Nucleotide sequence of the cDNA encoding the precursor of the beta subunit of rat lutropin.

abstract：:In the traditional Z scheme of photosynthesis the Emerson effects of red drop (decline in yield of photosynthesis in far-red light) and enhancement (of far-red yield by supplementary short-wavelength light) are taken to be evidence for the coupling in series of two photosystems that absorb unsymmetrically in the far-r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Warner JW,Berry RS

更新日期：1987-06-01 00:00:00

abstract：:We recently reported that the posttraumatic spread of degeneration in the damaged optic nerve can be attenuated by the adoptive transfer of autoimmune T cells specific to myelin basic protein. However, it would be desirable to obtain immune neuroprotection free of any possible autoimmune disease. In an attempt to obta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kipnis J,Yoles E,Porat Z,Cohen A,Mor F,Sela M,Cohen IR,Schwartz M

更新日期：2000-06-20 00:00:00

abstract：:Addition of Na+ to Na+-depleted Swiss 3T3 cells causes a rapid and dramatic increase in intracellular pH, as monitored by uptake of the weak acid 5,5-dimethyloxazolidine-2,4-dione. The effect of Na+ is concentration dependent (half-maximal effect at 38 mM); this cation can be replaced by Li+ but not by K+ or the choli...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schuldiner S,Rozengurt E

更新日期：1982-12-01 00:00:00

abstract：:In this era of continued emergence of zoonotic virus infections, the rapid development of rodent models represents a critical barrier to public health preparedness, including the testing of antivirus therapy and vaccines. The Middle East respiratory syndrome coronavirus (MERS-CoV) was recently identified as the causat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhao J,Li K,Wohlford-Lenane C,Agnihothram SS,Fett C,Zhao J,Gale MJ Jr,Baric RS,Enjuanes L,Gallagher T,McCray PB Jr,Perlman S

更新日期：2014-04-01 00:00:00

abstract：:The SecY protein of Escherichia coli is an integral membrane component of the protein export apparatus. Suppressor mutations in the secY gene (prlA alleles) have been isolated that restore the secretion of precursor proteins with defective signal sequences. These mutations have never been shown to affect the transloca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nouwen N,de Kruijff B,Tommassen J

更新日期：1996-06-11 00:00:00

abstract：:The tissue-specific expression of the chicken liver cell adhesion molecule (L-CAM) was studied by generating transgenic mice. The rat insulin II promoter was fused to a chicken L-CAM cDNA or to chicken genomic L-CAM sequences. Mice carrying the cDNA showed no expression of L-CAM. Mice carrying L-CAM genomic sequences ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Begemann M,Tan SS,Cunningham BA,Edelman GM

更新日期：1990-11-01 00:00:00

abstract：:Awareness that our planet is a self-supporting biosphere with sunlight as its major source of energy for life has resulted in a long-term historical fascination with the workings of self-supporting ecological systems. However, the studies of such systems have never entered the canon of ecological or evolutionary tools...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rillig MC,Antonovics J

更新日期：2019-06-04 00:00:00

abstract：:Metastatic spread is the leading cause of cancer mortality. Breast cancer (BCa) metastatic recurrence can happen years after removal of the primary tumor. Here we show that Ubc13, an E2 enzyme that catalyzes K63-linked protein polyubiquitination, is largely dispensable for primary mammary tumor growth but is required ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu X,Zhang W,Font-Burgada J,Palmer T,Hamil AS,Biswas SK,Poidinger M,Borcherding N,Xie Q,Ellies LG,Lytle NK,Wu LW,Fox RG,Yang J,Dowdy SF,Reya T,Karin M

更新日期：2014-09-23 00:00:00

abstract：:The image that best expresses Darwin's thinking is the tree of life. However, Darwin's human evolutionary tree lacked almost everything because only the Neanderthals were known at the time and they were considered one extreme expression of our own species. Darwin believed that the root of the human tree was very deep ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arsuaga JL

更新日期：2010-05-11 00:00:00

abstract：:We perform a generalized-ensemble simulation of a small peptide taking the interactions among all atoms into account. From this simulation we obtain thermodynamic quantities over a wide range of temperatures. In particular, we show that the folding of a small peptide is a multistage process associated with two charact...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hansmann UH,Masuya M,Okamoto Y

更新日期：1997-09-30 00:00:00

abstract：:Gamma delta (γδ) T cells represent a major IL-17 committed T-cell population (γδT17 cells) in the mouse dermis. Following exposure to the inflammatory agent imiquimod (IMQ) the Vγ4(+) subset of γδT cells produce IL-17 in the skin and expand rapidly in draining lymph nodes (LNs). Local IMQ treatment in humans is known ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ramírez-Valle F,Gray EE,Cyster JG

更新日期：2015-06-30 00:00:00

abstract：:Hydrogen bond networks are key elements of protein structure and function but have been challenging to study within the complex protein environment. We have carried out in-depth interrogations of the proton transfer equilibrium within a hydrogen bond network formed to bound phenols in the active site of ketosteroid is...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sigala PA,Fafarman AT,Schwans JP,Fried SD,Fenn TD,Caaveiro JM,Pybus B,Ringe D,Petsko GA,Boxer SG,Herschlag D

更新日期：2013-07-09 00:00:00

abstract：:The spleen is the lymphoid organ that induces immune responses toward blood-borne pathogens. Specialized macrophages in the splenic marginal zone are strategically positioned to phagocytose pathogens and cell debris, but are not known to play a role in the activation of T-cell responses. Here we demonstrate that splen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Backer R,Schwandt T,Greuter M,Oosting M,Jüngerkes F,Tüting T,Boon L,O'Toole T,Kraal G,Limmer A,den Haan JM

更新日期：2010-01-05 00:00:00

abstract：:A phylogeny of marine Rhodophyta has been inferred by a number of methods from nucleotide sequences of nuclear genes encoding small subunit rRNA from 39 species in 15 orders. Sequence divergences are relatively large, especially among bangiophytes and even among congeners in this group. Subclass Bangiophycidae appears...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ragan MA,Bird CJ,Rice EL,Gutell RR,Murphy CA,Singh RK

更新日期：1994-07-19 00:00:00

abstract：:Understanding the complexity of anisotropic turbulent processes over a wide range of spatiotemporal scales in engineering shear turbulence as well as climate atmosphere ocean science is a grand challenge of contemporary science with important societal impact. In such inhomogeneous turbulent dynamical systems there is ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Majda AJ

更新日期：2015-07-21 00:00:00

abstract：:Incorporation and conversion of icosapentaenoic acid (20:5, n - 3) by human polymorphonuclear leukocytes were studied in volunteers (n = 6) ingesting a normal Western diet supplemented with icosapentaenoic acid (approximately equal to 4 g daily). Ingestion of icosapentaenoic acid leads to formation of biologically les...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Strasser T,Fischer S,Weber PC

更新日期：1985-03-01 00:00:00

abstract：:The expanding behavioral repertoire of the developing brain during childhood and adolescence is shaped by complex brain-environment interactions and flavored by unique life experiences. The transition into young adulthood offers opportunities for adaptation and growth but also increased susceptibility to environmental...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alnæs D,Kaufmann T,Marquand AF,Smith SM,Westlye LT

更新日期：2020-06-02 00:00:00

abstract：:Nanos (Nos) is an evolutionarily conserved protein essential for the survival of primordial germ cells. In Drosophila, maternal Nos partitions into pole cells and suppresses apoptosis to permit proper germ-line development. However, how this critical event is regulated by Nos has remained elusive. Here, we report that...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sato K,Hayashi Y,Ninomiya Y,Shigenobu S,Arita K,Mukai M,Kobayashi S

更新日期：2007-05-01 00:00:00

abstract：:Disruption of Rauscher leukemia virus (RLV) with low levels of Nonidet P-40 yielded "immature" cores. These cores have a diameter of about 920 A, as opposed to the 1300-A diameter of RLV, possess knob-like protuberances, and contain a concentrically coiled internal strand apposed to the core shell. The two major polyp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yoshinaka Y,Luftig RB

更新日期：1977-08-01 00:00:00

abstract：:A high proportion of lymphocytes from F/St mice produce infectious xenotropic murine leukemia virus (X-MuLV) and express high levels of cell surface antigens, termed XenCSA, related to the major glycoprotein of X-MuLV. In crosses of F/St with AKR, the high-virus phenotype of F/St was found to be recessive and was show...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yetter RA,Hartley JW,Morse HC 3rd

更新日期：1983-01-01 00:00:00

abstract：:Many physical and chemical properties of the light rare-earths and actinides are governed by the active role of f electrons, and despite intensive efforts the details of the mechanisms of phase stability and transformation are not fully understood. A prominent example which has attracted a lot of interest, both experi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Krisch M,Farber DL,Xu R,Antonangeli D,Aracne CM,Beraud A,Chiang TC,Zarestky J,Kim DY,Isaev EI,Ahuja R,Johansson B

更新日期：2011-06-07 00:00:00

abstract：:Peptides bind MHC class I molecules by anchoring hydrophobic side chains into pockets in the peptide binding groove. Here, we report an immunogenic (in vitro and in vivo) MUC1 glycopeptide (MUC1-8-5GalNAc) bound to H-2Kb, fully crossreactive with the nonglycosylated variant. Molecular modeling showed that the central ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Apostolopoulos V,Yuriev E,Ramsland PA,Halton J,Osinski C,Li W,Plebanski M,Paulsen H,McKenzie IF

更新日期：2003-12-09 00:00:00

abstract：:For an excitable cell to function properly, a precise number of ion channel proteins need to be trafficked to distinct locations on the cell surface membrane, through a network and anchoring activity of cytoskeletal proteins. Not surprisingly, mutations in anchoring proteins have profound effects on membrane excitabil...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rafizadeh S,Zhang Z,Woltz RL,Kim HJ,Myers RE,Lu L,Tuteja D,Singapuri A,Bigdeli AA,Harchache SB,Knowlton AA,Yarov-Yarovoy V,Yamoah EN,Chiamvimonvat N

更新日期：2014-07-08 00:00:00

abstract：:A highly effective vaccine would be a valuable weapon in the drive toward malaria elimination. No such vaccine currently exists, and only a handful of the hundreds of potential candidates in the parasite genome have been evaluated. In this study, we systematically evaluated 29 antigens likely to be involved in erythro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bustamante LY,Powell GT,Lin YC,Macklin MD,Cross N,Kemp A,Cawkill P,Sanderson T,Crosnier C,Muller-Sienerth N,Doumbo OK,Traore B,Crompton PD,Cicuta P,Tran TM,Wright GJ,Rayner JC

更新日期：2017-11-07 00:00:00

abstract：:Using a water-based prebiotic model of sugar synthesis involving glycolaldehyde self-condensation, we demonstrate that homochiral L-dipeptide catalysts lead to the stereospecific syntheses of tetroses. The asymmetric effect is largest for erythrose, which may reach a D-enantiomeric excess of >80% with L-Val-L-Val cata...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weber AL,Pizzarello S

更新日期：2006-08-22 00:00:00

abstract：:The assembly of the three neuronal soluble N-ethylmaleimide-sensitive factor attachment protein (SNAP) receptor (SNARE) proteins synaptobrevin 2, syntaxin-1A, and SNAP-25 is the key step that leads to exocytotic fusion of synaptic vesicles. In the fully assembled SNARE complex, these three proteins form a coiled-coil ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liang B,Kiessling V,Tamm LK

更新日期：2013-11-26 00:00:00

abstract：:Maintaining active growth and effective immune responses is often costly for a living organism to survive. Fine-tuning the shared cross-regulators is crucial for metazoans and plants to make a trade-off between growth and immunity. The Arabidopsis regulatory receptor-like kinase BAK1 complexes with the receptor kinase...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin W,Lu D,Gao X,Jiang S,Ma X,Wang Z,Mengiste T,He P,Shan L

更新日期：2013-07-16 00:00:00

abstract：:Ancient DNA (aDNA) analysis provides a powerful means of investigating human migration, social organization, and a plethora of other crucial questions about humanity's past. Recently, specialists have suggested that the ideal research design involving aDNA would include multiple independent lines of evidence. In this ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bongers JL,Nakatsuka N,O'Shea C,Harper TK,Tantaleán H,Stanish C,Fehren-Schmitz L

更新日期：2020-08-04 00:00:00

abstract：:Free gangliosides bind fibroblast growth factor 2 (FGF2), thus preventing cell interaction and biological activity of the growth factor in endothelial cells. Here we investigated the role of cell-associated gangliosides in mediating the biological activity of FGF2. Treatment of endothelial cells of different origin wi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rusnati M,Urbinati C,Tanghetti E,Dell'Era P,Lortat-Jacob H,Presta M

更新日期：2002-04-02 00:00:00

abstract：:The anaphase-promoting complex/cyclosome (APC/C) is a multisubunit ubiquitin-protein ligase that targets for degradation cell-cycle regulatory proteins during exit from mitosis and in the G1 phase of the cell cycle. The activity of APC/C in mitosis and in G1 requires interaction with the activator proteins Cdc20 and C...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eytan E,Moshe Y,Braunstein I,Hershko A

更新日期：2006-02-14 00:00:00