Full-length and truncated neurokinin-1 receptor expression and function during monocyte/macrophage differentiation.

abstract：:The maintenance of robust blood flow to the brain is crucial to the health of brain tissue. We examined the pial network of the middle cerebral artery, which distributes blood from the cerebral arteries to the penetrating arterioles that source neocortical microvasculature, to characterize how vascular topology may su...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blinder P,Shih AY,Rafie C,Kleinfeld D

更新日期：2010-07-13 00:00:00

abstract：:Lactobacillus acidophilus NCFM is a probiotic bacterium that has been produced commercially since 1972. The complete genome is 1,993,564 nt and devoid of plasmids. The average GC content is 34.71% with 1,864 predicted ORFs, of which 72.5% were functionally classified. Nine phage-related integrases were predicted, but ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Altermann E,Russell WM,Azcarate-Peril MA,Barrangou R,Buck BL,McAuliffe O,Souther N,Dobson A,Duong T,Callanan M,Lick S,Hamrick A,Cano R,Klaenhammer TR

更新日期：2005-03-15 00:00:00

abstract：:EWS (Ewing sarcoma) encodes an RNA/ssDNA binding protein that is frequently rearranged in a number of different cancers by chromosomal translocations. Physiologically, EWS has diverse and essential roles in various organ development and cellular processes. In this study, we uncovered a new role of EWS in mitochondrial...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Park JH,Kang HJ,Lee YK,Kang H,Kim J,Chung JH,Chang JS,McPherron AC,Lee SB

更新日期：2015-05-12 00:00:00

abstract：:High-pressure single-crystal X-ray diffraction method with precise control of hydrostatic conditions, typically with helium or neon as the pressure-transmitting medium, has significantly changed our view on what happens with low-density silica phases under pressure. Coesite is a prototype material for pressure-induced...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu W,Wu X,Liang Y,Liu C,Miranda CR,Scandolo S

更新日期：2017-12-05 00:00:00

abstract：:Mechanical robustness of the cell under different modes of stress and deformation is essential to its survival and function. Under tension, mechanical rigidity is provided by the cytoskeletal network; with increasing stress, this network stiffens, providing increased resistance to deformation. However, a cell must als...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhou EH,Trepat X,Park CY,Lenormand G,Oliver MN,Mijailovich SM,Hardin C,Weitz DA,Butler JP,Fredberg JJ

更新日期：2009-06-30 00:00:00

abstract：:The Millennium Ecosystem Assessment (MA) introduced a new framework for analyzing social-ecological systems that has had wide influence in the policy and scientific communities. Studies after the MA are taking up new challenges in the basic science needed to assess, project, and manage flows of ecosystem services and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carpenter SR,Mooney HA,Agard J,Capistrano D,Defries RS,Díaz S,Dietz T,Duraiappah AK,Oteng-Yeboah A,Pereira HM,Perrings C,Reid WV,Sarukhan J,Scholes RJ,Whyte A

更新日期：2009-02-03 00:00:00

abstract：:Adult stem cells represent unique populations of undifferentiated cells with self-renewal capacity. In many tissues, stem cells divide less often than their progeny. It has been widely speculated, but largely untested, that their undifferentiated and quiescent state may make stem cells more efficient as donors for clo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li J,Greco V,Guasch G,Fuchs E,Mombaerts P

更新日期：2007-02-20 00:00:00

abstract：:Hepatitis C virus (HCV) infects nearly 3% of the population of the world and is a major cause of liver disease. However, the mechanism whereby the virus targets the liver for infection remains unknown, because none of the putative cellular receptors for HCV are both expressed specifically in the liver and capable of b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gardner JP,Durso RJ,Arrigale RR,Donovan GP,Maddon PJ,Dragic T,Olson WC

更新日期：2003-04-15 00:00:00

abstract：:In maturing T lineage cells, the helix-loop-helix protein E47 has been shown to enforce a critical proliferation and developmental checkpoint commonly referred to as beta selection. To examine how E47 regulates cellular expansion and developmental progression, we have used an E2A-deficient lymphoma cell line and DNA m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schwartz R,Engel I,Fallahi-Sichani M,Petrie HT,Murre C

更新日期：2006-06-27 00:00:00

abstract：:Hox5 genes (Hoxa5, Hoxb5, Hoxc5) are exclusively expressed in the lung mesenchyme during embryogenesis, and the most severe phenotypes result from constitutive loss of function of all three genes. Because Hox5 triple null mutants exhibit perinatal lethality, the contribution of this paralogous group to postembryonic l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hrycaj SM,Marty-Santos L,Cebrian C,Rasky AJ,Ptaschinski C,Lukacs NW,Wellik DM

更新日期：2018-11-06 00:00:00

abstract：:Prions are infectious agents which cause rapidly lethal neurodegenerative diseases in humans and animals following long, clinically silent incubation periods. They are composed of multichain assemblies of misfolded cellular prion protein. While it has long been assumed that prions are themselves neurotoxic, recent dev...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Benilova I,Reilly M,Terry C,Wenborn A,Schmidt C,Marinho AT,Risse E,Al-Doujaily H,Wiggins De Oliveira M,Sandberg MK,Wadsworth JDF,Jat PS,Collinge J

更新日期：2020-09-22 00:00:00

abstract：:We consider many-body problems in classical mechanics where a wide range of time scales limits what can be computed. We apply the method of optimal prediction to obtain equations that are easier to solve numerically. We demonstrate by examples that optimal prediction can reduce the amount of computation needed to obta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kast AP

更新日期：2000-06-06 00:00:00

abstract：:Enveloped viruses enter cells via a process of membrane fusion between the viral envelope and a cellular membrane. For influenza virus, mutational data have shown that the membrane-inserted portions of the hemagglutinin protein play a critical role in achieving fusion. In contrast to the relatively well-understood ect...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pabis A,Rawle RJ,Kasson PM

更新日期：2020-03-31 00:00:00

abstract：:During the early evolution of life, 8-oxo-7,8-dihydro-2'-deoxyguanosine (O) may have functioned as a proto-flavin capable of repairing cyclobutane pyrimidine dimers in DNA or RNA by photoinduced electron transfer using longer wavelength UVB radiation. To investigate the ability of O to act as an excited-state electron...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang Y,Dood J,Beckstead AA,Li XB,Nguyen KV,Burrows CJ,Improta R,Kohler B

更新日期：2014-08-12 00:00:00

abstract：:Active immunization using tumor antigen-loaded dendritic cells holds promise for the adjuvant treatment of cancer to eradicate or control residual disease, but so far, most dendritic cell trials have been performed in end-stage cancer patients with high tumor loads. Here, in a phase I/II trial, we investigated the eff...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Van Tendeloo VF,Van de Velde A,Van Driessche A,Cools N,Anguille S,Ladell K,Gostick E,Vermeulen K,Pieters K,Nijs G,Stein B,Smits EL,Schroyens WA,Gadisseur AP,Vrelust I,Jorens PG,Goossens H,de Vries IJ,Price DA,Oji Y

更新日期：2010-08-03 00:00:00

abstract：:The equations of motion of the coupled electron-phonon system are integrated in real time for the model of polyacetylene recently proposed. To illustrate the physical behavior of this nonlinear system we consider the time evolution starting from three physically relevant configurations: (i) end generated soliton, (ii)...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Su WP,Schrieffer JR

更新日期：1980-10-01 00:00:00

abstract：:Coincidence cloning allows the isolation of sequences held in common by two genomic DNA populations. Human DNA from two human-hamster hybrid cell lines was amplified by Alu-repeat primers (Alu PCR) and the products originating from the shared human chromosomal region were cloned. To achieve this, human sequences were ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aslanidis C,de Jong PJ

更新日期：1991-08-01 00:00:00

abstract：:Sugar transport across tonoplasts is essential for maintaining cellular sugar homeostasis and metabolic balance in plant cells. It remains unclear, however, how this process is regulated among different classes of sugar transporters. Here, we identified a tonoplast H+/glucose symporter, MdERDL6-1, from apples, which w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhu L,Li B,Wu L,Li H,Wang Z,Wei X,Ma B,Zhang Y,Ma F,Ruan YL,Li M

更新日期：2021-01-05 00:00:00

abstract：:Sensory receptor neurons match their dynamic range to ecologically relevant stimulus intensities. How this tuning is achieved is poorly understood in most receptors. The roundworm Caenorhabditis elegans avoids 21% O2 and hypoxia and prefers intermediate O2 concentrations. We show how this O2 preference is sculpted by ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oda S,Toyoshima Y,de Bono M

更新日期：2017-06-06 00:00:00

abstract：:Heme oxygenase (decyclizing) [heme,hydrogen-donor:oxygen oxidoreductase (alpha-methene-oxidizing, hydroxylating), EC 1.14.99.3] is greatly induced in the kidney by the administration of nickel or tin. Manganese, when administered simultaneously with nickel or tin in an equimolar amount, substantially inhibited the ind...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Drummond GS,Kappas A

更新日期：1979-10-01 00:00:00

abstract：:Participation of two medial temporal lobe structures, the hippocampal region and the amygdala, in long-term declarative memory encoding was examined by using positron emission tomography of regional cerebral glucose. Positron emission tomography scanning was performed in eight healthy subjects listening passively to a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alkire MT,Haier RJ,Fallon JH,Cahill L

更新日期：1998-11-24 00:00:00

abstract：:Paleoanthropologists and vertebrate paleontologists have for decades debated the etiology of tooth wear and its implications for understanding the diets of human ancestors and other extinct mammals. The debate has recently taken a twist, calling into question the efficacy of dental microwear to reveal diet. Some argue...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xia J,Zheng J,Huang D,Tian ZR,Chen L,Zhou Z,Ungar PS,Qian L

更新日期：2015-08-25 00:00:00

abstract：:The mitochondrial genome of Saccharomyces cerevisiae codes for 24 tRNAs. The nucleotide sequences of the tRNA genes suggest a unique set of rules that govern the decoding of the mitochondrial genetic code. The four codons of unmixed fmilies are recognized by single tRNAs that always have a U in the wobble position of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bonitz SG,Berlani R,Coruzzi G,Li M,Macino G,Nobrega FG,Nobrega MP,Thalenfeld BE,Tzagoloff A

更新日期：1980-06-01 00:00:00

abstract：:Alterations of human chromosome 8p occur frequently in many tumors. We identified a 1.5-Mb common region of allelic loss on 8p22 by allelotype analysis. cDNA selection allowed isolation of several genes, including FEZ1. The predicted Fez1 protein contained a leucine-zipper region with similarity to the DNA-binding dom...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ishii H,Baffa R,Numata SI,Murakumo Y,Rattan S,Inoue H,Mori M,Fidanza V,Alder H,Croce CM

更新日期：1999-03-30 00:00:00

abstract：:We report here the identification of a pollen-specific gene from Zea mays that contains multiple Ser-(Pro)n repeats, the motif found in the cell wall-associated extensins. Sequence analysis reveals that the encoded protein has a putative globular domain at the N terminus and an extensin-like domain at the C terminus. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rubinstein AL,Broadwater AH,Lowrey KB,Bedinger PA

更新日期：1995-04-11 00:00:00

abstract：:Adaptation of photosynthesis in marine environment has been examined in two strains of the green, picoeukaryote Ostreococcus: OTH95, a surface/high-light strain, and RCC809, a deep-sea/low-light strain. Differences between the two strains include changes in the light-harvesting capacity, which is lower in OTH95, and i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cardol P,Bailleul B,Rappaport F,Derelle E,Béal D,Breyton C,Bailey S,Wollman FA,Grossman A,Moreau H,Finazzi G

更新日期：2008-06-03 00:00:00

abstract：:5-enol-Pyruvylshikimate-3-phosphate synthase (EPSP synthase; phosphoenolpyruvate:3-phosphoshikimate 1-carboxyvinyltransferase, EC 2.5.1.19) is an enzyme on the pathway toward the synthesis of aromatic amino acids in plants, fungi, and bacteria and is the target of the broad-spectrum herbicide glyphosate. The three-dim...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stallings WC,Abdel-Meguid SS,Lim LW,Shieh HS,Dayringer HE,Leimgruber NK,Stegeman RA,Anderson KS,Sikorski JA,Padgette SR,Kishore GM

更新日期：1991-06-01 00:00:00

abstract：:Regulation of ion balance in spermatozoa has been shown to be essential for sperm motility and fertility. Control of intracellular ion levels requires the function of distinct ion-transport mechanisms at the cell plasma membrane. Active Na(+) and K(+) exchange in sperm is under the control of the Na,K-ATPase. Two mole...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jimenez T,McDermott JP,Sánchez G,Blanco G

更新日期：2011-01-11 00:00:00

abstract：:Branched polyethylenimine (PEI) chains with an average molecular mass of 2 kDa (PEI2) have been covalently attached to gold nanoparticles (GNPs), and the potency of the resulting PEI2-GNPs conjugates as vectors for the delivery of plasmid DNA into monkey kidney (COS-7) cells in the presence of serum in vitro has been ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thomas M,Klibanov AM

更新日期：2003-08-05 00:00:00

abstract：:Intergroup conflict is a persistent feature of many human societies yet little is known about why individuals participate when doing so imposes a mortality risk. To evaluate whether participation in warfare is associated with reproductive benefits, we present data on participation in small-scale livestock raids among ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Glowacki L,Wrangham R

更新日期：2015-01-13 00:00:00