Isolation and characterization of a highly enriched preparation of receptosomes (endosomes) from a human cell line.

abstract：:Prior incubation of quiescent cultures of Swiss 3T3 cells with vasopressin leads to loss of mitogenic stimulation on its subsequent addition in the presence of a synergistic growth factor. This desensitization is selective for vasopressin, requires prolonged incubation (half-maximal desensitization after 12 hr of trea...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Collins MK,Rozengurt E

更新日期：1983-04-01 00:00:00

abstract：:Biotin carboxylase [biotin-carboxyl-carrier-protein:carbon-dioxide ligase (ADP-forming), EC 6.3.4.14] is the enzyme mediating the first step of the acetyl-CoA carboxylase [acetyl-CoA:carbon-dioxide ligase (ADP-forming), EC 6.4.1.2] reaction. We screened an Escherichia coli DNA library and a DNA fragment carrying the b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kondo H,Shiratsuchi K,Yoshimoto T,Masuda T,Kitazono A,Tsuru D,Anai M,Sekiguchi M,Tanabe T

更新日期：1991-11-01 00:00:00

abstract：:Cells are dynamical systems of biomolecular interactions that process information from their environment to mount diverse yet specific responses. A key property of many self-organized systems is that of criticality: a state of a system in which, on average, perturbations are neither dampened nor amplified, but are pro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nykter M,Price ND,Aldana M,Ramsey SA,Kauffman SA,Hood LE,Yli-Harja O,Shmulevich I

更新日期：2008-02-12 00:00:00

abstract：:BCL6 encodes a transcriptional repressor that is essential for the germinal center (GC) reaction and important in lymphomagenesis. Although its promoter has been well studied, little is known concerning its possible regulation by more distal elements. To gain such information, we mapped critical histone modifications ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ramachandrareddy H,Bouska A,Shen Y,Ji M,Rizzino A,Chan WC,McKeithan TW

更新日期：2010-06-29 00:00:00

abstract：:The gene EPXH2 encodes for the soluble epoxide hydrolase (sEH), an enzyme involved in the regulation of cardiovascular and renal physiology containing two distinct domains connected via a proline-rich linker. The C-terminal domain containing the EH catalytic activity has been well studied. In contrast, a function for ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Newman JW,Morisseau C,Harris TR,Hammock BD

更新日期：2003-02-18 00:00:00

abstract：:Humans who have inherited the class I major histocompatibility allele HLA-A29 have a markedly increased relative risk of developing the eye disease termed birdshot chorioretinopathy. This disease affecting adults is characterized by symmetrically scattered, small, cream-colored spots in the fundus associated with reti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Szpak Y,Vieville JC,Tabary T,Naud MC,Chopin M,Edelson C,Cohen JH,Dausset J,de Kozak Y,Pla M

更新日期：2001-02-27 00:00:00

abstract：:The biosynthesis of the peroxisomal enzymes acyl-CoA oxidase, 3-oxoacyl-CoA thiolase (acetyl-CoA acyl-transferase, EC 2.3.1.16), and catalase (EC 1.11.1.6) was studied in cultured skin fibroblasts from a control subject and from patients with Zellweger syndrome and the infantile form of Refsum disease, inherited disor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schram AW,Strijland A,Hashimoto T,Wanders RJ,Schutgens RB,van den Bosch H,Tager JM

更新日期：1986-08-01 00:00:00

abstract：:We have isolated and characterized the complete human villin gene. The villin gene is located on chromosome 2q35-36 in humans and on chromosome 1 in mice. Villin belongs to a family of calcium-regulated actin-binding proteins that share structural and functional homologies. The villin gene is expressed mainly in cells...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pringault E,Robine S,Louvard D

更新日期：1991-12-01 00:00:00

abstract：:We have isolated a set of regulatory mutants defective in transcription termination at the attenuator in the leader region of the Escherichia coli tryptophan (trp) operon. In vivo the mutants have 2- to 4-fold increased levels of expression of the trp operon above the level of the trpR parental strain. These levels ar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stauffer GV,Zurawski G,Yanofsky C

更新日期：1978-10-01 00:00:00

abstract：:Proteolytic removal of the pre-segment from growing nascent chains of pre-human placental lactogen (hPL) occurred during in vitro translation of placental mRNA if crude membranes derived from ascites lysates, dog pancreas, or rat liver rough endoplasmic reticulum were added to the translation mixtures. The cotranslati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Strauss AW,Zimmerman M,Boime I,Ashe B,Mumford RA,Alberts AW

更新日期：1979-09-01 00:00:00

abstract：:Argonaute and Piwi proteins are key players in the RNA silencing pathway, with the former interacting with micro-RNAs (miRNAs) and siRNAs, whereas the latter targets piwi-interacting RNAs (piRNAs) that are 2'-O-methylated (2(')-OCH(3)) at their 3' ends. Germline-specific piRNAs and Piwi proteins play a critical role i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tian Y,Simanshu DK,Ma JB,Patel DJ

更新日期：2011-01-18 00:00:00

abstract：:Ferulic, caffeic, chlorogenic, and ellagic acids, four naturally occurring plant phenols, inhibit the mutagenicity and cytotoxicity of (+/-)-7beta,8alpha-dihydroxy-9alpha, 10alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (B[a]P 7,8-diol-9,10-epoxide-2), the only known ultimate carcinogenic metabolite of benzo[a]pyrene....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wood AW,Huang MT,Chang RL,Newmark HL,Lehr RE,Yagi H,Sayer JM,Jerina DM,Conney AH

更新日期：1982-09-01 00:00:00

abstract：:The recent emergence and reemergence of viruses in the human population has highlighted the need to develop broader panels of therapeutic molecules. High-throughput screening assays opening access to untargeted steps of the viral replication cycle will provide powerful leverage to identify innovative antiviral molecul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fernandez J,Hassen-Khodja C,Georget V,Rose T,Jacob Y,Janin YL,Nisole S,Vidalain PO,Arhel NJ

更新日期：2021-01-12 00:00:00

abstract：:The oxygenation of the atmosphere ∼2.45-2.32 billion years ago (Ga) is one of the most significant geological events to have affected Earth's redox history. Our understanding of the timing and processes surrounding this key transition is largely dependent on the development of redox-sensitive proxies, many of which re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chi Fru E,Rodríguez NP,Partin CA,Lalonde SV,Andersson P,Weiss DJ,El Albani A,Rodushkin I,Konhauser KO

更新日期：2016-05-03 00:00:00

abstract：:Steep topography, a tropical climate, and mafic lithologies contribute to efficient chemical weathering and carbon sequestration in the Southeast Asian islands. Ongoing arc-continent collision between the Sunda-Banda arc system and Australia has increased the area of subaerially exposed land in the region since the mi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Park Y,Maffre P,Goddéris Y,Macdonald FA,Anttila ESC,Swanson-Hysell NL

更新日期：2020-10-13 00:00:00

abstract：:The genomic concentrations of certain middle repetitive DNA sequences vary considerably among closely related species of Drosophila. In fact, the chromosomes of D. melanogaster appear to carry approximately 3 times as much middle repetitive DNA as those of the sibling species D. simulans. Although most of the middle r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dowsett AP,Young MW

更新日期：1982-08-01 00:00:00

abstract：:Genome engineering in human pluripotent stem cells (hPSCs) holds great promise for biomedical research and regenerative medicine. Recently, an RNA-guided, DNA-cleaving interference pathway from bacteria [the type II clustered, regularly interspaced, short palindromic repeats (CRISPR)-CRISPR-associated (Cas) pathway] h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hou Z,Zhang Y,Propson NE,Howden SE,Chu LF,Sontheimer EJ,Thomson JA

更新日期：2013-09-24 00:00:00

abstract：:Type I cadherin cell-adhesion proteins are similar in sequence and structure and yet are different enough to mediate highly specific cell-cell recognition phenomena. It has previously been shown that small differences in the homophilic and heterophilic binding affinities of different type I family members can account ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vendome J,Felsovalyi K,Song H,Yang Z,Jin X,Brasch J,Harrison OJ,Ahlsen G,Bahna F,Kaczynska A,Katsamba PS,Edmond D,Hubbell WL,Shapiro L,Honig B

更新日期：2014-10-07 00:00:00

abstract：:Regulated proteolysis is required to execute many cellular programs. In Caulobacter crescentus, timely degradation of the master regulator CtrA by ClpXP protease is essential for cell-cycle progression and requires the colocalization of CtrA and RcdA. Here, we establish a biochemical framework to understand regulated ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chien P,Perchuk BS,Laub MT,Sauer RT,Baker TA

更新日期：2007-04-17 00:00:00

abstract：:The bacterial pathogen Pseudomonas tolaasii severely damages white button mushrooms by secretion of the pore-forming toxin tolaasin, the main virulence factor of brown blotch disease. Yet, fungus-associated helper bacteria of the genus Mycetocola (Mycetocola tolaasinivorans and Mycetocola lacteus) may protect their ho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hermenau R,Kugel S,Komor AJ,Hertweck C

更新日期：2020-09-22 00:00:00

abstract：:In light of the rapid recent retreat of Arctic sea ice, a number of studies have discussed the possibility of a critical threshold (or "tipping point") beyond which the ice-albedo feedback causes the ice cover to melt away in an irreversible process. The focus has typically been centered on the annual minimum (Septemb...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eisenman I,Wettlaufer JS

更新日期：2009-01-06 00:00:00

abstract：:In the vertebrate central nervous system, the retina has been a useful model for studies of cell fate determination. Recent results from studies conducted in vitro and in vivo suggest a model of retinal development in which both the progenitor cells and the environment change over time. The model is based upon the not...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cepko CL,Austin CP,Yang X,Alexiades M,Ezzeddine D

更新日期：1996-01-23 00:00:00

abstract：:The rate of derepressed synthesis of a membrane protein required for lactose transport (M protein) by Escherichia coli is increased in response to increased gene dosage to the same extent as the rates of synthesis of beta-galactosidase and galactoside acetylase. However, elevated gene dosage does not increase beta-gal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fox CF

更新日期：1969-07-01 00:00:00

abstract：:Because neurogenesis persists in the adult mammalian brain and can be regulated by physiological and pathological events, we investigated its possible involvement in the brain's response to focal cerebral ischemia. Ischemia was induced by occlusion of the middle cerebral artery in the rat for 90 min, and proliferating...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jin K,Minami M,Lan JQ,Mao XO,Batteur S,Simon RP,Greenberg DA

更新日期：2001-04-10 00:00:00

abstract：:A Poincaré resolution is given for the supersymmetric ring of brackets over a signed alphabet. As a consequence, a resolution is found for the ring of coordinates of the Grassmanian variety in projective space over any infinite field. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Anick D,Rota GC

更新日期：1991-09-15 00:00:00

abstract：:We review a program of research that uses neuroimaging techniques to determine the functional and neural architecture of human working memory. A first set of studies indicates that verbal working memory includes a storage component, which is implemented neurally by areas in the left-hemisphere posterior parietal corte...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith EE,Jonides J

更新日期：1998-09-29 00:00:00

abstract：:Memory formation requires the placement of experienced events in the same order in which they appeared. A large body of evidence from human studies indicates that structures in the medial temporal lobe are critically involved in forming and maintaining such memories, and complementing evidence from lesion and electrop...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Paz R,Gelbard-Sagiv H,Mukamel R,Harel M,Malach R,Fried I

更新日期：2010-03-30 00:00:00

abstract：:In 100 primary colorectal carcinomas, we demonstrate by array comparative genomic hybridization (aCGH) that 33% show DNA copy number (DCN) loss involving PARK2, the gene encoding PARKIN, the E3 ubiquitin ligase whose deficiency is responsible for a form of autosomal recessive juvenile parkinsonism. PARK2 is located on...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Poulogiannis G,McIntyre RE,Dimitriadi M,Apps JR,Wilson CH,Ichimura K,Luo F,Cantley LC,Wyllie AH,Adams DJ,Arends MJ

更新日期：2010-08-24 00:00:00

abstract：:Eleocharis vivipara Link, a freshwater amphibious leafless plant belonging to the Cyperaceae can grow in both terrestrial and submersed aquatic conditions. Two forms of E. vivipara obtained from these contrasting environments were examined for the characteristics associated with C(4) and C(3) photosynthesis. In the te...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ueno O,Samejima M,Muto S,Miyachi S

更新日期：1988-09-01 00:00:00

abstract：:English and Russian color terms divide the color spectrum differently. Unlike English, Russian makes an obligatory distinction between lighter blues ("goluboy") and darker blues ("siniy"). We investigated whether this linguistic difference leads to differences in color discrimination. We tested English and Russian spe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Winawer J,Witthoft N,Frank MC,Wu L,Wade AR,Boroditsky L

更新日期：2007-05-08 00:00:00