Aggregation-triggering segments of SOD1 fibril formation support a common pathway for familial and sporadic ALS.

abstract：:ATM (ataxia-telangiectasia mutated) and ATR (ATM and Rad3-related) are large PI3 kinases whose human mutations result in complex syndromes that include a compromised DNA damage response (DDR) and prominent nervous system phenotypes. Both proteins are nuclear-localized in keeping with their DDR functions, yet both are ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheng A,Zhao T,Tse KH,Chow HM,Cui Y,Jiang L,Du S,Loy MMT,Herrup K

更新日期：2018-01-09 00:00:00

abstract：:Endothelial heterogeneity has important implications in health and disease. Molecular markers selectively expressed in the vasculature of different organs and tissues are currently being explored in targeted therapies with promising results in preclinical and clinical studies. Noteworthy is the role that combinatorial...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tang FHF,Staquicini FI,Teixeira AAR,Michaloski JS,Namiyama GM,Taniwaki NN,Setubal JC,da Silva AM,Sidman RL,Pasqualini R,Arap W,Giordano RJ

更新日期：2019-02-05 00:00:00

abstract：:The population genetic consequences of nearest-neighbor pollination in an outcrossing plant species were investigated through computer simulations. The genetic system consisted of two alleles at a single locus in a self-incompatible plant that mates by random pollen transfer from a neighboring individual. Beginning wi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Turner ME,Stephens JC,Anderson WW

更新日期：1982-01-01 00:00:00

abstract：:We present a mandible recovered in 2003 from the Aurora Stratum of the TD6 level of the Gran Dolina site (Sierra de Atapuerca, northern Spain). The specimen, catalogued as ATD6-96, adds to the hominin sample recovered from this site in 1994-1996, and assigned to Homo antecessor. ATD6-96 is the left half of a gracile m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carbonell E,Bermúdez de Castro JM,Arsuaga JL,Allue E,Bastir M,Benito A,Cáceres I,Canals T,Díez JC,van der Made J,Mosquera M,Ollé A,Pérez-González A,Rodríguez J,Rodríguez XP,Rosas A,Rosell J,Sala R,Vallverdú J,Vergés

更新日期：2005-04-19 00:00:00

abstract：:Almost all theoretical and experimental studies of the mechanisms underlying learning and memory focus on synaptic efficacy and make the implicit assumption that changes in synaptic efficacy are both necessary and sufficient to account for learning and memory. However, network dynamics depends on the complex interacti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marder E,Abbott LF,Turrigiano GG,Liu Z,Golowasch J

更新日期：1996-11-26 00:00:00

abstract：:Ca(2+) is known to have important roles in sperm chemotaxis, although the relationship between intracellular Ca(2+) concentration ([Ca(2+)](i)) and modulation of the swimming and chemotactic behavior of spermatozoa has not been elucidated. Using a high-speed Ca(2+) imaging system, we examined the chemotactic behavior ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shiba K,Baba SA,Inoue T,Yoshida M

更新日期：2008-12-09 00:00:00

abstract：:In December of 2015, the international community pledged to limit global warming to below 2 °C above preindustrial (PI) to prevent dangerous climate change. However, to what extent, and for whom, is danger avoided if this ambitious target is realized? We address these questions by scrutinizing heat stress, because the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Matthews TK,Wilby RL,Murphy C

更新日期：2017-04-11 00:00:00

abstract：:Ouabain-sensitive uncoupled Na+ efflux has been studied in human, pig, and rat red cells and in vesicles containing reconstituted kidney Na+/K+ pumps obtained from these same species. The red cells from the different species gave qualitatively similar results; the uncoupled Na+ efflux was 15-30% of the Na+/K+ exchange...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Martin WH,Richards DE,Marín R,Jack-Hays M,Hoffman JF

更新日期：1994-10-11 00:00:00

abstract：:Hair cells of the inner ear, the mechanosensory receptors, convert sound waves into neural signals that are passed to the brain via the auditory nerve. Little is known about the molecular mechanisms that govern the development of hair cell-neuronal connections. We ascertained a family with autosomal recessive deafness...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Diaz-Horta O,Abad C,Sennaroglu L,Foster J 2nd,DeSmidt A,Bademci G,Tokgoz-Yilmaz S,Duman D,Cengiz FB,Grati M,Fitoz S,Liu XZ,Farooq A,Imtiaz F,Currall BB,Morton CC,Nishita M,Minami Y,Lu Z,Walz K,Tekin M

更新日期：2016-05-24 00:00:00

abstract：:RS67333 is a partial serotonin subtype 4 receptor (5-HT4R) agonist that has been widely studied for its procognitive effect. More recently, it has been shown that its ability to promote the nonamyloidogenic cleavage of the precursor of the neurotoxic amyloid-β peptide leads to the secretion of the neurotrophic protein...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lecoutey C,Hedou D,Freret T,Giannoni P,Gaven F,Since M,Bouet V,Ballandonne C,Corvaisier S,Malzert Fréon A,Mignani S,Cresteil T,Boulouard M,Claeysen S,Rochais C,Dallemagne P

更新日期：2014-09-09 00:00:00

abstract：:Understanding protein-protein interactions is central to our understanding of almost all complex biological processes. Computational tools exploiting rapidly growing genomic databases to characterize protein-protein interactions are urgently needed. Such methods should connect multiple scales from evolutionary conserv...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gueudré T,Baldassi C,Zamparo M,Weigt M,Pagnani A

更新日期：2016-10-25 00:00:00

abstract：:Using both heterologous rabbit antisera and mouse monoclonal antibody to RNA.DNA hybrids, we have mapped the in situ hybridization locus of the 18/28S ribosomal RNA fraction to a single large band on polytene autosome 3 in Drosophila heteroneura and Drosophila silvestris. This portion of the chromosome is not physical...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stuart WD,Bishop JG,Carson HL,Frank MB

更新日期：1981-06-01 00:00:00

abstract：:L-2-hydroxyglutarate (L-2HG) has emerged as a putative oncometabolite that is capable of inhibiting enzymes involved in metabolism, chromatin modification, and cell differentiation. However, despite the ability of L-2HG to interfere with a broad range of cellular processes, this molecule is often characterized as a me...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li H,Chawla G,Hurlburt AJ,Sterrett MC,Zaslaver O,Cox J,Karty JA,Rosebrock AP,Caudy AA,Tennessen JM

更新日期：2017-02-07 00:00:00

abstract：:Theories of density-dependent natural selection predict that evolution should favor those genotypes with the highest per capita rates of population growth under the current density conditions. These theories are silent about the mechanisms that may give rise to these increases in density-dependent growth rates. We hav...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guo PZ,Mueller LD,Ayala FJ

更新日期：1991-12-01 00:00:00

abstract：:By manufacturing a single-particle system in two particulate forms (i.e., micrometer size and nanometer size), we have designed a bacterial vaccine form that exhibits improved efficacy of immunization. Microstructural properties are adapted to alter dispersive and aerosol properties independently. Dried "nanomicropart...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Garcia-Contreras L,Wong YL,Muttil P,Padilla D,Sadoff J,Derousse J,Germishuizen WA,Goonesekera S,Elbert K,Bloom BR,Miller R,Fourie PB,Hickey A,Edwards D

更新日期：2008-03-25 00:00:00

abstract：:Protein framework alterations in heritable Cu, Zn superoxide dismutase (SOD) mutants cause misassembly and aggregation in cells affected by the motor neuron disease ALS. However, the mechanistic relationship between superoxide dismutase 1 (SOD1) mutations and human disease is controversial, with many hypotheses postul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pratt AJ,Shin DS,Merz GE,Rambo RP,Lancaster WA,Dyer KN,Borbat PP,Poole FL 2nd,Adams MW,Freed JH,Crane BR,Tainer JA,Getzoff ED

更新日期：2014-10-28 00:00:00

abstract：:Germ-line stem cells (GSCs) are maintained by the somatic microenvironment, or GSC niche, which ensures that GSCs can both self-renew and produce functional gametes. However, it remains unclear how the proper niche size and location are regulated within the developing gonads. In the Drosophila testis, the hub cells th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kitadate Y,Kobayashi S

更新日期：2010-08-10 00:00:00

abstract：:Walker-256 carcinosarcoma cells grown in tissue culture medium containing inhibitory DNA prepared from the tumor are shown to have an unaltered growth in vitro, but a diminished capacity to produce malignant tumors on injection into the rat. Coincident with this change in virulence is the induction of tRNA methylase i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Halpern BC,Halpern RM,Chaney SQ,Smith RA

更新日期：1970-12-01 00:00:00

abstract：:Recent findings intriguingly place DNA double-strand break repair proteins at chromosome ends in yeast, where they help maintain normal telomere length and structure. In the present study, an essential telomere function, the ability to cap and thereby protect chromosomes from end-to-end fusions, was assessed in repair...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bailey SM,Meyne J,Chen DJ,Kurimasa A,Li GC,Lehnert BE,Goodwin EH

更新日期：1999-12-21 00:00:00

abstract：:8-Azido[2-3H]adenine was used as a photoaffinity label for the purine-cytosine transport system. After irradiation in the presence of the photoaffinity label, the cells were converted into protoplasts, their plasma membranes were purified, and the membrane proteins were extracted and separated by NaDodSO4/PAGE. The ra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schmidt R,Manolson MF,Chevallier MR

更新日期：1984-10-01 00:00:00

abstract：:Methods for the construction of ordered nanoscale arrays have been implicated in fields ranging from separation technologies to microelectronics. Yet, despite the plethora of nanoscale structures assembled in nature that use a templating strategy, chemists have been unable to replicate this success. A technology is re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Willis B,Eubanks LM,Wood MR,Janda KD,Dickerson TJ,Lerner RA

更新日期：2008-02-05 00:00:00

abstract：:The understanding of mechanisms controlling zinc absorption and metabolism at the molecular level has advanced recently. Kinetics of zinc transport have been investigated for many years, but only recently have genes coding for proteins thought to be involved in the transport process been cloned. Four putative zinc tra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McMahon RJ,Cousins RJ

更新日期：1998-04-28 00:00:00

abstract：:Explaining the variation between human languages and the constraints on that variation is a core goal of linguistics. In the last 20 y, it has been claimed that many striking universals of cross-linguistic variation follow from a hypothetical principle that dependency length--the distance between syntactically related...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Futrell R,Mahowald K,Gibson E

更新日期：2015-08-18 00:00:00

abstract：:Semaphorin 4D (sema4D; CD100) is an integral membrane protein and the ligand for two receptors, CD72 and plexin-B1. Soluble sema4D has been shown to evoke angiogenic responses from endothelial cells and impair monocyte migration, but the origin of soluble sema4D, particularly at sites of vascular injury, has been uncl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhu L,Bergmeier W,Wu J,Jiang H,Stalker TJ,Cieslak M,Fan R,Boumsell L,Kumanogoh A,Kikutani H,Tamagnone L,Wagner DD,Milla ME,Brass LF

更新日期：2007-01-30 00:00:00

abstract：:Several groups have attempted to develop gene therapy strategies to treat cancer via introduction of the wild-type (wt) p53 cDNA into cancer cells. Unfortunately, these approaches do not result in regulated expression of the p53 gene and do not reduce expression of the mutant p53 that is overexpressed in cancerous cel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Watanabe T,Sullenger BA

更新日期：2000-07-18 00:00:00

abstract：:The enzymes responsible for the oxidation of n-octane to octanoic acid or beyond in Pseudomonas oleovorans are octane inducible and are coded by genes borne on a transmissible extrachromosomal element. The octane to octanoate enzymes induced by octane are repressed by octanol. The chromosome also carries genes coding ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chakrabarty AM,Chou G,Gunsalus IC

更新日期：1973-04-01 00:00:00

abstract：:The effect of different total enzyme concentrations on the flux through the bacterial phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) in vitro was determined by measuring PTS-mediated carbohydrate phosphorylation at different dilutions of cell-free extract of Escherichia coli. The dependence of the fl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rohwer JM,Postma PW,Kholodenko BN,Westerhoff HV

更新日期：1998-09-01 00:00:00

abstract：:An electrophoretic karyotype of Aspergillus nidulans has been obtained using contour-clamped homogeneous electric field gel electrophoresis. Six chromosomal bands were separated, with two of the bands migrating as doublets. Using the Schizosaccharomyces pombe and Saccharomyces cerevisiae chromosomes as size standards,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brody H,Carbon J

更新日期：1989-08-01 00:00:00

abstract：:Mechanical stability in many biological materials is provided by the crosslinking of large structural proteins with gamma-glutamyl-epsilon-lysyl amide bonds. The three-dimensional structure of human recombinant factor XIII (EC 2.3.2.13 zymogen; protein-glutamine:amine gamma-glutamyltransferase a chain), a transglutami...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yee VC,Pedersen LC,Le Trong I,Bishop PD,Stenkamp RE,Teller DC

更新日期：1994-07-19 00:00:00

abstract：:The vaccinia virus early transcription factor (VETF), a heterodimeric protein composed of 82- and 70-kDa subunits, interacts with viral early promoters at both a sequence-specific core region upstream and a sequence-independent region downstream of the RNA start site. To determine the VETF subunit-promoter interaction...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cassetti MA,Moss B

更新日期：1996-07-23 00:00:00