Influence of guanine nucleotides and elongation factors on interaction of release factors with the ribosome.

abstract：:The in vivo biological activities of IgG antibodies result from their bifunctional nature, in which antigen recognition by the Fab is coupled to the effector and immunomodulatory diversity found in the Fc domain. This diversity, resulting from both amino acid and glycan heterogeneity, is translated into cellular respo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith P,DiLillo DJ,Bournazos S,Li F,Ravetch JV

更新日期：2012-04-17 00:00:00

abstract：:Gold nanoparticles quench the fluorescence of cationic polyfluorene with Stern-Volmer constants (KSV) approaching 1011 M-1, several orders of magnitude larger than any previously reported conjugated polymer-quencher pair and 9-10 orders of magnitude larger than small molecule dye-quencher pairs. The dependence of KSV ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fan C,Wang S,Hong JW,Bazan GC,Plaxco KW,Heeger AJ

更新日期：2003-05-27 00:00:00

abstract：:The HER2 gene encodes a cell-surface glycoprotein with extensive homology to the epidermal growth factor receptor. Recently it was found to be amplified in about 30% of primary human breast malignancies. In experiments designed to assess the role of the HER2 gene in oncogenesis, we found that overexpression of unalter...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hudziak RM,Schlessinger J,Ullrich A

更新日期：1987-10-01 00:00:00

abstract：:Immune-mediated pulmonary diseases are a significant public health concern. Analysis of leukocyte behavior in the lung is essential for understanding cellular mechanisms that contribute to normal and diseased states. Here, we used two-photon imaging to study neutrophil extravasation from pulmonary vessels and subseque...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kreisel D,Nava RG,Li W,Zinselmeyer BH,Wang B,Lai J,Pless R,Gelman AE,Krupnick AS,Miller MJ

更新日期：2010-10-19 00:00:00

abstract：:Cactus, a Drosophila homologue of I kappa B, binds to and inhibits Dorsal, a homologue of the p50 and p65 components of NF-kappa B. We describe experiments in yeast with various Dorsal and Cactus derivatives showing that Cactus blocks the DNA binding and nuclear localization functions of Dorsal. In contrast, Dorsal's ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lehming N,McGuire S,Brickman JM,Ptashne M

更新日期：1995-10-24 00:00:00

abstract：:Observations with the image tube scanner at the Shane 3-m telescope are combined with data obtained with the International Ultraviolet Explorer to assess the spectrum of the remarkable high-excitation planetary nebula NGC 6537. We have analyzed the spectrum of this nitrogen-rich object with the aid of the theoretical ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Feibelman W,Aller LH,Keyes CD,Czyzak SJ

更新日期：1985-04-01 00:00:00

abstract：:The kinetics of the reduction of horseheart ferricytochrome c by sodium dithionite (phosphate buffer-sodium chloride; pH 6.5, mu = 1.0, 25 degrees ) features two reaction pathways; one with the rate constant k(3) = 1.17 x 10(4) M(-1) sec(-1), the other with the rate constant k(1)k(2)/k(-1) = 6.0 x 10(4) M(-1) sec(-1)....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Creutz C,Sutin N

更新日期：1973-06-01 00:00:00

abstract：:The yeast genome becomes unstable during stress, which often results in adaptive aneuploidy, allowing rapid activation of protective mechanisms that restore cellular homeostasis. In this study, we performed a genetic screen in Saccharomyces cerevisiae to identify genome adaptations that confer resistance to tunicamyci...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Beaupere C,Dinatto L,Wasko BM,Chen RB,VanValkenburg L,Kiflezghi MG,Lee MB,Promislow DEL,Dang W,Kaeberlein M,Labunskyy VM

更新日期：2018-09-18 00:00:00

abstract：:The biological roles of estrogen-responsive finger protein (efp) in vivo were evaluated in mice carrying a loss-of-function mutation in efp by gene-targeted mutagenesis. Although efp homozygous mice were viable and fertile in both sexes, the uterus that expressed abundant estrogen receptor alpha exhibited significant ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Orimo A,Inoue S,Minowa O,Tominaga N,Tomioka Y,Sato M,Kuno J,Hiroi H,Shimizu Y,Suzuki M,Noda T,Muramatsu M

更新日期：1999-10-12 00:00:00

abstract：:Heat-shock factor 1 (HSF1) is the master transcriptional regulator of the cellular response to heat and a wide variety of other stressors. We previously reported that HSF1 promotes the survival and proliferation of malignant cells. At this time, however, the clinical and prognostic significance of HSF1 in cancer is un...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Santagata S,Hu R,Lin NU,Mendillo ML,Collins LC,Hankinson SE,Schnitt SJ,Whitesell L,Tamimi RM,Lindquist S,Ince TA

更新日期：2011-11-08 00:00:00

abstract：:ApcMin (Min, multiple intestinal neoplasia) is a point mutation in the murine homolog of the APC gene. Min/+ mice develop multiple intestinal adenomas, as do humans carrying germ-line mutations in APC. Female mice carrying Min are also prone to develop mammary tumors. Min/+ mammary glands are more sensitive to chemica...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Moser AR,Mattes EM,Dove WF,Lindstrom MJ,Haag JD,Gould MN

更新日期：1993-10-01 00:00:00

abstract：:The c-myc protooncogene has been implicated in control of growth and differentiation of mammalian cells. For instance, growth arrest is often preceded by reduction in c-myc mRNA and gene transcription. To elucidate the mechanisms of control of c-myc gene transcription, we have begun to characterize the interaction of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Duyao MP,Buckler AJ,Sonenshein GE

更新日期：1990-06-01 00:00:00

abstract：:Tripartite motif 39 (Trim39) is a RING domain-containing E3 ubiquitin ligase able to inhibit the anaphase-promoting complex (APC/C) directly. Through analysis of Trim39 function in p53-positive and p53-negative cells, we have found, surprisingly, that p53-positive cells lacking Trim39 could not traverse the G1/S trans...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang L,Huang NJ,Chen C,Tang W,Kornbluth S

更新日期：2012-12-18 00:00:00

abstract：:A genomic clone containing two linked human pregnancy-specific beta 1-glycoprotein (PS beta G) genes has been isolated and characterized. The two genes are arranged in the same 5'----3' orientation; the 3' region (including the A2 and B-C exons) of the upstream gene, PSGGA, is linked to the 5' region (including the 5'...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leslie KK,Watanabe S,Lei KJ,Chou DY,Plouzek CA,Deng HC,Torres J,Chou JY

更新日期：1990-08-01 00:00:00

abstract：:We report a signal-on, electronic DNA (E-DNA) sensor that is label-free and achieves a subpicomolar detection limit. The sensor, which is based on a target-induced strand displacement mechanism, is composed of a "capture probe" attached by its 5' terminus to a gold electrode and a 5' methylene blue-modified "signaling...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xiao Y,Lubin AA,Baker BR,Plaxco KW,Heeger AJ

更新日期：2006-11-07 00:00:00

abstract：:Behavioral models indicate that persistent small afferent input, as generated by tissue injury, results in a hyperalgesia at the site of injury and a tactile allodynia in areas adjacent to the injury site. Hyperalgesia reflects a sensitization of the peripheral terminal and a central facilitation evoked by the persist...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yaksh TL,Hua XY,Kalcheva I,Nozaki-Taguchi N,Marsala M

更新日期：1999-07-06 00:00:00

abstract：:Competing interpretations of human origins and evolution have recently proliferated despite the accelerated pace of fossil discovery. These controversies parallel those involving other vertebrate families and result from the difficulty of studying evolution among closely related species. Recent advances in development...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hlusko LJ

更新日期：2004-03-02 00:00:00

abstract：:The calcium-activated K(+) channel KCa3.1 plays an important role in T lymphocyte Ca(2+) signaling by helping to maintain a negative membrane potential, which provides an electrochemical gradient to drive Ca(2+) influx. To assess the role of KCa3.1 channels in lymphocyte activation in vivo, we studied T cell function ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Di L,Srivastava S,Zhdanova O,Ding Y,Li Z,Wulff H,Lafaille M,Skolnik EY

更新日期：2010-01-26 00:00:00

abstract：:Wild and managed bees are well documented as effective pollinators of global crops of economic importance. However, the contributions by pollinators other than bees have been little explored despite their potential to contribute to crop production and stability in the face of environmental change. Non-bee pollinators ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rader R,Bartomeus I,Garibaldi LA,Garratt MP,Howlett BG,Winfree R,Cunningham SA,Mayfield MM,Arthur AD,Andersson GK,Bommarco R,Brittain C,Carvalheiro LG,Chacoff NP,Entling MH,Foully B,Freitas BM,Gemmill-Herren B,Ghazoul

更新日期：2016-01-05 00:00:00

abstract：:We argue that folding of the compact domains of proteins can occur with adequate rapidity in the absence of a unique directed mechanism, provided that native-like local structure dominates the folding process. We further suggest that the evolution of amino acid sequences should favor multiple paths to the folded state...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harrison SC,Durbin R

更新日期：1985-06-01 00:00:00

abstract：:The N-terminal arginine-rich motif of phage HK022 Nun protein binds to NUT sequences in phage lambda nascent transcripts and induces transcription termination. Interactions between the Nun C terminus and RNA polymerase as well as the DNA template are required for termination. We have isolated Nun C-terminal point and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim HC,Zhou JG,Wilson HR,Mogilnitskiy G,Court DL,Gottesman ME

更新日期：2003-04-29 00:00:00

abstract：:Under typical conditions, medial prefrontal cortex (mPFC) connections with the amygdala are immature during childhood and become adult-like during adolescence. Rodent models show that maternal deprivation accelerates this development, prompting examination of human amygdala-mPFC phenotypes following maternal deprivati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gee DG,Gabard-Durnam LJ,Flannery J,Goff B,Humphreys KL,Telzer EH,Hare TA,Bookheimer SY,Tottenham N

更新日期：2013-09-24 00:00:00

abstract：:Cytosine methylation at CpG dinucleotides contributes to the epigenetic maintenance of gene silencing. Dynamic reprogramming of DNA methylation patterns is believed to play a key role during development and differentiation in vertebrates. The mechanisms of DNA demethylation remain unclear and controversial. Here, we p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kress C,Thomassin H,Grange T

更新日期：2006-07-25 00:00:00

abstract：:Nitrogen trifluoride (NF(3)) has potential to make a growing contribution to the Earth's radiative budget; however, our understanding of its atmospheric burden and emission rates has been limited. Based on a revision of our previous calibration and using an expanded set of atmospheric measurements together with an atm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arnold T,Harth CM,Mühle J,Manning AJ,Salameh PK,Kim J,Ivy DJ,Steele LP,Petrenko VV,Severinghaus JP,Baggenstos D,Weiss RF

更新日期：2013-02-05 00:00:00

abstract：:The gene encoding the glycolytic enzyme triose-phosphate isomerase (TPI; EC 5.3.1.1) has been central to the long-standing controversy on the origin and evolutionary significance of spliceosomal introns by virtue of its pivotal support for the introns-early view, or exon theory of genes. Putative correlations between ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Logsdon JM Jr,Tyshenko MG,Dixon C,D-Jafari J,Walker VK,Palmer JD

更新日期：1995-08-29 00:00:00

abstract：:During response of budding yeast to peptide mating pheromone, the cell becomes markedly polarized and MAPK scaffold protein Ste5 localizes to the resulting projection (shmoo tip). We demonstrated before that this recruitment is essential for sustained MAPK signaling and requires interaction of a pleckstrin homology (P...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Garrenton LS,Stefan CJ,McMurray MA,Emr SD,Thorner J

更新日期：2010-06-29 00:00:00

abstract：:We report the direct measurement of thermodynamic properties of colloidal hard spheres by optical microscopy. By using confocal microscopy, we obtain three-dimensional snapshots of a colloidal hard-sphere suspension over a wide range of densities. From these snapshots, the available volume to insert an additional sphe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dullens RP,Aarts DG,Kegel WK

更新日期：2006-01-17 00:00:00

abstract：:Cells are exposed to changes in extracellular stimulus concentration that vary as a function of rate. However, how cells integrate information conveyed from stimulation rate along with concentration remains poorly understood. Here, we examined how varying the rate of stress application alters budding yeast mitogen-act...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Johnson AN,Li G,Jashnsaz H,Thiemicke A,Kesler BK,Rogers DC,Neuert G

更新日期：2021-01-12 00:00:00

abstract：:Endothelial cells (EC) play a central role in inflammatory immune responses and efficiently induce effector functions in T cells, despite lacking the classical costimulatory ligands CD80 and CD86. By using the mAb HIL-131 we now demonstrate that human inducible costimulator-ligand (ICOS-L), a molecule related to CD80/...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Khayyamian S,Hutloff A,Büchner K,Gräfe M,Henn V,Kroczek RA,Mages HW

更新日期：2002-04-30 00:00:00

abstract：:The ATP-binding cassette (ABC) transporter of mitochondria (Atm1) mediates iron homeostasis in eukaryotes, while the prokaryotic homolog from Novosphingobium aromaticivorans (NaAtm1) can export glutathione derivatives and confer protection against heavy-metal toxicity. To establish the structural framework underlying ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fan C,Kaiser JT,Rees DC

更新日期：2020-08-11 00:00:00