Modulation of sensory information processing by a neuroglobin in Caenorhabditis elegans.

abstract：:T helper (Th) lymphocytes can develop memory for the expression of particular cytokines, like IL-4 or IL-10, in that reexpression of those cytokines is independent of the original costimulatory signal IL-4 and depends only on T cell receptor stimulation. Here, we show that in the course of Th2 cell differentiation in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Löhning M,Richter A,Stamm T,Hu-Li J,Assenmacher M,Paul WE,Radbruch A

更新日期：2003-10-14 00:00:00

abstract：:Cryptococcus neoformans (CN), an encapsulated, ubiquitous environmental yeast, is pathogenic for humans, primarily those with compromised immune function. CN is believed to be a facultative intracellular pathogen. Time-lapsed video microscopy revealed that yeast began to replicate and divide 2 hours after ingestion by...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tucker SC,Casadevall A

更新日期：2002-03-05 00:00:00

abstract：:Along the evolutionary path from single cells to multicellular organisms with a central nervous system are species of intermediate complexity that move in ways suggesting high-level coordination, yet have none. Instead, organisms of this type possess many autonomous cells endowed with programs that have evolved to ach...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Drescher K,Goldstein RE,Tuval I

更新日期：2010-06-22 00:00:00

abstract：:We have constructed three different fusion genes containing the herpes simplex virus thymidine kinase (HSV tk) and the bacterial neomycin phosphotransferase (neo) genes. All three fusion genes utilize the HSV tk promoter but differ at the junction of their components. We have determined if the fusion genes are bifunct...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schwartz F,Maeda N,Smithies O,Hickey R,Edelmann W,Skoultchi A,Kucherlapati R

更新日期：1991-12-01 00:00:00

abstract：:Newly translated tubulin molecules undergo a series of complex interactions with nascent chain-binding chaperones, including prefoldin (PFD) and chaperonin-containing TCP-1 (CCT). By screening for oryzalin hypersensitivity, we identified several mutants of Arabidopsis that have lesions in PFD subunits. The pfd6-1 muta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gu Y,Deng Z,Paredez AR,DeBolt S,Wang ZY,Somerville C

更新日期：2008-11-18 00:00:00

abstract：:Aggregation of p53 is initiated by first-order processes that generate an aggregation-prone state with parallel pathways of major or partial unfolding. Here, we elaborate the mechanism and explore its consequences, beginning with the core domain and extending to the full-length p53 mutant Y220C. Production of large li...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang G,Fersht AR

更新日期：2012-08-21 00:00:00

abstract：:Marked hypoalphalipoproteinemia was found together with relatively low serum cholesterol, triacylglycerol, and LDL levels in a triose-phosphate isomerase (TPI; D-glyceraldehyde-3-phosphate ketol-isomerase, EC 5.3.1.1)-deficient Hungarian family, especially in the two compound-heterozygote brothers. Apart from a slight...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hollán S,Dey I,Szollár L,Horányi M,Magócsi M,Harsányi V,Farkas T

更新日期：1995-01-03 00:00:00

abstract：:The major obstacle to the study of functional/structural interrelationships of spinach chloroplasts by using spin labels has been the rapid loss of the electron paramagnetic resonance (EPR) signals upon illumination with visible light. The present study demonstrates that the addition of ferredoxin and NADP+ in the pre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sun AS,Calvin M

更新日期：1975-08-01 00:00:00

abstract：:New approaches to the study of early hominin diets have refreshed interest in how and when our diets diverged from those of other African apes. A trend toward significant consumption of C4 foods in hominins after this divergence has emerged as a landmark event in human evolution, with direct evidence provided by stabl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wynn JG,Alemseged Z,Bobe R,Grine FE,Negash EW,Sponheimer M

更新日期：2020-09-08 00:00:00

abstract：:The nucleotide-binding oligomerization domain-containing protein 2 (NOD2) agonist muramyl dipeptide (MDP), a peptidoglycan motif common to all bacteria, supports leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5)+ intestinal stem cell (ISC) survival through NOD2 activation upon an otherwise lethal oxid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levy A,Stedman A,Deutsch E,Donnadieu F,Virgin HW,Sansonetti PJ,Nigro G

更新日期：2020-01-28 00:00:00

abstract：:This paper explores the explanations for, and consequences of, the early appearance of food production outside the Fertile Crescent of Southwest Asia, where it originated in the 10th/9th millennia cal BC. We present evidence that cultivation appeared in Central Anatolia through adoption by indigenous foragers in the m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baird D,Fairbairn A,Jenkins E,Martin L,Middleton C,Pearson J,Asouti E,Edwards Y,Kabukcu C,Mustafaoğlu G,Russell N,Bar-Yosef O,Jacobsen G,Wu X,Baker A,Elliott S

更新日期：2018-04-03 00:00:00

abstract：:Cells contain numerous enzymes that use molecular oxygen for their reactions. Often, their active sites are buried deeply inside the protein, which raises the question whether there are specific access channels guiding oxygen to the site of catalysis. Choosing 12/15-lipoxygenase as a typical example for such oxygen-de...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Saam J,Ivanov I,Walther M,Holzhütter HG,Kuhn H

更新日期：2007-08-14 00:00:00

abstract：:Numerous relatively short regions within intrinsically disordered proteins (IDPs) serve as molecular recognition elements (MoREs). They fold into ordered structures upon binding to their partner molecules. Currently, there is still a lack of in-depth understanding of how coupled binding and folding occurs in MoREs. He...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang Y,Chu X,Longhi S,Roche P,Han W,Wang E,Wang J

更新日期：2013-10-01 00:00:00

abstract：:Five instances of association between distinctive stromatolites and blue-green algal nannofossils are recorded from a 100-m sequence of carbonate rocks about 1.6 x 10(9) years old, along the south side of Paradise Creek, northwestern Queensland, Australia. No eukaryotes were identified in any of these systematically l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Licari GR,Cloud P

更新日期：1972-09-01 00:00:00

abstract：:The release of urine, or micturition, serves a fundamental physiological function and, in many species, is critical for social communication. In mice, the pattern of urine release is modulated by external and internal factors and transmitted to the spinal cord via the pontine micturition center (PMC). Here, we exploit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hyun M,Taranda J,Radeljic G,Miner L,Wang W,Ochandarena N,Huang KW,Osten P,Sabatini BL

更新日期：2021-01-05 00:00:00

abstract：:Absorbance changes in untreated intact leaf discs, produced upon excitation with high-intensity red light, were shown to be due to the photooxidation of cytochrome b-559. At low intensities (<100 W/m2), photooxidation was almost undetectable. Photooxidation occurred with a half-time of 4.3 sec and an extent of 0.64 mo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Canaani O,Havaux M

更新日期：1990-12-01 00:00:00

abstract：:The gene networks underlying closure of the optic fissure during vertebrate eye development are poorly understood. Here, we profile global gene expression during optic fissure closure using laser capture microdissected (LCM) tissue from the margins of the fissure. From these data, we identify a unique role for the C(2...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brown JD,Dutta S,Bharti K,Bonner RF,Munson PJ,Dawid IB,Akhtar AL,Onojafe IF,Alur RP,Gross JM,Hejtmancik JF,Jiao X,Chan WY,Brooks BP

更新日期：2009-02-03 00:00:00

abstract：:To determine the importance of the thrombin substrate recognition exosite for fibrinogen binding in the formation of both arterial and venous thrombi, we evaluated the antithrombotic effects of the tyrosine-sulfated dodecapeptide from residues 53-64 of hirudin (H peptide) in a nonhuman primate model. This peptide was ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cadroy Y,Maraganore JM,Hanson SR,Harker LA

更新日期：1991-02-15 00:00:00

abstract：:Gradients of extracellular signaling molecules and transcription factors are used in a variety of developmental processes, including the patterning of the Drosophila embryo, the establishment of diverse neuronal cell types in the vertebrate neural tube, and the anterior-posterior patterning of vertebrate limbs. Here, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hong JW,Hendrix DA,Papatsenko D,Levine MS

更新日期：2008-12-23 00:00:00

abstract：:The analysis of human whole-genome sequencing data presents significant computational challenges. The sheer size of datasets places an enormous burden on computational, disk array, and network resources. Here, we present an integrated computational package, PEMapper/PECaller, that was designed specifically to minimize...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Johnston HR,Chopra P,Wingo TS,Patel V,International Consortium on Brain and Behavior in 22q11.2 Deletion Syndrome.,Epstein MP,Mulle JG,Warren ST,Zwick ME,Cutler DJ

更新日期：2017-03-07 00:00:00

abstract：:As root symbionts of cycad trees, cyanobacteria of the genus Nostoc produce beta-methylamino-l-alanine (BMAA), a neurotoxic nonprotein amino acid. The biomagnification of BMAA through the Guam ecosystem fits a classic triangle of increasing concentrations of toxic compounds up the food chain. However, because BMAA is ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murch SJ,Cox PA,Banack SA

更新日期：2004-08-17 00:00:00

abstract：:Development of spatial patterns in multicellular organisms depends on gradients in the concentration of signaling molecules that control gene expression. In the Drosophila embryo, Bicoid (Bcd) morphogen controls cell fate along 70% of the anteroposterior axis but is translated from mRNA localized at the anterior pole....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gregor T,Bialek W,de Ruyter van Steveninck RR,Tank DW,Wieschaus EF

更新日期：2005-12-20 00:00:00

abstract：:Real-time visualization of intracellular calcium concentration ([Ca2+]i) changes in mammalian Purkinje cells in vitro, utilizing the dye Fura-2, indicates that calcium action potentials are generated in the dendritic tree and follow a particular activation sequence. During spontaneous oscillations or after direct curr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sugimori M,Llinás RR

更新日期：1990-07-01 00:00:00

abstract：:Chemical modifications of RNAs have long been established as key modulators of nonprotein-coding RNA structure and function in cells. There is a growing appreciation that messenger RNA (mRNA) sequences responsible for directing protein synthesis can also be posttranscriptionally modified. The enzymatic incorporation o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eyler DE,Franco MK,Batool Z,Wu MZ,Dubuke ML,Dobosz-Bartoszek M,Jones JD,Polikanov YS,Roy B,Koutmou KS

更新日期：2019-11-12 00:00:00

abstract：:The MARCKS protein is a widely distributed cellular substrate for protein kinase C. It is a myristoylprotein that binds calmodulin and actin in a manner reversible by protein kinase C-dependent phosphorylation. It is also highly expressed in nervous tissue, particularly during development. To evaluate a possible devel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stumpo DJ,Bock CB,Tuttle JS,Blackshear PJ

更新日期：1995-02-14 00:00:00

abstract：:We have compared the process of prophage lambda induction with that of prophage Mu. According to the Campbell model, rescue of lambda DNA from the host DNA involves reversal of lambda integration such that the prophage DNA is excised from the host chromosome. We have monitored this event by locating the prophage DNA w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ljungquist E,Bukhari AI

更新日期：1977-08-01 00:00:00

abstract：:Inward rectifying potassium (Kir) channels participate in regulating potassium concentration (K(+)) in the central nervous system (CNS), including in the retina. We explored the contribution of Kir channels to retinal function by delivering Kir antibodies (Kir-Abs) into the rat eye in vivo to interrupt channel activit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Raz-Prag D,Grimes WN,Fariss RN,Vijayasarathy C,Campos MM,Bush RA,Diamond JS,Sieving PA

更新日期：2010-07-13 00:00:00

abstract：:Peptide ligand selection by MHC class I molecules, which occurs by iterative optimization, is the centerpiece of immunodominance in antiviral and antitumor immune responses. For its understanding, the molecular mechanisms of peptide binding and dissociation by class I molecules must be elucidated. To this end, we have...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Saini SK,Schuster H,Ramnarayan VR,Rammensee HG,Stevanović S,Springer S

更新日期：2015-01-06 00:00:00

abstract：:Many newly synthesized proteins have to become unfolded during translocation across biological membranes. We have analyzed the effects of various stabilization/destabilization mutations in the Ig-like module of the muscle protein titin upon its import from the N terminus or C terminus into mitochondria. The effects of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sato T,Esaki M,Fernandez JM,Endo T

更新日期：2005-12-13 00:00:00

abstract：:We have constructed yeast strains that secrete functional mouse-human chimeric antibody and its Fab fragment into the culture medium. For chimeric whole antibody, cDNA copies of the chimeric light-chain and heavy-chain genes of an anti-tumor antibody were inserted into vectors containing the yeast phosphoglycerate kin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Horwitz AH,Chang CP,Better M,Hellstrom KE,Robinson RR

更新日期：1988-11-01 00:00:00