Visual memory-deficit amnesia: a distinct amnesic presentation and etiology.

abstract：:Inactivation of the recently identified murMN operon in penicillin-resistant strains of Streptococcus pneumoniae was shown already to cause two major effects: elimination of branched-structured muropeptides from the cell wall and complete loss of penicillin resistance. We now show that cells with inactivated murMN als...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Filipe SR,Severina E,Tomasz A

更新日期：2002-02-05 00:00:00

abstract：:Proofreading mechanisms increase specificity in biochemical reactions by allowing for the dissociation of intermediate complexes. These mechanisms disrupt and reset the reaction to undo errors at the cost of increased time of reaction and free energy expenditure. Here, we draw an analogy between proofreading and micro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murugan A,Huse DA,Leibler S

更新日期：2012-07-24 00:00:00

abstract：:Representations of scientific knowledge must reflect the dynamic nature of knowledge construction and the evolving networks of relations between scientific concepts. In this article, we describe initial work toward dynamic, visual methods and tools that support the construction, communication, revision, and applicatio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： MacEachren AM,Gahegan M,Pike W

更新日期：2004-04-06 00:00:00

abstract：:Using a novel Escherichia coli in vitro decay system in which polysomes are the source of both enzymes and mRNA, we demonstrate a requirement for poly(A) polymerase I (PAP I) in mRNA turnover. The in vitro decay of two different mRNAs (trxA and lpp) is triggered by the addition of ATP only when polysomes are prepared ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ingle CA,Kushner SR

更新日期：1996-11-12 00:00:00

abstract：:An excised patch of embryonic muscle membrane was used as a probe for measuring the release of acetylcholine (AcCho) from growing spinal neurons in Xenopus cell culture. The neuron was stimulated extracellularly at the soma, and the evoked AcCho release was monitored at the growth cone, along the neurite, and near the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sun YA,Poo MM

更新日期：1987-04-01 00:00:00

abstract：:Newly synthesized rat islet proteins have been analyzed by polyacrylamide slab gel electrophoresis and fluorography. A minor component having an apparent molecular weight of 11,100 was identified as preproinsulin by the sensitivity of its synthesis to glucose, the pattern of NH2-terminal leucine residues, and the rapi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Patzelt C,Labrecque AD,Duguid JR,Carroll RJ,Keim PS,Heinrikson RL,Steiner DF

更新日期：1978-03-01 00:00:00

abstract：:The B cell developmental pathway represents a leading system for the analysis of regulatory circuits that orchestrate cell fate specification and commitment. Considerable progress has been achieved within the past decade in the identification and genetic analysis of various regulatory components. These components incl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Singh H,Medina KL,Pongubala JM

更新日期：2005-04-05 00:00:00

abstract：:Extracellular matrix (ECM) profoundly influences the growth and differentiation of the mammary gland epithelium, both in culture and in vivo. Utilizing a clonal population of mouse mammary epithelial cells that absolutely requires an exogenous ECM for function, we developed a rapid assay to study signal transduction b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roskelley CD,Desprez PY,Bissell MJ

更新日期：1994-12-20 00:00:00

abstract：:Bacteriophage 434 encodes a repressor that, like bacteriophage lambda repressor, both activates and represses transcription. As in the lambda chromosome, a region of the 434 chromosome, called the right operator, contains three repressor binding sites (OR1, OR2, and OR3) that mediate these effects on two adjacent prom...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bushman FD,Ptashne M

更新日期：1986-12-01 00:00:00

abstract：:Exposure of Chinese hamster cells to reduced oxygen partial pressure results in a marked enhancement in the frequency of methotrexate resistance and dihydrofolate reductase gene amplification. The frequency of enhanced resistance is a function of the length of exposure to hypoxic conditions and the time after recovery...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rice GC,Hoy C,Schimke RT

更新日期：1986-08-01 00:00:00

abstract：:The importance of core histones in the regulation of DNA function by chromatin is clear. However, little is known about the role of the linker histone. We investigated the role of H1 in Saccharomyces cerevisiae during extensive transcriptional reprogramming in stationary phase. Although the levels of linker histone Hh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schäfer G,McEvoy CR,Patterton HG

更新日期：2008-09-30 00:00:00

abstract：:Two genes encoding steroid 21-hydroxylase [21-OHase; steroid 21-monooxygenase; steroid, hydrogen-donor: oxygen oxidoreductase (21-hydroxylating); EC 1.14.99.10], a cytochrome P-450 enzyme, have been located within the HLA major histocompatibility complex. Congenital adrenal hyperplasia due to 21-OHase deficiency is a ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： White PC,Grossberger D,Onufer BJ,Chaplin DD,New MI,Dupont B,Strominger JL

更新日期：1985-02-01 00:00:00

abstract：:Bacteria in the human oral cavity often grow in an attached multispecies biofilm community. Members of this community display defined interactions that have an impact on the physiology of the individual and the group. Here, we show that during coculture growth with streptococci, the oral pathogen Aggregatibacter actin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ramsey MM,Whiteley M

更新日期：2009-02-03 00:00:00

abstract：:A highly specific radioimmunoassay for one of the putative adrenomedullary [Met]enkephalin precursors, BAM-12P (Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val-Gly-Arg-Pro-Glu-OH), has been developed. The BAM-12P antibodies recognize the COOH-terminal fragment of the peptide from Arg7 to Glu12 and do not crossreact with [Met5]- or [L...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baird A,Ling N,Böhlen P,Benoit R,Klepper R,Guillemin R

更新日期：1982-03-01 00:00:00

abstract：:Absorbance changes of C-550 and cytochrome b(559), and fluorescence-yield changes were measured during irradiation of chloroplasts at -196 degrees . The photo-reduction of C-550 proceeded more rapidly than the photo-oxidation of cytochrome b(559), and the fluorescence-yield change had similar kinetics to the cytochrom...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Butler WL

更新日期：1972-11-01 00:00:00

abstract：:Dust grains of organic matter were the main reservoir of C and N in the forming Solar System and are thus considered to be an essential ingredient for the emergence of life. However, the physical environment and the chemical mechanisms at the origin of these organic grains are still highly debated. In this study, we r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tartèse R,Chaussidon M,Gurenko A,Delarue F,Robert F

更新日期：2018-08-21 00:00:00

abstract：:Porcine and bovine GH receptor (GHR) cDNAs were stably expressed in mouse L cells, which normally do not possess detectable levels of mouse GHR. Expression of the GHR cDNAs resulted in specific binding of 125I-labeled GH by these cell lines. To study GHR-related signaling events in these cells, protein tyrosine phosph...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang X,Xu B,Souza SC,Kopchick JJ

更新日期：1994-02-15 00:00:00

abstract：:Gold nanoparticles (NPs) wrapped in a membrane can be utilized as artificial virus nanoparticles (AVNs) that combine the large nonblinking or bleaching optical cross-section of the NP core with the biological surface properties and functionalities provided by a self-assembled lipid membrane. We used these hybrid nanom...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu F,Bandara A,Akiyama H,Eshaghi B,Stelter D,Keyes T,Straub JE,Gummuluru S,Reinhard BM

更新日期：2018-09-25 00:00:00

abstract：:Using single-cell sequence analysis, we discovered that a high proportion of cells in tissues as diverse as buccal epithelium and heart muscle contain high proportions of clonal mutant mtDNA expanded from single initial mutant mtDNA molecules. We demonstrate that intracellular clonal expansion of somatic point mutatio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nekhaeva E,Bodyak ND,Kraytsberg Y,McGrath SB,Van Orsouw NJ,Pluzhnikov A,Wei JY,Vijg J,Khrapko K

更新日期：2002-04-16 00:00:00

abstract：:Aptamers recognize their targets with extraordinary affinity and specificity. The aptamer-based therapeutic, Macugen, is derived from a modified 2'fluoro pyrimidine RNA inhibitor to vascular endothelial growth factor (VEGF) and is now being used to treat the wet form of age-related macular degeneration. This VEGF(165)...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee JH,Canny MD,De Erkenez A,Krilleke D,Ng YS,Shima DT,Pardi A,Jucker F

更新日期：2005-12-27 00:00:00

abstract：:Oocyte endowment dwindles away during prepubertal and adult life until menopause occurs, and apoptosis has been identified as a central mechanism responsible for oocyte elimination. A few recent reports suggest that uncontrolled inflammation may adversely affect ovarian reserve. We tested the possible role of the proi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Uri-Belapolsky S,Shaish A,Eliyahu E,Grossman H,Levi M,Chuderland D,Ninio-Many L,Hasky N,Shashar D,Almog T,Kandel-Kfir M,Harats D,Shalgi R,Kamari Y

更新日期：2014-08-26 00:00:00

abstract：:Advanced personalized medical diagnostics depend on the availability of high-quality biological samples. These are typically biofluids, such as blood, saliva, or urine; and their collection and storage is critical to obtain reliable results. Without proper temperature regulation, protein biomarkers in particular can d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kluge JA,Li AB,Kahn BT,Michaud DS,Omenetto FG,Kaplan DL

更新日期：2016-05-24 00:00:00

abstract：:We have attempted to model human metastatic disease by implanting human target organs into the immunodeficient C.B-17 scid/scid (severe combined immunodeficiency; SCID) mouse, creating SCID-hu mice. Preferential metastasis to implants of human fetal lung and human fetal bone marrow occurred after i.v. injection of hum...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shtivelman E,Namikawa R

更新日期：1995-05-09 00:00:00

abstract：:Calls for the eradication of malaria require the development of global and regional strategies based on a strong and consistent evidence base. Evidence from the previous global malaria eradication program and more recent transborder control campaigns have shown the importance of accounting for human movement in introd...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tatem AJ,Smith DL

更新日期：2010-07-06 00:00:00

abstract：:This article briefly summarizes the research activities in the field of hydrogen storage in sorbent materials and reports our recent works and future directions for the design of such materials. Distinct features of sorption-based hydrogen storage methods are described compared with metal hydrides and complex chemical...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Park N,Choi K,Hwang J,Kim DW,Kim DO,Ihm J

更新日期：2012-12-04 00:00:00

abstract：:Work with non-human primates had previously demonstrated that the mid-dorsolateral frontal cortex, which comprises cytoarchitectonic areas 46 and 9, plays a critical role in the performance of non-spatial self-ordered working memory tasks, whereas the immediately adjacent posterior dorsolateral frontal cortex (area 8)...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Petrides M,Alivisatos B,Evans AC,Meyer E

更新日期：1993-02-01 00:00:00

abstract：:The photosystem II (PSII) subunit S (PsbS) plays a key role in nonphotochemical quenching, a photoprotective mechanism for dissipation of excess excitation energy in plants. The precise function of PsbS in nonphotochemical quenching is unknown. By reconstituting PsbS together with the major light-harvesting complex of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wilk L,Grunwald M,Liao PN,Walla PJ,Kühlbrandt W

更新日期：2013-04-02 00:00:00

abstract：:The appearance of jaws was a turning point in vertebrate evolution because it allowed primitive vertebrates to capture and process large, motile prey. The vertebrate jaw consists of separate dorsal and ventral skeletal elements connected by a joint. How this structure evolved from the unjointed gill bar of a jawless a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cerny R,Cattell M,Sauka-Spengler T,Bronner-Fraser M,Yu F,Medeiros DM

更新日期：2010-10-05 00:00:00

abstract：:The NMR spectra at 220 MHz of lysinevasopressin and its precursors were measured in dimethyl sulfoxide, and the peaks were assigned to specific protons. Information about hydrogen bonding was obtained from the temperature coefficients of the chemical shifts. With these data, and with several chemical-shift positions a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Von Dreele PH,Brewster AI,Scheraga HA,Ferger MF,Du Vigneaud V

更新日期：1971-05-01 00:00:00

abstract：:We identified cell surface markers associated with repression of p16(INK4a)/cyclin-dependent kinase inhibitor 2A(CDKN2A), a critical determinant in the acquisition of a plastic state. These cell surface markers allowed direct isolation of rare cells from healthy human breast tissue that exhibit extensive lineage plast...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roy S,Gascard P,Dumont N,Zhao J,Pan D,Petrie S,Margeta M,Tlsty TD

更新日期：2013-03-19 00:00:00