Similar DNA recognition properties of alternatively spliced Drosophila POU factors.

abstract：:Helodermin is a vasoactive intestinal peptide-like peptide in the salivary gland venom of the lizard Heloderma suspectum. Helodermin-like immunofluorescence was observed in the parafollicular (C) cells in several mammals and in the C cell homologues of the chicken ultimobranchial gland. Thus, helodermin-like peptides ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grunditz T,Persson P,Håkanson R,Absood A,Böttcher G,Rerup C,Sundler F

更新日期：1989-02-01 00:00:00

abstract：:The poison frogs (family Dendrobatidae) are terrestrial anuran amphibians displaying a wide range of coloration and toxicity. These frogs generally have been considered to be aposematic, but relatively little research has been carried out to test the predictions of this hypothesis. Here we use a comparative approach t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Summers K,Clough ME

更新日期：2001-05-22 00:00:00

abstract：:Vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) are key drivers of blood and lymph vessel formation in development, but also in several pathological processes. VEGF-C signaling through VEGFR-3 promotes lymphangiogenesis, which is a clinically relevant target for treating lymphatic insufficienc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leppänen VM,Tvorogov D,Kisko K,Prota AE,Jeltsch M,Anisimov A,Markovic-Mueller S,Stuttfeld E,Goldie KN,Ballmer-Hofer K,Alitalo K

更新日期：2013-08-06 00:00:00

abstract：:Tumor-associated myeloid cells (TAMCs) are key drivers of immunosuppression in the tumor microenvironment, which profoundly impedes the clinical response to immune-dependent and conventional therapeutic modalities. As a hallmark of glioblastoma (GBM), TAMCs are massively recruited to reach up to 50% of the brain tumor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang P,Miska J,Lee-Chang C,Rashidi A,Panek WK,An S,Zannikou M,Lopez-Rosas A,Han Y,Xiao T,Pituch KC,Kanojia D,Balyasnikova IV,Lesniak MS

更新日期：2019-11-19 00:00:00

abstract：:We have developed a high-efficiency nucleic acid delivery system that uses receptor-mediated endocytosis to carry DNA macromolecules into cells. We accomplished this by conjugating the iron-transport protein transferrin to polycations that bind nucleic acids. Human transferrin, as well as the chicken homologue conalbu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wagner E,Zenke M,Cotten M,Beug H,Birnstiel ML

更新日期：1990-05-01 00:00:00

abstract：:This article considers replicability of the performance of predictors across studies. We suggest a general approach to investigating this issue, based on ensembles of prediction models trained on different studies. We quantify how the common practice of training on a single study accounts in part for the observed chal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Patil P,Parmigiani G

更新日期：2018-03-13 00:00:00

abstract：:We have examined the kinetics of the interaction between endodeoxyribonuclease EcoRI (EC 3.1.23.13) and nine linear DNA fragments that range in size between 34 and 6,200 base pairs and contain the EcoRI site of plasmid pBR322 in a central location. The kinetic parameters governing both formation and decay of specific ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jack WE,Terry BJ,Modrich P

更新日期：1982-07-01 00:00:00

abstract：:The discovery of high-temperature superconductivity in iron pnictides raised the possibility of an unconventional superconducting mechanism in multiband materials. The observation of Fermi-surface (FS)-dependent nodeless superconducting gaps suggested that inter-FS interactions may play a crucial role in superconducti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Terashima K,Sekiba Y,Bowen JH,Nakayama K,Kawahara T,Sato T,Richard P,Xu YM,Li LJ,Cao GH,Xu ZA,Ding H,Takahashi T

更新日期：2009-05-05 00:00:00

abstract：:A complete description of protein metabolism requires knowledge of the rates of protein production and destruction within cells. Using an epitope-tagged strain collection, we measured the half-life of >3,750 proteins in the yeast proteome after inhibition of translation. By integrating our data with previous measureme...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Belle A,Tanay A,Bitincka L,Shamir R,O'Shea EK

更新日期：2006-08-29 00:00:00

abstract：:Early B cell factor (EBF)1 is essential for B lineage specification. Previously, we demonstrated the synergistic activation of Cd79a (mb-1) genes by EBF1 and its functional partner, RUNX1. Here, we identified consequences of Ebf1 haploinsufficiency together with haploinsufficiency of Runx1 genes in mice. Although numb...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lukin K,Fields S,Lopez D,Cherrier M,Ternyak K,Ramírez J,Feeney AJ,Hagman J

更新日期：2010-04-27 00:00:00

abstract：:We identify a gene, organ boundary1 (OBO1), by its unique pattern of enhancer- driven GFP expression at the boundaries between the apical meristems and lateral organs in Arabidopsis embryos, seedlings, and mature plants. OBO1 also is expressed at the root apical meristem and in distinct cell files surrounding this are...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cho E,Zambryski PC

更新日期：2011-02-01 00:00:00

abstract：:Systemic inflammation occurring around the course of tumor progression and treatment are often correlated with adverse oncological outcomes. As such, it is suspected that neutrophils, the first line of defense against infection, may play important roles in linking inflammation and metastatic seeding. To decipher the d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen MB,Hajal C,Benjamin DC,Yu C,Azizgolshani H,Hynes RO,Kamm RD

更新日期：2018-07-03 00:00:00

abstract：:Effects of thyrotropin-releasing hormone (TRH; thyroliberin) on membrane electrical properties were studied in the clonal rat anterior pituitary cell (GH3) by continuous recording of the intracellular potential. Application of TRH, which stimulates the release of prolactin and growth hormone from the GH3 cell, elicite...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ozawa S,Kimura N

更新日期：1979-11-01 00:00:00

abstract：:Veratridine or high potassium concentration increased guanosine 3',5'-cyclic monophosphate (cGMP) levels in neuroblastoma cells of clone N1E-115 without affecting levels of adenosine 3',5'-cyclic monophosphate (cAMP). The increases in cGMP appear to be a direct result of the depolarizing action of these agents and not...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Study RE,Breakefield XO,Bartfai T,Greengard P

更新日期：1978-12-01 00:00:00

abstract：:We have identified a cDNA from a human phytohemagglutinin-activated lymphoblast library encoding a protein that binds 125I-labeled human interleukin 12 (125I-huIL-12) with a Kd of about 5 nM when expressed in COS-7 cells. When coexpressed in COS-7 cells with the previously identified IL-12 beta receptor (IL-12R beta) ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Presky DH,Yang H,Minetti LJ,Chua AO,Nabavi N,Wu CY,Gately MK,Gubler U

更新日期：1996-11-26 00:00:00

abstract：:Thymidine dinucleotide (pTpT) stimulates melanogenesis in mammalian pigment cells and intact skin, mimicking the effects of UV irradiation and UV-mimetic DNA damage. Here it is shown that, in addition to tanning, pTpT induces a second photoprotective response, enhanced repair of UV-induced DNA damage. This enhanced re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eller MS,Maeda T,Magnoni C,Atwal D,Gilchrest BA

更新日期：1997-11-11 00:00:00

abstract：:We describe a fractionation and purification scheme for the Drosophila RNA polymerase II general transcription factors. Drosophila TFIIE, TFIIF, TFIIH, and RNA polymerase II have been purified to greater than 50% homogeneity from Drosophila embryo nuclear extracts. TFIID has been purified 80-fold and is not significan...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Austin RJ,Biggin MD

更新日期：1996-06-11 00:00:00

abstract：:To test the hypothesis that periodic signals and chemotaxis direct later morphogenesis in Dictyostelium discoideum, we investigated cell behavior and cell movement in slugs. Trails of neutral red-stained prestalk and anterior-like cells were recorded by high-resolution digital image processing. Neutral red-stained ant...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Siegert F,Weijer CJ

更新日期：1992-07-15 00:00:00

abstract：:Natural killer (NK) cells mediate vital control of cancer and viral infection. They rely on MHC class I (MHC I)-specific self-receptors to identify and lyse diseased cells without harming self-MHC I-bearing host cells. NK cells bearing inhibitory self-receptors for host MHC I also undergo education, referred to as lic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gamache A,Cronk JM,Nash WT,Puchalski P,Gillespie A,Wei H,Gray L,Hammarskjold ML,Xu W,Brown MG

更新日期：2019-12-16 00:00:00

abstract：:A common design principle of heteromeric signaling proteins is the use of shared subunits. This allows encoding of complex messages while maintaining evolutionary flexibility. How cells regulate and control assembly of such composite signaling proteins remains an important open question. An example of particular compl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Müller SI,Friedl A,Aschenbrenner I,Esser-von Bieren J,Zacharias M,Devergne O,Feige MJ

更新日期：2019-01-29 00:00:00

abstract：:Electron micrographs are shown of the first component of human complement (C1) which has been crosslinked with a water-soluble carbodiimide to prevent dissociation into its C1q and C1r2C1s2 subunits. Two projections of the crosslinked molecule are seen in the electron micrographs, which are called "top" and "profile."...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Strang CJ,Siegel RC,Phillips ML,Poon PH,Schumaker VN

更新日期：1982-01-01 00:00:00

abstract：:Loss or reduction in function of tumor suppressor genes contributes to tumorigenesis. Here, by allelic DNA copy number analysis using single-nucleotide polymorphism genotyping array and mass spectrometry, we report homozygous deletion in glioblastoma multiformes at chromosome 13q21, where DACH1 gene is located. We fou...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Watanabe A,Ogiwara H,Ehata S,Mukasa A,Ishikawa S,Maeda D,Ueki K,Ino Y,Todo T,Yamada Y,Fukayama M,Saito N,Miyazono K,Aburatani H

更新日期：2011-07-26 00:00:00

abstract：:Extracellular growth and differentiation factors induce changes in gene expression in the nucleus by initiating a series of protein associations that alter the subcellular localization of intracellular signaling proteins. Initial events involve receptor homo- or heterodimerization and subsequent recruitment of cytosol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Belshaw PJ,Ho SN,Crabtree GR,Schreiber SL

更新日期：1996-05-14 00:00:00

abstract：:Molybdate- and ATP-dependent in vitro synthesis of the iron-molybdenum cofactor (FeMo-co) of nitrogenase requires the protein products of at least the nifB, nifN, and nifE genes. Extracts of FeMo-co-negative mutants of Klebsiella pneumoniae and Azotobacter vinelandii with lesions in different genes can be complemented...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shah VK,Imperial J,Ugalde RA,Ludden PW,Brill WJ

更新日期：1986-03-01 00:00:00

abstract：:Systemic amyloid A (AA) amyloidosis is a serious complication of chronic inflammation. Serum AA protein (SAA), an acute phase plasma protein, is deposited extracellularly as insoluble amyloid fibrils that damage tissue structure and function. Clinical AA amyloidosis is typically preceded by many years of active inflam...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Simons JP,Al-Shawi R,Ellmerich S,Speck I,Aslam S,Hutchinson WL,Mangione PP,Disterer P,Gilbertson JA,Hunt T,Millar DJ,Minogue S,Bodin K,Pepys MB,Hawkins PN

更新日期：2013-10-01 00:00:00

abstract：:It is well documented that human modification of the hydrological cycle has profoundly affected the flow of liquid water across the Earth's land surface. Alteration of water vapor flows through land-use changes has received comparatively less attention, despite compelling evidence that such alteration can influence th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gordon LJ,Steffen W,Jönsson BF,Folke C,Falkenmark M,Johannessen A

更新日期：2005-05-24 00:00:00

abstract：:The IL-2R gamma chain (IL-2R gamma) is an essential component of high- and intermediate-affinity IL-2Rs, playing critical roles for ligand binding and internalization. Recently, our laboratory has demonstrated that IL-2R gamma mutation results in X chromosome-linked severe combined immunodeficiency in humans, suggesti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cao X,Kozak CA,Liu YJ,Noguchi M,O'Connell E,Leonard WJ

更新日期：1993-09-15 00:00:00

abstract：:We recently showed that the mammalian genome encodes >1,000 large intergenic noncoding (linc)RNAs that are clearly conserved across mammals and, thus, functional. Gene expression patterns have implicated these lincRNAs in diverse biological processes, including cell-cycle regulation, immune surveillance, and embryonic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Khalil AM,Guttman M,Huarte M,Garber M,Raj A,Rivea Morales D,Thomas K,Presser A,Bernstein BE,van Oudenaarden A,Regev A,Lander ES,Rinn JL

更新日期：2009-07-14 00:00:00

abstract：:The complexity and specificity of metazoan transcription are determined by combinatorial control of the composition and activity of regulatory complexes. To investigate the basis of this specificity, we focused on the glucocorticoid receptor (GR), a single regulatory factor that integrates multiple signals to give ris...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen SH,Masuno K,Cooper SB,Yamamoto KR

更新日期：2013-01-29 00:00:00

abstract：:Intracellular bacterial pathogens evade the bactericidal functions of mammalian cells by physical escape from their phagosome and replication into the cytoplasm or through the modulation of phagosome maturation and biogenesis of a membrane-bound replicative organelle. Here, we detail in murine primary macrophages the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Checroun C,Wehrly TD,Fischer ER,Hayes SF,Celli J

更新日期：2006-09-26 00:00:00