Fidelity of adaptive phototaxis.

abstract：:It has been shown previously that the binding of oxidized low-density lipoprotein (OxLDL) to resident mouse peritoneal macrophages can be inhibited (up to 70%) by the apoprotein B (apoB) isolated from OxLDL, suggesting that macrophage recognition of OxLDL is primarily dependent on its modified protein moiety. However,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bird DA,Gillotte KL,Hörkkö S,Friedman P,Dennis EA,Witztum JL,Steinberg D

更新日期：1999-05-25 00:00:00

abstract：:We have screened a large number of isolated human genomic clones that hybridize to a cloned HLA cDNA probe for their ability to direct the synthesis of HLA-A, -B, and -C surface antigens on mouse L cells following DNA-mediated gene transfer. The surface expression of human histocompatibility antigens, monitored by ind...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barbosa JA,Kamarck ME,Biro PA,Weissman SM,Ruddle FH

更新日期：1982-10-01 00:00:00

abstract：:Collective intelligence refers to the ability of groups to outperform individual decision makers when solving complex cognitive problems. Despite its potential to revolutionize decision making in a wide range of domains, including medical, economic, and political decision making, at present, little is known about the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kurvers RH,Herzog SM,Hertwig R,Krause J,Carney PA,Bogart A,Argenziano G,Zalaudek I,Wolf M

更新日期：2016-08-02 00:00:00

abstract：:Differential rates of AIDS development and/or T4 lymphocyte depletion in HIV-1-infected individuals remain unexplained. The hypothesis that qualitative differences in selection pressure in vivo may account for different rates of disease progression was addressed in nine eligible study participants from a cohort of 315...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang WK,Essex M,McLane MF,Mayer KH,Hsieh CC,Brumblay HG,Seage G,Lee TH

更新日期：1996-06-25 00:00:00

abstract：:Endothelial heterogeneity has important implications in health and disease. Molecular markers selectively expressed in the vasculature of different organs and tissues are currently being explored in targeted therapies with promising results in preclinical and clinical studies. Noteworthy is the role that combinatorial...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tang FHF,Staquicini FI,Teixeira AAR,Michaloski JS,Namiyama GM,Taniwaki NN,Setubal JC,da Silva AM,Sidman RL,Pasqualini R,Arap W,Giordano RJ

更新日期：2019-02-05 00:00:00

abstract：:The S100A8/S100A9 heterodimer calprotectin (CP) functions in the host response to pathogens through a mechanism termed "nutritional immunity." CP binds Mn(2+) and Zn(2+) with high affinity and starves bacteria of these essential nutrients. Combining biophysical, structural, and microbiological analysis, we identified ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Damo SM,Kehl-Fie TE,Sugitani N,Holt ME,Rathi S,Murphy WJ,Zhang Y,Betz C,Hench L,Fritz G,Skaar EP,Chazin WJ

更新日期：2013-03-05 00:00:00

abstract：:Fatty acid compositions of phospholipids of heart, liver, kidney, aorta, and serum from rats having streptozotocin-induced diabetes were determined and compared with those of nondiabetic controls. Linoleic and dihomo-gamma-linolenic acids were increased whereas arachidonic acid was decreased in most tissues, suggestin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Holman RT,Johnson SB,Gerrard JM,Mauer SM,Kupcho-Sandberg S,Brown DM

更新日期：1983-04-01 00:00:00

abstract：:Cells within a genetically identical population exhibit phenotypic variation that in some cases can persist across multiple generations. However, information about the temporal variation and familial dependence of protein levels remains hidden when studying the population as an ensemble. To correlate phenotypes with t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rowat AC,Bird JC,Agresti JJ,Rando OJ,Weitz DA

更新日期：2009-10-27 00:00:00

abstract：:We have isolated two cDNA clones, NaPi-2 and NaPi-3, by screening rat kidney cortex and human kidney cortex cDNA libraries, respectively, for expression of sodium-dependent phosphate transport in Xenopus laevis oocytes. Substrate specificity and a detailed kinetic analysis (Na, Pi, H+ concentrations) suggested that ex...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Magagnin S,Werner A,Markovich D,Sorribas V,Stange G,Biber J,Murer H

更新日期：1993-07-01 00:00:00

abstract：:Nonsteroidal antiinflammatory drugs reduce the risk of colon cancer, possibly via cyclooxygenase (COX) inhibition. The growth factor-inducible COX-2, which is overexpressed in neoplastic colonic tissue, is an attractive target to mediate this effect. Herein we have exploited the ability of a human colon cancer cell li...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Coffey RJ,Hawkey CJ,Damstrup L,Graves-Deal R,Daniel VC,Dempsey PJ,Chinery R,Kirkland SC,DuBois RN,Jetton TL,Morrow JD

更新日期：1997-01-21 00:00:00

abstract：:This paper reports the results of a large-scale field experiment designed to test the hypothesis that group membership can increase participation and prosocial lending for an online crowdlending community, Kiva. The experiment uses variations on a simple email manipulation to encourage Kiva members to join a lending t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ai W,Chen R,Chen Y,Mei Q,Phillips W

更新日期：2016-12-27 00:00:00

abstract：:It is shown that, under certain standard assumptions, such as extended Riemann hypotheses, the scattering matrix varphi(s) for generic Gamma

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Deshouillers JM,Iwaniec H,Phillips RS,Sarnak P

更新日期：1985-06-01 00:00:00

abstract：:Melittin messenger RNA from queen bee venom glands has been translated in a cell-free system from wheat germ. A product larger than promelittin is formed which has the carboxy-terminal sequence-Gln-Gln-GlyCOOH. Melittin and promelittin from venom glands terminate in -Gln-GlnCONH2. The possible role of the extra glycin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Suchanek G,Kreil G

更新日期：1977-03-01 00:00:00

abstract：:Release of formylmethionine from the reticulocyte ribosomal substrate, f[(3)H]Met-tRNA.ribosome, is promoted by reticulocyte release factor (RF). The initial rate of this reaction is stimulated by GTP but inhibited by GDPCP. Formation of an RF.UA[(3)H]A(2).ribosome complex is a measure of the binding of reticulocyte R...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tate WP,Beaudet AL,Caskey CT

更新日期：1973-08-01 00:00:00

abstract：:MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) are protein-serine/threonine kinases that are activated by ERK or p38 and phosphorylate eIF4E, which is involved in cap-dependent translation initiation. However, Mnk1/2 double knockout (Mnk-DKO) mice show normal cell growth and development despite an absence of eI...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ueda T,Sasaki M,Elia AJ,Chio II,Hamada K,Fukunaga R,Mak TW

更新日期：2010-08-10 00:00:00

abstract：:The prognosis for adults with precursor B-cell acute lymphoblastic leukemia (B-ALL) remains poor, in part from a lack of therapeutic targets. We identified the type I cytokine receptor subunit CRLF2 in a functional screen for B-ALL-derived mRNA transcripts that can substitute for IL3 signaling. We demonstrate that CRL...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yoda A,Yoda Y,Chiaretti S,Bar-Natan M,Mani K,Rodig SJ,West N,Xiao Y,Brown JR,Mitsiades C,Sattler M,Kutok JL,DeAngelo DJ,Wadleigh M,Piciocchi A,Dal Cin P,Bradner JE,Griffin JD,Anderson KC,Stone RM,Ritz J,Foà R,

更新日期：2010-01-05 00:00:00

abstract：:Two features make the tooth an excellent model in the study of evolutionary innovations: the relative simplicity of its structure and the fact that the major tooth-forming genes have been identified in eutherian mammals. To understand the nature of the innovation at the molecular level, it is necessary to identify the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Toyosawa S,O'hUigin C,Figueroa F,Tichy H,Klein J

更新日期：1998-10-27 00:00:00

abstract：:A set of at least 30 proteins disappears from the two-dimensional electrophoretic pattern of human lymphoid cells treated with various antimitochondrial agents. This set is similar to the set of proteins found in isolated mitochondria (except for the presence of action in the latter group), indicating that the inhibit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Anderson L

更新日期：1981-04-01 00:00:00

abstract：:Aposematic coloration, or warning coloration, is a visual signal that acts to minimize contact between predator and unprofitable prey. The conditions favoring the evolution of aposematic coloration remain largely unidentified. Recent work suggests that diet specialization and resultant toxicity may play a role in faci...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Prudic KL,Oliver JC,Sperling FA

更新日期：2007-12-04 00:00:00

abstract：:Cell variants resistant to the cytotoxic effect of mycophenolic acid, an inhibitor of IMP dehydrogenase (IMP:NAD+ oxidoreductase, EC 1.2.1.14), were selected by a one-step procedure from Chinese hamster V79 cells. The frequency of these variants was increased in a dose-dependent manner after treatment with the mutagen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huberman E,McKeown CK,Friedman J

更新日期：1981-05-01 00:00:00

abstract：:Covariance analysis of protein sequence alignments uses coevolving pairs of sequence positions to predict features of protein structure and function. However, current methods ignore the phylogenetic relationships between sequences, potentially corrupting the identification of covarying positions. Here, we use random m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Qin C,Colwell LJ

更新日期：2018-01-23 00:00:00

abstract：:Regulation of translation is critical for maintaining cellular protein levels, and thus protein homeostasis. The conserved RNA-binding protein CsrA (also called RsmA; for carbon storage regulator and regulator of secondary metabolism, respectively; hereafter called CsrA) represents a well-characterized example of regu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Altegoer F,Rensing SA,Bange G

更新日期：2016-09-06 00:00:00

abstract：:We reported in previous studies that prostaglandin E2 (PGE2) has central effects of augmenting wakefulness and suppressing slow-wave sleep (SWS) and paradoxical sleep (PS) in rats. In the present study, we tested the effect of AH 6809, an antagonist of PGE2 receptors, on sleep-wake activities. AH 6809 in saline was in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Matsumura H,Honda K,Choi WS,Inoué S,Sakai T,Hayaishi O

更新日期：1989-07-01 00:00:00

abstract：:In vitro tests for predicting the response of tumors to chemotherapeutic agents might be improved if they were modified to take into account tumor-cell heterogeneity. We have studied the heterogeneity of cellular growth rate and drug response in mouse fibroblast NIH 3T3 cells and in NIH 3T3 cells transformed with the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kuczek T,Axelrod DE

更新日期：1987-07-01 00:00:00

abstract：:Treatment of quiescent cultures of mouse embryo-derived AKR-2B cells with transforming growth factor beta resulted in an early induction of c-sis mRNA. The increase in c-sis mRNA was followed by a corresponding increase in protein similar to platelet-derived growth factor (PDGF) in the culture medium. In addition, PDG...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leof EB,Proper JA,Goustin AS,Shipley GD,DiCorleto PE,Moses HL

更新日期：1986-04-01 00:00:00

abstract：:Immediate postretrieval bilateral blockade of long-acting voltage-dependent calcium channels (L-VDCCs), but not of glutamatergic NMDA receptors, in the dorsal CA1 region of the hippocampus hinders retention of long-term spatial memory in the Morris water maze. Immediate postretrieval bilateral inhibition of calcium/ca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Da Silva WC,Cardoso G,Bonini JS,Benetti F,Izquierdo I

更新日期：2013-04-16 00:00:00

abstract：:In eukaryotes, RNA polymerase I transcription is controlled by DNA elements located within the spacers that separate the tandemly arranged rRNA genes. Unlike rRNA coding sequences, the intergenic spacers evolve rapidly and have little sequence similarity even among closely related species. Nonetheless, the arrangement...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Doelling JH,Gaudino RJ,Pikaard CS

更新日期：1993-08-15 00:00:00

abstract：:Recent reports on the dystrophic mouse mutant suggest that the prominent extracellular matrix component of peripheral nerve tissues plays an important role in peripheral nerve development. We have examined the disposition of two prominent extracellular matrix components, fibronectin and laminin, both in mature periphe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cornbrooks CJ,Carey DJ,McDonald JA,Timpl R,Bunge RP

更新日期：1983-06-01 00:00:00

abstract：:Understanding how electric fields and their fluctuations in the active site of enzymes affect efficient catalysis represents a critical objective of biochemical research. We have directly measured the dynamics of the electric field in the active site of a highly proficient enzyme, Δ(5)-3-ketosteroid isomerase (KSI), i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jha SK,Ji M,Gaffney KJ,Boxer SG

更新日期：2011-10-04 00:00:00

abstract：:HIV type 1 (HIV-1) uses the chemokine receptors CCR5 and CXCR4 as coreceptors for entry into target cells. Here we show that the HIV-1 envelope gp120 (Env) activates multiple ionic signaling responses in primary human macrophages, which are important targets for HIV-1 in vivo. Env from both CCR5-dependent JRFL (R5) an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu QH,Williams DA,McManus C,Baribaud F,Doms RW,Schols D,De Clercq E,Kotlikoff MI,Collman RG,Freedman BD

更新日期：2000-04-25 00:00:00