Carbohydrate self-recognition mediates marine sponge cellular adhesion.

abstract：:A transient transfection assay using Drosophila S2 tissue culture cells and WT and mutant Drosophila vnd/NK-2 homeobox cDNAs was used to localize repression and activation domains of vnd/NK-2 homeodomain protein. A repression domain was identified near the N terminus of vnd/NK-2 homeodomain protein (amino acid residue...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stepchenko A,Nirenberg M

更新日期：2004-09-07 00:00:00

abstract：:A recA-independent recombinational event is described which results in insertion of an entire plasmid genome at a unique site of another plasmid, and coincident excision of a precisely defined DNA segment originally present at the point of the insertion. The resulting recombinant molecules subsequently can undergo sit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kopecko DJ,Cohen SN

更新日期：1975-04-01 00:00:00

abstract：:125I-Labeled L-fucose-albumin complex and rat preputial beta-glucuronidase are rapidly cleared from plasma after intravenous infusion. L-Fucose-albumin retards the plasma clearance of beta-glucuronidase whereas D-fucose-albumin is inactive. In vitro, 125I-labeled L-fucose-albumin is taken up into rat or rabbit alveola...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shepherd VL,Lee YC,Schlesinger PH,Stahl PD

更新日期：1981-02-01 00:00:00

abstract：:The spontaneous assembly of proteins into amyloid fibrils is a phenomenon central to many increasingly common and currently incurable human disorders, including Alzheimer's and Parkinson's diseases. Oligomeric species form transiently during this process and not only act as essential intermediates in the assembly of n...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dear AJ,Michaels TCT,Meisl G,Klenerman D,Wu S,Perrett S,Linse S,Dobson CM,Knowles TPJ

更新日期：2020-06-02 00:00:00

abstract：:Members of the platelet-derived growth factor (PDGF) ligand family are known to play important roles in wound healing and fibrotic disease. We show that both transient and stable expression of PDGF-C results in the development of liver fibrosis consisting of the deposition of collagen in a pericellular and perivenular...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Campbell JS,Hughes SD,Gilbertson DG,Palmer TE,Holdren MS,Haran AC,Odell MM,Bauer RL,Ren HP,Haugen HS,Yeh MM,Fausto N

更新日期：2005-03-01 00:00:00

abstract：:Much debate has revolved around the question of whether the mode of evolutionary and ecological turnover in the fossil record of African mammals was continuous or pulsed, and the degree to which faunal turnover tracked changes in global climate. Here, we assembled and analyzed large specimen databases of the fossil re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bibi F,Kiessling W

更新日期：2015-08-25 00:00:00

abstract：:Rift Valley fever (RVF) is a vector-borne viral disease widespread in Africa. The primary cycle involves mosquitoes and wild and domestic ruminant hosts. Humans are usually contaminated after contact with infected ruminants. As many environmental, agricultural, epidemiological, and anthropogenic factors are implicated...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lancelot R,Béral M,Rakotoharinome VM,Andriamandimby SF,Héraud JM,Coste C,Apolloni A,Squarzoni-Diaw C,de La Rocque S,Formenty PB,Bouyer J,Wint GR,Cardinale E

更新日期：2017-01-31 00:00:00

abstract：:The concept of contagion has steadily expanded from its original grounding in epidemic disease to describe a vast array of processes that spread across networks, notably social phenomena such as fads, political opinions, the adoption of new technologies, and financial decisions. Traditional models of social contagion ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ugander J,Backstrom L,Marlow C,Kleinberg J

更新日期：2012-04-17 00:00:00

abstract：:Synechococcus elongatus PCC 7942 is a genetically tractable model cyanobacterium that has been engineered to produce industrially relevant biomolecules and is the best-studied model for a prokaryotic circadian clock. However, the organism is commonly grown in continuous light in the laboratory, and data on metabolic p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Diamond S,Jun D,Rubin BE,Golden SS

更新日期：2015-04-14 00:00:00

abstract：:Type 2 diabetes mellitus (T2DM) is strongly associated with obesity in most, but not all, ethnic groups, suggesting important ethnic differences in disease susceptibility. Although it is clear that insulin resistance plays a major role in the pathogenesis of T2DM and that insulin resistance is strongly associated with...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Petersen KF,Dufour S,Feng J,Befroy D,Dziura J,Dalla Man C,Cobelli C,Shulman GI

更新日期：2006-11-28 00:00:00

abstract：:Indole-3-acetic acid is the major auxin in most plants. In Cruciferae, including Brassicaceae, indole-3-acetic acid is synthesized from indole-3-acetonitrile by nitrilase, after indole-3-acetonitrile is formed from tryptophan via indole-3-acetaldoxime or indole glycosinolates as the intermediate. We cloned and sequenc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kobayashi M,Izui H,Nagasawa T,Yamada H

更新日期：1993-01-01 00:00:00

abstract：:An electrophoretically slow albumin variant was detected with a phenotype frequency of about 1:1000 in Sweden and was also found in a family of Scottish descent from Kaikoura, New Zealand, and in five families in Tradate, Italy. Structural study established that the major variant component was arginyl-albumin, in whic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brennan SO,Arai K,Madison J,Laurell CB,Galliano M,Watkins S,Peach R,Myles T,George P,Putnam FW

更新日期：1990-05-01 00:00:00

abstract：:Humans choose actions based on both habit and planning. Habitual control is computationally frugal but adapts slowly to novel circumstances, whereas planning is computationally expensive but can adapt swiftly. Current research emphasizes the competition between habits and plans for behavioral control, yet many complex...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cushman F,Morris A

更新日期：2015-11-10 00:00:00

abstract：:The identification and targeting of key molecular drivers of melanoma and breast and lung cancer have substantially improved their therapy. However, subtypes of each of these three common, lethal solid tumors lack identified molecular drivers, and are thus not amenable to targeted therapies. Here we show that pleckstr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： de Semir D,Bezrookove V,Nosrati M,Dar AA,Wu C,Shen J,Rieken C,Venkatasubramanian M,Miller JR 3rd,Desprez PY,McAllister S,Soroceanu L,Debs RJ,Salomonis N,Schadendorf D,Cleaver JE,Kashani-Sabet M

更新日期：2018-06-19 00:00:00

abstract：:Significant liquid-structure theory has been used to calculate the transport properties of the alkali metals. Unlike previous calculations, the volume and temperature dependence of the solid-like structure has been taken into consideration. Equations for the potential energy as a function of volume of the alkali metal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hsu CC,Eyring H

更新日期：1972-06-01 00:00:00

abstract：:Bipolar-cell axon terminals receive direct synaptic input from amacrine-cell processes, suggesting a possible pathway for modulation of transmitter release. In retinal slices, bath-applied baclofen, a gamma-aminobutyrate type B (GABAB) receptor agonist, reduced a patch-clamp-recorded L-type calcium channel current in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maguire G,Maple B,Lukasiewicz P,Werblin F

更新日期：1989-12-01 00:00:00

abstract：:A type of heritable cellular change, known as habituation, occurs spontaneously in plant tissue and cell culture. This phenomenon is characterized by a newly acquired capacity of plant cells to produce growth regulatory substances. Using cloned lines of tobacco pith parenchyma cells, we demonstrated that a newly acqui...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Binns A,Meins F

更新日期：1973-09-01 00:00:00

abstract：:The trinucleotide CCA sequence is present at the 3' terminus of all mature tRNAs. Despite this high degree of conservation, we have been able to prepare in vitro transcripts of Escherichia coli tRNA(Val) with altered 3' termini that are readily aminoacylated and can function in polypeptide synthesis. Replacement of th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu M,Horowitz J

更新日期：1994-10-25 00:00:00

abstract：:It has long been recognized that the T-cell compartment has more CD4 helper than CD8 cytotoxic T cells, and this is most evident looking at T-cell development in the thymus. However, it remains unknown how thymocyte development so favors CD4 lineage development. To identify the basis of this asymmetry, we analyzed dev...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sinclair C,Bains I,Yates AJ,Seddon B

更新日期：2013-07-30 00:00:00

abstract：:The role of DNA polymerase alpha (pol alpha) and DNA primase has been investigated in the simian virus 40 (SV40) DNA replication system in vitro. Removal of pol alpha and primase activities from crude extracts of HeLa cells or monkey cells by use of an anti-pol alpha immunoaffinity column resulted in the loss of repli...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murakami Y,Wobbe CR,Weissbach L,Dean FB,Hurwitz J

更新日期：1986-05-01 00:00:00

abstract：:Reinforcement learning models now provide principled guides for a wide range of reward learning experiments in animals and humans. One key learning (error) signal in these models is experiential and reports ongoing temporal differences between expected and experienced reward. However, these same abstract learning mode...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lohrenz T,McCabe K,Camerer CF,Montague PR

更新日期：2007-05-29 00:00:00

abstract：:Cells from the spleens and thymuses of BALB/c mice whose Moloney sarcoma virus (MSV)-induced, primary sarcomas have regressed 2-3 months earlier ("MSV regressors") or are in the process of regressing can, when adoptively transferred to syngeneic mice given MSV at the age of 20 days, prevent the natural regression of t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hellström I,Hellström KE,Bernstein ID

更新日期：1979-10-01 00:00:00

abstract：:Perfusion of rat hearts with Krebs--Henseleit medium containing 10 mM L-leucine methyl ester leads to swelling of lysosomes and loss of lysosomal integrity within 30-60 min. No morphological changes can be detected in the nuclei, mitochondria, sarcoplasmic reticulum, or Golgi complex as a result of the treatment with ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reeves JP,Decker RS,Crie JS,Wildenthal K

更新日期：1981-07-01 00:00:00

abstract：:The conformation of DNA molecules tethered to the surface of a microarray may significantly affect the efficiency of hybridization. Although a number of methods have been applied to determine the structure of the DNA layer, they are not very sensitive to variations in the shape of DNA molecules. Here we describe the a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Moiseev L,Unlü MS,Swan AK,Goldberg BB,Cantor CR

更新日期：2006-02-21 00:00:00

abstract：:Long QT syndrome (LQT) is an autosomal dominant disorder that can cause sudden death from cardiac arrhythmias. We recently discovered that mutations in HERG, a K+-channel gene, cause chromosome 7-linked LQT. Heterologous expression of HERG in Xenopus oocytes revealed that HERG current was similar to a well-characteriz...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sanguinetti MC,Curran ME,Spector PS,Keating MT

更新日期：1996-03-05 00:00:00

abstract：:Stressor exposure biases decision-making strategies from those based on the relationship between actions and their consequences to others restricted by stimulus-response associations. Chronic stressor exposure also desensitizes glucocorticoid receptors (GR) and diminishes motivation to acquire food reinforcement, alth...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gourley SL,Swanson AM,Jacobs AM,Howell JL,Mo M,Dileone RJ,Koleske AJ,Taylor JR

更新日期：2012-12-11 00:00:00

abstract：:The substance P (SP)-preferring receptor neurokinin-1 receptor (NK-1R) has two forms: a full-length receptor consisting of 407 aa and a truncated receptor consisting of 311 aa. These two receptors differ in the length of the C terminus of NK-1R. We studied the undifferentiated and phorbol myristate acetate (PMA)-diffe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lai JP,Ho WZ,Kilpatrick LE,Wang X,Tuluc F,Korchak HM,Douglas SD

更新日期：2006-05-16 00:00:00

abstract：:The transformation of new experiences into lasting memories is thought to be mediated by postencoding reactivation or the reexpression of activity patterns that characterize prior encoding experiences during subsequent offline periods. Although hippocampal reactivation has been well-described in the rodent, evidence f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tambini A,Davachi L

更新日期：2013-11-26 00:00:00

abstract：:Coat components localize to specific membrane domains, where they sort selected transmembrane proteins. To study how clathrin coats are stabilized on such domains and to identify the protein networks involved, we combined proteomic screens and in vitro liposome-based assays that recapitulate the fidelity of protein so...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baust T,Czupalla C,Krause E,Bourel-Bonnet L,Hoflack B

更新日期：2006-02-28 00:00:00

abstract：:An oligoribonucleotide (a 27-mer) that mimics the sarcin/ricin (S/R) domain of Escherichia coli 23S rRNA binds elongation factor EF-G; the Kd is 6.9 microM, whereas for binding to ribosomes it is 0.7 microM. Binding saturates when EF-G and the S/R RNA are equimolar; at saturation 70% of the input RNA is in complexes w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Munishkin A,Wool IG

更新日期：1997-11-11 00:00:00