Abstract:
:Bacteria in the human oral cavity often grow in an attached multispecies biofilm community. Members of this community display defined interactions that have an impact on the physiology of the individual and the group. Here, we show that during coculture growth with streptococci, the oral pathogen Aggregatibacter actinomycetemcomitans displays enhanced resistance to killing by host innate immunity. The mechanism of resistance involves sensing of the streptococcal metabolite hydrogen peroxide by A. actinomycetemcomitans, which stimulates a genetic program resulting in enhanced expression of the complement resistance protein ApiA. The oxidative stress response regulator OxyR mediates induction of apiA transcription, and this induction is required for coculture resistance to killing by human serum. These findings provide evidence that interaction between community members mediates prokaryotic resistance to host innate immunity and reinforce the need to understand how polymicrobial growth affects interaction with the host immune system.
journal_name
Proc Natl Acad Sci U S Aauthors
Ramsey MM,Whiteley Mdoi
10.1073/pnas.0809533106subject
Has Abstractpub_date
2009-02-03 00:00:00pages
1578-83issue
5eissn
0027-8424issn
1091-6490pii
0809533106journal_volume
106pub_type
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更新日期:2016-12-20 00:00:00