Age-dependent changes in prefrontal intrinsic connectivity.

abstract：:Measles virus (MeV) is the poster child for acute infection followed by lifelong immunity. However, recent work shows the presence of MeV RNA in multiple sites for up to 3 mo after infection in a proportion of infected children. Here, we use experimental infection of rhesus macaques to show that prolonged RNA presence...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin WH,Kouyos RD,Adams RJ,Grenfell BT,Griffin DE

更新日期：2012-09-11 00:00:00

abstract：:Some cells from cultured embryonic mouse hypothalamus were found to express aromatic-L-amino acid decarboxylase (EC 4.1.1.28) activity and serotonin uptake and storage. These neuron-like cells differed from serotoninergic neurons in cultured embryonic mouse brain stem since they did not contain tryptophan hydroxylase....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： De Vitry F,Hamon M,Catelon J,Dubois M,Thibault J

更新日期：1986-11-01 00:00:00

abstract：:Immigration and demographic change have become highly salient in American politics, partly because of the 2016 campaign of Donald Trump. Previous research indicates that local influxes of immigrants or unfamiliar ethnic groups can generate threatened responses, but has either focused on nonelectoral outcomes or analyz...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hill SJ,Hopkins DJ,Huber GA

更新日期：2019-12-10 00:00:00

abstract：:An intense investigation of possible non-Fermi liquid states of matter has been inspired by two of the most intriguing phenomena discovered in the past quarter century, namely, high-temperature superconductivity and the fractional quantum Hall effect. Despite enormous conceptual strides, these two fields have develope...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jain JK,Anderson PW

更新日期：2009-06-09 00:00:00

abstract：:Both treatment of disease and basic studies of complex tissues can benefit from directing viral vector infection to specific cell types. We have used a unique cell targeting method to direct viral vector transduction to cerebral cortical neurons expressing the neuregulin (NRG) receptor ErbB4; both NRG and ErbB4 have b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Choi J,Young JA,Callaway EM

更新日期：2010-09-21 00:00:00

abstract：:The human gut is home to trillions of microbes, thousands of bacterial phylotypes, as well as hydrogen-consuming methanogenic archaea. Studies in gnotobiotic mice indicate that Methanobrevibacter smithii, the dominant archaeon in the human gut ecosystem, affects the specificity and efficiency of bacterial digestion of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Samuel BS,Hansen EE,Manchester JK,Coutinho PM,Henrissat B,Fulton R,Latreille P,Kim K,Wilson RK,Gordon JI

更新日期：2007-06-19 00:00:00

abstract：:Multiple drug resistance of tumor cells is a common problem in cancer therapy. We have demonstrated that membrane vesicles from highly multidrug-resistant human KB carcinoma cell lines exhibit increased specific and saturable binding of vinblastine. To identify the molecules that bind vinblastine, membrane vesicles fr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cornwell MM,Safa AR,Felsted RL,Gottesman MM,Pastan I

更新日期：1986-06-01 00:00:00

abstract：:Retinal prosthetics offer hope for patients with retinal degenerative diseases. There are 20-25 million people worldwide who are blind or facing blindness due to these diseases, and they have few treatment options. Drug therapies are able to help a small fraction of the population, but for the vast majority, their bes...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nirenberg S,Pandarinath C

更新日期：2012-09-11 00:00:00

abstract：:p63 inhibits metastasis. Here, we show that p63 (both TAp63 and ΔNp63 isoforms) regulates expression of miR-205 in prostate cancer (PCa) cells, and miR-205 is essential for the inhibitory effects of p63 on markers of epithelial-mesenchymal transition (EMT), such as ZEB1 and vimentin. Correspondingly, the inhibitory ef...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tucci P,Agostini M,Grespi F,Markert EK,Terrinoni A,Vousden KH,Muller PA,Dötsch V,Kehrloesser S,Sayan BS,Giaccone G,Lowe SW,Takahashi N,Vandenabeele P,Knight RA,Levine AJ,Melino G

更新日期：2012-09-18 00:00:00

abstract：:Through use of a synthetic oligonucleotide probe, human insulin-like growth factor I (IGF-I) cDNA clones were isolated from a liver library. Two types of cDNAs were defined by restriction enzyme analysis and DNA sequencing. Both encode IGF-I precursors of either 195 or 153 amino acids. The two predicted protein precur...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rotwein P

更新日期：1986-01-01 00:00:00

abstract：:The question was addressed whether the risk of cancer of an individual in a heterogeneous population can be predicted on the basis of measurable biochemical and biological variables postulated to be associated with the process of chemical carcinogenesis. Using the skin tumor model with outbred male NMRI mice, the late...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fischer WH,Lutz WK

更新日期：1995-06-20 00:00:00

abstract：:An enduring question in correlated systems concerns whether superconductivity is favored at a quantum critical point (QCP) characterized by a divergent quasiparticle effective mass. Despite such a scenario being widely postulated in high T(c) cuprates and invoked to explain non-Fermi liquid transport signatures, exper...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sebastian SE,Harrison N,Altarawneh MM,Mielke CH,Liang R,Bonn DA,Hardy WN,Lonzarich GG

更新日期：2010-04-06 00:00:00

abstract：:Telomerase activity was identified in extracts from several different mouse cell lines. Addition of telomeric TTAGGG repeats was specific to telomeric oligonucleotide primers and sensitive to pretreatment with RNase A. In contrast to the hundreds of repeats synthesized by the human and Tetrahymena telomerase enzymes i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Prowse KR,Avilion AA,Greider CW

更新日期：1993-02-15 00:00:00

abstract：:Hypertension, a remediable risk factor for stroke, cardiovascular disease, and renal failure, affects 50 million individuals in the United States alone. African Americans (blacks) have a higher incidence and prevalence of hypertension and hypertension-associated target organ damage compared with Caucasian Americans (w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Suthanthiran M,Li B,Song JO,Ding R,Sharma VK,Schwartz JE,August P

更新日期：2000-03-28 00:00:00

abstract：:COVID-19 has emerged as one of the deadliest and most disruptive events in recent human history. Drawing from political science and psychological theories, we examine the effects of daily confirmed cases in a country on citizens' support for the political leader through the first 120 d of 2020. Using three unique data...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yam KC,Jackson JC,Barnes CM,Lau J,Qin X,Lee HY

更新日期：2020-10-13 00:00:00

abstract：:The product of the Escherichia coli secB gene is required for efficient export of proteins across the cytoplasmic membrane. The studies described in this report show that in wild-type growing cells, SecB protein associates with precursor forms of exported proteins, such as the periplasmic maltose-binding protein (MBP)...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kumamoto CA

更新日期：1989-07-01 00:00:00

abstract：:Direct reciprocity and conditional cooperation are important mechanisms to prevent free riding in social dilemmas. However, in large groups, these mechanisms may become ineffective because they require single individuals to have a substantial influence on their peers. However, the recent discovery of zero-determinant ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hilbe C,Wu B,Traulsen A,Nowak MA

更新日期：2014-11-18 00:00:00

abstract：:The production of hybridomas between immunologically activated T cells and malignant T-cell lines offers a potentially unlimited source of soluble T-cell-derived products. Recently, human T-T hybrids have been described; however, their use has been hampered by slow growth and chromosomal instability due at least in pa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Foung SK,Sasaki DT,Grumet FC,Engleman EG

更新日期：1982-12-01 00:00:00

abstract：:The interaction between mutations in the tumor-suppressor genes Apc and p53 was studied in congenic mouse strains to minimize the influence of polymorphic modifiers. The multiplicity and invasiveness of intestinal adenomas of Apc(Min/+) (Min) mice was enhanced by deficiency for p53. In addition, the occurrence of desm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Halberg RB,Katzung DS,Hoff PD,Moser AR,Cole CE,Lubet RA,Donehower LA,Jacoby RF,Dove WF

更新日期：2000-03-28 00:00:00

abstract：:The generation of high-titer, helper-free retroviruses by transient transfection has been achieved by using the highly transfectable 293T cell line into which are stably introduced constructs that express retroviral packaging functions. The resulting ecotropic virus packaging cell line BOSC 23 produces infectious retr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pear WS,Nolan GP,Scott ML,Baltimore D

更新日期：1993-09-15 00:00:00

abstract：:Cloned DNA probes containing genes coding for the large subunit of ribulose-1,5-bisphosphate carboxylase (rbcA) of corn and of Chlamydomonas were used to identify, by heterologous hybridization, DNA fragments from Anabaena 7120 carrying the corresponding gene sequence. The same probes were used to isolate, from a reco...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Curtis SE,Haselkorn R

更新日期：1983-04-01 00:00:00

abstract：:In mantle cell lymphoma (MCL), the translocation t(11;14) is considered the cytogenetic hallmark of the disease. Recently, however, deletion of the chromosomal region 11q22-q23 has been identified as a frequent event in this type of cancer, indicating the existence of a pathogenically relevant tumor suppressor gene in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schaffner C,Idler I,Stilgenbauer S,Döhner H,Lichter P

更新日期：2000-03-14 00:00:00

abstract：:Recombinational repair of double-stranded DNA gaps was investigated in Ustilago maydis. The experimental system was designed for analysis of repair of an autonomously replicating plasmid containing a cloned gene disabled by an internal deletion. It was discovered that crossing over rarely accompanied gap repair. The s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ferguson DO,Holloman WK

更新日期：1996-05-28 00:00:00

abstract：:Flowering plants often prevent selfing through mechanisms of self-incompatibility (S.I.). The loss of S.I. has occurred many times independently, because it provides short-term advantages in situations where pollinators or mates are rare. The genus Capsella, which is closely related to Arabidopsis, contains a pair of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guo YL,Bechsgaard JS,Slotte T,Neuffer B,Lascoux M,Weigel D,Schierup MH

更新日期：2009-03-31 00:00:00

abstract：:The sophistication of the insect olfactory system is elegantly demonstrated by the reception of sex pheromone by the Japanese beetle. In this insect, two olfactory receptor neurons housed in antennal sensilla placodea are highly sensitive. One neuron specifically detects the sex pheromone produced by conspecific femal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ishida Y,Leal WS

更新日期：2008-07-01 00:00:00

abstract：:A 2.5-fold stimulation of cyclic AMP cellular content is measured 60 sec after addition of 100 nM synthetic ovine corticotropin-releasing factor (C-RF; corticoliberin) to rat anterior pituitary cells in culture. A maximal response of cyclic AMP content at 400% above control is observed between 2 and 30 min after addit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Giguère V,Labrie F,Côté J,Coy DH,Sueiras-Diaz J,Schally AV

更新日期：1982-06-01 00:00:00

abstract：:Apolipoprotein(a) [apo(a)] is the distinguishing protein component of lipoprotein(a), a major inherited risk factor for atherosclerosis. Human apo(a) is homologous to plasminogen. It contains from 15 to 50 repeated domains closely related to plasminogen kringle four, plus single kringle five-like and inactive protease...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lawn RM,Schwartz K,Patthy L

更新日期：1997-10-28 00:00:00

abstract：:We have developed three computer programs for comparisons of protein and DNA sequences. They can be used to search sequence data bases, evaluate similarity scores, and identify periodic structures based on local sequence similarity. The FASTA program is a more sensitive derivative of the FASTP program, which can be us...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pearson WR,Lipman DJ

更新日期：1988-04-01 00:00:00

abstract：:A detailed experimental investigation of Fe1+y Te (y = 0.11, 0.12) using pulsed magnetic fields up to 60 T confirms remarkable magnetic shape-memory (MSM) effects. These effects result from magnetoelastic transformation processes in the low-temperature antiferromagnetic state of these materials. The observation of mod...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rößler S,Koz C,Wang Z,Skourski Y,Doerr M,Kasinathan D,Rosner H,Schmidt M,Schwarz U,Rößler UK,Wirth S

更新日期：2019-08-20 00:00:00

abstract：:Immunological memory is a hallmark of adaptive immunity, and understanding T cell memory will be central to the development of effective cell-mediated vaccines. The characteristics and functions of CD4 memory cells have not been well defined. Here we demonstrate that the increased size of the secondary response is sol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： MacLeod MK,McKee A,Crawford F,White J,Kappler J,Marrack P

更新日期：2008-09-23 00:00:00