Stimulation of cyclic AMP accumulation and corticotropin release by synthetic ovine corticotropin-releasing factor in rat anterior pituitary cells: site of glucocorticoid action.

abstract：:The fdhF gene encoding the 80-kDa selenopolypeptide subunit of formate dehydrogenase H from Escherichia coli contains an in-frame TGA codon at amino acid position 140, which encodes selenocysteine. We have analyzed how this UGA "sense codon" is discriminated from a UGA codon signaling polypeptide chain termination. De...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zinoni F,Heider J,Böck A

更新日期：1990-06-01 00:00:00

abstract：:Sustained activation of N-methyl-d-aspartate (NMDA) -type glutamate receptors leads to excitotoxic neuronal death in stroke, brain trauma, and neurodegenerative disorders. Superoxide production by NADPH oxidase is a requisite event in the process leading from NMDA receptor activation to excitotoxic death. NADPH oxidas...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lam TI,Brennan-Minnella AM,Won SJ,Shen Y,Hefner C,Shi Y,Sun D,Swanson RA

更新日期：2013-11-12 00:00:00

abstract：:We describe a form of amnesia, which we have called visual memory-deficit amnesia, that is caused by damage to areas of the visual system that store visual information. Because it is caused by a deficit in access to stored visual material and not by an impaired ability to encode or retrieve new material, it has the ot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rubin DC,Greenberg DL

更新日期：1998-04-28 00:00:00

abstract：:With 13C NMR, phosphoglucose isomerase (PGI; D-glucose-6-phosphate ketol-isomerase, EC 5.3.1.9) is shown to produce mannose 6-phosphate (M6P) slowly from a much more rapidly catalyzed equilibrium between glucose 6-phosphate (G6P) and fructose 6-phosphate (F6P). The identity of M6P and its formation from G6P plus F6P a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seeholzer SH

更新日期：1993-02-15 00:00:00

abstract：:Isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) represent the two central intermediates in the biosynthesis of isoprenoids. The recently discovered deoxyxylulose 5-phosphate pathway generates a mixture of IPP and DMAPP in its final step by reductive dehydroxylation of 1-hydroxy-2-methyl-2-butenyl 4...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gräwert T,Span I,Eisenreich W,Rohdich F,Eppinger J,Bacher A,Groll M

更新日期：2010-01-19 00:00:00

abstract：:The genetic basis for virulence in influenza virus is largely unknown. To explore the mutational basis for increased virulence in the lung, the H3N2 prototype clinical isolate, A/HK/1/68, was adapted to the mouse. Genomic sequencing provided the first demonstration, to our knowledge, that a group of 11 mutations can c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brown EG,Liu H,Kit LC,Baird S,Nesrallah M

更新日期：2001-06-05 00:00:00

abstract：:The incidence of pediatric adrenal cortical carcinoma (ACC) in southern Brazil is 10-15 times higher than that of pediatric ACC worldwide. Because childhood ACC is associated with Li-Fraumeni syndrome, we examined the cancer history and p53 status of 36 Brazilian patients and their families. Remarkably, 35 of 36 patie...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ribeiro RC,Sandrini F,Figueiredo B,Zambetti GP,Michalkiewicz E,Lafferty AR,DeLacerda L,Rabin M,Cadwell C,Sampaio G,Cat I,Stratakis CA,Sandrini R

更新日期：2001-07-31 00:00:00

abstract：:The rat brain increases >6x in mass from birth to adulthood, presumably through the addition of glial cells and increasing neuronal size, without the addition of neurons. To test this hypothesis, here we investigate quantitatively the postnatal changes in the total number of neuronal and non-neuronal cells in the deve...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bandeira F,Lent R,Herculano-Houzel S

更新日期：2009-08-18 00:00:00

abstract：:Emergence of antiestrogen-resistant cells in MCF-7 cells during suppression of estrogen signaling is a widely accepted model of acquired breast cancer resistance to endocrine therapy. To obtain insight into the genomic basis of endocrine therapy resistance, we characterized MCF-7 monoclonal sublines that survived 21-d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Coser KR,Wittner BS,Rosenthal NF,Collins SC,Melas A,Smith SL,Mahoney CJ,Shioda K,Isselbacher KJ,Ramaswamy S,Shioda T

更新日期：2009-08-25 00:00:00

abstract：:Ubiquitin C-terminal hydrolase L1 (UCH-L1) is one of the most abundant and enigmatic enzymes of the CNS. Based on existing UCH-L1 knockout models, UCH-L1 is thought to be required for the maintenance of axonal integrity, but not for neuronal development despite its high expression in neurons. Several lines of evidence...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reinicke AT,Laban K,Sachs M,Kraus V,Walden M,Damme M,Sachs W,Reichelt J,Schweizer M,Janiesch PC,Duncan KE,Saftig P,Rinschen MM,Morellini F,Meyer-Schwesinger C

更新日期：2019-04-16 00:00:00

abstract：:We report the use of engineered ribozymes to shuffle exon cassettes in vitro. Specifically, we have designed derivatives of a group II intron that insert into selected sites in the human tissue plasminogen activator (t-PA) mRNA. The insertion reaction links t-PA sequences to the group II intron sequences so that trans...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mikheeva S,Jarrell KA

更新日期：1996-07-23 00:00:00

abstract：:CHD7 encodes an ATP-dependent chromatin remodeling factor. Mutation of this gene causes multiple developmental disorders, including CHARGE (Coloboma of the eye, Heart defects, Atresia of the choanae, Retardation of growth/development, Genital abnormalities, and Ear anomalies) syndrome, in which conotruncal anomalies a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yan S,Thienthanasit R,Chen D,Engelen E,Brühl J,Crossman DK,Kesterson R,Wang Q,Bouazoune K,Jiao K

更新日期：2020-11-17 00:00:00

abstract：:Future nuclear arms reduction efforts will require technologies to verify that warheads slated for dismantlement are authentic without revealing any sensitive weapons design information to international inspectors. Despite several decades of research, no technology has met these requirements simultaneously. Recent wor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vavrek JR,Henderson BS,Danagoulian A

更新日期：2018-04-24 00:00:00

abstract：:In 2005 four outstanding multiple burials were discovered near Eulau, Germany. The 4,600-year-old graves contained groups of adults and children buried facing each other. Skeletal and artifactual evidence and the simultaneous interment of the individuals suggest the supposed families fell victim to a violent event. In...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Haak W,Brandt G,de Jong HN,Meyer C,Ganslmeier R,Heyd V,Hawkesworth C,Pike AW,Meller H,Alt KW

更新日期：2008-11-25 00:00:00

abstract：:This paper shows that the most predictable components of internal variability in coupled atmosphere-ocean models are remarkably similar to the most predictable components of climate models without interactive ocean dynamics (i.e., models whose ocean is represented by a 50-m-deep slab ocean mixed layer with no interact...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Srivastava A,DelSole T

更新日期：2017-02-28 00:00:00

abstract：:To determine whether the human pituitary contains a previously unidentified, nonprolactin (non-hPRL), non-growth-hormone (non-hGH) factor capable of stimulating mammary development, we tested the effects of whole human pituitary extract (hPE) and pituitary extracts depleted of hPRL and hGH ("stripped hPE") in hypophys...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Newman CB,Cosby H,Friesen HG,Feldman M,Cooper P,De Crescito V,Pilon M,Kleinberg DL

更新日期：1987-11-01 00:00:00

abstract：:A patient with type II diabetes associated with hyperproinsulinemia has been shown to have a point mutation in one insulin gene allele, resulting in replacement of histidine with aspartic acid at position 10 of the B-chain. To investigate the basis of the proinsulin processing defect, we introduced an identical mutati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gross DJ,Halban PA,Kahn CR,Weir GC,Villa-Komaroff L

更新日期：1989-06-01 00:00:00

abstract：:Apolipoprotein A-I (apo A-I), the major apolipoprotein in human high density lipoproteins, is involved in the disease atherosclerosis. Cloned apo A-I cDNA (pA1-3) was used as a probe in chromosome mapping studies to detect the human apo A-I structural gene sequence in human-Chinese hamster cell hybrids. Southern blot ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheung P,Kao FT,Law ML,Jones C,Puck TT,Chan L

更新日期：1984-01-01 00:00:00

abstract：:The toxic, mutagenic, and carcinogenic effects of alkylating agents have been attributed to their ability to damage DNA. Reaction at the O6 position of guanine results in miscoding during DNA replication, has been shown to be mutagenic in both bacteriophage and bacteria, and may be responsible for malignant transforma...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brennand J,Margison GP

更新日期：1986-09-01 00:00:00

abstract：:Efficient execution of perceptual-motor tasks requires rapid voluntary reconfiguration of cognitive task sets as circumstances unfold. Such acts of cognitive control, which are thought to rely on a network of cortical regions in prefrontal and posterior parietal cortex, include voluntary shifts of attention among perc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Esterman M,Chiu YC,Tamber-Rosenau BJ,Yantis S

更新日期：2009-10-20 00:00:00

abstract：:The spectrum of cellular targets in the autoimmune diseases is both large and varied and includes among the nuclear components the so-called Sm and RNP antigens associated with systemic lupus erythematosus. The use of immunoaffinity chromatography with dual specificity for the Sm and RNP antigens has allowed for their...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： White PJ,Gardner WD,Hoch SO

更新日期：1981-01-01 00:00:00

abstract：:Social insects are promising new models in aging research. Within single colonies, longevity differences of several magnitudes exist that can be found elsewhere only between different species. Reproducing queens (and, in termites, also kings) can live for several decades, whereas sterile workers often have a lifespan ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Elsner D,Meusemann K,Korb J

更新日期：2018-05-22 00:00:00

abstract：:Membrane-integrated type II phosphatidic acid phosphatases (PAP2s) are important for numerous bacterial to human biological processes, including glucose transport, lipid metabolism, and signaling. Escherichia coli phosphatidylglycerol-phosphate phosphatase B (ecPgpB) catalyzes removing the terminal phosphate group fro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fan J,Jiang D,Zhao Y,Liu J,Zhang XC

更新日期：2014-05-27 00:00:00

abstract：:Two mouse monoclonal anti-anti-idiotopic antibodies (anti-anti-Id, Ab3), AF14 and AF52, were prepared by immunizing BALB/c mice with rabbit polyclonal anti-idiotypic antibodies (anti-Id, Ab2) raised against antibody D1.3 (Ab1) specific for the antigen hen egg lysozyme. AF14 and AF52 react with an "internal image" mono...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goldbaum FA,Velikovsky CA,Dall'Acqua W,Fossati CA,Fields BA,Braden BC,Poljak RJ,Mariuzza RA

更新日期：1997-08-05 00:00:00

abstract：:The p21(WAF1) (p21) cyclin-dependent kinase inhibitor plays a major role in regulating cell cycle arrest. It was recently reported that the p53-independent elevation of p21 protein levels is essential in mediating the G(1) arrest resulting from signal transduction events initiated by the crosslinking of membrane IgM o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marches R,Hsueh R,Uhr JW

更新日期：1999-07-20 00:00:00

abstract：:The tails of newborn rats, consisting of slender continuous cones of avascular cartilage, were transplanted in subcutaneous spaces of allogeneic adolescents; colloidal carbon was injected in a vein before the transplants were harvested on days 7-28. Between 97 and 100% of the transplants were accepted, underwent diffe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huggins CB,Anderson KP

更新日期：1976-09-01 00:00:00

abstract：:Chaperones of the Hsp70 family bind to unfolded or partially folded polypeptides to facilitate many cellular processes. ATP hydrolysis and substrate binding, the two key molecular activities of this chaperone, are modulated by the cochaperone DnaJ. By using both genetic and biochemical approaches, we provide evidence ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Suh WC,Burkholder WF,Lu CZ,Zhao X,Gottesman ME,Gross CA

更新日期：1998-12-22 00:00:00

abstract：:The phagocyte NADPH oxidase, dormant in resting cells, is activated during phagocytosis to produce superoxide, a precursor of microbicidal oxidants. The activated oxidase is a complex of membrane-integrated cytochrome b558, composed of 91-kDa (gp91phox) and 22-kDa (p22phox) subunits, and two cytosolic factors (p47phox...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sumimoto H,Kage Y,Nunoi H,Sasaki H,Nose T,Fukumaki Y,Ohno M,Minakami S,Takeshige K

更新日期：1994-06-07 00:00:00

abstract：:Nascent precursors of phosphatidylinositol-glycan (PI-G)-linked membrane proteins contain a hydrophobic COOH-terminal sequence of 15-30 residues that is eliminated during processing to yield a newly exposed COOH terminus to which the PI-G moiety is added. There is no consensus as to the primary structure of the termin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Micanovic R,Kodukula K,Gerber LD,Udenfriend S

更新日期：1990-10-01 00:00:00

abstract：:The exquisite selectivity and catalytic activity of enzymes have been shaped by the effects of positive and negative selection pressure during the course of evolution. In contrast, enzyme variants engineered by using in vitro screening techniques to accept novel substrates typically display a higher degree of catalyti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Varadarajan N,Gam J,Olsen MJ,Georgiou G,Iverson BL

更新日期：2005-05-10 00:00:00