Abstract：
:Prior incubation of quiescent cultures of Swiss 3T3 cells with vasopressin leads to loss of mitogenic stimulation on its subsequent addition in the presence of a synergistic growth factor. This desensitization is selective for vasopressin, requires prolonged incubation (half-maximal desensitization after 12 hr of treatment) for its induction, and is reversed after a 48-hr incubation in the absence of vasopressin. It is elicited by concentrations of vasopressin, and several analogues, similar to those required for stimulation of DNA synthesis. Inhibition of 125I-labeled epidermal growth factor binding and stimulation of 86Rb+ uptake by vasopressin are also selectively decreased in the refractory cells. The vasopressin receptors that mediate mitogenesis in Swiss 3T3 cells are of the pressor type, not coupled to adenylate cyclase. These cells bind [3H]vasopressin in a specific and saturable (Kd = 1 X 10(-8) M) manner. The receptors are down-regulated after prolonged vasopressin treatment; however, this cannot provide a complete explanation of desensitization because cells that are completely refractory to vasopressin retain 60% of their [3H]vasopressin binding sites. Vasopressin refractoriness must therefore occur partly at a post-receptor locus.
journal_name
Proc Natl Acad Sci U S Aauthors
Collins MK,Rozengurt Edoi
10.1073/pnas.80.7.1924subject
Has Abstractpub_date
1983-04-01 00:00:00pages
1924-8issue
7eissn
0027-8424issn
1091-6490journal_volume
80pub_type
杂志文章abstract：:Actin filaments and integrin-based focal adhesions (FAs) form integrated systems that mediate dynamic cell interactions with their environment or other cells during migration, the immune response, and tissue morphogenesis. How adhesion-associated actin structures obtain their functional specificity is unclear. Here we...
journal_title：Proceedings of the National Academy of Sciences of the United States of America
pub_type： 杂志文章,收录出版
doi：10.1073/pnas.1505035112
更新日期：2015-05-12 00:00:00
abstract：:Protein synthesis in all living organisms occurs on ribonucleoprotein particles, called ribosomes. Despite the universality of this process, eukaryotic ribosomes are significantly larger in size than their bacterial counterparts due in part to the presence of 80 r proteins rather than 54 in bacteria. Using cryoelectro...
journal_title：Proceedings of the National Academy of Sciences of the United States of America
pub_type： 杂志文章
doi：10.1073/pnas.1010005107
更新日期：2010-11-16 00:00:00
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journal_title：Proceedings of the National Academy of Sciences of the United States of America
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doi：10.1073/pnas.1217227110
更新日期：2013-03-12 00:00:00
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journal_title：Proceedings of the National Academy of Sciences of the United States of America
pub_type： 杂志文章
doi：10.1073/pnas.81.21.6881
更新日期：1984-11-01 00:00:00
abstract：:In cat retina, antisera directed against tyrosine hydroxylase (tyrosine 3-monooxygenase; EC 1.14.16.2) labeled three morphologically distinct classes of neurons; amacrine cells, displaced amacrine cells, and interplexiform cells. These three cell populations differed not only in their morphologies but also in their nu...
journal_title：Proceedings of the National Academy of Sciences of the United States of America
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doi：10.1073/pnas.82.18.6335
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journal_title：Proceedings of the National Academy of Sciences of the United States of America
pub_type： 杂志文章
doi：10.1073/pnas.1617948114
更新日期：2017-02-14 00:00:00
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journal_title：Proceedings of the National Academy of Sciences of the United States of America
pub_type： 杂志文章
doi：10.1073/pnas.1304238110
更新日期：2013-04-16 00:00:00
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journal_title：Proceedings of the National Academy of Sciences of the United States of America
pub_type： 杂志文章
doi：10.1073/pnas.75.9.4553
更新日期：1978-09-01 00:00:00
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journal_title：Proceedings of the National Academy of Sciences of the United States of America
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更新日期：2019-07-16 00:00:00
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journal_title：Proceedings of the National Academy of Sciences of the United States of America
pub_type： 杂志文章
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更新日期：2011-12-13 00:00:00
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pub_type： 杂志文章
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更新日期：1997-04-29 00:00:00
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journal_title：Proceedings of the National Academy of Sciences of the United States of America
pub_type： 杂志文章
doi：10.1073/pnas.92.18.8507
更新日期：1995-08-29 00:00:00
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journal_title：Proceedings of the National Academy of Sciences of the United States of America
pub_type： 杂志文章
doi：10.1073/pnas.93.19.10167
更新日期：1996-09-17 00:00:00
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journal_title：Proceedings of the National Academy of Sciences of the United States of America
pub_type： 杂志文章
doi：10.1073/pnas.1007888107
更新日期：2010-11-23 00:00:00
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journal_title：Proceedings of the National Academy of Sciences of the United States of America
pub_type： 杂志文章
doi：10.1073/pnas.151111298
更新日期：2001-07-31 00:00:00
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journal_title：Proceedings of the National Academy of Sciences of the United States of America
pub_type： 杂志文章
doi：10.1073/pnas.91.8.2920
更新日期：1994-04-12 00:00:00
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journal_title：Proceedings of the National Academy of Sciences of the United States of America
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更新日期：2006-12-05 00:00:00
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journal_title：Proceedings of the National Academy of Sciences of the United States of America
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更新日期：2001-12-18 00:00:00
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journal_title：Proceedings of the National Academy of Sciences of the United States of America
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更新日期：2010-08-03 00:00:00
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journal_title：Proceedings of the National Academy of Sciences of the United States of America
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更新日期：2000-02-15 00:00:00
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journal_title：Proceedings of the National Academy of Sciences of the United States of America
pub_type： 杂志文章
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更新日期：1991-03-15 00:00:00
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journal_title：Proceedings of the National Academy of Sciences of the United States of America
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更新日期：2003-05-27 00:00:00
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journal_title：Proceedings of the National Academy of Sciences of the United States of America
pub_type： 杂志文章
doi：10.1073/pnas.0710902105
更新日期：2008-01-15 00:00:00
abstract：:Interleukin 16 (IL-16) is a chemotactic cytokine that binds to the CD4 receptor and affects the activation of T cells and replication of HIV. It is expressed as a large 67-kDa precursor protein (pro-IL-16) in lymphocytes, macrophages, and mast cells, as well as in airway epithelial cells from asthmatics after challeng...
journal_title：Proceedings of the National Academy of Sciences of the United States of America
pub_type： 杂志文章
doi：10.1073/pnas.96.4.1541
更新日期：1999-02-16 00:00:00
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journal_title：Proceedings of the National Academy of Sciences of the United States of America
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doi：10.1073/pnas.95.16.9506
更新日期：1998-08-04 00:00:00
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journal_title：Proceedings of the National Academy of Sciences of the United States of America
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doi：10.1073/pnas.1216146110
更新日期：2013-08-13 00:00:00
abstract：:Focal electric stimulation of the auditory cortex is well suited for exploration of the function of the corticofugal (descending) system and the neural mechanism of plasticity in the central auditory system, because it evokes changes in frequency-tuning, called best frequency (BF) shifts, as does auditory fear conditi...
journal_title：Proceedings of the National Academy of Sciences of the United States of America
pub_type： 杂志文章
doi：10.1073/pnas.0509761102
更新日期：2005-12-27 00:00:00
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journal_title：Proceedings of the National Academy of Sciences of the United States of America
pub_type： 杂志文章
doi：10.1073/pnas.83.24.9749
更新日期：1986-12-01 00:00:00
abstract：:Transmission electron microscope images were obtained of fractions of poly(1-tetradecene sulfone) and poly(cyclohexene sulfone) cast from very dilute solutions (0.007%, wt/vol) and rapidly freeze-dried on a mica surface. The samples were then vertically platinum-carbon (Pt-C) replicated with 9 +/- 0.3-A Pt-C and held ...
journal_title：Proceedings of the National Academy of Sciences of the United States of America
pub_type： 杂志文章
doi：10.1073/pnas.89.17.7991
更新日期：1992-09-01 00:00:00
