00:00

abstract：:Intestinal trefoil factor (ITF) is an essential regulator of colonic epithelial restitution, the rapid migration of colonocytes over mucosal wounds. High levels of ITF are frequently present in colorectal cancers and derived cell lines. Mucosal restitution requires the detachment of epithelium from substrate, which wo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Taupin DR,Kinoshita K,Podolsky DK

更新日期：2000-01-18 00:00:00

abstract：:In response to hypoxia the hypoxia-inducible factor-1 (HIF-1) mediates transcriptional activation of a network of genes encoding erythropoietin, vascular endothelial growth factor, and several glycolytic enzymes. HIF-1 consists of a heterodimer of two basic helix-loop-helix PAS (Per/Arnt/Sim) proteins, HIF-1alpha and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kallio PJ,Pongratz I,Gradin K,McGuire J,Poellinger L

更新日期：1997-05-27 00:00:00

abstract：:The human epidermal growth factor receptor (EGFR) is a key representative of tyrosine kinase receptors, ubiquitous actors in cell signaling, proliferation, differentiation, and migration. Although the receptor is well-studied, a central issue remains: How does the compositional diversity and functional diversity of th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Coskun Ü,Grzybek M,Drechsel D,Simons K

更新日期：2011-05-31 00:00:00

abstract：:Human infants are predisposed to rapidly acquire their native language. The nature of these predispositions is poorly understood, but is crucial to our understanding of how infants unpack their speech input to recover the fundamental word-like units, assign them referential roles, and acquire the rules that govern the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shukla M,White KS,Aslin RN

更新日期：2011-04-12 00:00:00

abstract：:Leucine analogs were tested in the Krebs II ascites cell-free translation system for the ability to inhibit preprotein cleavage by replacing leucine in nascent chains of bovine preprolactin, rat preprolactin, human placental prelactogen (pre-hPL), and pre-alpha subunit of human chorionic gonadotropin (alpha-hCG). In t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hortin G,Boime I

更新日期：1980-03-01 00:00:00

abstract：:Helicobacter pylori VacA, a pore-forming toxin secreted by an autotransporter pathway, causes multiple alterations in human cells, contributes to the pathogenesis of peptic ulcer disease and gastric cancer, and is a candidate antigen for inclusion in an H. pylori vaccine. Here, we present a 2.4-A crystal structure of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gangwer KA,Mushrush DJ,Stauff DL,Spiller B,McClain MS,Cover TL,Lacy DB

更新日期：2007-10-09 00:00:00

abstract：:In some countries across the globe, tropical forest cover is increasing. The national-scale reforestation of Vietnam since 1992 is assumed to contribute to this recovery. It is achieved, however, by the displacement of forest extraction to other countries on the order of 49 (34-70) M m(3), or approximately 39% of the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meyfroidt P,Lambin EF

更新日期：2009-09-22 00:00:00

abstract：:The androgen receptor (AR) binds to androgen response elements and regulates target genes via a mechanism involving coregulators. Here we demonstrate that the AR can interact with the testicular orphan receptor-4 (TR4) and function as a repressor to down-regulate the TR4 target genes by preventing the TR4 binding to i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee YF,Shyr CR,Thin TH,Lin WJ,Chang C

更新日期：1999-12-21 00:00:00

abstract：:Recent years have witnessed an increased public outcry in certain quarters about a perceived lack of attention given to successful members of disadvantaged groups relative to equally meritorious members of advantaged groups, exemplified by social media campaigns centered around hashtags, such as #OscarsSoWhite and #Wo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kteily NS,Rocklage MD,McClanahan K,Ho AK

更新日期：2019-01-29 00:00:00

abstract：:Intracerebral hemorrhagic stroke and vascular dementia are age- and hypertension-associated manifestations of human cerebral small vessel disease (SVD). Cerebral microvessels are formed by endothelial cells (ECs), which are connected through tight junctions, adherens junctions, and stabilizing basement membrane struct...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weinl C,Castaneda Vega S,Riehle H,Stritt C,Calaminus C,Wolburg H,Mauel S,Breithaupt A,Gruber AD,Wasylyk B,Olson EN,Adams RH,Pichler BJ,Nordheim A

更新日期：2015-08-11 00:00:00

abstract：:The major small nuclear ribonucleoproteins (snRNPs) U1, U2, U4/U6, and U5 share a set of common proteins denoted B/B', D1, D2, D3, E, F, and G which play an important part in the biogenesis of the snRNPs. In addition, there is a link between the common proteins and autoimmunity; the three D proteins, together with B/B...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lehmeier T,Raker V,Hermann H,Lührmann R

更新日期：1994-12-06 00:00:00

abstract：:Heterochromatin protein 1 (HP1), first discovered in Drosophila melanogaster, is a highly conserved chromosomal protein implicated in both heterochromatin formation and gene silencing. We report here characterization of an HP1-interacting protein, heterochromatin protein 2 (HP2), which codistributes with HP1 in the pe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shaffer CD,Stephens GE,Thompson BA,Funches L,Bernat JA,Craig CA,Elgin SC

更新日期：2002-10-29 00:00:00

abstract：:The HLA class II-associated invariant chain (Ii)-derived peptide (CLIP) occupies the peptide binding groove during assembly in the endoplasmic reticulum, travels with HLA class II to endosomal compartments, and is subsequently released to allow binding of antigenic peptides. We investigated whether the exchange of CLI...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： van Bergen J,Schoenberger SP,Verreck F,Amons R,Offringa R,Koning F

更新日期：1997-07-08 00:00:00

abstract：:Coiled-coil motifs are ubiquitous mediators of specific protein-protein interactions through the formation of interlocking hydrophobic seams between alpha-helical chains. Residues that form these seams occur at the first (a) and fourth (d) positions of a characteristic 7-aa repeat and are primarily aliphatic. The pote...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu J,Yong W,Deng Y,Kallenbach NR,Lu M

更新日期：2004-11-16 00:00:00

abstract：:Optical waveguides simultaneously transport light at different colors, forming the basis of fiber-optic telecommunication networks that shuttle data in dozens of spectrally separated channels. Here, we reimagine this wavelength division multiplexing (WDM) paradigm in a novel context--the differentiated detection and i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ozcelik D,Parks JW,Wall TA,Stott MA,Cai H,Parks JW,Hawkins AR,Schmidt H

更新日期：2015-10-20 00:00:00

abstract：:The mangrove killifish (Kryptolebias marmoratus) is the only vertebrate known to be capable of self-fertilization. Its gonad is typically an ovotestis that simultaneously produces eggs and sperm, and fertilization is internal. Although most populations of this species consist primarily or exclusively of hermaphroditic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mackiewicz M,Tatarenkov A,Taylor DS,Turner BJ,Avise JC

更新日期：2006-06-27 00:00:00

abstract：:Plants produce a wide range of allelochemicals to defend against herbivore attack, and generalist herbivores have evolved mechanisms to avoid, sequester, or detoxify a broad spectrum of natural defense compounds. Successful arthropod pests have also developed resistance to diverse classes of pesticides and this adapta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dermauw W,Wybouw N,Rombauts S,Menten B,Vontas J,Grbic M,Clark RM,Feyereisen R,Van Leeuwen T

更新日期：2013-01-08 00:00:00

abstract：:Neural crest cell derivatives have been suggested to be involved in thymus development. We established nonlymphoid thymic stromal cell cultures capable of supporting T-cell differentiation. In these nonlymphoid cell cultures, we identified cells with phenotypic and biochemical markers specific for neuronal cells. Neur...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Screpanti I,Meco D,Scarpa S,Morrone S,Frati L,Gulino A,Modesti A

更新日期：1992-04-15 00:00:00

abstract：:Effects of thyrotropin-releasing hormone (TRH; thyroliberin) on membrane electrical properties were studied in the clonal rat anterior pituitary cell (GH3) by continuous recording of the intracellular potential. Application of TRH, which stimulates the release of prolactin and growth hormone from the GH3 cell, elicite...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ozawa S,Kimura N

更新日期：1979-11-01 00:00:00

abstract：:Previous research has implicated a large network of brain regions in the processing of risk during decision making. However, it has not yet been determined if activity in these regions is predictive of choices on future risky decisions. Here, we examined functional MRI data from a large sample of healthy subjects perf...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Helfinstein SM,Schonberg T,Congdon E,Karlsgodt KH,Mumford JA,Sabb FW,Cannon TD,London ED,Bilder RM,Poldrack RA

更新日期：2014-02-18 00:00:00

abstract：:E-Cadherin, a cell adhesion molecule, which plays a key role in maintaining the epithelial phenotype, is regarded as an invasion-suppressor gene in light of accumulating evidence from in vitro experiments and clinical observations. In an attempt to clarify the mechanism responsible for inactivation of this gene in car...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yoshiura K,Kanai Y,Ochiai A,Shimoyama Y,Sugimura T,Hirohashi S

更新日期：1995-08-01 00:00:00