Sodium pump isozymes are differentially expressed in electrically dissimilar regions of colonic circular smooth muscle.

abstract：:The POU-IV or "Brn-3" class of POU-domain transcription factors is represented in Drosophila by I-POU and twin-of-I-POU, alternative splice products of the I-POU gene. I-POU has been previously reported to inhibit DNA binding by the POU-III class factor drifter/Cf1a via the formation of heterodimeric complexes. Here w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Turner EE

更新日期：1996-12-24 00:00:00

abstract：:To explore the pathogenic mechanism of dominant mutations affecting the carboxyl terminus of rhodopsin that cause retinitis pigmentosa, we generated five lines of transgenic mice carrying the proline-347 to serine (P347S) mutation. The severity of photoreceptor degeneration correlated with the levels of transgene expr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li T,Snyder WK,Olsson JE,Dryja TP

更新日期：1996-11-26 00:00:00

abstract：:Lead pollution in Arctic ice reflects large-scale historical changes in midlatitude industrial activities such as ancient lead/silver production and recent fossil fuel burning. Here we used measurements in a broad array of 13 accurately dated ice cores from Greenland and Severnaya Zemlya to document spatial and tempor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McConnell JR,Chellman NJ,Wilson AI,Stohl A,Arienzo MM,Eckhardt S,Fritzsche D,Kipfstuhl S,Opel T,Place PF,Steffensen JP

更新日期：2019-07-23 00:00:00

abstract：:We have detected a variant species of bovine growth hormone mRNA in bovine pituitary tissue and in a stably transfected bovine growth hormone-producing cell line. Analysis of this variant mRNA indicated that the last intervening sequence (intron D) had not been removed by splicing. Inspection of the sequence of intron...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hampson RK,Rottman FM

更新日期：1987-05-01 00:00:00

abstract：:We have determined the nucleotide sequences of cDNAs encoding the precursor of the beta subunit of rat lutropin, a polypeptide hormone that regulates gonadal function, including the development of gametes and the production of steroid sex hormones. The cDNAs were prepared from poly(A)+ RNA derived from the pituitary g...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chin WW,Godine JE,Klein DR,Chang AS,Tan LK,Habener JF

更新日期：1983-08-01 00:00:00

abstract：:The embryonic neuroepithelium gives rise to the components of the central nervous system in the mature animal. To study the early development of the murine central nervous system we have sought to isolate growth factor receptors from the neuroepithelium of the neural tube of 10-day-old mouse embryos. Because many grow...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reid HH,Wilks AF,Bernard O

更新日期：1990-02-01 00:00:00

abstract：:A technique involving 5-bromodeoxyuridine, 33258 Hoechst, and fluorescence microscopy has been used to analyze replication kinetics in cells from embryonic and adult mice bearing the Cattanach [T(X;7)ICt] translocation in a balanced or an unbalanced form. In balanced 9- and 13-day female embryos, the translocated X wa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Disteche CM,Eicher EM,Latt SA

更新日期：1979-10-01 00:00:00

abstract：:Proofreading mechanisms increase specificity in biochemical reactions by allowing for the dissociation of intermediate complexes. These mechanisms disrupt and reset the reaction to undo errors at the cost of increased time of reaction and free energy expenditure. Here, we draw an analogy between proofreading and micro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murugan A,Huse DA,Leibler S

更新日期：2012-07-24 00:00:00

abstract：:Retinitis pigmentosa (RP) is an inherited neurodegenerative disease, in which the death of mutant rod photoreceptors leads secondarily to the non-cell autonomous death of cone photoreceptors. Gene therapy is a promising treatment strategy. Unfortunately, current methods of gene delivery treat only a fraction of diseas...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koch SF,Duong JK,Hsu CW,Tsai YT,Lin CS,Wahl-Schott CA,Tsang SH

更新日期：2017-05-16 00:00:00

abstract：:Despite extensive efforts to understand the monogenic contributions to perturbed glucose homeostasis, the complexity of genetic events that fractionally contribute to the spectrum of this pathology remain poorly understood. Proper maintenance of glucose homeostasis is the central feature of a constellation of comorbid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fleet T,Zhang B,Lin F,Zhu B,Dasgupta S,Stashi E,Tackett B,Thevananther S,Rajapakshe KI,Gonzales N,Dean A,Mao J,Timchenko N,Malovannaya A,Qin J,Coarfa C,DeMayo F,Dacso CC,Foulds CE,O'Malley BW,York B

更新日期：2015-11-03 00:00:00

abstract：:Multiple sclerosis is a chronic disease of the central nervous system (CNS) characterized by inflammation, demyelination, and axonal loss. The immunopathogenesis of demyelination in multiple sclerosis involves an autoantibody response to myelin oligodendrocyte glycoprotein (MOG), a type I transmembrane protein located...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Breithaupt C,Schubart A,Zander H,Skerra A,Huber R,Linington C,Jacob U

更新日期：2003-08-05 00:00:00

abstract：:Unlike other cation channels, each subunit of most transient receptor potential (TRP) channels has an additional TRP-domain helix with an invariant tryptophan immediately trailing the gate-bearing S6. Recent cryo-electron microscopy of TRP vanilloid subfamily, member 1 structures revealed that this domain is a five-tu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Teng J,Loukin SH,Anishkin A,Kung C

更新日期：2015-03-17 00:00:00

abstract：:We sequenced the genome of Saccharomyces cerevisiae strain YJM789, which was derived from a yeast isolated from the lung of an AIDS patient with pneumonia. The strain is used for studies of fungal infections and quantitative genetics because of its extensive phenotypic differences to the laboratory reference strain, i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wei W,McCusker JH,Hyman RW,Jones T,Ning Y,Cao Z,Gu Z,Bruno D,Miranda M,Nguyen M,Wilhelmy J,Komp C,Tamse R,Wang X,Jia P,Luedi P,Oefner PJ,David L,Dietrich FS,Li Y,Davis RW,Steinmetz LM

更新日期：2007-07-31 00:00:00

abstract：:The rise of peptides with secondary structures and functions would have been a key step in the chemical evolution which led to life. As with modern biology, amino acid sequence would have been a primary determinant of peptide structure and activity in an origins-of-life scenario. It is a commonly held hypothesis that ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Forsythe JG,Petrov AS,Millar WC,Yu SS,Krishnamurthy R,Grover MA,Hud NV,Fernández FM

更新日期：2017-09-12 00:00:00

abstract：:Innate immunity is the primary and most ancient defense against infection. Although critical to survival, coordinating protection against a foreign organism is energetically costly, creating the need to reallocate substrates from nonessential functions, such as growth and nutrient storage. However, the mechanism by wh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： DiAngelo JR,Bland ML,Bambina S,Cherry S,Birnbaum MJ

更新日期：2009-12-08 00:00:00

abstract：:It was proved that the protoplasts prepared from mesophyll of Nicotiana tabacum are infected by tobacco mosaic virus. The infection occurred when purified tobacco mosaic virus particles were added to a protoplast suspension in the presence of poly-L-ornithine. The virus multiplied in these protoplasts to a level of 10...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takebe I,Otsuki Y

更新日期：1969-11-01 00:00:00

abstract：:The measurement of any nonchromosomal genetic contribution to the heritability of a trait is often confounded by the inability to control both the chromosomal and nonchromosomal information in a population. We have designed a unique system in yeast where we can control both sources of information so that the phenotype...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Edwards MD,Symbor-Nagrabska A,Dollard L,Gifford DK,Fink GR

更新日期：2014-05-27 00:00:00

abstract：:Understanding the ecological impacts of climate change is a crucial challenge of the twenty-first century. There is a clear lack of general rules regarding the impacts of global warming on biota. Here, we present a metaanalysis of the effect of climate change on body size of ectothermic aquatic organisms (bacteria, ph...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Daufresne M,Lengfellner K,Sommer U

更新日期：2009-08-04 00:00:00

abstract：:The use of fluorescent probes to give continuous readouts of the structural states of mitochondrial membranes during energy coupling seems a logical extension of their use in the study of protein structural changes. A clear correlation of the probes' fluorescence characteristics with the acquisition of energy coupling...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chance B

更新日期：1970-10-01 00:00:00

abstract：:Fusions with the bacterial gene for chloramphenicol acetyltransferase followed by P-element-mediated germ-line transformation in Drosophila have permitted localization of the DNA sequence that confers a high degree of developmental specificity on a pair of silkmoth eggshell (chorion) genes. The short, 272-base-pair, 5...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mitsialis SA,Spoerel N,Leviten M,Kafatos FC

更新日期：1987-11-01 00:00:00

abstract：:Chromosomal locations of members of the xenotropic-related env gene family in the mouse genome have been determined. Endonuclease restriction site polymorphisms detected by molecular hybridization were used to study the inheritance of mink cell-focus inducing and xenotropic env gene-related sequences in recombinant in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blatt C,Mileham K,Haas M,Nesbitt MN,Harper ME,Simon MI

更新日期：1983-10-01 00:00:00

abstract：:Despite high structural homology between NO reductases (NORs) and heme-copper oxidases (HCOs), factors governing their reaction specificity remain to be understood. Using a myoglobin-based model of NOR (FeBMb) and tuning its heme redox potentials (E°') to cover the native NOR range, through manipulating hydrogen bondi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bhagi-Damodaran A,Reed JH,Zhu Q,Shi Y,Hosseinzadeh P,Sandoval BA,Harnden KA,Wang S,Sponholtz MR,Mirts EN,Dwaraknath S,Zhang Y,Moënne-Loccoz P,Lu Y

更新日期：2018-06-12 00:00:00

abstract：:A common design principle of heteromeric signaling proteins is the use of shared subunits. This allows encoding of complex messages while maintaining evolutionary flexibility. How cells regulate and control assembly of such composite signaling proteins remains an important open question. An example of particular compl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Müller SI,Friedl A,Aschenbrenner I,Esser-von Bieren J,Zacharias M,Devergne O,Feige MJ

更新日期：2019-01-29 00:00:00

abstract：:In the human, cone photoreceptors (L, M, and S) and the melanopsin-containing, intrinsically photosensitive retinal ganglion cells (ipRGCs) are active at daytime light intensities. Signals from cones are combined both additively and in opposition to create the perception of overall light and color. Similar mechanisms ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spitschan M,Jain S,Brainard DH,Aguirre GK

更新日期：2014-10-28 00:00:00

abstract：:The [A] allele of SNP rs965513 in 9q22 has been consistently shown to be highly associated with increased papillary thyroid cancer (PTC) risk with an odds ratio of ∼1.8 as determined by genome-wide association studies, yet the molecular mechanisms remain poorly understood. Previously, we noted that the expression of t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： He H,Li W,Liyanarachchi S,Srinivas M,Wang Y,Akagi K,Wang Y,Wu D,Wang Q,Jin V,Symer DE,Shen R,Phay J,Nagy R,de la Chapelle A

更新日期：2015-05-12 00:00:00

abstract：:Addition of antisense oligonucleotides to cell cultures has been used to specifically inhibit gene expression. We have investigated the mechanism by which oligonucleotides enter living cells. These compounds are taken up by cells in a saturable, size-dependent manner compatible with receptor-mediated endocytosis. Poly...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Loke SL,Stein CA,Zhang XH,Mori K,Nakanishi M,Subasinghe C,Cohen JS,Neckers LM

更新日期：1989-05-01 00:00:00

abstract：:Carbon can exist as isolated dumbbell, 1D chain, 2D plane, and 3D network in carbon solids or carbon-based compounds, which attributes to its rich chemical binding way, including sp-, sp(2)-, and sp(3)-hybridized bonds. sp(2)-hybridizing carbon always captures special attention due to its unique physical and chemical ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li YL,Luo W,Zeng Z,Lin HQ,Mao HK,Ahuja R

更新日期：2013-06-04 00:00:00

abstract：:Swarming bacteria move in multicellular groups and exhibit adaptive resistance to multiple antibiotics. Analysis of this phenomenon has revealed the protective power of high cell densities to withstand exposure to otherwise lethal antibiotic concentrations. We find that high densities promote bacterial survival, even ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Butler MT,Wang Q,Harshey RM

更新日期：2010-02-23 00:00:00

abstract：:The core structures of many viruses move within cells by association with host cytoskeletal motor proteins; however, the mechanisms by which intracellular viral particles are transported toward sites of replication or the cell periphery at distinct stages of infection remain to be understood. The regulation of herpesv...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith GA,Pomeranz L,Gross SP,Enquist LW

更新日期：2004-11-09 00:00:00

abstract：:Soybean plants and Rhizobium japonicum 122 DES, a hydrogen uptake-positive strain, were cultured in media purified to remove Ni. Supplemental Ni had no significant effect on the dry matter or total N content of plants. However, the addition of Ni to both nitrate-grown and symbiotically grown plants resulted in a 7- to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Klucas RV,Hanus FJ,Russell SA,Evans HJ

更新日期：1983-04-01 00:00:00