Genetic rescue models refute nonautonomous rod cell death in retinitis pigmentosa.

abstract：:High-resolution analyses of a late Holocene core from Kettle Lake in North Dakota reveal coeval fluctuations in loss-on-ignition carbonate content, percentage of grass pollen, and charcoal flux. These oscillations are indicative of climate-fuel-fire cycles that have prevailed on the Northern Great Plains (NGP) for mos...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brown KJ,Clark JS,Grimm EC,Donovan JJ,Mueller PG,Hansen BC,Stefanova I

更新日期：2005-06-21 00:00:00

abstract：:UDP-xylose is a sugar donor required for the synthesis of diverse and important glycan structures in animals, plants, fungi, and bacteria. Xylose-containing glycans are particularly abundant in plants and in the polysaccharide capsule that is the major virulence factor of the pathogenic fungus Cryptococcus neoformans....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bar-Peled M,Griffith CL,Doering TL

更新日期：2001-10-09 00:00:00

abstract：:We determined the complete mtDNA sequence of the centipede Lithobius forficatus and found that only one of the 22 inferred tRNA genes encodes a fully paired aminoacyl acceptor stem. The other 21 genes encode tRNAs with up to five mismatches in these stems, and some of these overlap extensively with the downstream gene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lavrov DV,Brown WM,Boore JL

更新日期：2000-12-05 00:00:00

abstract：:RNA molecules perform diverse regulatory functions in natural biological systems, and numerous synthetic RNA-based control devices that integrate sensing and gene-regulatory functions have been demonstrated, predominantly in bacteria and yeast. Despite potential advantages of RNA-based genetic control strategies in cl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen YY,Jensen MC,Smolke CD

更新日期：2010-05-11 00:00:00

abstract：:Self-assembling dendrimers have facilitated the discovery of periodic and quasiperiodic arrays of supramolecular architectures and the diverse functions derived from them. Examples are liquid quasicrystals and their approximants plus helical columns and spheres, including some that disregard chirality. The same period...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rodriguez-Emmenegger C,Xiao Q,Kostina NY,Sherman SE,Rahimi K,Partridge BE,Li S,Sahoo D,Reveron Perez AM,Buzzacchera I,Han H,Kerzner M,Malhotra I,Möller M,Wilson CJ,Good MC,Goulian M,Baumgart T,Klein ML,Percec V

更新日期：2019-03-19 00:00:00

abstract：:A key question in clarifying human-environment interactions is how dynamic complexity develops across integrative scales from molecular to population and global levels. Apart from its public health importance, measles is an excellent test bed for such an analysis. Simple mechanistic models have successfully illuminate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Becker AD,Birger RB,Teillant A,Gastanaduy PA,Wallace GS,Grenfell BT

更新日期：2016-12-20 00:00:00

abstract：:Homeostasis of intravascular volume, Na(+), Cl(-), and K(+) is interdependent and determined by the coordinated activities of structurally diverse mediators in the distal nephron and the distal colon. The behavior of these flux pathways is regulated by the renin-angiotensin-aldosterone system; however, the mechanisms ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ring AM,Cheng SX,Leng Q,Kahle KT,Rinehart J,Lalioti MD,Volkman HM,Wilson FH,Hebert SC,Lifton RP

更新日期：2007-03-06 00:00:00

abstract：:We have isolated overlapping phage genomic clones covering an area of 26 kilobases that encodes the human alpha 2-plasmin inhibitor. The alpha 2-plasmin inhibitor gene contains 10 exons and 9 introns distributed over approximately 16 kilobases of DNA. To our knowledge, the number of introns is the highest yet reported...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hirosawa S,Nakamura Y,Miura O,Sumi Y,Aoki N

更新日期：1988-09-01 00:00:00

abstract：:A 32-base-pair (bp) DNA duplex with deletions in one strand, and thus extra bases in the opposing strand, was ligated head-to-tail to produce linear and circular multimers. The electrophoretic mobility of the linear multimers was analyzed in polyacrylamide gels and the size of the circular DNA was determined by electr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hsieh CH,Griffith JD

更新日期：1989-07-01 00:00:00

abstract：:Biochemically, the syntrophic bacteria constitute the missing link in our understanding of anaerobic flow of carbon in the biosphere. The completed genome sequence of Syntrophus aciditrophicus SB, a model fatty acid- and aromatic acid-degrading syntrophic bacterium, provides a glimpse of the composition and architectu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McInerney MJ,Rohlin L,Mouttaki H,Kim U,Krupp RS,Rios-Hernandez L,Sieber J,Struchtemeyer CG,Bhattacharyya A,Campbell JW,Gunsalus RP

更新日期：2007-05-01 00:00:00

abstract：:Because virtually all organisms compete with others in their social environment, mechanisms that reduce conflict between interacting individuals are crucial for the evolution of stable families, groups, and societies. Here, we tested whether costs of social conflict over territorial space between Seychelles warblers (...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bebbington K,Kingma SA,Fairfield EA,Dugdale HL,Komdeur J,Spurgin LG,Richardson DS

更新日期：2017-10-24 00:00:00

abstract：:The 30S ribosomal subunit of E. coli was treated with the bifunctional reagent bis-(methyl)suberimidate. Crosslinked ribosomal proteins were identified as bands with increased molecular weight after electrophoresis in polyacrylamide gels containing sodium dodecyl sulphate. The pattern of crosslinked products was alter...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bickle TA,Hershey JW,Traut RR

更新日期：1972-05-01 00:00:00

abstract：:Antibodies from three different lines of monoclonal hybridomas crossreact with both the beta subunit of spectrin and the 90-kDa peptide present in highly purified preparations of the heme-controlled eIF-2 alpha (initiation factor 2 alpha-subunit) kinase from rabbit reticulocytes. Antibodies from two of the three lines...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kudlicki W,Fullilove S,Kramer G,Hardesty B

更新日期：1985-08-01 00:00:00

abstract：:When animals move, respiration increases to adapt for increased energy demands; the underlying mechanisms are still not understood. We investigated the neural substrates underlying the respiratory changes in relation to movement in lampreys. We showed that respiration increases following stimulation of the mesencephal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gariépy JF,Missaghi K,Chevallier S,Chartré S,Robert M,Auclair F,Lund JP,Dubuc R

更新日期：2012-01-10 00:00:00

abstract：:In this study, we quantified 249 mature micro-RNA (miRNA) transcripts in estrogen receptor-positive (ER(+)) primary breast tumors of patients with lymph node-negative (LNN) disease to identify miRNAs associated with metastatic capability. In addition, the prognostic value of the candidate miRNAs was determined in ER(-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Foekens JA,Sieuwerts AM,Smid M,Look MP,de Weerd V,Boersma AW,Klijn JG,Wiemer EA,Martens JW

更新日期：2008-09-02 00:00:00

abstract：:ALS is a terminal disease of motor neurons that is characterized by accumulation of proteinaceous deposits in affected cells. Pathological deposition of mutated Cu/Zn superoxide dismutase (SOD1) accounts for ∼20% of the familial ALS (fALS) cases. However, understanding the molecular link between mutation and disease h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ivanova MI,Sievers SA,Guenther EL,Johnson LM,Winkler DD,Galaleldeen A,Sawaya MR,Hart PJ,Eisenberg DS

更新日期：2014-01-07 00:00:00

abstract：:We present whole-genome assemblies of four divergent Arabidopsis thaliana strains that complement the 125-Mb reference genome sequence released a decade ago. Using a newly developed reference-guided approach, we assembled large contigs from 9 to 42 Gb of Illumina short-read data from the Landsberg erecta (Ler-1), C24,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schneeberger K,Ossowski S,Ott F,Klein JD,Wang X,Lanz C,Smith LM,Cao J,Fitz J,Warthmann N,Henz SR,Huson DH,Weigel D

更新日期：2011-06-21 00:00:00

abstract：:We demonstrate the successful fabrication on CaF2 substrates of FeSe(1-x)Tex films with 0 ≤ x ≤ 1, including the region of 0.1 ≤ x ≤ 0.4, which is well known to be the "phase-separation region," via pulsed laser deposition that is a thermodynamically nonequilibrium method. In the resulting films, we observe a giant en...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Imai Y,Sawada Y,Nabeshima F,Maeda A

更新日期：2015-02-17 00:00:00

abstract：:Ca channel currents were studied in freshly dispersed bovine adrenal glomerulosa cells to better understand the control of aldosterone secretion by extracellular K concentration (Ko) and angiotensin II (AII). The whole-cell variation of the patch voltage clamp technique was used. Two types of Ca channels were found. O...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cohen CJ,McCarthy RT,Barrett PQ,Rasmussen H

更新日期：1988-04-01 00:00:00

abstract：:Dopamine causes a significant retraction of neurites of bull-head catfish horizontal cells maintained in culture. The effects of dopamine are blocked by haloperidol and SCH 23390, a D1 antagonist, but not by sulpiride, a D2 antagonist. The dopamine-induced morphological changes were mimicked by SKF 38393, a D1 agonist...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rodrigues Pdos S,Dowling JE

更新日期：1990-12-01 00:00:00

abstract：:The goal of the current study was to investigate the role of exogenous and endogenous hydrogen sulfide (H(2)S) on neovascularization and wound healing in vitro and in vivo. Incubation of endothelial cells (ECs) with H(2)S enhanced their angiogenic potential, evidenced by accelerated cell growth, migration, and capilla...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Papapetropoulos A,Pyriochou A,Altaany Z,Yang G,Marazioti A,Zhou Z,Jeschke MG,Branski LK,Herndon DN,Wang R,Szabó C

更新日期：2009-12-22 00:00:00

abstract：:A wide range of research has promised new tools for forecasting infectious disease dynamics, but little of that research is currently being applied in practice, because tools do not address key public health needs, do not produce probabilistic forecasts, have not been evaluated on external data, or do not provide suff...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Johansson MA,Apfeldorf KM,Dobson S,Devita J,Buczak AL,Baugher B,Moniz LJ,Bagley T,Babin SM,Guven E,Yamana TK,Shaman J,Moschou T,Lothian N,Lane A,Osborne G,Jiang G,Brooks LC,Farrow DC,Hyun S,Tibshirani RJ,Rosenfe

更新日期：2019-11-26 00:00:00

abstract：:Metastatic colorectal cancer (mCRC) patients have poor overall survival despite using irinotecan- or oxaliplatin-based chemotherapy combined with anti-EGFR (epidermal growth factor receptor) drugs, especially those with the oncogene mutation of KRAS Metformin has been reported as a potentially novel antitumor agent in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xie J,Xia L,Xiang W,He W,Yin H,Wang F,Gao T,Qi W,Yang Z,Yang X,Zhou T,Gao G

更新日期：2020-06-09 00:00:00

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV), etiologically associated with Kaposi's sarcoma, uses integrins (α3β1, αVβ3, and αVβ5) and associated signaling to enter human dermal microvascular endothelial cells (HMVEC-d), an in vivo target of infection. KSHV infection activated c-Cbl, which induced the selective tra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chakraborty S,Veettil MV,Bottero V,Chandran B

更新日期：2012-05-08 00:00:00

abstract：:Tropical forest degradation emits carbon at a rate of approximately 0.5 Pgxy(-1), reduces biodiversity, and facilitates forest clearance. Understanding degradation drivers and patterns is therefore crucial to managing forests to mitigate climate change and reduce biodiversity loss. Putative patterns of degradation aff...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ahrends A,Burgess ND,Milledge SA,Bulling MT,Fisher B,Smart JC,Clarke GP,Mhoro BE,Lewis SL

更新日期：2010-08-17 00:00:00

abstract：:Plant metabolites are crucial for both plant life and human nutrition. Despite recent advance in metabolomics, the genetic control of plant metabolome remains largely unknown. Here, we performed a genetic analysis of the rice metabolome that provided over 2,800 highly resolved metabolic quantitative trait loci for 900...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gong L,Chen W,Gao Y,Liu X,Zhang H,Xu C,Yu S,Zhang Q,Luo J

更新日期：2013-12-10 00:00:00

abstract：:DNA "breathing" is a thermally driven process in which base-paired DNA sequences transiently adopt local conformations that depart from their most stable structures. Polymerases and other proteins of genome expression require access to single-stranded DNA coding templates located in the double-stranded DNA "interior,"...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Phelps C,Lee W,Jose D,von Hippel PH,Marcus AH

更新日期：2013-10-22 00:00:00

abstract：:Negative-stranded RNA viruses cover their genome with nucleoprotein (N) to protect it from the human innate immune system. Abrogation of the function of N offers a unique opportunity to combat the spread of the viruses. Here, we describe a unique fold of N from Leanyer virus (LEAV, Orthobunyavirus genus, Bunyaviridae ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Niu F,Shaw N,Wang YE,Jiao L,Ding W,Li X,Zhu P,Upur H,Ouyang S,Cheng G,Liu ZJ

更新日期：2013-05-28 00:00:00

abstract：:Although advances in microfluidic technology have enabled increasingly sophisticated biosensing and bioassay operations to be performed at the microscale, many of these applications employ such small amounts of charged biomolecules (DNA, proteins, and peptides) that they must first be preconcentrated to a detectable l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shaikh FA,Ugaz VM

更新日期：2006-03-28 00:00:00

abstract：:We demonstrate that the receptor binding moiety of Escherichia coli heat-labile enterotoxin (EtxB) can completely prevent autoimmune disease in a murine model of arthritis. Injection of male DBA/1 mice at the base of the tail with type II collagen in the presence of complete Freund's adjuvant normally leads to arthrit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Williams NA,Stasiuk LM,Nashar TO,Richards CM,Lang AK,Day MJ,Hirst TR

更新日期：1997-05-13 00:00:00